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Aliases for MGRN1 Gene

Aliases for MGRN1 Gene

  • Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase 2 3
  • Mahogunin RING Finger Protein 1 3 4
  • Mahogunin, Ring Finger 1 2 3
  • RING Finger Protein 156 3 4
  • KIAA0544 4 6
  • RNF156 3 4
  • Probable E3 Ubiquitin-Protein Ligase MGRN1 3
  • E3 Ubiquitin-Protein Ligase MGRN1 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for MGRN1 Gene

Previous GeneCards Identifiers for MGRN1 Gene

  • GC16P004708
  • GC16P004675
  • GC16P004614
  • GC16P004674

Summaries for MGRN1 Gene

Entrez Gene Summary for MGRN1 Gene

  • Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]

GeneCards Summary for MGRN1 Gene

MGRN1 (Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF157.

UniProtKB/Swiss-Prot for MGRN1 Gene

  • E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGRN1 Gene

Genomics for MGRN1 Gene

Regulatory Elements for MGRN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGRN1 Gene

Start:
4,616,493 bp from pter
End:
4,690,974 bp from pter
Size:
74,482 bases
Orientation:
Plus strand

Genomic View for MGRN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGRN1 Gene

Proteins for MGRN1 Gene

  • Protein details for MGRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60291-MGRN1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MGRN1
    Protein Accession:
    O60291
    Secondary Accessions:
    • A4URL3
    • A4URL4
    • Q86W76

    Protein attributes for MGRN1 Gene

    Size:
    552 amino acids
    Molecular mass:
    60753 Da
    Quaternary structure:
    • Interacts with MC1R and MC4R, but not with TBXA2R. Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity).
    SequenceCaution:
    • Sequence=BAA25470.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MGRN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGRN1 Gene

Proteomics data for MGRN1 Gene at MOPED

Post-translational modifications for MGRN1 Gene

Antibody Products

Domains for MGRN1 Gene

Gene Families for MGRN1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for MGRN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MGRN1 Gene

Graphical View of Domain Structure for InterPro Entry

O60291

UniProtKB/Swiss-Prot:

MGRN1_HUMAN :
  • O60291
Domain:
  • The RING finger is required for ubiquitin ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MGRN1: view

Function for MGRN1 Gene

Molecular function for MGRN1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.

Enzyme Numbers (IUBMB) for MGRN1 Gene

Gene Ontology (GO) - Molecular Function for MGRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 17229889
GO:0005515 protein binding IPI 17229889
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with MGRN1: view
genes like me logo Genes that share phenotypes with MGRN1: view

Animal Model Products

CRISPR Products

miRNA for MGRN1 Gene

miRTarBase miRNAs that target MGRN1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGRN1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MGRN1 Gene

Localization for MGRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGRN1 Gene

Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101.
Isoform 1: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 3: Cytoplasm, cytosol. Cell membrane.
Isoform 4: Cytoplasm, cytosol. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGRN1 Gene COMPARTMENTS Subcellular localization image for MGRN1 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
plasma membrane 5
lysosome 2
vacuole 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MGRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17229889
GO:0005737 cytoplasm IDA 17229889
GO:0005769 early endosome IDA 17229889
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with MGRN1: view

Pathways for MGRN1 Gene

genes like me logo Genes that share pathways with MGRN1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O60291-MGRN1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for MGRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006513 protein monoubiquitination IMP 17229889
GO:0008152 metabolic process --
GO:0008333 endosome to lysosome transport IMP 17229889
GO:0043951 negative regulation of cAMP-mediated signaling IDA 19737927
genes like me logo Genes that share ontologies with MGRN1: view

Compounds for MGRN1 Gene

(4) HMDB Compounds for MGRN1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with MGRN1: view

Transcripts for MGRN1 Gene

Unigene Clusters for MGRN1 Gene

Mahogunin ring finger 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGRN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MGRN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGRN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MGRN1 Gene

GeneLoc Exon Structure for
MGRN1
ECgene alternative splicing isoforms for
MGRN1

Expression for MGRN1 Gene

mRNA expression in normal human tissues for MGRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGRN1 Gene

SOURCE GeneReport for Unigene cluster for MGRN1 Gene Hs.526494

genes like me logo Genes that share expressions with MGRN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MGRN1 Gene

Orthologs for MGRN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGRN1 35
  • 99.28 (n)
  • 99.1 (a)
MGRN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 91 (a)
OneToMany
MGRN1 35
  • 87.21 (n)
  • 88.56 (a)
MGRN1 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MGRN1 35
  • 87.68 (n)
  • 89.15 (a)
MGRN1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgrn1 35
  • 86.07 (n)
  • 90.72 (a)
Mgrn1 16
Mgrn1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MGRN1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgrn1 35
  • 85.49 (n)
  • 90.72 (a)
chicken
(Gallus gallus)
Aves MGRN1 35
  • 78.64 (n)
  • 82.05 (a)
MGRN1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGRN1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgrn1 35
  • 75.76 (n)
  • 82.52 (a)
zebrafish
(Danio rerio)
Actinopterygii mgrn1a 36
  • 70 (a)
OneToMany
mgrn1b 35
  • 69.88 (n)
  • 78.07 (a)
mgrn1b 36
  • 74 (a)
OneToMany
wufi38c03 35
fruit fly
(Drosophila melanogaster)
Insecta CG9941 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11H1.3 36
  • 30 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0374900 35
  • 53.39 (n)
  • 44.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MGRN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGRN1 Gene

ENSEMBL:
Gene Tree for MGRN1 (if available)
TreeFam:
Gene Tree for MGRN1 (if available)

Paralogs for MGRN1 Gene

Paralogs for MGRN1 Gene

Selected SIMAP similar genes for MGRN1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MGRN1: view

Variants for MGRN1 Gene

Sequence variations from dbSNP and Humsavar for MGRN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs744156 -- 4,650,055(-) aaggt(G/T)ctggg intron-variant
rs841171 -- 4,639,318(+) CTGCG(G/T)GGTGG intron-variant
rs841172 -- 4,638,492(-) CATGG(G/T)CTGAG intron-variant
rs841173 -- 4,638,476(-) TATTT(A/T)TTTTT intron-variant
rs841174 -- 4,630,128(+) gggtg(C/G)attgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGRN1 Gene

Variant ID Type Subtype PubMed ID
nsv905234 CNV Loss 21882294
dgv2587n71 CNV Loss 21882294
dgv2588n71 CNV Loss 21882294
dgv2589n71 CNV Loss 21882294
nsv905243 CNV Loss 21882294
esv2659384 CNV Deletion 23128226
esv28573 CNV Gain 19812545
esv2671090 CNV Deletion 23128226
dgv2590n71 CNV Loss 21882294
nsv905248 CNV Loss 21882294
nsv905249 CNV Loss 21882294

Relevant External Links for MGRN1 Gene

HapMap Linkage Disequilibrium report
MGRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGRN1 Gene

Disorders for MGRN1 Gene

Relevant External Links for MGRN1

Genetic Association Database (GAD)
MGRN1
Human Genome Epidemiology (HuGE) Navigator
MGRN1
genes like me logo Genes that share disorders with MGRN1: view

No data available for UniProtKB/Swiss-Prot for MGRN1 Gene

Publications for MGRN1 Gene

  1. Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. (PMID: 19737927) Perez-Oliva A.B. … Garcia-Borron J.C. (J. Biol. Chem. 2009) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Pigmentation-related genes and their implication in malignant melanoma susceptibility. (PMID: 19320733) Fernandez L.P. … Ribas G. (Exp. Dermatol. 2009) 3 48
  5. Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. (PMID: 17229889) Kim B.Y. … Li L. (Mol. Biol. Cell 2007) 3 4

Products for MGRN1 Gene

Sources for MGRN1 Gene

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