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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MGRN1 Gene

protein-coding GIFtS: 60
GCID: GC16P004641

mahogunin ring finger 1, E3 ubiquitin protein ligase

(Previous names: mahogunin, ring finger 1 )

Explore 4 diseases affiliated with
MGRN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase¹ ²		RING Finger Protein 156² ³
RNF156¹ ² ³		E3 Ubiquitin-Protein Ligase MGRN1²
KIAA0544¹ ³ ⁵		Probable E3 Ubiquitin-Protein Ligase MGRN1²
Mahogunin, Ring Finger 1¹ ²		EC 6.3.2.-³
Mahogunin RING Finger Protein 1² ³		EC 6.3.2⁸

External Ids:	HGNC: 20254¹	Entrez Gene: 23295²	Ensembl: ENSG00000102858⁷	OMIM: 607559⁵	UniProtKB: O60291³

Export aliases for MGRN1 gene to outside databases

Previous GC identifers: GC16P004708 GC16P004675 GC16P004614 GC16P004674

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGRN1:

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.(supplied by OMIM, Apr

2004)

UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291

Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of

UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs

MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does

not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MGRN1 gene promoter:
GATA-3 Nkx2-2 RORalpha2 GATA-2 GATA-1 CREB SRY FOXO4 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MGRN1 promoter sequence

Search SABiosciences Chromatin IP Primers for MGRN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGRN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13

MGRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGRN1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P004641: view genomic region (about GC identifiers)

Start:	4,666,494 bp from pter	End:	4,740,975 bp from pter
Size:	74,482 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase MGRN1

Size: 552 amino acids; 60753 Da

Subunit: Interacts with MC1R and MC4R, but not with TBXA2R. Interacts with TSG101. Interacts with mislocalized

cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By

similarity)

Subcellular location: Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101

Subcellular location: Isoform 1: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is

seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli

Subcellular location: Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is

seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli

Subcellular location: Isoform 3: Cytoplasm, cytosol. Cell membrane

Subcellular location: Isoform 4: Cytoplasm, cytosol. Cell membrane

Sequence caution: Sequence=BAA25470.1; Type=Erroneous initiation;

Secondary accessions: A4URL3 A4URL4 Q86W76

Alternative splicing: 4 isoforms: O60291-1 O60291-2 O60291-3 O60291-4

Explore the universe of human proteins at neXtProt for MGRN1: NX_O60291

Post-translational modifications:

Autoubiquitinated in vitro (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60291

4/7 DME Specific Peptides for MGRN1 (O60291) (see all 7)

SETVHYKRG

IPSAPLYEEI

RPVQFPYVTPA

QQFSLPSFKIDF

MGRN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001135761.2 NP_001135762.1 NP_001135763.2 NP_056061.1

ENSEMBL proteins:

ENSP00000468171 ENSP00000262370 ENSP00000443810 ENSP00000467414 ENSP00000382487

ENSP00000468819 ENSP00000465860 ENSP00000464811 ENSP00000465249 ENSP00000393311

Reactome Protein details: O60291
Human Recombinant Protein Products for MGRN1:

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	Novus Biologicals MGRN1 Proteins Novus Biologicals MGRN1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MGRN1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	19737927
GO:0005737	cytoplasm	IDA	19737927
GO:0005769	early endosome	IDA	17229889
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IEA	--

MGRN1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MGRN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MGRN1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry O60291

ProtoNet protein and cluster: O60291

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291

Domain: The RING finger is required for ubiquitin ligase activity (By similarity)

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MGRN1_HUMAN, O60291

Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of

UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs

MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does

not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	19737927
GO:0005515	protein binding	IPI	19737927
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	--	--

MGRN1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for MGRN1:

Increased cell death in DLD-1

Increased cell number in S

11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Mgrn1):

cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism	integument
mortality/aging	muscle	nervous system	pigmentation	reproductive system
respiratory system

MGRN1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MGRN1

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MGRN1 Browse MicroRNA Expression Plasmids
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		hsa-miR-320a hsa-miR-137 hsa-miR-520d-5p hsa-miR-144 hsa-miR-548x hsa-miR-556-3p hsa-miR-626 hsa-miR-615-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MGRN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGRN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for MGRN1

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

1 Kegg Pathway (Kegg details for MGRN1):

Ubiquitin mediated proteolysis

UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291

Pathway: Protein modification; protein ubiquitination

MGRN1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MGRN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/21 Interacting proteins for MGRN1 (O60291³ ENSP00000262370⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSG101	Q99816³, ENSP00000251968⁴	I2D: score=3 STRING: ENSP00000251968
UBE2D2	P62837³, ENSP00000381717⁴	I2D: score=2 STRING: ENSP00000381717
UBE2D3	P61077³, ENSP00000349722⁴	I2D: score=2 STRING: ENSP00000349722
UBE2G2	P60604³, ENSP00000338348⁴	I2D: score=2 STRING: ENSP00000338348
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=2 STRING: ENSP00000324897

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IEA	--
GO:0006513	protein monoubiquitination	IMP	17229889
GO:0008333	endosome to lysosome transport	IMP	17229889
GO:0016567	protein ubiquitination	--	--
GO:0043951	negative regulation of cAMP-mediated signaling	IDA	19737927

MGRN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MGRN1

4 HMDB Compounds for MGRN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about MGRN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MGRN1 gene (4 alternative transcripts):

NM_001142289.2 NM_001142290.2 NM_001142291.2 NM_015246.3

Unigene Cluster for MGRN1:

Mahogunin ring finger 1, E3 ubiquitin protein ligase

Hs.526494 [show with all ESTs]

Unigene Representative Sequence: NM_001142290

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591895 ENST00000262370(uc002cxa.3 uc010uxo.2 uc010uxq.2)

ENST00000536343 ENST00000587747 ENST00000399577(uc002cwz.3) ENST00000588994

ENST00000586183 ENST00000590790 ENST00000593224 ENST00000587145 ENST00000590457

ENST00000588015 ENST00000591673 ENST00000592256 ENST00000588111 ENST00000585676

ENST00000415496(uc010uxp.2 uc010btw.3)

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		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MGRN1 (see all 23):
		hsa-miR-320a hsa-miR-137 hsa-miR-520d-5p hsa-miR-144 hsa-miR-548x hsa-miR-556-3p hsa-miR-626 hsa-miR-615-5p

		SwitchGear 3'UTR luciferase reporter plasmid: MGRN1 3' UTR sequence

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Additional cDNA sequence:

AB011116.1 AK126175.1 BC007627.1 BC014199.2 BC050389.1 EF471397.2 EF471398.2

16 DOTS entries:

DT.100827979 DT.455485 DT.92444899 DT.100827985 DT.100827968 DT.92426879 DT.40315287 DT.95341873

DT.97859550 DT.100827967 DT.120675094 DT.120675110 DT.40294059 DT.92062913 DT.92426875 DT.95239697

24/242 AceView cDNA sequences (see all 242):

BU161418 CR606461 BM466445 BM928502 BM127055 BF056839 BQ882656 BU180354

BM791410 AL135085 BU538498 BX282539 AW192619 BQ232094 BQ881256 BU856976

BF813078 BM995487 CB117544 BU856790 AA743081 BU430322 AI675170 BU956203

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MGRN1 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21a	·	21b	^
SP1:															-		-																		-		-												-		-
SP2:															-		-																		-		-
SP3:															-		-																-		-		-
SP4:																																	-		-		-
SP5:																	-

ExUns:	22a	·	22b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MGRN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MGRN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCAAAAAA

About this image

MGRN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MGRN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGRN1

SOURCE GeneReport for Unigene cluster: Hs.526494

SABiosciences Expression via Pathway-Focused PCR Array including MGRN1:

Ubiquitin Ligases in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGRN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGRN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGRN1 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mgrn1^{1 , 5}	mahogunin, ring finger 1^{1, 5}	86.18(n)¹ 90.89(a)¹		16 (2.48 cM)⁵ 17237¹ NM_001252437.1¹ NP_001239366.1¹ 4886100⁵
chicken (Gallus gallus)	Aves	MGRN1¹	mahogunin, ring finger 1	78.88(n) 83.36(a)		416660 XM_414957.3 XP_414957.3
lizard (Anolis carolinensis)	Reptilia	MGRN1⁶	--	80(a)	1 ↔ 1	GL343691.1(23381-33180)
African clawed frog (Xenopus laevis)	Amphibia	BC061651.1²	--	77.17(n)		BC061651.1
zebrafish (Danio rerio)	Actinopterygii	wufi38c03²	wufi38c03	76.76(n)		334260 BC048069.1
fruit fly (Drosophila melanogaster)	Insecta	CG9941⁶	--	26(a)	1 → many	X(13612767-13616058)
worm (Caenorhabditis elegans)	Secernentea	C11H1.3⁶	Protein C11H1.3	28(a)	1 → many	X(14307793-14311613)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G53410⁶ AT5G03200⁶ (see all 5)	RING/U-box domain-containing protein (see all 5)	29(a) 27(a) (see all 5)	many ↔ many many ↔ many (see all 5)	3(19800951-19802328) 5(760319-761803)
rice (Oryza sativa)	Liliopsida	Os01g0374900¹	hypothetical protein	53.39(n) 44.25(a)		4325441 NM_001049610.1 NP_001043075.1

ENSEMBL Gene Tree for MGRN1 (if available)
TreeFam Gene Tree for MGRN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MGRN1 gene

RNF157²

1 SIMAP similar gene for MGRN1 using alignment to 7 protein entries: MGRN1_HUMAN (see all proteins):

RNF157

MGRN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7200863^1,2	C,F,A	--	4672841(+)	`CCCTTG/AACCTC`	4	--	us2k¹		1		WA	118
rs7202305^1,2	C,H	--	4672843(+)	`cttgaC/Actcaa`	4	--	us2k¹		5		NS EA WA	530
rs2450393^1,2	C,F,A,H	--	4672892(+)	`ACAGGC/TGTGAG`	4	--	us2k¹		5		NA	10
rs140071509^1,2		--	4672959(+)	`TAGAGA/TTAGGG`	4	--	us2k¹		0	--	--	--	--
rs115439456^1,2	F	--	4673063(+)	`CTCCAG/CAGTAG`	4	--	us2k¹		1		WA	118
rs7201474^1,2	C,F,A	--	4673085(+)	`GGGGCG/ATGCCA`	4	--	us2k¹		2		WA NA	238
rs142303427^1,2		--	4673186(+)	`GCCTGC/TCTCGG`	4	--	us2k¹		0	--	--	--	--
rs4337299^1,2	C,F,A	--	4673190(+)	`GCCTCG/AGCCTC`	4	--	us2k¹		1		NA	120
rs117724468^1,2	F	--	4673197(+)	`CCTCCC/GAAAGT`	4	--	us2k¹		1		NA	120
rs55650610^1,2	C,F	--	4673207(+)	`TGTTAC/GGATTA`	4	--	us2k¹		6		NA WA CSA	129

HapMap Linkage Disequilibrium report for MGRN1 (4666494 - 4740975 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MGRN1
1 Indel: 72440

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MGRN1 for disorders           About GeneDecksing

OMIM gene information: 607559    OMIM disorders: --

4 diseases for MGRN1:    About MalaCards

situs inversus neurodegeneration melanoma malaria

Human Genome Epidemiology (HuGE) Navigator: MGRN1 (2 documents)

Export disorders for MGRN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MGRN1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MGRN1)

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world of online information

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2, 3} Nagase T....Ohara O. (1998)
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase i nhibits signaling from melanocortin receptor by competition with Galphas. (PubMed id 19737927)^{1, 2, 9} PAcrez-Oliva A.B....GarcA-a-BorrA^n J.C. (2009)
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. (PubMed id 19703557)^{1, 2} Jiao J....Gunn T.M. (2009)
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. (PubMed id 17229889)^{1, 2} Kim B.Y....Li L. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)¹ Liu B....Wang L.S. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23295	HGNC: 20254	AceView: MGRN1	Ensembl:ENSG00000102858	euGenes: HUgn23295
ECgene: MGRN1	Kegg: 23295	H-InvDB: MGRN1

(According to HUGE)
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HUGE: KIAA0544

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MGRN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MGRN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MGRN1 gene:
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GeneCards and IP:
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mahogunin ring finger 1, E3 ubiquitin protein ligase

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mahogunin ring finger 1, E3 ubiquitin protein ligase

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