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MGRN1 Gene

protein-coding   GIFtS: 63
GCID: GC16P004641

Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase

(Previous names: mahogunin, ring finger 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mahogunin Ring Finger 1, E3 Ubiquitin Protein Ligase1 2     KIAA05443 5
Mahogunin, Ring Finger 11 2     E3 Ubiquitin-Protein Ligase MGRN12
Mahogunin RING Finger Protein 12 3     Probable E3 Ubiquitin-Protein Ligase MGRN12
RNF1562 3     EC 6.3.2.-3
RING Finger Protein 1562 3     EC 6.3.28

External Ids:    HGNC: 202541   Entrez Gene: 232952   Ensembl: ENSG000001028587   OMIM: 6075595   UniProtKB: O602913   

Export aliases for MGRN1 gene to outside databases

Previous GC identifers: GC16P004708 GC16P004675 GC16P004614 GC16P004674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGRN1 Gene:
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.(supplied by OMIM,
Apr 2004)

GeneCards Summary for MGRN1 Gene:
MGRN1 (mahogunin ring finger 1, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is RNF157.

UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291
Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of
UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs
MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production.
Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGRN1 gene promoter:
         GATA-3   Nkx2-2   RORalpha2   GATA-2   GATA-1   CREB   SRY   FOXO4   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MGRN1 promoter sequence
   Search Chromatin IP Primers for MGRN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13

MGRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGRN1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004641:  view genomic region     (about GC identifiers)

Start:
4,666,494 bp from pter      End:
4,740,975 bp from pter
Size:
74,482 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MGRN1  
Size: 552 amino acids; 60753 Da
Subunit: Interacts with MC1R and MC4R, but not with TBXA2R. Interacts with TSG101. Interacts with mislocalized
cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement
(By similarity)
Sequence caution: Sequence=BAA25470.1; Type=Erroneous initiation;
Secondary accessions: A4URL3 A4URL4 Q86W76
Alternative splicing: 4 isoforms:  O60291-1   O60291-2   O60291-3   O60291-4   

Explore the universe of human proteins at neXtProt for MGRN1: NX_O60291

Explore proteomics data for MGRN1 at MOPED

Post-translational modifications: 

  • Autoubiquitinated in vitro (By similarity)1
  • Ubiquitination2 at Lys82, Lys164
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MGRN1 (O60291) (see all 7)
     SETVHYKRG  IPSAPLYEEI  RPVQFPYVTPA  QQFSLPSFKIDF 


    See MGRN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135761.2  NP_001135762.1  NP_001135763.2  NP_056061.1  

    ENSEMBL proteins: 
     ENSP00000468171   ENSP00000262370   ENSP00000443810   ENSP00000467414   ENSP00000382487  
     ENSP00000468819   ENSP00000465860   ENSP00000464811   ENSP00000465249   ENSP00000393311  
    Reactome Protein details: O60291

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    antibodies-online proteins for MGRN1 (6 products) 

     
    antibodies-online peptides for MGRN1

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    MGRN1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O60291

    ProtoNet protein and cluster: O60291

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291
    Domain: The RING finger is required for ubiquitin ligase activity (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with MGRN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGRN1_HUMAN, O60291
    Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of
    UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs
    MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production.
    Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA17229889
    GO:0005515protein binding IPI17229889
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity ----
         
    Find genes that share ontologies with MGRN1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MGRN1:
     Increased cell death in DLD-1   Increased cell number in S 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Mgrn1):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging  muscle  nervous system  pigmentation  reproductive system 
     respiratory system 

    Find genes that share phenotypes with MGRN1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MGRN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MGRN1:
    hsa-mir-744-5p (MIRT037554), hsa-mir-455-3p (MIRT037832), hsa-mir-181d-5p (MIRT041179)

    Block miRNA regulation of human, mouse, rat MGRN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MGRN1 (see all 23):
    hsa-miR-320a hsa-miR-137 hsa-miR-520d-5p hsa-miR-144 hsa-miR-548x hsa-miR-556-3p hsa-miR-626 hsa-miR-615-5p
    SwitchGear 3'UTR luciferase reporter plasmidMGRN1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGRN1_HUMAN, O60291: Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101
    MGRN1_HUMAN, O60291: Isoform 1: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus
    is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli
    MGRN1_HUMAN, O60291: Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus
    is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli
    MGRN1_HUMAN, O60291: Isoform 3: Cytoplasm, cytosol. Cell membrane
    MGRN1_HUMAN, O60291: Isoform 4: Cytoplasm, cytosol. Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    nucleus5
    plasma membrane5
    lysosome2
    vacuole2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17229889
    GO:0005737cytoplasm IDA17229889
    GO:0005769early endosome IDA17229889
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with MGRN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGRN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with MGRN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MGRN1
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for MGRN1):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: MGRN1_HUMAN, O60291
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including MGRN1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGRN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for MGRN1 (O602913 ENSP000002623704) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998163, ENSP000002519684I2D: score=3 STRING: ENSP00000251968
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0006513protein monoubiquitination IMP17229889
    GO:0008333endosome to lysosome transport IMP17229889
    GO:0043951negative regulation of cAMP-mediated signaling IDA19737927
    GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway IDA19737927

    Find genes that share ontologies with MGRN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGRN1

    4 HMDB Compounds for MGRN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGRN1 gene (4 alternative transcripts): 
    NM_001142289.2  NM_001142290.2  NM_001142291.2  NM_015246.3  

    Unigene Cluster for MGRN1:

    Mahogunin ring finger 1, E3 ubiquitin protein ligase
    Hs.526494  [show with all ESTs]
    Unigene Representative Sequence: NM_001142290
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591895 ENST00000262370(uc002cxa.3 uc010uxo.2 uc010uxq.2)
    ENST00000536343 ENST00000587747 ENST00000399577(uc002cwz.3) ENST00000588994
    ENST00000586183 ENST00000590790 ENST00000593224 ENST00000587145 ENST00000590457
    ENST00000588015 ENST00000591673 ENST00000592256 ENST00000588111 ENST00000585676
    ENST00000415496(uc010uxp.2 uc010btw.3)
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      QuantiFast Probe-based Assays in human, mouse, rat MGRN1

    Additional mRNA sequence: 

    AB011116.1 AK126175.1 BC007627.1 BC014199.2 BC050389.1 EF471397.2 EF471398.2 NR_102267.1 

    16 DOTS entries:

    DT.100827979  DT.455485  DT.92444899  DT.100827985  DT.100827968  DT.92426879  DT.40315287  DT.95341873 
    DT.97859550  DT.100827967  DT.120675094  DT.120675110  DT.40294059  DT.92062913  DT.92426875  DT.95239697 

    Selected AceView cDNA sequences (see all 242):

    BX282539 BM466445 AW192619 BF813078 BU538498 BM928502 CR606461 BQ232094 
    BU856976 AL135085 BM127055 AA338303 BQ216850 BM465105 BU956203 BF801696 
    AI675170 BX332654 BU180354 BF056839 BQ882656 BU856790 AA743081 CB117544 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGRN1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                                            -     -                                                     -     -                                   -     -   
    SP2:                                            -     -                                                     -     -                                             
    SP3:                                            -     -                                               -     -     -                                             
    SP4:                                                                                                  -     -     -                                             
    SP5:                                                  -                                                                                                         

    ExUns: 22a · 22b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MGRN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCAAAAAA
    MGRN1 Expression
    About this image


    MGRN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Heart (Cardiovascular System)
    MGRN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGRN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526494
        Pathway & Disease-focused RT2 Profiler PCR Array including MGRN1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGRN1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgrn11 , 5 mahogunin, ring finger 11, 5 86.07(n)1
    90.72(a)1
      16 (2.48 cM)5
    172371  NM_029657.41  NP_083933.11 
     48861005 
    chicken
    (Gallus gallus)
    Aves MGRN11 mahogunin, ring finger 1 78.64(n)
    82.05(a)
      416660  XM_004945374.1  XP_004945431.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGRN16
    mahogunin ring finger 1, E3 ubiquitin protein liga...
    78(a)
    1 ↔ 1
    GL343691.1(23381-33184)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC061651.12   -- 77.17(n)    BC061651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi38c032 wufi38c03 76.76(n)   334260  BC048069.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99416
    --
    28(a)
    1 → many
    X(13612767-13616058)
    worm
    (Caenorhabditis elegans)
    Secernentea C11H1.36
    Protein C11H1.3 (C11H1.3) mRNA, complete cds
    30(a)
    1 → many
    X(14307863-14311683) WBGene00007529
    rice
    (Oryza sativa)
    Liliopsida Os01g03749001 Os01g0374900 53.39(n)
    44.25(a)
      4325441  NM_001049610.1  NP_001043075.1 


    ENSEMBL Gene Tree for MGRN1 (if available)
    TreeFam Gene Tree for MGRN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGRN1 gene
    RNF1572  
    1 SIMAP similar gene for MGRN1 using alignment to 7 protein entries:     MGRN1_HUMAN (see all proteins):
    RNF157

    Find genes that share paralogs with MGRN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGRN1 (see all 2318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72008631,2
    C,F,A--4672841(+) CCCTTG/AACCTC 5 -- us2k11Minor allele frequency- A:0.31WA 118
    rs72023051,2
    C,F,H--4672843(+) cttgaC/Actcaa 5 -- us2k15Minor allele frequency- A:0.07NS EA WA 530
    rs24503931,2
    C,F,A,H--4672892(+) acaggC/Tgtgag 5 -- us2k15Minor allele frequency- T:0.40NA 10
    rs1400715091,2
    --4672959(+) TAGAGA/TTAGGG 5 -- us2k10--------
    rs1154394561,2
    F--4673063(+) CTCCAG/CAGTAG 5 -- us2k11Minor allele frequency- C:0.07WA 118
    rs72014741,2
    C,F,A--4673085(+) GGGGCG/ATGCCA 5 -- us2k12Minor allele frequency- A:0.15WA NA 238
    rs1423034271,2
    --4673186(+) GCCTGC/TCTCGG 5 -- us2k10--------
    rs43372991,2
    C,F,A--4673190(+) GCCTCG/AGCCTC 5 -- us2k11Minor allele frequency- A:0.08NA 120
    rs1177244681,2
    C,F--4673197(+) CCTCCC/GAAAGT 5 -- us2k11Minor allele frequency- G:0.12NA 120
    rs556506101,2
    C,F--4673207(+) TGTTAC/GGATTA 5 -- us2k16Minor allele frequency- G:0.30NA WA CSA 129

    HapMap Linkage Disequilibrium report for MGRN1 (4666494 - 4740975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MGRN1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671090CNV Deletion23128226
    esv2659384CNV Deletion23128226
    dgv2587n71CNV Loss21882294
    nsv905234CNV Loss21882294
    nsv905248CNV Loss21882294
    dgv2590n71CNV Loss21882294
    nsv905243CNV Loss21882294
    nsv905249CNV Loss21882294
    dgv2588n71CNV Loss21882294
    dgv2589n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGRN1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607559    OMIM disorders: --


    Find genes that share disorders with MGRN1           About GenesLikeMe

    Genetic Association Database (GAD): MGRN1
    Human Genome Epidemiology (HuGE) Navigator: MGRN1 (2 documents)

    Export disorders for MGRN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGRN1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MGRN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. (PubMed id 19737927)1, 2, 9 Perez-Oliva A.B....Garcia-Borron J.C. (J. Biol. Chem. 2009)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Pigmentation-related genes and their implication in malignant melanoma susceptibility. (PubMed id 19320733)1, 4 Fernandez L.P....Ribas G. (Exp. Dermatol. 2009)
    5. Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. (PubMed id 19703557)1, 2 Jiao J.... Gunn T.M. (Biochim. Biophys. Acta 2009)
    6. Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. (PubMed id 17229889)1, 2 Kim B.Y.... Li L. (Mol. Biol. Cell 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases. (PubMed id 24036454)1 Guerra D.D....Pilot G. (FEBS Lett. 2013)
    9. MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4. (PubMed id 23253940)1 Gunn T.M....Walker K.K. (amp 2013)
    10. Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity. (PubMed id 23756845)1 Chhangani D. and Mishra A. (Sci Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23295 HGNC: 20254 AceView: MGRN1 Ensembl:ENSG00000102858 euGenes: HUgn23295
    ECgene: MGRN1 Kegg: 23295 H-InvDB: MGRN1

    (According to HUGE)
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    HUGE: KIAA0544

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGRN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGRN1 gene:
    Search GeneIP for patents involving MGRN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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