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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGP Gene

protein-coding   GIFtS: 60
GCID: GC12M015034

matrix Gla protein
 Explore 48 diseases affiliated with
MGP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MGP    

Aliases
for MGP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Matrix Gla Protein1 2
Cell Growth-Inhibiting Gene 36 Protein2 3
MGLAP2 3
NTI2 5

External Ids:    HGNC: 70601   Entrez Gene: 42562   Ensembl: ENSG000001113417   OMIM: 1548705   UniProtKB: P084933   

Export aliases for MGP gene to outside databases

Previous GC identifers: GC12M014774 GC12M015179 GC12M014934 GC12M014926


Summaries
for MGP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGP:
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is
found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation

Gene Wiki entry for MGP (Matrix gla protein)


Genomic Views
for MGP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGP gene promoter:
         STAT5B   HFH-3   AML1a   AP-1   ATF-2   MyoD   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGP promoter sequence
   Search SABiosciences Chromatin IP Primers for MGP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

MGP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M015034:  view genomic region     (about GC identifiers)

Start:
 15,034,115 bp from pter      End:
 15,038,860 bp from pter
Size:
 4,746 bases      Orientation:
 minus strand

Proteins
for MGP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGP_HUMAN, P08493 (See protein sequence)
Recommended Name: Matrix Gla protein precursor  
Size: 103 amino acids; 12353 Da
Subcellular location: Secreted
Secondary accessions: A0M8W5 B2R519 Q2TU41 Q567P9 Q6ICN5

Explore the universe of human proteins at neXtProt for MGP: NX_P08493

Post-translational modifications:

  • Requires vitamin K-dependent gamma-carboxylation for its function1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08493

    • MGP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000891.2  NP_001177768.1  

    ENSEMBL proteins: 
     ENSP00000445907   ENSP00000445436   ENSP00000228938  

    Human Recombinant Protein Products: 
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    Novus Biologicals MGP Proteins
    Novus Biologicals MGP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MGP
    Uscn Proteins for MGP

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS9916809
    GO:0005615extracellular space ----
    GO:0005783endoplasmic reticulum ----
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0043234protein complex ----


    MGP for ontologies           About GeneDecksing



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    Uscn Antibodies for MGP
    Search ThermoFisher Antibodies for MGP

    Assay Products for MGP: 
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    Uscn ELISAs and CLIAs for MGP

    Protein Domains /
    Families
    for MGP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR027118 MGP
     IPR002384 Osteocalcin/MGP
     IPR000294 GLA_domain

    Graphical View of Domain Structure for InterPro Entry P08493

    ProtoNet protein and cluster: P08493

    2 Blocks protein families:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002384 Bone matrix GLA domain signature


    UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
    Similarity: Belongs to the osteocalcin/matrix Gla protein family
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain


    Function
    for MGP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
    Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation

         Genatlas biochemistry entry for MGP:
    bone matrix GLA protein,vitamin K dependent,vitamin D regulated

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MGP:
    hsa-miR-637 hsa-miR-155 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: MGP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGP (see all 7)
    OriGene shRNA RFP: MGP
    OriGene siRNA: MGP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MGP

    Clone
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    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MGP
    LifeMap BioReagents: cell lines associated with MGP: Chondrogenic Package 4D20.8,
    Chondrogenic Package 7PEND24, Chondrogenic Package 7SMOO32, Chondrogenic Package E15,
    Chondrogenic Package MEL2, Chondrogenic Package SK11, Chondrogenic Package SM30

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGP

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS9916809
    GO:0005509calcium ion binding IEA--
    GO:0008147structural constituent of bone TAS9916809
    GO:0048306calcium-dependent protein binding ----


    MGP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MGP:
     Increased G2M DNA content  Increased number of mitotic ce 

    Animal Models:
         Mouse knock-out Mgptm1Kry for MGP
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mgp):
     cardiovascular system  growth/size  mortality/aging  muscle  renal/urinary system 
     respiratory system  skeleton 

    MGP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MGP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    		Validated transcriptional targets of AP1 family members Fra1 and Fra21.00
    2Endochondral Ossification
    		Endochondral Ossification1.00
    3Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    		Warfarin Pathway, Pharmacodynamics0.67


    2 BioSystems Pathways for MGP 
        Endochondral Ossification
    Validated transcriptional targets of AP1 family members Fra1 and Fra2

    1 PharmGKB Pathway for MGP
        Warfarin Pathway, Pharmacodynamics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MGP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MGP (P084933 ENSP000002289384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP2P126433, ENSP000003681044I2D: score=2 STRING: ENSP00000368104
    FOSL1ENSP000003101704STRING: ENSP00000310170
    JUNENSP000003602664STRING: ENSP00000360266
    TXLNGENSP000003694654STRING: ENSP00000369465
    JUNBENSP000003033154STRING: ENSP00000303315
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation TAS9916809
    GO:0001503ossification IEA--
    GO:0007584response to nutrient ----
    GO:0009612response to mechanical stimulus ----
    GO:0009725response to hormone stimulus ----


    MGP for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGP
    10/14 Novoseek chemical compound relationships for MGP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gamma-carboxyglutamic acid 92 78 17848178 (2), 15961706 (2), 1540125 (2), 1727694 (1) (see all 28)
    vitamin k1 77.6 2 19386744 (1), 12559675 (1)
    hydroxyapatite 60.6 12 12151082 (5), 19816015 (1), 17890861 (1), 1540125 (1) (see all 5)
    warfarin 56.5 13 16528009 (2), 17643059 (1), 18495950 (1), 19692494 (1) (see all 10)
    calcium 49 33 12151082 (2), 11374034 (1), 17848178 (1), 19084518 (1) (see all 21)
    pyrophosphate 45.1 7 16408509 (1), 16205469 (1), 19004191 (1), 19345526 (1) (see all 5)
    vitamin d 37.2 6 2394711 (1), 11694617 (1), 14961167 (1), 19785816 (1) (see all 6)
    retinoic acid 22.4 36 8319825 (7), 1727694 (4), 8125154 (2), 9122176 (1) (see all 6)
    calcitriol 14 2 1686347 (1)
    glutamate 6.61 3 1686347 (1), 8061611 (1), 1807167 (1)

    Search CenterWatch for drugs/clinical trials and news about MGP 

    Transcripts
    for MGP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGP gene (2 alternative transcripts): 
    NM_000900.3  NM_001190839.1  

    Unigene Cluster for MGP:

    Matrix Gla protein
    Hs.365706  [show with all ESTs]
    Unigene Representative Sequence: NM_001190839
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539261(uc021qvr.1 uc001rcn.2) ENST00000545199 ENST00000228938
    ENST00000507170

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MGP:
    hsa-miR-637 hsa-miR-155 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: MGP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGP (see all 7)
    OriGene shRNA RFP: MGP
    OriGene siRNA: MGP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MGP (NM_000900)
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    Primer
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    Additional cDNA sequence: 

    AK310040.1 AK312029.1 AY542304.1 BC005272.1 BC070314.1 BC093078.1 BT006733.1 CR450358.1 
    M58549.1 X07362.1 X53331.1 

    12 DOTS entries:

    DT.449366  DT.92450231  DT.92450226  DT.449367  DT.95136499  DT.95136509  DT.100697650  DT.92450212 
    DT.100697656  DT.40115984  DT.91850911  DT.97847182 

    24/625 AceView cDNA sequences (see all 625):

    AI803755 BQ632579 AV707983 CA395547 CB068540 AU076956 AA404957 AI372839 
    CR623037 CD357212 AA737219 AA971294 BI754530 CD103230 BU602258 CB962654 
    AI954968 CK823811 CD511214 CB998695 BG193052 BE439654 BP374132 CB962616 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MGP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                    -               
    SP2:        -                           


    ECgene alternative splicing isoforms for MGP

    Expression
    for MGP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTATGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MGP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White PreadipocytesAdipose
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/33 LifeMap Cells (see all 33) 
    NameCategory
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    White adipocyte-like cells (Differentiation of ...)Adipose
    Trophoblast-like cells (Generation of tropho...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

    See MGP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGP

    SOURCE GeneReport for Unigene cluster: Hs.365706
        SABiosciences Expression via Pathway-Focused PCR Array including MGP: 
              Nephrotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGP

    Orthologs
    for MGP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MGP gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mgp1 , 5 matrix Gla protein1, 5 81.23(n)1
    83.5(a)1    		   6 (66.72 cM)5
    173131  NM_008597.31  NP_032623.11 
     1368724365 
    chicken
    (Gallus gallus)    		 Aves MGP1 matrix Gla protein 62(n)
    57(a)    		   395912  NM_205044.1  NP_990375.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MGP6
    		 --
    		 53(a)
    		 1 ↔ 1
    		 5(27709649-27716411)
    zebrafish
    (Danio rerio)    		 Actinopterygii mgp6
    		 matrix Gla protein
    		 25(a)
    		 1 ↔ 1
    		 3(2202873-2222138)


    ENSEMBL Gene Tree for MGP (if available)
    TreeFam Gene Tree for MGP (if available) 

    Paralogs
    for MGP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MGP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 NCBI SNPs in MGP are shown (see all 156)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs715376911,2
    		C,--14803374(+) AGAAAC/TGTGGC 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs348292491,2
    		C,--14803580(-) GAAAAG/TAAAGA 2 -- ut313Minor allele frequency- T:0.01NS NA 92
    rs341815331,2
    		C,F,--14803914(-) CAAATA/GAAAGC 2 -- ut315Minor allele frequency- G:0.05NS NA WA 98
    rs351129621,2
    		C,F,H,--14804186(-) ATCTAG/ATATTA 2 -- ut3110Minor allele frequency- A:0.04NS NA WA 1106
    rs1124500191,2
    		C--14804288(+) AAAGTT/ATCACA 2 -- ut311Minor allele frequency- A:0.00CSA 1
    rs123041,2
    		H--14804603(-) TTTGCG/TAACGC 4 E * stg1 ese35Minor allele frequency- T:0.00MN NS EA 590
    rs767373861,2
    		--14804774(+) GCCCCC/TCTATA 2 -- int10--------
    rs24307361,2
    		C--14805010(+) CCACTA/GTAATC 2 -- int12Minor allele frequency- G:0.01NS 94
    rs343615641,2
    		C,--14805277(-) TTTCAT/CCATAT 2 -- int15Minor allele frequency- C:0.01NS NA WA 216
    rs136171,2
    		H--14805368(-) AGTCCA/GAGAGA 4 Q R mis16Minor allele frequency- G:0.00NS EA NA 406

    HapMap Linkage Disequilibrium report for MGP (15034115 - 15038860 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MGP: --
    Human Gene Mutation Database (HGMD): MGP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGP
    DNA2.0 Custom Variant and Variant Library Synthesis for MGP

    Disorders / Diseases
    for MGP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGP for disorders           About GeneDecksing

    OMIM gene information: 154870   
    OMIM disorders: 245150  
    UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
  • Defects in MGP are the cause of Keutel syndrome (KS) [MIM:245150]. KS is an autosomal recessive disorder
    • characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial
    hypoplasia

    20/48 diseases for MGP (see all 48):    About MalaCards
    keutel syndrome    natural teeth remaining intact    vitamin k deficiency hemorrhagic disease    acute apical periodontitis
    euthyroid sick syndrome    aortic valve stenosis    coronary heart disease    hyperphosphatemia
    myocardial infarction    ischemic heart disease    atrial fibrillation    renal osteodystrophy
    arterial calcification    hypercalcemia    arteriosclerosis    hemorrhagic disease
    glaucoma    intrahepatic cholangiocarcinoma    vascular disease    calcinosis

    6 diseases from the University of Copenhagen DISEASES database for MGP:
    Vitamin K deficiency hemorrhagic disease     Vascular disease     Pain agnosia     Kidney disease
    Pseudoxanthoma elasticum     Acute apical periodontitis

    10/33 Novoseek disease relationships for MGP gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 88.2 297 14587031 (7), 17848178 (6), 15045141 (6), 11716499 (5) (see all 99)
    keutel syndrome 83.9 3 11405537 (1), 15810001 (1), 9916809 (1)
    hyperphosphatemia 65.2 1 19121777 (1)
    vitamin k deficiency 64 4 11410932 (1), 18401181 (1), 19363777 (1), 19692494 (1)
    arterial vessels 58.8 3 11716499 (1), 16505034 (1), 17509359 (1)
    renal disease 54 2 20133489 (2)
    atherosclerosis 53 17 15210134 (3), 10807741 (1), 11374034 (1), 17074310 (1) (see all 10)
    atherosclerotic plaque 51.9 8 12151082 (1), 13677259 (1), 15775403 (1), 15045141 (1) (see all 5)
    arteriosclerosis 47.6 2 15744522 (1)
    cardiovascular diseases 43.2 6 15775403 (2), 19692494 (1), 16973975 (1), 18841280 (1) (see all 5)

    Genetic Association Database (GAD): MGP
    Human Genome Epidemiology (HuGE) Navigator: MGP (24 documents)

    Export disorders for MGP gene to outside databases

    Publications
    for MGP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGP gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with MGP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PubMed id 2394711)1, 2, 3, 9 Cancela L....Price P.A. (1990)
    2. Carboxyl-terminal proteolytic processing of matrix Gla protein. (PubMed id 1939157)1, 2, 9 Hale J.E.... Price P.A. (1991)
    3. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction. (PubMed id 11073842)1, 4, 9 Herrmann S.M....Cambien F. (2000)
    4. Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. (PubMed id 15744522)1, 4, 9 Taylor B.C....Sidney S. (2005)
    5. Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human. (PubMed id 8061611)1, 2, 9 Price P.A.... Williamson M.K. (1994)
    6. Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients. (PubMed id 16210837)1, 4, 9 Brancaccio D....Cozzolino M. (2005)
    7. T-138C polymorphism of matrix gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification. (PubMed id 15864013)1, 4, 9 Kobayashi N....Kitazawa S. (2004)
    8. Association of natural tooth loss with genetic variation at the human matrix Gla protein locus in elderly women. (PubMed id 12721790)1, 4, 9 Hirano H....Emi M. (2003)
    9. Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization. (PubMed id 2216462)1, 2, 9 Chen L.... Liu E. (1990)
    10. [Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children] (PubMed id 14963895)1, 4, 9 Zhang W....Wang Y. (2003)

    External Searches for MGP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MGP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4256 HGNC: 7060 AceView: MGP Ensembl:ENSG00000111341 euGenes: HUgn4256
    ECgene: MGP H-InvDB: MGP

    Other Databases showing MGP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/mgp/

    Intellectual Property
    for MGP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGP gene:
    Search GeneIP for patents involving MGP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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