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MGP Gene

protein-coding   GIFtS: 61
GCID: GC12M015034

Matrix Gla Protein

  See MGP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Matrix Gla Protein1 2
Cell Growth-Inhibiting Gene 36 Protein2 3
MGLAP2 3
NTI2 5

External Ids:    HGNC: 70601   Entrez Gene: 42562   Ensembl: ENSG000001113417   OMIM: 1548705   UniProtKB: P084933   

Export aliases for MGP gene to outside databases

Previous GC identifers: GC12M014774 GC12M015179 GC12M014934 GC12M014926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGP Gene:
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded
protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome
(KS). Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2010)

GeneCards Summary for MGP Gene:
MGP (matrix Gla protein) is a protein-coding gene. Diseases associated with MGP include keutel syndrome, and natural teeth remaining intact. GO annotations related to this gene include structural constituent of bone and calcium ion binding.

UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone
formation

Gene Wiki entry for MGP (Matrix gla protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGP gene promoter:
         STAT5B   HFH-3   AML1a   AP-1   ATF-2   MyoD   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGP promoter sequence
   Search Chromatin IP Primers for MGP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

MGP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M015034:  view genomic region     (about GC identifiers)

Start:
15,034,115 bp from pter      End:
15,038,860 bp from pter
Size:
4,746 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGP_HUMAN, P08493 (See protein sequence)
Recommended Name: Matrix Gla protein precursor  
Size: 103 amino acids; 12353 Da
Secondary accessions: A0M8W5 B2R519 J3KMX7 Q2TU41 Q567P9 Q6ICN5
Alternative splicing: 2 isoforms:  P08493-1   P08493-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MGP: NX_P08493

Explore proteomics data for MGP at MOPED

Post-translational modifications: 

  • Requires vitamin K-dependent gamma-carboxylation for its function1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MGP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000891.2  NP_001177768.1  

    ENSEMBL proteins: 
     ENSP00000445907   ENSP00000445436   ENSP00000228938  

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    Cloud-Clone Corp. Proteins for MGP

     
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    LSBio Antibodies in human, mouse, rat for MGP

    MGP Assay Products:

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    Search eBioscience for ELISAs for MGP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027118 MGP
     IPR002384 Osteocalcin/MGP
     IPR000294 GLA_domain

    Graphical View of Domain Structure for InterPro Entry P08493

    ProtoNet protein and cluster: P08493

    2 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002384 Bone matrix GLA domain signature


    UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
    Similarity: Belongs to the osteocalcin/matrix Gla protein family
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain


    Find genes that share domains with MGP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGP_HUMAN, P08493
    Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone
    formation

         Genatlas biochemistry entry for MGP:
    bone matrix GLA protein,vitamin K dependent,vitamin D regulated

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS9916809
    GO:0005509calcium ion binding IEA--
    GO:0008147structural constituent of bone TAS9916809
         
    Find genes that share ontologies with MGP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MGP:
     Increased G2M DNA content  Increased number of mitotic ce 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mgp):
     cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging  muscle 
     renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with MGP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mgptm1Kry for MGP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGP

    miRNA
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    miRTarBase miRNAs that target MGP:
    hsa-mir-26b-5p (MIRT029487), hsa-mir-335-5p (MIRT017975)

    Block miRNA regulation of human, mouse, rat MGP using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate MGP:
    hsa-miR-637 hsa-miR-155 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMGP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MGP

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    GenScript: all cDNA clones in your preferred vector (see all 2): MGP (NM_000900)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGP

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    eBioscience FlowRNA Probe Sets ( VA1-13330) for MGP 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGP_HUMAN, P08493: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix TAS9916809
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with MGP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGP About    
    See pathways by source

    SuperPathContained pathways About
    1PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    Warfarin Pathway, Pharmacodynamics0.31
    2Validated transcriptional targets of AP1 family members Fra1 and Fra2
    Validated transcriptional targets of AP1 family members Fra1 and Fra2
    3Endochondral Ossification
    Endochondral Ossification


    2 BioSystems Pathways for MGP
        Endochondral Ossification
    Validated transcriptional targets of AP1 family members Fra1 and Fra2

    1 PharmGKB Pathway for MGP
        Warfarin Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including MGP: 
              Nephrotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MGP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MGP (P084933 ENSP000002289384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP2P126433, ENSP000003681044I2D: score=2 STRING: ENSP00000368104
    FOSL1ENSP000003101704STRING: ENSP00000310170
    JUNENSP000003602664STRING: ENSP00000360266
    TXLNGENSP000003694654STRING: ENSP00000369465
    JUNBENSP000003033154STRING: ENSP00000303315
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation TAS9916809
    GO:0001503ossification IEA--
    GO:0030154cell differentiation IEA--
    GO:0030500regulation of bone mineralization IEA--

    Find genes that share ontologies with MGP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGP

    Selected Novoseek inferred chemical compound relationships for MGP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gamma-carboxyglutamic acid 92 78 17848178 (2), 15961706 (2), 1540125 (2), 1727694 (1) (see all 28)
    vitamin k1 77.6 2 19386744 (1), 12559675 (1)
    hydroxyapatite 60.6 12 12151082 (5), 19816015 (1), 17890861 (1), 1540125 (1) (see all 5)
    warfarin 56.5 13 16528009 (2), 17643059 (1), 18495950 (1), 19692494 (1) (see all 10)
    calcium 49 33 12151082 (2), 11374034 (1), 17848178 (1), 19084518 (1) (see all 21)
    pyrophosphate 45.1 7 16408509 (1), 16205469 (1), 19004191 (1), 19345526 (1) (see all 5)
    vitamin d 37.2 6 2394711 (1), 11694617 (1), 14961167 (1), 19785816 (1) (see all 6)
    retinoic acid 22.4 36 8319825 (7), 1727694 (4), 8125154 (2), 9122176 (1) (see all 6)
    calcitriol 14 2 1686347 (1)
    glutamate 6.61 3 1686347 (1), 8061611 (1), 1807167 (1)



    Find genes that share compounds with MGP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGP gene (2 alternative transcripts): 
    NM_000900.3  NM_001190839.1  

    Unigene Cluster for MGP:

    Matrix Gla protein
    Hs.365706  [show with all ESTs]
    Unigene Representative Sequence: NM_001190839
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539261(uc021qvr.1 uc001rcn.2) ENST00000545199 ENST00000228938
    ENST00000507170
    miRNA
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    hsa-miR-637 hsa-miR-155 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMGP 3' UTR sequence
    Inhib. RNA
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    Primer
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK310040.1 AK312029.1 AY542304.1 BC005272.1 BC070314.1 BC093078.1 BT006733.1 CR450358.1 
    M58549.1 X07362.1 X53331.1 

    12 DOTS entries:

    DT.449366  DT.92450231  DT.92450226  DT.449367  DT.95136499  DT.95136509  DT.100697650  DT.92450212 
    DT.100697656  DT.40115984  DT.91850911  DT.97847182 

    Selected AceView cDNA sequences (see all 625):

    AV707983 AA404957 AU076956 AI803755 BQ632579 AI372839 CR623037 CA395547 
    CB068540 F27562 AA345043 CF596073 BE439643 AW338822 AA962019 CD512537 
    AA317473 CD104740 CB963940 BG429150 CB998691 F25646 CD678720 AV733652 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MGP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                    -               
    SP2:        -                           


    ECgene alternative splicing isoforms for MGP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTATGGAT
    MGP Expression
    About this image


    MGP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 24 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
             Micromass-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 21 entries
             Mesenchymal Condensate Cells Zeugopod
             Micromass-induced chondrocytes
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Visceral White Preadipocytes Visceral White Adipose
             White adipocyte-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Mature Cardiac Fibroblasts Myocardium
             Atrioventricular Node
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
    MGP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.365706
        Pathway & Disease-focused RT2 Profiler PCR Array including MGP: 
              Nephrotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MGP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MGP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgp1 , 5 matrix Gla protein1, 5 81.23(n)1
    83.5(a)1
      6 (66.72 cM)5
    173131  NM_008597.31  NP_032623.11 
     1368724365 
    chicken
    (Gallus gallus)
    Aves MGP6
    Gallus gallus matrix Gla protein (MGP), mRNA.
    55(a)
    1 ↔ 1
    1(47886140-47891373)
    lizard
    (Anolis carolinensis)
    Reptilia MGP6
    matrix Gla protein
    51(a)
    1 ↔ 1
    5(27709526-27723015)


    ENSEMBL Gene Tree for MGP (if available)
    TreeFam Gene Tree for MGP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGP (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895729491,2
    C--14902504(+) ATTTTC/TCTAAT 2 -- ds50010--------
    rs715376911,2
    C,F--14902749(+) AGAAAC/TGTGGC 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1921879631,2
    C--14902801(+) AAAAAC/TAAGCA 2 -- ds50010--------
    rs348292491,2
    C--14902955(-) GAAAAG/TAAAGA 2 -- ut313Minor allele frequency- T:0.01NS NA 92
    rs1427735841,2
    C--14903149(+) TGGAAA/CCTTTA 2 -- ut310--------
    rs341815331,2
    C,F--14903289(-) CAAATA/GAAAGC 2 -- ut315Minor allele frequency- G:0.05NS NA WA 98
    rs1145127851,2
    C,F--14903300(+) TCCCTT/CCTGCT 2 -- ut311Minor allele frequency- C:0.02WA 118
    rs10498971,2
    C,F,O,A,H--14903352(-) TTCTGA/TATCAA 2 -- ut31 ese314Minor allele frequency- T:0.30MN NS EA NA WA 1060
    rs1390693211,2
    C--14903366(+) TTTTTC/GACTTT 2 -- ut310--------
    rs1849165171,2
    --14903428(+) TTACAA/GTAGGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MGP (15034115 - 15038860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MGP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898818CNV Loss21882294
    nsv898817CNV Gain21882294

    Human Gene Mutation Database (HGMD): MGP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154870   
    OMIM disorders: 245150  
    UniProtKB/Swiss-Prot: MGP_HUMAN, P08493
  • Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage
    calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 9 diseases for MGP:    
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    keutel syndrome    natural teeth remaining intact    acute apical periodontitis    hemorrhagic disease
    vitamin k deficiency hemorrhagic disease    varicose veins    hyperphosphatemia    pseudoxanthoma elasticum
    aortic valve stenosis

    6 diseases from the University of Copenhagen DISEASES database for MGP:
    Vitamin K deficiency hemorrhagic disease     Pseudoxanthoma elasticum     Vascular disease     Pain agnosia
    Kidney disease     Acute apical periodontitis

    Find genes that share disorders with MGP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MGP gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 88.2 297 14587031 (7), 17848178 (6), 15045141 (6), 11716499 (5) (see all 99)
    keutel syndrome 83.9 3 11405537 (1), 15810001 (1), 9916809 (1)
    hyperphosphatemia 65.2 1 19121777 (1)
    vitamin k deficiency 64 4 11410932 (1), 18401181 (1), 19363777 (1), 19692494 (1)
    arterial vessels 58.8 3 11716499 (1), 16505034 (1), 17509359 (1)
    renal disease 54 2 20133489 (2)
    atherosclerosis 53 17 15210134 (3), 10807741 (1), 11374034 (1), 17074310 (1) (see all 10)
    atherosclerotic plaque 51.9 8 12151082 (1), 13677259 (1), 15775403 (1), 15045141 (1) (see all 5)
    arteriosclerosis 47.6 2 15744522 (1)
    cardiovascular diseases 43.2 6 15775403 (2), 19692494 (1), 16973975 (1), 18841280 (1) (see all 5)

    Genetic Association Database (GAD): MGP
    Human Genome Epidemiology (HuGE) Navigator: MGP (24 documents)

    Export disorders for MGP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGP gene, integrated from 10 sources (see all 253):
    (articles sorted by number of sources associating them with MGP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PubMed id 2394711)1, 2, 3, 9 Cancela M.L.... Price P.A. (J. Biol. Chem. 1990)
    2. Carboxyl-terminal proteolytic processing of matrix Gla protein. (PubMed id 1939157)1, 2, 9 Hale J.E.... Price P.A. (J. Biol. Chem. 1991)
    3. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction. (PubMed id 11073842)1, 4, 9 Herrmann S.M....Cambien F. (Arterioscler. Thromb. Vasc. Biol. 2000)
    4. The local calcification inhibitor matrix Gla protein in pseudoxanthoma elasticum. (PubMed id 18222176)1, 4, 9 Hendig D....GAPtting C. (Clin. Biochem. 2008)
    5. A polymorphism of matrix Gla protein gene is associated with kidney stones. (PubMed id 17509359)1, 4, 9 Gao B....Kohri K. (J. Urol. 2007)
    6. Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. (PubMed id 15744522)1, 4, 9 Taylor B.C....Sidney S. (Hum. Genet. 2005)
    7. Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human. (PubMed id 8061611)1, 2, 9 Price P.A.... Williamson M.K. (Protein Sci. 1994)
    8. Polymorphisms in MGP gene and their association with lead toxicity. (PubMed id 19730704)1, 4, 9 Shaik A.P. and Jamil K. (Toxicol. Mech. Methods 2009)
    9. Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients. (PubMed id 16210837)1, 4, 9 Brancaccio D....Cozzolino M. (Am. J. Nephrol. 2005)
    10. T-138C polymorphism of matrix gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification. (PubMed id 15864013)1, 4, 9 Kobayashi N....Kitazawa S. (Kobe J Med Sci 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4256 HGNC: 7060 AceView: MGP Ensembl:ENSG00000111341 euGenes: HUgn4256
    ECgene: MGP H-InvDB: MGP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGP Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/mgp/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGP gene:
    Search GeneIP for patents involving MGP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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