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Aliases for MGP Gene

Aliases for MGP Gene

  • Matrix Gla Protein 2 3 5
  • Cell Growth-Inhibiting Gene 36 Protein 3 4
  • MGLAP 3 4
  • GIG36 3
  • NTI 3

External Ids for MGP Gene

Previous GeneCards Identifiers for MGP Gene

  • GC12M014774
  • GC12M015179
  • GC12M014934
  • GC12M014926
  • GC12M015034

Summaries for MGP Gene

Entrez Gene Summary for MGP Gene

  • The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for MGP Gene

MGP (Matrix Gla Protein) is a Protein Coding gene. Diseases associated with MGP include keutel syndrome and vitamin k deficiency hemorrhagic disease. Among its related pathways are Endochondral Ossification and Warfarin Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and structural constituent of bone.

UniProtKB/Swiss-Prot for MGP Gene

  • Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Gene Wiki entry for MGP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGP Gene

Genomics for MGP Gene

Regulatory Elements for MGP Gene

Promoters for MGP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGP on UCSC Golden Path with GeneCards custom track

Genomic Location for MGP Gene

Chromosome:
12
Start:
14,881,181 bp from pter
End:
14,885,926 bp from pter
Size:
4,746 bases
Orientation:
Minus strand

Genomic View for MGP Gene

Genes around MGP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGP Gene

Proteins for MGP Gene

  • Protein details for MGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08493-MGP_HUMAN
    Recommended name:
    Matrix Gla protein
    Protein Accession:
    P08493
    Secondary Accessions:
    • A0M8W5
    • B2R519
    • J3KMX7
    • Q2TU41
    • Q567P9
    • Q6ICN5

    Protein attributes for MGP Gene

    Size:
    103 amino acids
    Molecular mass:
    12353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGP Gene

Proteomics data for MGP Gene at MOPED

Post-translational modifications for MGP Gene

  • Requires vitamin K-dependent gamma-carboxylation for its function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MGP Gene

Antibody Products

No data available for DME Specific Peptides for MGP Gene

Domains & Families for MGP Gene

Gene Families for MGP Gene

Suggested Antigen Peptide Sequences for MGP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08493

UniProtKB/Swiss-Prot:

MGP_HUMAN :
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Belongs to the osteocalcin/matrix Gla protein family.
Domain:
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
Family:
  • Belongs to the osteocalcin/matrix Gla protein family.
genes like me logo Genes that share domains with MGP: view

Function for MGP Gene

Molecular function for MGP Gene

GENATLAS Biochemistry:
bone matrix GLA protein,vitamin K dependent,vitamin D regulated
UniProtKB/Swiss-Prot Function:
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Gene Ontology (GO) - Molecular Function for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 9916809
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MGP: view
genes like me logo Genes that share phenotypes with MGP: view

Human Phenotype Ontology for MGP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MGP Gene

MGI Knock Outs for MGP:

Animal Model Products

miRNA for MGP Gene

miRTarBase miRNAs that target MGP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MGP Gene

Localization for MGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGP Gene COMPARTMENTS Subcellular localization image for MGP gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MGP Gene

Pathways & Interactions for MGP Gene

genes like me logo Genes that share pathways with MGP: view

Pathways by source for MGP Gene

Gene Ontology (GO) - Biological Process for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation TAS 9916809
genes like me logo Genes that share ontologies with MGP: view

No data available for SIGNOR curated interactions for MGP Gene

Drugs & Compounds for MGP Gene

(9) Drugs for MGP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MGP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MGP: view

Transcripts for MGP Gene

Unigene Clusters for MGP Gene

Matrix Gla protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for MGP Gene

GeneLoc Exon Structure for
MGP
ECgene alternative splicing isoforms for
MGP

Expression for MGP Gene

mRNA expression in normal human tissues for MGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGP Gene

This gene is overexpressed in Artery - Aorta (x12.2) and Artery - Coronary (x5.9).

Protein differential expression in normal tissues from HIPED for MGP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.8), Breast (9.8), and Saliva (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MGP Gene



SOURCE GeneReport for Unigene cluster for MGP Gene Hs.365706

genes like me logo Genes that share expression patterns with MGP: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MGP Gene

Orthologs for MGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGP 35
  • 83.82 (n)
  • 83.5 (a)
dog
(Canis familiaris)
Mammalia MGP 35
  • 85.11 (n)
  • 86.41 (a)
mouse
(Mus musculus)
Mammalia Mgp 35
  • 81.23 (n)
  • 83.5 (a)
Mgp 16
Mgp 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGP 35
  • 99.35 (n)
  • 98.06 (a)
MGP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgp 35
  • 79.94 (n)
  • 79.61 (a)
oppossum
(Monodelphis domestica)
Mammalia MGP 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGP 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGP 36
  • 51 (a)
OneToOne
Species with no ortholog for MGP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MGP Gene

ENSEMBL:
Gene Tree for MGP (if available)
TreeFam:
Gene Tree for MGP (if available)

Paralogs for MGP Gene

No data available for Paralogs for MGP Gene

Variants for MGP Gene

Sequence variations from dbSNP and Humsavar for MGP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1801716 - 14,882,985(-) GAGCT(A/G)AAGTC reference, missense
rs4236 - 14,882,147(-) GAGGG(A/G)CCAAA reference, missense
rs12304 -- 14,882,213(-) TTTGC(A/G/T)AACGC reference, missense, stop-gained
rs13617 -- 14,882,978(-) AGTCC(A/G)AGAGA reference, missense
rs972744 -- 14,887,858(+) TTTCA(A/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MGP Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
nsv898818 CNV Loss 21882294

Variation tolerance for MGP Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGP Gene

HapMap Linkage Disequilibrium report
MGP
Human Gene Mutation Database (HGMD)
MGP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGP Gene

Disorders for MGP Gene

MalaCards: The human disease database

(12) MalaCards diseases for MGP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
keutel syndrome
  • pulmonic stenosis brachytelephalangism and calcification of cartilages
vitamin k deficiency hemorrhagic disease
  • deficiency of vitamin k
relapsing polychondritis
  • chondromalacia, systemic
arteriosclerosis
  • arteriosclerosis nos
ureter cancer
  • malignant tumour of ureter
- elite association - COSMIC cancer census association via MalaCards
Search MGP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MGP_HUMAN
  • Keutel syndrome (KTLS) [MIM:245150]: An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. {ECO:0000269 PubMed:9916809}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MGP

Genetic Association Database (GAD)
MGP
Human Genome Epidemiology (HuGE) Navigator
MGP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGP
genes like me logo Genes that share disorders with MGP: view

No data available for Genatlas for MGP Gene

Publications for MGP Gene

  1. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PMID: 2394711) Cancela M.L. … Price P.A. (J. Biol. Chem. 1990) 2 3 4 23 67
  2. Immunohistochemical localization and mRNA expression of matrix Gla protein and fetuin-A in bone biopsies of hemodialysis patients. (PMID: 19151998) Coen G. … Bonucci E. (Virchows Arch. 2009) 3 23
  3. Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. (PMID: 19190822) Cranenburg E.C. … Schurgers L.J. (Thromb. Haemost. 2009) 3 23
  4. Individual susceptibility and genotoxicity in workers exposed to hazardous materials like lead. (PMID: 19327888) Shaik A.P. … Jamil K. (J. Hazard. Mater. 2009) 3 23
  5. Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification. (PMID: 19350115) Koos R. … Schurgers L.J. (Thromb. Haemost. 2009) 3 23

Products for MGP Gene

Sources for MGP Gene

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