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MGMT Gene

protein-coding   GIFtS: 69
GCID: GC10P131195

O-6-Methylguanine-DNA Methyltransferase

  See MGMT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
O-6-Methylguanine-DNA Methyltransferase1 2     Methylated-DNA--Protein-Cysteine Methyltransferase2
6-O-Methylguanine-DNA Methyltransferase2 3     Methylguanine-DNA Methyltransferase2
O-6-methylguanine-DNA-alkyltransferase2 3     O6-Methylguanine-DNA Methyltransferase2
EC 2.1.1.633 8     

External Ids:    HGNC: 70591   Entrez Gene: 42552   Ensembl: ENSG000001704307   OMIM: 1565695   UniProtKB: P164553   

Export aliases for MGMT gene to outside databases

Previous GC identifers: GC10P130078 GC10P130307 GC10P130739 GC10P130808 GC10P131155 GC10P124842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MGMT Gene:
MGMT (O-6-methylguanine-DNA methyltransferase) is a protein-coding gene. Diseases associated with MGMT include spinal cord astrocytoma, and oligoastrocytoma. GO annotations related to this gene include DNA-methyltransferase activity and calcium ion binding.

UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455
Function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.
Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a
cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated

summary for MGMT Gene:
MGMT encodes O-6-methylguanine-DNA methyltransferase, an enzyme involved in DNA repair. This enzyme removes
alkylating lesions at the O6 of guanine residues. This can undermine cancer therapy using alkylating agents,
and thus inhibitors of MGMT activity are of interest in cancer research.

Gene Wiki entry for MGMT (O-6-methylguanine-DNA methyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGMT gene promoter:
         GR   GR-beta   CUTL1   IRF-1   NF-kappaB   POU2F1   POU2F1a   IRF-7A   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGMT promoter sequence
   Search Chromatin IP Primers for MGMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26

MGMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGMT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P131195:  view genomic region     (about GC identifiers)

Start:
131,265,448 bp from pter      End:
131,566,271 bp from pter
Size:
300,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455 (See protein sequence)
Recommended Name: Methylated-DNA--protein-cysteine methyltransferase  
Size: 207 amino acids; 21646 Da
Cofactor: Binds 1 zinc ion
Miscellaneous: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one
definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles
Selected PDB 3D structures from and Proteopedia for MGMT (see all 7):
1EH6 (3D)        1EH7 (3D)        1EH8 (3D)        1QNT (3D)        1T38 (3D)        1T39 (3D)    
Secondary accessions: Q5VY78

Explore the universe of human proteins at neXtProt for MGMT: NX_P16455

Explore proteomics data for MGMT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys125, Lys178
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MGMT (P16455) (see all 5)
     KEWLLAHEG  PALHHPVFQQ  NPVPILIPCHRV  SFTRQVLWKLLKVVKFGE 


    See MGMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002403.2  
    ENSEMBL proteins: 
     ENSP00000302111  
    Reactome Protein details: P16455

    MGMT Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for MGMT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008332 MethylG_MeTrfase
     IPR001497 MethylDNA_cys_MeTrfase_AS
     IPR014048 MethylDNA_cys_MeTrfase_DNA-bd
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P16455

    ProtoNet protein and cluster: P16455

    1 Blocks protein domain: IPB001497 Methylated-DNA-[protein]-cysteine S-methyltransferase

    UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455
    Similarity: Belongs to the MGMT family


    Find genes that share domains with MGMT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGMT_HUMAN, P16455
    Function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.
    Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a
    cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
    Catalytic activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) +
    protein S-methyl-L-cysteine

         Genatlas biochemistry entry for MGMT:
    O6-methylguanine-DNA-methyltransferase

         Enzyme Number (IUBMB): EC 2.1.1.631 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003908methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008168methyltransferase activity TAS2188979
         
    Find genes that share ontologies with MGMT           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mgmt):
     endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with MGMT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MGMT: Mgmttm1Mse Mgmttm1Lds

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGMT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGMT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGMT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGMT

    miRNA
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    miRTarBase miRNAs that target MGMT:
    hsa-mir-181d-5p (MIRT006937)

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    3 qRT-PCR Assays for microRNAs that regulate MGMT:
    hsa-miR-3607-3p hsa-miR-1197 hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MGMT

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MGMT (NM_002412)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGMT_HUMAN, P16455: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS2188979
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with MGMT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGMT About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1DNA Repair
    DNA Repair0.45
    DNA Damage Reversal0.00
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4Selected targets of p53
    Selected targets of p53
    5Selected targets of GCR alpha
    Selected targets of GCR alpha


    Find genes that share SuperPaths with MGMT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MGMT
        DNA Repair Mechanisms
    Glioblastoma Multiforme

    3 Cell Signaling Technology (CST) Pathways for MGMT
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control
    DNA Damage


    1 Reactome Pathway for MGMT
        DNA Damage Reversal

    2 PharmGKB Pathways for MGMT
        Busulfan Pathway, Pharmacodynamics
    Cyclophosphamide Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGMT (see all 7): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MGMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MGMT (ENSP000003021114) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP12ENSP000002839434STRING: ENSP00000283943
    UBCENSP000003448184STRING: ENSP00000344818
    BRCA2ENSP000003694974STRING: ENSP00000369497
    UBA1ENSP000003384134STRING: ENSP00000338413
    CREBBPENSP000002623674STRING: ENSP00000262367
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    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006266DNA ligation TAS2188979
    GO:0006281DNA repair TAS--
    GO:0006306DNA methylation TAS2405387
    GO:0006307DNA dealkylation involved in DNA repair IEA--
    GO:0006974cellular response to DNA damage stimulus ----

    Find genes that share ontologies with MGMT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MGMT
      Browse compounds at ApexBio 

    Compounds for MGMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    UNC 0638Selective G9a and GLP histone lysine methyltransferase inhibitor[1255517-77-1]
    BIX 01294G9a-like protein and G9a histone lysine methyltransferase inhibitor[935693-62-2]
    SGC 0946Highly potent and selective DOT1L inhibitor; cell permeable--
    3-Deazaneplanocin A hydrochlorideHistone methyltransferase inhibitor[120964-45-6]
    UNC 0646Potent and selective G9a/GLP inhibitor[1320288-17-2]

    1 HMDB Compound for MGMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--

    3 DrugBank Compounds for MGMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzylcysteine-- --target--17139284 17016423
    S-Methylcysteine-- 1187-84-4target--17139284 17016423
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--16950796

    Selected Novoseek inferred chemical compound relationships for MGMT gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    o6-methylguanine 97.2 418 12449729 (6), 8366118 (4), 9422728 (4), 9875292 (3) (see all 99)
    temozolomide 95.5 530 18952979 (7), 16405512 (7), 15297393 (6), 19067722 (6) (see all 99)
    o6-benzylguanine 94.3 314 11303039 (7), 10647505 (7), 8364924 (6), 10565851 (6) (see all 87)
    chloroethylnitrosourea 89.2 91 10352868 (6), 10454526 (5), 8900378 (5), 8993023 (3) (see all 21)
    chloroethyl nitrosoureas 88.9 54 8393842 (3), 1518162 (2), 7558444 (2), 8605218 (2) (see all 19)
    bcnu 88 288 8364924 (8), 1825618 (7), 8044784 (7), 14742745 (5) (see all 66)
    o(6)-benzyl-2'-deoxyguanosine 85.8 17 8797031 (5), 8044784 (2), 10589786 (1), 8616853 (1) (see all 6)
    lomeguatrib 85.4 22 19367283 (3), 17500047 (3), 20068091 (3), 17577032 (3) (see all 8)
    acnu 85.2 94 9257312 (5), 8145054 (5), 1518162 (4), 15809756 (4) (see all 29)
    nitrosourea 83.2 20 15853207 (2), 9779706 (1), 11778552 (1), 15455376 (1) (see all 13)



    Find genes that share compounds with MGMT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGMT gene: 
    NM_002412.3  

    Unigene Cluster for MGMT:

    O-6-methylguanine-DNA methyltransferase
    Hs.501522  [show with all ESTs]
    Unigene Representative Sequence: AK293593
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306010(uc001lkh.2) ENST00000482653 ENST00000482547 ENST00000462672

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    Additional mRNA sequence: 

    AK293593.1 BC000824.1 BT006714.1 M29971.1 M31767.1 M60761.1 X54228.1 

    7 DOTS entries:

    DT.455458  DT.91694817  DT.75113319  DT.100781623  DT.121244429  DT.91969540  DT.95073525 

    Selected AceView cDNA sequences (see all 139):

    CR602497 CR618411 CB992752 BU845865 CF130478 BG764104 BQ217761 BU859113 
    BU172662 AL520114 BM670373 BM972582 AU102451 BU786059 BI772512 BU737340 
    BG183775 BM973348 BI771279 BM970224 BM974121 BI225271 BI520938 BE464809 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCCACCG
    MGMT Expression
    About this image

    MGMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501522
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGMT (see all 7): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Breast Cancer in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MGMT
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MGMT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgmt1 , 5 O-6-methylguanine-DNA methyltransferase1, 5 75.57(n)1
    70.39(a)1
      7 (82.07 cM)5
    173141  NM_008598.21  NP_032624.11 
     1368946115 
    chicken
    (Gallus gallus)
    Aves MGMT1 O-6-methylguanine-DNA methyltransferase 63.8(n)
    59.68(a)
      423965  XM_421823.4  XP_421823.2 
    lizard
    (Anolis carolinensis)
    Reptilia MGMT6
    O-6-methylguanine-DNA methyltransferase
    69(a)
    1 ↔ 1
    3(55377044-55641252)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.84552 Transcribed sequence with weak similarity to protein more 72.86(n)    BI313560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgmt1 O-6-methylguanine-DNA methyltransferase 51.9(n)
    48.5(a)
      553368  NM_001256243.1  NP_001243172.1 


    ENSEMBL Gene Tree for MGMT (if available)
    TreeFam Gene Tree for MGMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGMT (see all 6915)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17624381,2
    C,F,A,H--131263457(-) GTGCCA/GACTGA 1 -- us2k121Minor allele frequency- G:0.49NS EA NA WA CSA 2348
    rs758809871,2
    F--131263477(+) ATTTCG/AGCATT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1846841591,2
    C--131263562(+) TATAGC/TATTAT 1 -- us2k10--------
    rs1886573231,2
    --131263636(+) AAGGAC/TAGTTT 1 -- us2k10--------
    rs107648811,2
    C,F,A,H--131263831(+) GTTGAG/AAAGGA 1 -- us2k120Minor allele frequency- A:0.24NS EA NA 2222
    rs561513241,2
    C,F--131263928(+) CAAGCC/AGCTAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs572301751,2
    C,F--131263929(+) AAGCAG/CCTATT 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1164194751,2
    F--131263969(+) GGGTGG/TGGAAC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1437277011,2
    --131264198(+) AGGCCC/TGTAGC 1 -- us2k10--------
    rs789253431,2
    F--131264282(+) GATGAT/CACTAC 1 -- us2k11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for MGMT (131265448 - 131515448 bp, first 250kb of MGMT)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MGMT (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673844CNV Deletion23128226
    dgv174e199CNV Deletion23128226
    esv2743445CNV Deletion23290073
    esv2673495CNV Deletion23128226
    nsv513300CNV Insertion21212237
    nsv7617CNV Insertion18451855
    nsv24217CNV Insertion16902084
    nsv896102CNV Loss21882294
    esv21706CNV Loss19812545
    nsv896101CNV Loss21882294

    Human Gene Mutation Database (HGMD): MGMT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGMT
    DNA2.0 Custom Variant and Variant Library Synthesis for MGMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156569    OMIM disorders: --

    19 diseases for MGMT:    
    About MalaCards
    spinal cord astrocytoma    oligoastrocytoma    galactokinase deficiency    central nervous system lymphoma
    astrocytoma    anaplastic ependymoma    nelson syndrome    gliosarcoma
    oligodendroglioma    pleomorphic xanthoastrocytoma    male germ cell tumor    giant cell glioblastoma
    barrett's esophagus    familial melanoma    ependymoma    glioblastoma multiforme
    medulloblastoma    colorectal cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for MGMT:
    Malignant glioma

    Find genes that share disorders with MGMT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MGMT gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 87.5 244 19100509 (6), 19224454 (5), 18695875 (4), 19536096 (4) (see all 99)
    glioma 80.8 256 15363200 (7), 15297393 (6), 18580490 (6), 1893534 (5) (see all 99)
    glioblastoma multiforme 77.8 36 17473190 (3), 15455376 (2), 18400046 (2), 19637364 (2) (see all 23)
    malignant glioma 75.5 45 16849758 (5), 17166381 (4), 17691113 (2), 18757334 (2) (see all 21)
    tumors 75.3 1000 10404091 (7), 7729942 (6), 11297257 (6), 8706038 (6) (see all 99)
    microsatellite instability 75.3 26 17342321 (3), 12763209 (1), 17971589 (1), 15888787 (1) (see all 18)
    oligodendroglial tumors 73.5 15 16038527 (3), 15455350 (3), 16116609 (2), 19901104 (2) (see all 8)
    anaplastic astrocytoma 70.5 16 9779706 (2), 17721049 (2), 15455376 (1), 7549044 (1) (see all 13)
    anaplastic oligodendroglioma 70.2 3 18347414 (1), 16944363 (1), 15455350 (1)
    oligodendroglioma 70 25 16116609 (3), 11907807 (2), 17332285 (2), 7627911 (2) (see all 17)

    Genetic Association Database (GAD): MGMT
    Human Genome Epidemiology (HuGE) Navigator: MGMT (128 documents)

    Export disorders for MGMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGMT gene, integrated from 10 sources (see all 1306):
    (articles sorted by number of sources associating them with MGMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations. (PubMed id 19100509)1, 4, 9 Jesien-Lewandowicz E....Kordek R. (Cancer Genet. Cytogenet. 2009)
    2. MGMT methylation is associated primarily with the germline C&gt;T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. (PubMed id 19734844)1, 4, 9 Hawkins N.J....Hitchins M.P. (Mod. Pathol. 2009)
    3. Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. (PubMed id 17285603)1, 4, 9 Hu Z....Shen H. (Hum. Mutat. 2007)
    4. Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism. (PubMed id 15140540)1, 4, 9 Yang M....Kadlubar F.F. (Lung Cancer 2004)
    5. A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. (PubMed id 14669534)1, 4, 9 Inoue R....Kobayashi H. (Neurol. Res. 2003)
    6. Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA. (PubMed id 8202360)1, 2, 9 Liem L.-K.... Li B.F.L. (Nucleic Acids Res. 1994)
    7. Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians. (PubMed id 19741564)1, 4, 9 Boeckmann L....Emmert S. (Pharmacogenet. Genomics 2009)
    8. DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. (PubMed id 17898525)1, 4, 9 Felini M.J....Wrensch M.R. (Neuroepidemiology 2007)
    9. O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). (PubMed id 16633920)1, 4, 9 Tranah G.J....Hunter D.J. (amp 2006)
    10. Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk. (PubMed id 16777993)1, 4, 9 Han J....De Vivo I. (Carcinogenesis 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4255 HGNC: 7059 AceView: MGMT Ensembl:ENSG00000170430 euGenes: HUgn4255
    ECgene: MGMT H-InvDB: MGMT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGMT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGMT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGMT gene:
    Search GeneIP for patents involving MGMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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