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MGMT Gene

protein-coding GIFtS: 69

GC10P131155

O-6-methylguanine-DNA methyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.1.1.63 ^³
O-6-methylguanine-DNA-alkyltransferase ^³
OTTHUMP00000020741 ^²

Descriptions
6-O-methylguanine-DNA methyltransferase ^³
O-6-methylguanine-DNA methyltransferase ^²
O6-methylguanine-DNA methyltransferase ^²
methylguanine-DNA methyltransferase ^²

External Ids
HGNC: 7059¹
Entrez Gene: 4255²
UniProtKB: P16455³
Ensembl: ENSG00000170430⁷

Search outside databases for aliases for MGMT gene

Previous GC identifers: GC10P130078 GC10P130307 GC10P131195 GC10P130739 GC10P130808

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455

Function: Involved in the cellular defense against the biological effects of O6-methylguanine

(O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl

group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the

enzyme is irreversibly inactivated

Gene Wiki entry for MGMT (O-6-methylguanine-DNA_methyltransferase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MGMT gene

Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26

MGMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P131155: (about GC identifiers)

Start:	131,155,456 bp from pter
End:	131,455,358 bp from pter
Size:	299,903 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008818.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455 (See protein sequence)

Recommended Name: Methylated-DNA--protein-cysteine methyltransferase

Size: 207 amino acids; 21646 Da

Cofactor: Binds 1 zinc ion

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1EH6 (3D)

1EH7 (3D)

1EH8 (3D)

1QNT (3D)

1T38 (3D)

1T39 (3D)

1YFH (3D)

Secondary accessions: Q5VY78

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002403.2

ENSEMBL proteins:

ENSP00000302111

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for MGMT
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MGMT)
	Human Recombinant Proteins from Abnova (MGMT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	2188979
GO:0005654	nucleoplasm	EXP	8434121

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Antibodies for MGMT:

	Invitrogen Antibodies for MGMT
	Millipore Mono- and Polyclonal Antibodies for the study of MGMT
	Sigma-Aldrich Antibody Arrays and Antibodies for MGMT
	R&D Systems Antibodies for MGMT
	Cell Signaling Technology (CST) Antibodies for MGMT
	Antibodies from Abcam (MGMT), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for MGMT

Assays for MGMT:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of MGMT
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P16455

ProtoNet protein and cluster: P16455

1 Blocks protein family: IPB001497 Methylated-DNA-[protein]-cysteine S-methyltransferase

UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455

Similarity: Belongs to the MGMT family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MGMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MGMT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002412

Applied Biosystems Silencer® siRNAs for MGMT

Sigma-Aldrich siRNA and siRNA Panels for MGMT

Sigma-Aldrich shRNA Panels and shRNA for MGMT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002412
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002412
untagged cDNA clones in CMV expression vector (see all 2): NM_002412

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002412

UniProtKB/Swiss-Prot: MGMT_HUMAN, P16455

Function: Involved in the cellular defense against the biological effects of O6-methylguanine

(O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl

group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the

enzyme is irreversibly inactivated

Catalytic activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without

6-O-methylguanine) + protein S-methyl-L-cysteine

Enzyme Number (IUBMB): EC 2.1.1.63

Genatlas biochemistry entry for MGMT:

O6-methylguanine-DNA-methyltransferase

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mgmt):

digestive/alimentary	endocrine/exocrine gland	homeostasis/metabolism	life span-post-weaning/aging	no phenotypic analysis
tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	2188979
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0009008	DNA-methyltransferase activity	TAS	2405387
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for MGMT (Your Favorite Gene powered by Ingenuity) (see all 9 )

Histidine Metabolism
Tyrosine Metabolism
Aminophosphonate Metabolism
Ubiquinone Biosynthesis
Tryptophan Metabolism

GeneDecks MGMT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MGMT

5/54 Interacting proteins for MGMT (ENSP00000302111³) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	ENSP00000269305³	STRING (score=.966)
DNMT1	ENSP00000352516³	STRING (score=.944)
MECP2	ENSP00000358973³	STRING (score=.908)
CDKN2A	ENSP00000355153³	STRING (score=.903)
CDKN2B	ENSP00000276925³	STRING (score=.873)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006266	DNA ligation	TAS	2188979
GO:0006307	DNA dealkylation	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0043281	regulation of caspase activity	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for MGMT:

Inhibitor

Browse Tocris compounds for MGMT
10/41 Novoseek chemical compound relationships for MGMT gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
o6-methylguanine	97.14	377	12449729 (6), 8366118 (4), 9422728 (4), 9875292 (3) (see all 99)
chloroethylnitrosourea	90.03	91	10352868 (6), 10454526 (5), 8900378 (5), 8993023 (3) (see all 21)
chloroethyl nitrosoureas	89.67	54	8393842 (3), 1518162 (2), 7558444 (2), 8605218 (2) (see all 19)
o(6)-benzyl-2'-deoxyguanosine	86.63	17	8797031 (5), 8044784 (2), 10589786 (1), 8616853 (1) (see all 6)
lomeguatrib	84.84	19	19367283 (3), 17500047 (3), 17577032 (3), 15486188 (1) (see all 7)
nitrosourea	83.28	20	15853207 (2), 9779706 (1), 11778552 (1), 15455376 (1) (see all 13)
mnng	71.84	35	1875945 (4), 1657427 (4), 8033107 (3), 7605582 (2) (see all 13)
n-methyl-n'-nitrosourea	70.97	20	17507295 (2), 15870882 (2), 2320583 (1), 10439048 (1) (see all 7)
o-4-methylthymine	70.36	3	8276875 (2)
hecnu	69.63	3	1657427 (1), 8621235 (1)

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1 PharmGKB drug compound relationship for MGMT gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
carmustine	PD	11229339

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MGMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MGMT)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002412

Sigma-Aldrich siRNA and siRNA Panels for MGMT

Sigma-Aldrich shRNA Panels and shRNA for MGMT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002412

REFSEQ mRNAs for MGMT gene:

NM_002412.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002412

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002412
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002412
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002412

Additional cDNA sequence:

AK293593.1 BC000824.1 BT006714.1 CR599817.1 CR602497.1 CR618411.1 M29971.1 M31767.1

M60761.1 X54228.1

7 DOTS entries:

DT.455458 DT.91694817 DT.75113319 DT.100781623 DT.121244429 DT.91969540 DT.95073525

24/139 AceView cDNA sequences (see all 139 ):

CR602497 BU737340 BU947266 BQ072274 BG183775 BI520938 BU786059 CR599817

BM758658 CF130478 BI771279 BU845865 AU102451 AL520114 BX102721 BQ641434

AU098362 BU172662 BG764104 CB992752 CR618411 BU616455 CB993639 AL524961

highest scoring ESTs for MGMT:

M31767 AA126722 AA531469 AA677158 AA862955 AA948354 AA978354 AI040746 AI052155 AI057145

Unigene Cluster for MGMT:

O-6-methylguanine-DNA methyltransferase

Hs.501522 [show with all ESTs]

Unigene Representative Sequence: CR618411

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000306010

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MGMT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MGMT

¹ / ² / ³

4 probe-sets matching MGMT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2052_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.10	M31767	1.00	1.00	1.00	1
2051_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.90	M31767	1.00	1.00	1.00	1
204880_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002412	0.60	1.00	0.82	1
204880_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MGMT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGCCACCG

SOURCE GeneReport for Unigene cluster: Hs.501522
Expression variation in blood from EXPOLDB for MGMT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MGMT gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MGMT¹	--	O-6-methylguanine-DNA methyltransferase	75.36(n) 64.73(a)	442978 NM_001003376.1 NP_001003376.1
chimpanzee (Pan troglodytes)	MGMT¹	--	O-6-methylguanine-DNA methyltransferase	98.87(n) 97.58(a)	737624 XM_001142341.1 XP_001142341.1
cow (Bos taurus)	MGMT¹	--	O-6-methylguanine-DNA methyltransferase	77.62(n) 68.6(a)	616091 XM_001249417.1 XP_001249418.1
rat (Rattus norvegicus)	Mgmt¹	--	O-6-methylguanine-DNA methyltransferase	74.67(n) 70.59(a)	25332 NM_012861.1 NP_036993.1
mouse (Mus musculus)	Mgmt^{1, 5}	7 (66.00 cM)⁵	O-6-methylguanine-DNA methyltransferase^{1, 5}	75.89(n)¹ 70.87(a)¹	17314¹ NM_008598.2¹ NP_032624.1¹ AB092489⁵ AB092490⁵ (see all 14)

About this table Species with no ortholog for MGMT

ENSEMBL Gene Tree for MGMT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1919 NCBI SNPs in MGMT are shown (see all 1919 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 786)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10764881^1,2	A,C,F,H	131153821(+)	`GTTGAG/AAAGGA`	1	--	ng5¹		1		WA	120
	rs12917^1,2	C,F,H	131396273(+)	`CGGCTC/TTTCAC`	1	L/F	mis¹ ese³		21		MN NA EA CSAM EU WA	3996
	rs2020893^1,2	C,F,H	131224594(+)	`TGCACG/AAAATA`	1	K/E	mis¹ ese³		14		NA MN EU EA WA	2280
	rs2282164^1,2	C,F,H	131396218(-)	`TTCAGC/GCAGGC`	1	W/C	mis¹		11		EA MN CSAM EU WA	2484
	rs11591545^1,2	A,C	131209612(+)	`GCCCCA/GCCCAG`	1	--	ut5¹		0	--	--	--	--
--	rs1711646^1,2	A,C	131154571(-)	`ggcagA/Caggcc`	1	--	ng5¹		0	--	--	--	--
	rs1625649^1,2	A,F	131154921(-)	`CCTGGT/GGCCGC`	1	--	ng5¹		1		MN	184
	rs3750824^1,2	H	131447564(+)	`CGCGCG/AAGCAG`	1	Q/R	mis¹ ese³		4		EU EA WA	420
	rs1803965^1,2	C,F,H	131396182(+)	`GTTCTC/TGGAGG`	1	L/L	syn¹ ese³		20		NA EA MN CSAM EU WA	3926
--	rs16906252^1,2	F	131155535(-)	`ACGGTG/ACGCAC`	1	R/R	syn¹ ese³		1		MN	184

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HapMap Linkage Disequilibrium images for MGMT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 156569

10/94 Novoseek disease relationships for MGMT gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	84.58	173	19100509 (6), 19224454 (5), 18695875 (4), 18647495 (4) (see all 79)
glioma	78.17	218	15363200 (7), 15297393 (6), 18580490 (6), 1893534 (5) (see all 83)
microsatellite instability	74.97	24	17342321 (3), 12763209 (1), 17971589 (1), 15888787 (1) (see all 16)
glioblastoma multiforme	74.52	29	17473190 (3), 15455376 (2), 17721049 (2), 18400046 (2) (see all 17)
tumors	73.74	886	10404091 (7), 7729942 (6), 11297257 (6), 10029064 (6) (see all 99)
malignant glioma	72.98	39	16849758 (5), 17166381 (4), 17691113 (2), 1501894 (2) (see all 16)
oligodendroglioma	70.69	23	16116609 (3), 11907807 (2), 17332285 (2), 7627911 (2) (see all 15)
oligodendroglial tumors	69.89	12	16038527 (3), 15455350 (3), 16116609 (2), 19333441 (1) (see all 6)
anaplastic astrocytoma	69.84	16	9779706 (2), 17721049 (2), 15455376 (1), 7549044 (1) (see all 13)
brain tumors	68.68	77	1518162 (4), 12503076 (4), 8393842 (3), 7729942 (3) (see all 33)

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1 PharmGKB disease relationship for MGMT gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Glioma	PD	11229339

About this table

Human Gene Mutation Database: MGMT
Genetic Association Database: MGMT
Human Genome Epidemiology Navigator: MGMT (66 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/921 PubMed articles for MGMT gene (see all 921 ):

Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism. (PubMed id 15140540)^{1, 3, 6} Yang M....Kadlubar F.F. (2004)
A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. (PubMed id 14669534)^{1, 3, 6} Inoue R....Kobayashi H. (2003)
Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. (PubMed id 15225156)^{1, 3, 6} Krzesniak M....Rusin M. (2004)
Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. (PubMed id 15885889)^{1, 3, 6} Li C....Zhang Z. (2005)
Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. (PubMed id 16030116)^{1, 3, 6} Wiencke J.K....Wrensch M. (2005)
DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. (PubMed id 16284370)^{1, 3, 6} Bigler J....Potter J.D. (2005)
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). (PubMed id 12883749)^{1, 3, 6} Xing D....Lin D. (2003)
Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden. (PubMed id 12402349)^{1, 3, 6} Egyhazi S....Ringborg U. (2002)
Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA. (PubMed id 8202360)^{1, 3, 4} Liem L.-K.... Li B.F.L. (1994)
cDNA cloning and chromosomal assignment of the human O6- methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. (PubMed id 2188979)^{1, 3, 4} Rydberg B.... Karran P. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4255	HGNC: 7059	AceView: MGMT	Ensembl:ENSG00000170430	euGenes: HUgn4255
ECgene: MGMT	H-InvDB: MGMT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MGMT	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MGMT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MGMT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MGMT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MGMT		Antibodies for MGMT
	Explore super-pooled esiRNAs		Proteins for MGMT
	Lentivirus-delivered shRNAs for MGMT		Small molecules for MGMT
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MGMT)
	Search for Antibodies
	Chimera RNAi (MGMT)
	Custom Service for Mouse Mab
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Antibodies & Assays for MGMT

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	Antibodies (MGMT)

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Antibodies for MGMT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MGMT Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for MGMT

Summaries
for MGMT

Genomic Location
for MGMT

Proteins
for MGMT

Protein Domains/
Families
for MGMT

Gene Function
for MGMT

Pathways & Interactions
for MGMT

Drugs & Compounds
for MGMT

Transcripts
for MGMT

Expression
for MGMT

Orthologs
for MGMT

Paralogs
for MGMT

SNPs/Variants
for MGMT

Disorders & Mutations
for MGMT

Medical News
for MGMT

Publications
for MGMT

Search for MGMT

Genome Databases showing MGMT

Other Databases showing MGMT

Specialized Databases showing MGMT

Licensable Technologies
for MGMT

Services
for MGMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MGMT Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor MGMT

Summariesfor MGMT

Genomic Locationfor MGMT

Proteinsfor MGMT

Protein Domains/Familiesfor MGMT

Gene Functionfor MGMT

Pathways & Interactionsfor MGMT

Drugs & Compoundsfor MGMT

Transcriptsfor MGMT

Expression for MGMT

Orthologsfor MGMT

Paralogsfor MGMT

SNPs/Variantsfor MGMT

Disorders & Mutationsfor MGMT

Medical Newsfor MGMT

Publicationsfor MGMT

Search for MGMT

Genome Databases showing MGMT

Other Databases showing MGMT

Specialized Databases showing MGMT

Licensable Technologiesfor MGMT

Servicesfor MGMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MGMT

Summaries
for MGMT

Genomic Location
for MGMT

Proteins
for MGMT

Protein Domains/
Families
for MGMT

Gene Function
for MGMT

Pathways & Interactions
for MGMT

Drugs & Compounds
for MGMT

Transcripts
for MGMT

Expression
for MGMT

Orthologs
for MGMT

Paralogs
for MGMT

SNPs/Variants
for MGMT

Disorders & Mutations
for MGMT

Medical News
for MGMT

Publications
for MGMT

Licensable Technologies
for MGMT

Services
for MGMT