Aliases for MGMT Gene
External Ids for MGMT Gene
Previous GeneCards Identifiers for MGMT Gene
GeneCards Summary for MGMT Gene
MGMT (O-6-Methylguanine-DNA Methyltransferase) is a Protein Coding gene. Diseases associated with MGMT include spinal cord astrocytoma and oligoastrocytoma. Among its related pathways are Cell Cycle / Checkpoint Control and Chks in Checkpoint Regulation. GO annotations related to this gene include calcium ion binding and DNA-methyltransferase activity.
UniProtKB/Swiss-Prot for MGMT Gene
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
MGMT encodes O-6-methylguanine-DNA methyltransferase, an enzyme involved in DNA repair. This enzyme removes alkylating lesions at the O6 of guanine residues. This can undermine cancer therapy using alkylating agents, and thus inhibitors of MGMT activity are of interest in cancer research.