Aliases for MGMT Gene
External Ids for MGMT Gene
Previous GeneCards Identifiers for MGMT Gene
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
GeneCards Summary for MGMT Gene
MGMT (O-6-Methylguanine-DNA Methyltransferase) is a Protein Coding gene. Diseases associated with MGMT include spinal cord astrocytoma and central nervous system lymphoma, primary. Among its related pathways are DNA Damage and Chks in Checkpoint Regulation. GO annotations related to this gene include calcium ion binding and damaged DNA binding.
UniProtKB/Swiss-Prot for MGMT Gene
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Histone methyltransferases (HMTs) are a group of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to histones. This occurs predominantly on the side chains of lysine and arginine residues in histones H3 and H4.