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MGME1 Gene

protein-coding   GIFtS: 42
GCID: GC20P017952

Mitochondrial Genome Maintenance Exonuclease 1

(Previous name: chromosome 20 open reading frame 72)
(Previous symbol: C20orf72)
  See MGME1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Genome Maintenance Exonuclease 11 2     Chromosome 20 Open Reading Frame 721
C20orf721 2 3 5     bA504H3.42
DDK12 3     EC 3.1.-.-3
MTDPS112 5     

External Ids:    HGNC: 162051   Entrez Gene: 926672   Ensembl: ENSG000001258717   OMIM: 6150765   UniProtKB: Q9BQP73   

Export aliases for MGME1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MGME1 Gene:
MGME1 (mitochondrial genome maintenance exonuclease 1) is a protein-coding gene. Diseases associated with MGME1 include mitochondrial dna depletion syndrome 11, and mitochondrial dna depletion syndrome. GO annotations related to this gene include single-stranded DNA exodeoxyribonuclease activity.

UniProtKB/Swiss-Prot: MGME1_HUMAN, Q9BQP7
Function: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates.
Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair,
possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the
lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds
5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MGME1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MGME1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.23

MGME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGME1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P017952:  view genomic region     (about GC identifiers)

Start:
17,949,556 bp from pter      End:
17,971,765 bp from pter
Size:
22,210 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGME1_HUMAN, Q9BQP7 (See protein sequence)
Recommended Name: Mitochondrial genome maintenance exonuclease 1 precursor  
Size: 344 amino acids; 39421 Da
Secondary accessions: B2RDG5 D3DW29 Q96SW3

Explore the universe of human proteins at neXtProt for MGME1: NX_Q9BQP7

Explore proteomics data for MGME1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MGME1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443097.1  
    ENSEMBL proteins: 
     ENSP00000366939   ENSP00000366938   ENSP00000366933  

    MGME1 Human Recombinant Protein Products:

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    Novus Biologicals MGME1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MGME1 

    MGME1 Antibody Products:

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    ThermoFisher Antibodies for MGME1
    LSBio Antibodies in human, mouse, rat for MGME1

    MGME1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MGME1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011335 Restrct_endonuc-II-like
     IPR026970 MGME1

    Graphical View of Domain Structure for InterPro Entry Q9BQP7

    ProtoNet protein and cluster: Q9BQP7

    UniProtKB/Swiss-Prot: MGME1_HUMAN, Q9BQP7
    Similarity: Belongs to the MGME1 family


    Find genes that share domains with MGME1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGME1_HUMAN, Q9BQP7
    Function: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
    Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates.
    Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair,
    possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the
    lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds
    5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008297single-stranded DNA exodeoxyribonuclease activity IDA--
         
    Find genes that share ontologies with MGME1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGME1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGME1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGME1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGME1

    miRNA
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    miRTarBase miRNAs that target MGME1:
    hsa-let-7b-5p (MIRT005230)

    Block miRNA regulation of human, mouse, rat MGME1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MGME1
    SwitchGear 3'UTR luciferase reporter plasmidMGME1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MGME1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGME1

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGME1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGME1_HUMAN, Q9BQP7: Mitochondrion

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with MGME1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MGME1
    Interactions:

        Search GeneGlobe Interaction Network for MGME1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MGME1 (Q9BQP72, 3 ENSP000003669394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-66028 I2D: score=5 STRING: ENSP00000347358
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000002mitochondrial genome maintenance IMP--
    GO:0000738DNA catabolic process, exonucleolytic IDA--
    GO:0043504mitochondrial DNA repair TAS--

    Find genes that share ontologies with MGME1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGME1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGME1 gene: 
    NM_052865.2  

    Unigene Cluster for MGME1:

    Mitochondrial genome maintenance exonuclease 1
    Hs.320823  [show with all ESTs]
    Unigene Representative Sequence: BX647404
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377710(uc002wqh.3 uc010gco.3) ENST00000377709(uc010gcp.3)
    ENST00000377704 ENST00000463219 ENST00000467391
    miRNA
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    Block miRNA regulation of human, mouse, rat MGME1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MGME1
    SwitchGear 3'UTR luciferase reporter plasmidMGME1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MGME1
    Predesigned siRNA for gene silencing in human, mouse, rat MGME1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MGME1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGME1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGME1
    Primer
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    OriGene qPCR primer pairs and template standards for MGME1
    OriGene qSTAR qPCR primer pairs in human, mouse for MGME1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MGME1
      QuantiTect SYBR Green Assays in human, mouse, rat MGME1
      QuantiFast Probe-based Assays in human, mouse, rat MGME1

    Additional mRNA sequence: 

    AF306684.1 AF306685.1 AF306686.1 AK027503.1 AK309563.1 AK309995.1 AK310282.1 AK315532.1 
    BC016869.1 BX647404.1 

    16 DOTS entries:

    DT.75146083  DT.312690  DT.120812413  DT.100719624  DT.40311753  DT.95084664  DT.120812411  DT.120812442 
    DT.100812934  DT.95084651  DT.95084652  DT.100677807  DT.100766873  DT.100637984  DT.100882196  DT.120812514 

    Selected AceView cDNA sequences (see all 135):

    BP354075 NM_052865 BE710973 AI365327 AA749387 AW751077 BM452569 BM874642 
    BM750186 BC016869 BQ686224 AA612877 CA432464 BU192675 AL121114 BE221169 
    AL121113 BQ721986 BQ050031 BG686731 CA440293 BE888796 AA426218 AA262745 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGME1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
    SP1:              -                                         -                                                         
    SP2:              -                                   -     -                                                         
    SP3:                                                  -                                                               
    SP4:                                                                                                                  
    SP5:                                                  -     -                                                         


    ECgene alternative splicing isoforms for MGME1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MGME1 Expression
    About this image

    MGME1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGME1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.320823
        Custom PCR Arrays for MGME1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGME1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MGME1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgme11 , 5 RIKEN cDNA 8430406I07 gene5
    mitochondrial genome maintainance exonuclease 11
    79(n)1
    71.94(a)1
      2 (70.98 cM)5
    745281  NM_028984.41  NP_083260.11 
     1442706635 
    chicken
    (Gallus gallus)
    Aves C3H20ORF721 chromosome 3 open reading frame, human C20orf72 63.94(n)
    60.91(a)
      416719  NM_001277518.1  NP_001264447.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGME16
    mitochondrial genome maintenance exonuclease 1
    55(a)
    1 ↔ 1
    4(74454287-74463795)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mgme11 mitochondrial genome maintenance exonuclease 1 61.11(n)
    56.85(a)
      100145685  NM_001127060.1  NP_001120532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgme11 mitochondrial genome maintenance exonuclease 1 59.17(n)
    52.81(a)
      494097  NM_001008640.1  NP_001008640.1 


    ENSEMBL Gene Tree for MGME1 (if available)
    TreeFam Gene Tree for MGME1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGME1 (see all 467)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0691024
    Mitochondrial DNA depletion syndrome 11 (MTDPS11)4--see VAR_0691022 Y C mis40--------
    rs1856836271,2
    --17951498(+) ACATAA/CTCAGA 1 -- int10--------
    rs1905911251,2
    --17951633(+) CACTGC/GTGAAT 1 -- int10--------
    rs1420371861,2
    --17951701(+) CATTCC/GTTTAC 1 -- int10--------
    rs9109031,2
    C,F,A,H--17951779(+) AATAGT/CGTACT 1 -- int112Minor allele frequency- C:0.34EA NS NA WA 2270
    rs1817767331,2
    --17951795(+) TTGCCA/GTAGCC 1 -- int10--------
    rs1149789531,2
    C,F--17951831(+) CCCTAA/TTCCAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs9109041,2
    C,F,A--17951904(+) TATATA/GTAGGT 1 -- int18Minor allele frequency- G:0.31NA CSA WA EA 367
    rs9109051,2
    C,F,A--17951914(+) TGGTAT/CTGGAT 1 -- int18Minor allele frequency- C:0.32NA CSA WA EA 367
    rs37622261,2
    C,F,H--17951957(-) GAGGAA/GTATTA 1 -- int114Minor allele frequency- G:0.15EA NS NA WA 2518

    HapMap Linkage Disequilibrium report for MGME1 (17949556 - 17971765 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MGME1: --
    Human Gene Mutation Database (HGMD): MGME1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGME1
    DNA2.0 Custom Variant and Variant Library Synthesis for MGME1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615076   
    OMIM disorders: 615084  
    UniProtKB/Swiss-Prot: MGME1_HUMAN, Q9BQP7
  • Mitochondrial DNA depletion syndrome 11 (MTDPS11) [MIM:615084]: An autosomal recessive mitochondrial
    disorder characterized by onset in childhood or adulthood of progressive external ophthalmoplegia, muscle
    weakness and atrophy, exercise intolerance, and respiratory insufficiency due to muscle weakness. More variable
    features include spinal deformity, emaciation, and cardiac abnormalities. Skeletal muscle biopsies show deletion
    and depletion of mitochondrial DNA (mtDNA) with variable defects in respiratory chain enzyme activities. Note=The
    disease may be caused by mutations affecting the gene represented in this entry

  • 2 diseases for MGME1:    
    About MalaCards
    mitochondrial dna depletion syndrome 11    mitochondrial dna depletion syndrome


    Find genes that share disorders with MGME1           About GenesLikeMe


    Export disorders for MGME1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGME1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MGME1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. (PubMed id 23313956)1, 2, 3 Kornblum C.... Prokisch H. (Nat. Genet. 2013)
    2. Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels. (PubMed id 23358826)1, 2, 3 Szczesny R.J.... Dziembowski A. (Nucleic Acids Res. 2013)
    3. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. (PubMed id 23434322)1, 3 Spruijt C.G....Vermeulen M. (Cell 2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92667 HGNC: 16205 AceView: C20orf72 Ensembl:ENSG00000125871 euGenes: HUgn92667
    ECgene: MGME1 H-InvDB: MGME1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGME1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGME1 gene:
    Search GeneIP for patents involving MGME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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