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Aliases for MGLL Gene

Aliases for MGLL Gene

  • Monoglyceride Lipase 2 3
  • Lysophospholipase Homolog 3 4
  • Monoacylglycerol Lipase 3 4
  • HU-K5 3 4
  • MAGL 3 4
  • MGL 3 4
  • Lysophospholipase-Like 4
  • EC 3.1.1.23 4
  • HUK5 3

External Ids for MGLL Gene

Previous GeneCards Identifiers for MGLL Gene

  • GC03M124242
  • GC03M127569
  • GC03M128692
  • GC03M128731
  • GC03M128893
  • GC03M127407
  • GC03M124788

Summaries for MGLL Gene

Entrez Gene Summary for MGLL Gene

  • This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for MGLL Gene

MGLL (Monoglyceride Lipase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include protein homodimerization activity and lipid binding.

UniProtKB/Swiss-Prot for MGLL Gene

  • Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).

Tocris Summary for MGLL Gene

  • Monoacylglycerol lipase (MAGL, MGL) is a hydrolase that is involved in endocannabinoid and triglyceride hydrolysis. It is the primary enzyme responsible for the metabolism of 2-arachidonylglycerol (2-AG) in the brain, and is also involved in lipid signaling.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGLL Gene

Genomics for MGLL Gene

Regulatory Elements for MGLL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGLL Gene

Chromosome:
3
Start:
127,689,062 bp from pter
End:
127,823,250 bp from pter
Size:
134,189 bases
Orientation:
Minus strand

Genomic View for MGLL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGLL Gene

Proteins for MGLL Gene

  • Protein details for MGLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99685-MGLL_HUMAN
    Recommended name:
    Monoglyceride lipase
    Protein Accession:
    Q99685
    Secondary Accessions:
    • B3KRC2
    • B7Z9D1
    • Q6IBG9
    • Q96AA5

    Protein attributes for MGLL Gene

    Size:
    303 amino acids
    Molecular mass:
    33261 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.
    SequenceCaution:
    • Sequence=AAB39616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH00551.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH06230.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG37910.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAG33116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79331.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MGLL Gene

    Alternative splice isoforms for MGLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGLL Gene

Proteomics data for MGLL Gene at MOPED

Post-translational modifications for MGLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MGLL Gene

Domains & Families for MGLL Gene

Gene Families for MGLL Gene

Graphical View of Domain Structure for InterPro Entry

Q99685

UniProtKB/Swiss-Prot:

MGLL_HUMAN :
  • Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
genes like me logo Genes that share domains with MGLL: view

Function for MGLL Gene

Molecular function for MGLL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=110 uM for 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151}; Vmax=120 nmol/min/mg enzyme toward 2-arachidonoyglycerol {ECO:0000269 PubMed:22969151};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolyzes glycerol monoesters of long-chain fatty acids.
UniProtKB/Swiss-Prot Function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).

Enzyme Numbers (IUBMB) for MGLL Gene

Gene Ontology (GO) - Molecular Function for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 9495531
GO:0042803 protein homodimerization activity IPI 19957260
GO:0047372 acylglycerol lipase activity TAS --
genes like me logo Genes that share ontologies with MGLL: view
genes like me logo Genes that share phenotypes with MGLL: view

Animal Models for MGLL Gene

MGI Knock Outs for MGLL:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGLL

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MGLL Gene

Localization for MGLL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGLL Gene

Cytoplasm, cytosol. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGLL Gene COMPARTMENTS Subcellular localization image for MGLL gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with MGLL: view

Pathways & Interactions for MGLL Gene

genes like me logo Genes that share pathways with MGLL: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q99685-MGLL_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol degradation.

Interacting Proteins for MGLL Gene

Gene Ontology (GO) - Biological Process for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9495531
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006954 inflammatory response TAS 9495531
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with MGLL: view

No data available for SIGNOR curated interactions for MGLL Gene

Drugs & Compounds for MGLL Gene

(6) Drugs for MGLL Gene - From: NovoSeek, IUPHAR, ApexBio, DGIdb, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Experimental Pharma 176
arachidonic acid Experimental Nutra Potentiation, Activator 27
JZL184 Pharma Inhibition, Inhibitor MAGL inhibitor 0
2-arachidonoylglycerol Pharma Partial agonist, Agonist 0
Anandamide Pharma Channel blocker 0

(75) Additional Compounds for MGLL Gene - From: HMDB, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • 1-Monoacylglyceride
53847-30-6
MG(0:0/14:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Myristoyl-glycerol
  • 2-Tetradecanoyl-rac-glycerol
  • b-Monoacylglycerol
MG(0:0/14:1(9Z)/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-(9Z-Tetradecenoyl)-rac-glycerol
  • 2-Myristoleoyl-glycerol
  • b-Monoacylglycerol
MG(0:0/15:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Pentadecanoyl-glycerol
  • 2-Pentadecanoyl-rac-glycerol
  • b-Monoacylglycerol
MG(0:0/16:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Hexadecanoyl-rac-glycerol
  • 2-Palmitoyl-glycerol
  • b-Monoacylglycerol
genes like me logo Genes that share compounds with MGLL: view

Transcripts for MGLL Gene

Unigene Clusters for MGLL Gene

Monoglyceride lipase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGLL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGLL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10: - -

Relevant External Links for MGLL Gene

GeneLoc Exon Structure for
MGLL
ECgene alternative splicing isoforms for
MGLL

Expression for MGLL Gene

mRNA expression in normal human tissues for MGLL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGLL Gene

This gene is overexpressed in Platelet (18.9), Adipocyte (14.7), and Nasopharynx (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGLL Gene



SOURCE GeneReport for Unigene cluster for MGLL Gene Hs.277035

mRNA Expression by UniProt/SwissProt for MGLL Gene

Q99685-MGLL_HUMAN
Tissue specificity: Detected in adipose tissue, lung, liver, kidney, brain and heart.
genes like me logo Genes that share expression patterns with MGLL: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MGLL Gene

Orthologs for MGLL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGLL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGLL 35
  • 84.16 (n)
  • 85.81 (a)
MGLL 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGLL 35
  • 89.99 (n)
  • 92.65 (a)
MGLL 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgll 35
  • 83.17 (n)
  • 83.71 (a)
Mgll 16
Mgll 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGLL 35
  • 99.79 (n)
  • 100 (a)
MGLL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgll 35
  • 83.17 (n)
  • 83.83 (a)
oppossum
(Monodelphis domestica)
Mammalia MGLL 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGLL 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGLL 35
  • 71.31 (n)
  • 69.9 (a)
MGLL 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGLL 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgll 35
  • 63.34 (n)
  • 62.46 (a)
Str.4432 35
zebrafish
(Danio rerio)
Actinopterygii mgll 35
  • 60.22 (n)
  • 56.33 (a)
zgc56561 35
mgll 36
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YJU3 36
  • 22 (a)
OneToOne
YJU3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16120 35
  • 41.7 (n)
  • 32.36 (a)
rice
(Oryza sativa)
Liliopsida Os10g0135600 35
  • 41.07 (n)
  • 29.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
CSA.8597 36
  • 37 (a)
OneToMany
Species with no ortholog for MGLL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGLL Gene

ENSEMBL:
Gene Tree for MGLL (if available)
TreeFam:
Gene Tree for MGLL (if available)

Paralogs for MGLL Gene

(1) SIMAP similar genes for MGLL Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MGLL: view

No data available for Paralogs for MGLL Gene

Variants for MGLL Gene

Sequence variations from dbSNP and Humsavar for MGLL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4881 -- 127,695,038(-) CGCCT(A/G)TGTGA reference, synonymous-codon
rs7578 -- 127,689,396(-) GCCTC(C/T)CTCCC utr-variant-3-prime
rs9383 -- 127,689,339(-) TCACC(A/G)AGGGA utr-variant-3-prime
rs471662 -- 127,730,606(+) CTTAG(C/G)GTGGG intron-variant
rs477554 -- 127,716,013(+) CCCCC(C/T)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGLL Gene

Variant ID Type Subtype PubMed ID
dgv5249n71 CNV Loss 21882294
nsv460848 CNV Loss 19166990
esv1191118 CNV Deletion 17803354
dgv1492e1 CNV Complex 17122850
nsv3990 CNV Insertion 18451855
esv268655 CNV Insertion 20981092
esv274547 CNV Insertion 20981092
esv268225 CNV Insertion 20981092
esv2659152 CNV Deletion 23128226
esv27043 CNV Loss 19812545
esv2664028 CNV Deletion 23128226

Variation tolerance for MGLL Gene

Residual Variation Intolerance Score: 56.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGLL Gene

HapMap Linkage Disequilibrium report
MGLL
Human Gene Mutation Database (HGMD)
MGLL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGLL Gene

Disorders for MGLL Gene

Relevant External Links for MGLL

Genetic Association Database (GAD)
MGLL
Human Genome Epidemiology (HuGE) Navigator
MGLL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGLL
genes like me logo Genes that share disorders with MGLL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGLL Gene

Publications for MGLL Gene

  1. Proteomic profiling of non-obese type 2 diabetic skeletal muscle. (PMID: 20127051) Mullen E. … Ohlendieck K. (Int. J. Mol. Med. 2010) 23 67
  2. Structural basis for human monoglyceride lipase inhibition. (PMID: 19962385) Bertrand T. … Mathieu M. (J. Mol. Biol. 2010) 23 67
  3. Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique. (PMID: 20005861) Savinainen J.R. … Laitinen J.T. (Anal. Biochem. 2010) 23 67
  4. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. (PMID: 18952573) Zechner R. … Lass A. (J. Lipid Res. 2009) 23 67
  5. Candidate genes for cannabis use disorders: findings, challenges and directions. (PMID: 19335651) Agrawal A. … Lynskey M.T. (Addiction 2009) 23 67

Products for MGLL Gene

Sources for MGLL Gene

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