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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MGLL Gene

protein-coding GIFtS: 65
GCID: GC03M127407

monoglyceride lipase

Explore 15 diseases affiliated with
MGLL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Monoglyceride Lipase¹ ²		MAGL² ³
MGL¹ ² ³ ⁵		HUK5² ⁵
HU-K5¹ ² ³		EC 3.1.1.23³
Lysophospholipase Homolog² ³		Lysophospholipase-Like¹
Monoacylglycerol Lipase² ³

External Ids:	HGNC: 17038¹	Entrez Gene: 11343²	Ensembl: ENSG00000074416⁷	OMIM: 609699⁵	UniProtKB: Q99685³

Export aliases for MGLL gene to outside databases

Previous GC identifers: GC03M124242 GC03M127569 GC03M128692 GC03M128731 GC03M128893 GC03M124788

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGLL:

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of

monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several

physiological processes including pain and nociperception through hydrolysis of the endocannabinoid

2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively

spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Feb

2012)

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685

Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid

2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and

perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote

cancer cell migration, invasion and tumor growth

summary for MGLL:

Monoacylglycerol lipase (MAGL) catalyzes hydrolysis of intracellular triglyceride stores, forming fatty

acids and glycerol. It is a key enzyme in the metabolism of 2'AG, hence is involved in a similar pathway to

DAGL. MAGL is localized in the enteric nervous system where it functions to regulate levels of

endocannabinoids, and as a result, regulates intestinal motility. It is also found in the gut epithelium

where it may have a role in digestion.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MGLL gene promoter:
FOXI1 IRF-2 CP2 Evi-1 FOXL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGLL promoter sequence

Search SABiosciences Chromatin IP Primers for MGLL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGLL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3p13-q13.33

MGLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGLL gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M127407: view genomic region (about GC identifiers)

Start:	127,407,909 bp from pter	End:	127,542,051 bp from pter
Size:	134,143 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685 (See protein sequence)

Recommended Name: Monoglyceride lipase

Size: 303 amino acids; 33261 Da

Subunit: Homodimer

Miscellaneous: Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids

acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity (By similarity)

Sequence caution: Sequence=AAB39616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAH00551.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH06230.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG37910.1; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=CAG33116.1; Type=Erroneous initiation; Note=Translation N-terminally

shortened; Sequence=EAW79330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=EAW79331.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

4 PDB 3D structures from and Proteopedia for MGLL:

3HJU (3D)

3JW8 (3D)

3JWE (3D)

3PE6 (3D)

Secondary accessions: B7Z9D1 Q6IBG9 Q96AA5

Alternative splicing: 2 isoforms: Q99685-1 Q99685-2

Explore the universe of human proteins at neXtProt for MGLL: NX_Q99685

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99685

MGLL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001003794.1 NP_001243514.1 NP_009214.1

ENSEMBL proteins:

ENSP00000402798 ENSP00000417060 ENSP00000381173 ENSP00000420125 ENSP00000419340

ENSP00000417689 ENSP00000417489 ENSP00000265052 ENSP00000404146 ENSP00000381176

Reactome Protein details: Q99685
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for MGLL
	Uscn Proteins for MGLL

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0045202	synapse	IEA	--

MGLL for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MGLL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MGLL for domains About GeneDecksing

1 InterPro domain/family:

IPR000073 AB_hydrolase_1

Graphical View of Domain Structure for InterPro Entry Q99685

ProtoNet protein and cluster: Q99685

3 Blocks protein families:

IPB000073 Alpha/beta hydrolase fold

IPB003089 Alpha/beta hydrolase fold signature

IPB008262 Lipase

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685

Similarity: Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685

Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid

2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and

perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote

cancer cell migration, invasion and tumor growth

Catalytic activity: Hydrolyzes glycerol monoesters of long-chain fatty acids

Enzyme Number (IUBMB): EC 3.1.1.23¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MGLL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGLL
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate MGLL (see all 47):
		hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-1260b hsa-miR-25 hsa-miR-938 hsa-miR-570 hsa-let-7g

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGLL (see all 7) OriGene shRNA RFP: MGLL OriGene siRNA: MGLL
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGLL

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004091	carboxylesterase activity	IEA	--
GO:0004622	lysophospholipase activity	TAS	9495531
GO:0008289	lipid binding	IEA	--
GO:0016787	hydrolase activity	--	--
GO:0042803	protein homodimerization activity	IPI	19957260

MGLL for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MGLL:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Mgll^tm1.1Mwa for MGLL
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mgll):

behavior/neurological	growth/size	homeostasis/metabolism	integument	liver/biliary system
no phenotypic analysis

MGLL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis

1.00

Phospholipid metabolism

0.64

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MGLL

Development Alpha-2 adrenergic receptor activation of ERK

1 GeneGo (Thomson Reuters) Pathway for MGLL

Development Alpha-2 adrenergic receptor activation of ERK

1 BioSystems Pathway for MGLL

triacylglycerol degradation

5/16 Reactome Pathways for MGLL (see all 16)

	Metabolism
	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
	Arachidonate production from DAG
	Signal Transduction
	G alpha (q) signalling events

2 Kegg Pathways (Kegg details for MGLL):

	Glycerolipid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685

Pathway: Glycerolipid metabolism; triacylglycerol degradation

MGLL for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MGLL

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/24 Interacting proteins for MGLL (Q99685³ ENSP00000265052⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHGB	P05060³	I2D: score=5
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
DAGLA	ENSP00000257215⁴	STRING: ENSP00000257215
DAGLB	ENSP00000297056⁴	STRING: ENSP00000297056
FABP4	ENSP00000256104⁴	STRING: ENSP00000256104

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	--
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006954	inflammatory response	TAS	9495531
GO:0007596	blood coagulation	TAS	--

MGLL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MGLL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MGLL available from Tocris Bioscience About this table

Compound	Action	CAS #
Pristimerin	Potent, reversible MAGL inhibitor	[1258-84-0]
N-Arachidonyl maleimide	Potent, competitive MAGL inhibitor	[876305-42-9]

10/355 HMDB Compounds for MGLL (see all 355) About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Arachidonylglycerol	2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)	53847-30-6	--
Glycerol	1,2,3-Trihydroxypropane (see all 22)	56-81-5	--
MG(0:0/14:0/0:0)	beta-monoacylglycerol (see all 10)	--	--
MG(0:0/14:1(9Z)/0:0)	2-myristoleoyl-glycerol (see all 14)	--	--
MG(0:0/15:0/0:0)	MG(15:0) (see all 10)	--	--
MG(0:0/16:0/0:0)	beta-monoacylglycerol (see all 10)	--	--
MG(0:0/16:1(9Z)/0:0)	MG(0:0/16:1w7) (see all 14)	--	--
MG(0:0/18:0/0:0)	MG(0:0/18:0) (see all 10)	--	--
MG(0:0/18:1(11Z)/0:0)	beta-monoacylglycerol (see all 14)	--	--
MG(0:0/18:1(9Z)/0:0)	MAG(0:0/18:1n9) (see all 15)	--	--

8 Novoseek chemical compound relationships for MGLL gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
monoacylglycerol	96.8	82	17848545 (3), 18855964 (3), 19883085 (2), 20005861 (2) (see all 46)
2-arachidonoylglycerol	90.3	43	18597752 (3), 17649977 (2), 19543978 (2), 18452279 (2) (see all 13)
anandamide	70.6	3	17649977 (1), 17950616 (1), 15063097 (1)
glycerol	45	8	11470505 (1), 19962385 (1), 1959050 (1), 16232941 (1) (see all 5)
arachidonic acid	27.9	7	16935556 (1), 19962385 (1), 1905023 (1)
lipid	27.7	10	17848545 (1), 18855964 (1), 19233690 (1), 18981578 (1) (see all 5)
fatty acid	24	4	15063097 (1), 16232941 (1), 16232953 (1)
serine	0	4	19875078 (1), 20005861 (1), 18452279 (1), 19962385 (1)

Search CenterWatch for drugs/clinical trials and news about MGLL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MGLL gene (3 alternative transcripts):

NM_001003794.2 NM_001256585.1 NM_007283.6

Unigene Cluster for MGLL:

Monoglyceride lipase

Hs.277035 [show with all ESTs]

Unigene Representative Sequence: NM_007283

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000434178(uc003ejv.3 uc003ejw.3 uc011bko.2) ENST00000496306

ENST00000476682 ENST00000398101 ENST00000487473 ENST00000484451 ENST00000465597

ENST00000479967(uc010hsp.1) ENST00000493611 ENST00000476654 ENST00000494830

ENST00000265052 ENST00000453507 ENST00000398104(uc003ejx.3)

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		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate MGLL (see all 47):
		hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-1260b hsa-miR-25 hsa-miR-938 hsa-miR-570 hsa-let-7g

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGLL

Additional cDNA sequence:

AF131821.1 AJ270950.1 AK025983.1 AK026389.1 AK091314.1 AK093841.1 AK304844.1 AK310874.1

AK315529.1 AL365376.1 AL833254.1 AY172950.1 BC000551.2 BC006230.2 BC047298.1 BC073823.1

CR456835.1 EU660904.1 U67963.1

24/28 DOTS entries (see all 28):

DT.91642727 DT.451832 DT.99953481 DT.100795967 DT.100640805 DT.120891373 DT.75132067 DT.95351809

DT.100811512 DT.120891234 DT.100045119 DT.120891295 DT.120891464 DT.91824705 DT.120891438 DT.120891479

DT.100795966 DT.120891392 DT.91741086 DT.120891143 DT.120891177 DT.91764633 DT.91958306 DT.91974122

24/540 AceView cDNA sequences (see all 540):

BQ688080 AU076588 AI343251 BM711949 BE250245 BU543714 BQ691186 AA131410

CB529747 CN482378 BU542405 CB529174 BU625188 BC000551 BM926322 BE259991

BQ711862 BQ889242 BC006230 AI086890 BI752220 BP341058 NM_007283 BQ679896

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MGLL (see all 10) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:													-				-		-								-		-
SP2:					-		-						-				-		-								-		-
SP3:													-														-		-
SP4:																											-		-
SP5:					-		-						-

ECgene alternative splicing isoforms for MGLL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MGLL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTGGGGGA

About this image

MGLL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MGLL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGLL

SOURCE GeneReport for Unigene cluster: Hs.277035

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685

Tissue specificity: Detected in adipose tissue, lung, liver, kidney, brain and heart

SABiosciences Expression via Pathway-Focused PCR Arrays including MGLL:

Polycomb & Trithorax Target Genes in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MGLL gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mgll^{1 , 5}	monoglyceride lipase^{1, 5}	83.17(n)¹ 83.71(a)¹		6 (39.51 cM)⁵ 23945¹ NM_001166251.1¹ NP_001159723.1¹ 88724412⁵
chicken (Gallus gallus)	Aves	MGLL¹	monoglyceride lipase	71.32(n) 70.43(a)		416024 XM_414365.3 XP_414365.2
lizard (Anolis carolinensis)	Reptilia	MGLL⁶	--	66(a)	1 ↔ 1	2(166012074-166033165)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4432²	Transcribed sequence with weak similarity to protein more	70.47(n)		AL850963.2
zebrafish (Danio rerio)	Actinopterygii	zgc56561²	hypothetical protein MGC56561	73.87(n)		393267 AY398382.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G16120¹	hydrolase, alpha/beta fold family protein	42.06(n) 32.36(a)		831469 NM_121617.4 NP_568327.1
rice (Oryza sativa)	Liliopsida	Os10g0135600¹	hypothetical protein	41.26(n) 29.37(a)		4348060 NM_001070656.1 NP_001064121.2

ENSEMBL Gene Tree for MGLL (if available)
TreeFam Gene Tree for MGLL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115882687^1,2		--	127407644(+)	`GGGGAG/AGGTGG`	3	--	ds500¹		1		NA	120
rs76802560^1,2		--	127407653(+)	`GGCCTG/TGGCTC`	3	--	ds500¹		2		CSA WA	120
rs182772297^1,2		--	127407740(+)	`AAGATA/GAACTC`	3	--	ds500¹		0	--	--	--	--
rs6801421^1,2	C,F,H,	--	127407753(+)	`CACACG/ACTGAT`	3	--	ds500¹		16		NS EA NA CSA WA	2217
rs114330903^1,2	C,	--	127407799(+)	`TGACAG/AGCATG`	3	--	ds500¹		1		WA	118
rs188652400^1,2		--	127407819(+)	`GGGATC/TAGCCT`	3	--	ds500¹		0	--	--	--	--
rs192985213^1,2		--	127407922(+)	`ACATCA/GGATTT`	3	--	ut3¹		0	--	--	--	--
rs72969613^1,2	C,	--	127407988(+)	`TGCCCC/TGCAGA`	3	--	ut3¹		2		WA	120
rs115970931^1,2	C,F,	--	127407995(+)	`CAGACA/GGTATA`	3	--	ut3¹		1		WA	118
rs185527525^1,2		--	127408004(+)	`TACACA/GCAGGG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MGLL (127407909 - 127542051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MGLL
1 CNV: 2471
4 Indels: 91528 79887 79886 63580
Human Gene Mutation Database (HGMD): MGLL

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MGLL for disorders           About GeneDecksing

OMIM gene information: 609699    OMIM disorders: --

15 diseases for MGLL:    About MalaCards

abdominal aortic aneurysm aortic aneurysm anorexia nervosa neurodegenerative disease

pancreatic cancer colorectal cancer prostate cancer breast cancer

pancreatitis obesity prostatitis tuberculosis

hepatitis mycobacterium tuberculosis alcoholism

Human Genome Epidemiology (HuGE) Navigator: MGLL (9 documents)

Export disorders for MGLL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MGLL gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with MGLL)

Utopia: connect your pdf to the dynamic
world of online information

A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase. (PubMed id 9495531)^{1, 2, 3} Wall E.M.... Upton C. (1997)
Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. (PubMed id 11470505)^{1, 2, 9} Karlsson M....Holm C. (2001)
Structural basis for human monoglyceride lipase inhib ition. (PubMed id 19962385)^{1, 2, 9} Bertrand T....Mathieu M. (2010)
Monoacylglycerol lipase regulates a fatty acid networ k that promotes cancer pathogenesis. (PubMed id 20079333)^{1, 2} Nomura D.K....Cravatt B.F. (2010)
Crystal structure of the human monoacylglycerol lipas e, a key actor in endocannabinoid signaling. (PubMed id 19957260)^{1, 2} Labar G....Lambert D.M. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PubMed id 19014633)^{1, 9} Muller T.D....Hinney A. (2008)
Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. (PubMed id 17621164)^{1, 9} Iwasaki S....Arinami T. (2007)
Full mass spectrometric characterization of human monoacylglycerol lipase generated by large-scale expression and single-step purification. (PubMed id 18452279)^{1, 9} Zvonok N....Makriyannis A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11343	HGNC: 17038	AceView: MGLL	Ensembl:ENSG00000074416	euGenes: HUgn11343
ECgene: MGLL	Kegg: 11343	H-InvDB: MGLL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MGLL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MGLL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MGLL gene:
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GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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