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MGLL Gene

protein-coding   GIFtS: 66
GCID: GC03M127407

Monoglyceride Lipase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monoglyceride Lipase1 2     MAGL2 3
MGL2 3 5     HUK52 5
Lysophospholipase Homolog2 3     EC 3.1.1.233
Monoacylglycerol Lipase2 3     Lysophospholipase-like3
HU-K52 3     

External Ids:    HGNC: 170381   Entrez Gene: 113432   Ensembl: ENSG000000744167   OMIM: 6096995   UniProtKB: Q996853   

Export aliases for MGLL gene to outside databases

Previous GC identifers: GC03M124242 GC03M127569 GC03M128692 GC03M128731 GC03M128893 GC03M124788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGLL Gene:
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of
monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several
physiological processes including pain and nociperception through hydrolysis of the endocannabinoid
2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, Feb 2012)

GeneCards Summary for MGLL Gene:
MGLL (monoglyceride lipase) is a protein-coding gene. Diseases associated with MGLL include venous thrombosis, and abdominal aortic aneurysm. GO annotations related to this gene include and protein homodimerization activity.

UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685
Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid
2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception
and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and
promote cancer cell migration, invasion and tumor growth

summary for MGLL Gene:
Monoacylglycerol lipase (MAGL) catalyzes hydrolysis of intracellular triglyceride stores, forming fatty
acids and glycerol. It is a key enzyme in the metabolism of 2'AG, hence is involved in a similar pathway to
DAGL. MAGL is localized in the enteric nervous system where it functions to regulate levels of
endocannabinoids, and as a result, regulates intestinal motility. It is also found in the gut epithelium
where it may have a role in digestion.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGLL gene promoter:
         FOXI1   IRF-2   CP2   Evi-1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGLL promoter sequence
   Search Chromatin IP Primers for MGLL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3p13-q13.33

MGLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGLL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M127407:  view genomic region     (about GC identifiers)

Start:
127,407,909 bp from pter      End:
127,542,051 bp from pter
Size:
134,143 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685 (See protein sequence)
Recommended Name: Monoglyceride lipase  
Size: 303 amino acids; 33261 Da
Subunit: Homodimer
Miscellaneous: Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to
endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1
activity (By similarity)
Sequence caution: Sequence=AAB39616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH00551.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH06230.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG37910.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAG33116.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=EAW79330.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=EAW79331.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for MGLL:
3HJU (3D)        3JW8 (3D)        3JWE (3D)        3PE6 (3D)    
Secondary accessions: B3KRC2 B7Z9D1 Q6IBG9 Q96AA5
Alternative splicing: 2 isoforms:  Q99685-1   Q99685-2   

Explore the universe of human proteins at neXtProt for MGLL: NX_Q99685

Explore proteomics data for MGLL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MGLL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001003794.1  NP_001243514.1  NP_009214.1  

    ENSEMBL proteins: 
     ENSP00000402798   ENSP00000417060   ENSP00000420125   ENSP00000381173   ENSP00000419340  
     ENSP00000417689   ENSP00000417489   ENSP00000265052   ENSP00000404146   ENSP00000381176  
    Reactome Protein details: Q99685

    MGLL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MGLL (Monoglyceride Lipase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MGLL
    OriGene Protein Over-expression Lysate for MGLL
    OriGene MassSpec for MGLL
    OriGene Custom Protein Services for MGLL
    GenScript Custom Purified and Recombinant Proteins Services for MGLL
    Novus Biologicals MGLL Proteins
    Novus Biologicals MGLL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MGLL
    Browse Proteins at Cloud-Clone Corp.

    MGLL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MGLL
    Browse R&D Systems for Antibodies
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    Novus Biologicals MGLL Antibodies
    Abcam antibodies for MGLL
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MGLL
    LSBio Antibodies in human, mouse, rat for MGLL

    MGLL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MGLL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MGLL
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Monoacylglycerol lipase
    Endocannabinoid turnover

    1 InterPro protein domain:
     IPR000073 AB_hydrolase_1

    Graphical View of Domain Structure for InterPro Entry Q99685

    ProtoNet protein and cluster: Q99685

    3 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB003089 Alpha/beta hydrolase fold signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685
    Similarity: Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family


    MGLL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGLL_HUMAN, Q99685
    Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid
    2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception
    and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and
    promote cancer cell migration, invasion and tumor growth
    Catalytic activity: Hydrolyzes glycerol monoesters of long-chain fatty acids

         Enzyme Number (IUBMB): EC 3.1.1.231

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004622lysophospholipase activity TAS9495531
    GO:0004806triglyceride lipase activity ----
    GO:0008289lipid binding IEA--
    GO:0016787hydrolase activity ----
    GO:0042803protein homodimerization activity IPI19957260
         
    MGLL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MGLL:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mgll):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  liver/biliary system 
     no phenotypic analysis 

    MGLL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mglltm1.1Mwa for MGLL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGLL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGLL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGLL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGLL

    miRNA
    Products:
        
    miRTarBase miRNAs that target MGLL:
    hsa-mir-30c-5p (MIRT047880), hsa-mir-7-5p (MIRT025844)

    Block miRNA regulation of human, mouse, rat MGLL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MGLL (see all 47):
    hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-1260b hsa-miR-25 hsa-miR-938 hsa-miR-570 hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MGLL
    Predesigned siRNA for gene silencing in human, mouse, rat MGLL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MGLL

    Clone
    Products:
         
    OriGene clones in human, mouse for MGLL (see all 11)
    OriGene ORF clones in mouse, rat for MGLL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MGLL (NM_001003794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGLL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGLL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MGLL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGLL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane4
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0045202synapse IEA--

    MGLL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGLL About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2Glycerolipid metabolism
    Glycerolipid metabolism
    Acyl chain remodeling of DAG and TAG0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Phospholipid metabolism0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MGLL
        Development Alpha-2 adrenergic receptor activation of ERK

    1 BioSystems Pathway for MGLL
        triacylglycerol degradation

    3 Reactome Pathways for MGLL
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
    Arachidonate production from DAG
    Acyl chain remodeling of DAG and TAG


    3 Kegg Pathways  (Kegg details for MGLL):
        Glycerolipid metabolism
    Metabolic pathways
    Retrograde endocannabinoid signaling

    UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685
    Pathway: Glycerolipid metabolism; triacylglycerol degradation


    MGLL for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGLL: 

              Polycomb & Trithorax Target Genes in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGLL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MGLL (Q996853 ENSP000002650524) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050603I2D: score=5 
    AGKENSP000003475814STRING: ENSP00000347581
    CELENSP000003611514STRING: ENSP00000361151
    DAGLAENSP000002572154STRING: ENSP00000257215
    DAGLBENSP000002970564STRING: ENSP00000297056
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9495531
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006954inflammatory response TAS9495531
    GO:0007596blood coagulation TAS--

    MGLL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MGLL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JZL 184Monoacylglycerol lipase (MAGL) inhibitor[1101854-58-3]
    Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]
    Pristimerin Potent, reversible MAGL inhibitor [1258-84-0]
    GSK 264220AEndothelial lipase and lipoprotein lipase inhibitor[685506-42-7]

    Selected HMDB Compounds for MGLL (see all 355)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
    Glycerol1,2,3-Trihydroxypropane (see all 22)56-81-5--
    MG(0:0/14:0/0:0)beta-monoacylglycerol (see all 10)----
    MG(0:0/14:1(9Z)/0:0)2-myristoleoyl-glycerol (see all 14)----
    MG(0:0/15:0/0:0)MG(15:0) (see all 10)----
    MG(0:0/16:0/0:0)beta-monoacylglycerol (see all 10)----
    MG(0:0/16:1(9Z)/0:0)MG(0:0/16:1w7) (see all 14)----
    MG(0:0/18:0/0:0)MG(0:0/18:0) (see all 10)----
    MG(0:0/18:1(11Z)/0:0)beta-monoacylglycerol (see all 14)----
    MG(0:0/18:1(9Z)/0:0)MAG(0:0/18:1n9) (see all 15)----

    1 IUPHAR Ligand for MGLL (Monoacylglycerol lipase)    About this table
    LigandTypeActionAffinityPubmed IDs
    JZL184
    InhibitorInhibition8.119029917

    8 Novoseek inferred chemical compound relationships for MGLL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monoacylglycerol 96.8 82 17848545 (3), 18855964 (3), 19883085 (2), 20005861 (2) (see all 46)
    2-arachidonoylglycerol 90.3 43 18597752 (3), 17649977 (2), 19543978 (2), 18452279 (2) (see all 13)
    anandamide 70.6 3 17649977 (1), 17950616 (1), 15063097 (1)
    glycerol 45 8 11470505 (1), 19962385 (1), 1959050 (1), 16232941 (1) (see all 5)
    arachidonic acid 27.9 7 16935556 (1), 19962385 (1), 1905023 (1)
    lipid 27.7 10 17848545 (1), 18855964 (1), 19233690 (1), 18981578 (1) (see all 5)
    fatty acid 24 4 15063097 (1), 16232941 (1), 16232953 (1)
    serine 0 4 19875078 (1), 20005861 (1), 18452279 (1), 19962385 (1)



    MGLL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MGLL gene (3 alternative transcripts): 
    NM_001003794.2  NM_001256585.1  NM_007283.6  

    Unigene Cluster for MGLL:

    Monoglyceride lipase
    Hs.277035  [show with all ESTs]
    Unigene Representative Sequence: NM_007283
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434178(uc003ejv.3 uc003ejw.3 uc011bko.2) ENST00000496306
    ENST00000476682 ENST00000487473 ENST00000398101 ENST00000484451 ENST00000465597
    ENST00000479967(uc010hsp.1) ENST00000493611 ENST00000476654 ENST00000494830
    ENST00000265052 ENST00000453507 ENST00000398104(uc003ejx.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MGLL (see all 47):
    hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-1260b hsa-miR-25 hsa-miR-938 hsa-miR-570 hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MGLL (NM_001003794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGLL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGLL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MGLL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MGLL
      QuantiTect SYBR Green Assays in human, mouse, rat MGLL
      QuantiFast Probe-based Assays in human, mouse, rat MGLL

    Additional mRNA sequence: 

    AF131821.1 AJ270950.1 AK025983.1 AK026389.1 AK091314.1 AK093841.1 AK304844.1 AK310874.1 
    AK315529.1 AL365376.1 AL833254.1 AY172950.1 BC000551.2 BC006230.2 BC047298.1 BC073823.1 
    CR456835.1 EU660904.1 U67963.1 

    Selected DOTS entries (see all 28):

    DT.91642727  DT.451832  DT.99953481  DT.100795967  DT.100640805  DT.120891373  DT.75132067  DT.95351809 
    DT.100811512  DT.120891234  DT.100045119  DT.120891295  DT.120891464  DT.91824705  DT.120891438  DT.120891479 
    DT.100795966  DT.120891392  DT.91741086  DT.120891143  DT.120891177  DT.91764633  DT.91958306  DT.91974122 

    Selected AceView cDNA sequences (see all 540):

    AX748332 BU162613 CD742541 CA395353 AL119566 CB158645 BM797778 CD675417 
    BU501241 CB528591 AL833254 BI869841 AW166623 BQ023691 BM794856 CR622559 
    CD365285 BQ575438 BU147266 BQ691581 BX488505 C04714 BM717851 BG827100 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGLL (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                      -           -     -                       -     -                                             
    SP2:              -     -                 -           -     -                       -     -                                             
    SP3:                                      -                                         -     -                                             
    SP4:                                                                                -     -                                             
    SP5:              -     -                 -                                                                                             


    ECgene alternative splicing isoforms for MGLL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGLL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGGGGGA
    MGLL Expression
    About this image


    MGLL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    MGLL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGLL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277035

    UniProtKB/Swiss-Prot: MGLL_HUMAN, Q99685
    Tissue specificity: Detected in adipose tissue, lung, liver, kidney, brain and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGLL: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGLL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgll1 , 5 monoglyceride lipase1, 5 83.17(n)1
    83.71(a)1
      6 (39.51 cM)5
    239451  NM_001166251.11  NP_001159723.11 
     887244125 
    chicken
    (Gallus gallus)
    Aves MGLL1 monoglyceride lipase 71.31(n)
    69.9(a)
      416024  NM_001277142.1  NP_001264071.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGLL6
    monoglyceride lipase
    61(a)
    1 ↔ 1
    2(165909774-166034150)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.44322 Transcribed sequence with weak similarity to protein more 70.47(n)    AL850963.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565612 hypothetical protein MGC56561 73.87(n)   393267  AY398382.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YJU3(YKL094W)4 Monoglyceride lipase (MGL), functional ortholog of more   --   11(263349-264290) 853768  NP_012829.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G161201 AT5G16120 41.7(n)
    32.36(a)
      831469  NM_001125762.1  NP_001119234.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g01356001 Os10g0135600 41.07(n)
    29.59(a)
      4348060  NM_001070656.1  NP_001064121.2 


    ENSEMBL Gene Tree for MGLL (if available)
    TreeFam Gene Tree for MGLL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGLL gene
    1 SIMAP similar gene for MGLL using alignment to 8 protein entries:     MGLL_HUMAN (see all proteins):
    PPME1

    MGLL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGLL (see all 2896)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716159451,2
    C--124827830(+) TGTTTATCC/-  
            
    ATCCA
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs1158826871,2
    F--127407644(+) GGGGAG/AGGTGG 3 -- ds50011Minor allele frequency- A:0.01NA 120
    rs768025601,2
    C,F--127407653(+) GGCCTG/TGGCTC 3 -- ds50012Minor allele frequency- T:0.30CSA WA 120
    rs1827722971,2
    --127407740(+) AAGATA/GAACTC 3 -- ds50010--------
    rs68014211,2
    C,F,H--127407753(+) CACACG/ACTGAT 3 -- ds500116Minor allele frequency- A:0.07NS EA NA CSA WA 2217
    rs1143309031,2
    C,F--127407799(+) TGACAG/AGCATG 3 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1886524001,2
    --127407819(+) GGGATC/TAGCCT 3 -- ds50010--------
    rs1929852131,2
    --127407922(+) ACATCA/GGATTT 3 -- ut310--------
    rs729696131,2
    C,F--127407988(+) TGCCCC/TGCAGA 3 -- ut312Minor allele frequency- T:0.03WA 120
    rs1159709311,2
    C,F--127407995(+) CAGACA/GGTATA 3 -- ut311Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for MGLL (127407909 - 127542051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MGLL (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1191118CNV Deletion17803354
    esv2659152CNV Deletion23128226
    esv2664028CNV Deletion23128226
    esv268655CNV Insertion20981092
    esv274547CNV Insertion20981092
    nsv3990CNV Insertion18451855
    esv268225CNV Insertion20981092
    dgv5249n71CNV Loss21882294
    nsv460848CNV Loss19166990
    esv27043CNV Loss19812545

    Human Gene Mutation Database (HGMD): MGLL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGLL
    DNA2.0 Custom Variant and Variant Library Synthesis for MGLL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609699    OMIM disorders: --

    16 diseases for MGLL:    
    About MalaCards
    venous thrombosis    abdominal aortic aneurysm    aortic aneurysm    anorexia nervosa
    inflammatory bowel disease    obesity    pancreatic cancer    tuberculosis
    pancreatitis    colorectal cancer    prostatitis    prostate cancer
    hepatitis    breast cancer    cerebritis    endotheliitis


    MGLL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MGLL
    Human Genome Epidemiology (HuGE) Navigator: MGLL (9 documents)

    Export disorders for MGLL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGLL gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with MGLL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase. (PubMed id 9495531)1, 2, 3 Wall E.M.... Upton C. (Virus Res. 1997)
    2. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. (PubMed id 11470505)1, 2, 9 Karlsson M....Holm C. (Gene 2001)
    3. Structural basis for human monoglyceride lipase inhibition. (PubMed id 19962385)1, 2, 9 Bertrand T.... Mathieu M. (J. Mol. Biol. 2010)
    4. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PubMed id 19014633)1, 4, 9 MA1ller T.D....Hinney A. (Child Adolesc Psychiatry Ment Health 2008)
    5. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. (PubMed id 17621164)1, 4, 9 Iwasaki S....Arinami T. (Psychiatr. Genet. 2007)
    6. A covering method for detecting genetic associations between rare variants and common phenotypes. (PubMed id 20976246)1, 4 Bhatia G....Bafna V. (PLoS Comput. Biol. 2010)
    7. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. (PubMed id 20079333)1, 2 Nomura D.K....Cravatt B.F. (Cell 2010)
    8. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. (PubMed id 19957260)1, 2 Labar G.... Lambert D.M. (ChemBioChem 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11343 HGNC: 17038 AceView: MGLL Ensembl:ENSG00000074416 euGenes: HUgn11343
    ECgene: MGLL Kegg: 11343 H-InvDB: MGLL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGLL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGLL gene:
    Search GeneIP for patents involving MGLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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