V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

KITLG Gene

protein-coding GIFtS: 68

GC12M087393

KIT ligand
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MGF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686F2250 ^²
KL-1 ^¹, ²
Kitl ^¹, ²
MGF ^², ³, ⁵
SCF ^¹, ², ³, ⁵
SF ^¹, ², ⁵
SHEP7 ^², ⁵

Descriptions
C-kit ligand ^³
KIT ligand ^²
Mast cell growth factor ^², ³
Stem cell factor ^², ³
steel factor ^²

External Ids
HGNC: 6343¹
Entrez Gene: 4254²
UniProtKB: P21583³
Ensembl: ENSG00000049130⁷

Search outside databases for aliases for KITLG gene

Previous GC identifers: GC12M088158 GC12M089338 GC12M088823

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KITLG:

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand

is a pleiotropic factor that acts in utero in germ cell and neural cell development, and

hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions

pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript

variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: SCF_HUMAN, P21583

Function: Stimulates the proliferation of mast cells. Able to augment the proliferation of both

myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell

adhesion. Acts synergistically with other cytokines, probably interleukins

Gene Wiki entry for KITLG (Stem_cell_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KITLG gene

Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q21.32 HGNC cytogenetic band: 12q22

KITLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M087393: (about GC identifiers)

Start:	87,410,697 bp from pter
End:	87,498,369 bp from pter
Size:	87,673 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_019546.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SCF_HUMAN, P21583 (See protein sequence)

Recommended Name: Kit ligand precursor

Size: 273 amino acids; 30899 Da

Subunit: Homodimer, non-covalently linked (Probable)

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (By

similarity). Secreted (By similarity). Note=Also exists as a secreted soluble form (isoform 1

only) (By similarity)

Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (By

similarity). Cytoplasm, cytoskeleton (By similarity)

Developmental stage: Acts in the early stages of hematopoiesis

PDB structures from and Proteopedia :

1EXZ (3D)

1SCF (3D)

2E9W (3D)

Secondary accessions: A0AV09 A8K2Q4 Q16487 Q68DZ2 Q7M4N8 Q9UQK7

Alternative splicing: 3 isoforms: P21583-1 P21583-2 P21583-3

Post-translational modifications:

A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain¹

Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully

N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168

and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118,

Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97¹

REFSEQ proteins (2 alternative transcripts):

NP_000890.1 NP_003985.2

ENSEMBL proteins:

ENSP00000367796 ENSP00000349630 ENSP00000054216 ENSP00000228280

Human Recombinant Proteins

	Invitrogen human recombinant proteins for KITLG
	Millipore Purified and/or Recombinant KITLG Protein
	Sigma-Aldrich Proteins for KITLG
	R&D Systems Recombinant & Natural Proteins for KITLG (SCF)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SCF)
	Human Recombinant Proteins from Abnova (KITLG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	NAS	10049787

About this table

Antibodies for KITLG:

	Invitrogen Antibodies for KITLG
	Millipore Mono- and Polyclonal Antibodies for the study of KITLG
	Sigma-Aldrich Antibodies for KITLG
	R&D Systems Antibodies for KITLG (SCF)
	Cell Signaling Technology (CST) Antibodies for KITLG (SCF)
	Antibodies from Abcam (SCF), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for KITLG

Assays for KITLG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems Flow Cytometry Kits for KITLG (SCF) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21583

ProtoNet protein and cluster: P21583

1 Blocks protein family: IPB003452 Stem cell factor

UniProtKB/Swiss-Prot: SCF_HUMAN, P21583

Similarity: Belongs to the SCF family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KITLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KITLG)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003994

Applied Biosystems Silencer® siRNAs for KITLG

Sigma-Aldrich siRNA and siRNA Panels for KITLG

Sigma-Aldrich shRNA for KITLG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KITLG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000899
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000899
untagged cDNA clones in CMV expression vector (see all 2): NM_000899

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000899

UniProtKB/Swiss-Prot: SCF_HUMAN, P21583

Function: Stimulates the proliferation of mast cells. Able to augment the proliferation of both

myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell

adhesion. Acts synergistically with other cytokines, probably interleukins

15/22 MGI mutant phenotypes (inferred from 48 alleles) (MGI details for Kitl) (see all 22 ):

	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005173	stem cell factor receptor binding	NAS	--
GO:0008083	growth factor activity	IEA	--
GO:0042802	identical protein binding	IPI	10884405

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for KITLG (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
Melanocyte Development and Pigmentation Signaling

GeneDecks KITLG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for KITLG

5/84 Interacting proteins for KITLG (ENSP00000228280³ P21583¹) via UniProtKB, MINT, and/or STRING (see all 84 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIT	P10721¹	EBI-1379527, EBI-1379503
KITLG	P21583¹	EBI-1379527, EBI-1379527
EPOR	ENSP00000222139³	STRING (score=.988)
EPO	ENSP00000252723³	STRING (score=.982)
BCL2	ENSP00000329623³	STRING (score=.964)

About this table

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001755	neural crest cell migration	IEA	--
GO:0002763	positive regulation of myeloid leukocyte differentiation	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	2208279
GO:0008284	positive regulation of cell proliferation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KITLG
10/50 Novoseek chemical compound relationships for KITLG gene (see all 50 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	70.70	321	9444944 (4), 10921922 (3), 1721591 (3), 7526158 (3) (see all 99)
pixy321	67.08	13	1383918 (6), 9922079 (1), 8692093 (1), 12881174 (1) (see all 6)
pkh 2	61.42	5	8807087 (1), 9573006 (1), 7536490 (1)
pbhp	58.06	4	7682456 (2)
daniplestim	58.06	1	10781904 (1)
gp 130	54.53	21	9389693 (2), 8642288 (2), 7535932 (1), 8547494 (1) (see all 13)
h 121	53.59	3	9750020 (2), 8609154 (1)
pyronin y	47.50	1	12461294 (1)
toluidine	45.94	7	10432289 (1), 11564169 (1), 7524750 (1), 7524746 (1) (see all 5)
rhodamine 123	41.36	5	8704205 (1), 10084251 (1), 10395370 (1)

About this table

1 PharmGKB drug compound relationship for KITLG gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	14563684

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KITLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KITLG)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003994

Sigma-Aldrich siRNA and siRNA Panels for KITLG

Sigma-Aldrich shRNA for KITLG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000899 NM_003994

REFSEQ mRNAs for KITLG gene (2 alternative transcripts):

NM_000899.3 NM_003994.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000899 NM_003994

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000899
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000899
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000899

Additional cDNA sequence:

AF119835.1 AF400436.1 AF400437.1 AK025245.1 AK055903.1 AK127865.1 AK290319.1 AK293002.1

BC069733.1 BC069783.1 BC069797.1 BC074725.2 BC126166.1 BC143899.1 CR613468.1 CR749222.1

M59964.1 S42571.1 S45995.1

8 DOTS entries:

DT.405991 DT.211805 DT.86840824 DT.100707042 DT.421705 DT.121155851 DT.121155857 DT.86849774

24/95 AceView cDNA sequences (see all 95 ):

CD617798 BC069783 BC074725 CB243467 CN482622 NM_003994 BF448859 BF115172

CR613468 CD617800 AL597797 BQ024940 S42571 AI583137 T28310 CD617804

NM_000899 BM564582 AA384587 AW131339 Z39030 BC069733 BQ016775 AF400437

highest scoring ESTs for KITLG:

M59964 BX473946 BX474960 BX504658 AF119835 AF400436 AF400437 BC069733 BC069783 BC069797

Unigene Cluster for KITLG:

KIT ligand

Hs.1048 [show with all ESTs]

Unigene Representative Sequence: NM_000899

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KITLG

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:
SP2:			-						-
SP3:			-		-		-		-		-		-		-		-		-
SP4:									-
SP5:			-

About this scheme

ECgene alternative splicing isoforms for KITLG

4 Ensembl transcripts including schematic representations:

ENST00000378535 ENST00000357116 ENST00000347404 ENST00000228280

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KITLG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KITLG

¹ / ² / ³

9 probe-sets matching KITLG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62480_at²^{, 3}	U95-C	1	1.00	1.00	0.96	1.81	AI446414	0.40	1.00	0.76	1
597_at²^{, 3}	U95-A	1	1.00	1.00	0.83	0.26	M59964	1.00	0.90	0.95	1
83799_at²^{, 3}	U95-D	1	0.88	1.00	0.93	1.15	AI393022	0.60	1.00	0.82	1
211124_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF119835	0.80	0.88	0.84	1
226534_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI446414	0.40	1.00	0.76	1
207029_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000899	0.60	1.00	0.82	1
211124_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226534_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207029_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KITLG for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATATATACAT

SOURCE GeneReport for Unigene cluster: Hs.1048
Expression variation in blood from EXPOLDB for KITLG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KITLG gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KITLG¹	--	KIT ligand	91.33(n) 85.71(a)	403507 NM_001012735.1 NP_001012753.1
chimpanzee (Pan troglodytes)	KITLG¹	--	KIT ligand	99.88(n) 100(a)	452114 XM_509255.2 XP_509255.2
cow (Bos taurus)	KITLG¹	--	KIT ligand	90.6(n) 84.98(a)	281885 NM_174375.2 NP_776800.1
rat (Rattus norvegicus)	Kitlg¹	--	KIT ligand	89.5(n) 82.42(a)	60427 NM_021843.2 NP_068615.1
mouse (Mus musculus)	Kitl^{1, 5}	10 (57.00 cM)⁵	kit ligand^{1, 5}	89.13(n)¹ 82.78(a)¹	17311¹ NM_013598.1¹ NP_038626.1¹ AK018777⁵ AK088655⁵ (see all 28)

About this table Species with no ortholog for KITLG

ENSEMBL Gene Tree for KITLG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: SCF_HUMAN, P21583

Polymorphism: Genetic variations in KITLG are associated with variation in skin/hair/eye

pigmentation type 7 (SHEP7) [MIM:611664]. Hair, eye and skin pigmentation are among the most

visible examples of human phenotypic variation, with a broad normal range that is subject to

substantial geographic stratification. In the case of skin, individuals tend to have lighter

pigmentation with increasing distance from the equator. By contrast, the majority of variation in

human eye and hair color is found among individuals of European ancestry, with most other human

populations fixed for brown eyes and black hair

10/516 NCBI SNPs in KITLG are shown (see all 516 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 167)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1907699^1,2	A,C,F,H,O	87414108(+)	`CCCATT/ATTAGC`	2	--	ut3¹		11	NA EU EA WA	920
	rs995029^1,2	A,C,F,H,O	87414652(+)	`TTTTCT/CAGATC`	2	--	ut3¹		9	NA EU EA WA	736
	rs995030^1,2	A,C,F,H,O	87414802(+)	`ATGGTG/ACATGC`	2	--	ut3¹ ese³		9	MN EA NA EU WA	2232
	rs4842625^1,2	A,C,F,H	87412378(+)	`TATTTC/TTTCAT`	2	--	ut3¹		7	NA EU EA WA	556
	rs869408^1,2	A,C,F,H	87498886(-)	`TTTTTA/TAAAAA`	2	--	ng3¹		7	NA EA EU WA	654
	rs1508594^1,2	A,C,F,H	87412022(+)	`AAAAAT/CTGAGA`	2	--	ut3¹ ese³		5	MN EU EA WA	590
	rs12344^1,2	C,F,H,O	87411094(-)	`TACTCA/GCTAAA`	2	--	ut3¹ ese³		8	MN EU EA WA NA	740
	rs1061981^1,2	A,C,F,O	87411420(+)	`CAATCC/TGAATG`	2	--	ut3¹		7	EA NA	274
	rs1388789^1,2	A,C,F,H	87412346(+)	`CTTACT/CAAAAC`	2	--	ut3¹		8	MN NA EU EA WA	738
	rs11104905^1,2	C,F,H	87414712(+)	`AGAGAC/GCAGGA`	2	--	ut3¹ ese³		11	NA EU EA WA	978

About this table

HapMap Linkage Disequilibrium images for KITLG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 184745 disorders: 611664

10/93 Novoseek disease relationships for KITLG gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mastocytosis	79.24	35	9584135 (5), 7547385 (2), 9609630 (1), 11231001 (1) (see all 25)
leukemia mast cell	73.59	2	7512180 (1), 7691885 (1)
diamond-blackfan anemia	70.39	18	1370205 (4), 7544739 (3), 1718487 (2), 7691319 (2) (see all 7)
mastocytosis systemic	67.10	6	8876560 (1), 12162685 (1), 12688351 (1), 7527672 (1) (see all 5)
leukemia	66.25	107	8677752 (3), 7686791 (2), 7693028 (2), 7687220 (1) (see all 68)
gastrointestinal stromal tumor	62.87	9	14686698 (1), 16127511 (1), 15743318 (1), 18602222 (1) (see all 6)
myeloid leukemia	62.16	19	8677752 (3), 1381238 (3), 7687773 (3), 8425202 (1) (see all 12)
myeloid leukemia chronic	58.11	16	9746786 (2), 16127511 (1), 7544854 (1), 12297464 (1) (see all 11)
anemia aplastic	57.33	40	7532030 (3), 7522518 (2), 10027723 (2), 1378317 (2) (see all 19)
mastocytoma	55.42	5	7547385 (2), 8809429 (1), 19397569 (1), 9371257 (1)

About this table

Genetic Association Database: KITLG
Human Genome Epidemiology Navigator: KITLG (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1543 PubMed articles for KITLG gene (see all 1543 ):

Primary structure and functional expression of rat and human stem cell factor DNAs. (PubMed id 2208279)^{2, 3, 4} Martin F.H.... Zsebo K.M. (1990)
Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells. (PubMed id 10049787)^{1, 3, 4} Blair H.C.... Dong S.S. (1999)
Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. (PubMed id 1707188)^{1, 2, 3} Geissler E.N....Galli S.J. (1991)
Genetic determinants of hair, eye and skin pigmentation in Europeans. (PubMed id 17952075)^{3, 4} Sulem P.... Stefansson K. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. (PubMed id 10884405)^{3, 4} Zhang Z....Kong X.P. (2000)
Structure of the active core of human stem cell factor and analysis of binding to its receptor kit. (PubMed id 10880433)^{3, 4} Jiang X....Hendrickson W.A. (2000)
Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells. (PubMed id 1381905)^{3, 4} Lu H.S.... Langley K.E. (1992)
Expression of two types of kit ligand mRNAs in human tumor cells. (PubMed id 1379846)^{3, 4} Toyota M.... Yachi A. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4254	HGNC: 6343	AceView: KITLG	Ensembl:ENSG00000049130	euGenes: HUgn4254
ECgene: KITLG	H-InvDB: KITLG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KITLG	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KITLG
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for KITLG gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KITLG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KITLG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KITLG		Antibodies for KITLG
	Explore super-pooled esiRNAs		Proteins for KITLG
	Lentivirus-delivered shRNAs for KITLG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KITLG)
	Search for Antibodies
	Chimera RNAi (KITLG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for KITLG (SCF)

	Recombinant Proteins (SCF)
	Antibodies (SCF)

Search OriGene for KITLG

Search Tocris compounds for KITLG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KITLG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KITLG Gene at Home site.
Version 2.41.1
server5.xennexinc.com

KITLG Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for KITLG

Summaries
for KITLG

Genomic Location
for KITLG

Proteins
for KITLG

Protein Domains/
Families
for KITLG

Gene Function
for KITLG

Pathways & Interactions
for KITLG

Drugs & Compounds
for KITLG

Transcripts
for KITLG

Expression
for KITLG

Orthologs
for KITLG

Paralogs
for KITLG

SNPs/Variants
for KITLG

Disorders & Mutations
for KITLG

Medical News
for KITLG

Publications
for KITLG

Search for KITLG

Genome Databases showing KITLG

Other Databases showing KITLG

Specialized Databases showing KITLG

Licensable Technologies
for KITLG

Services
for KITLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KITLG Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor KITLG

Summariesfor KITLG

Genomic Locationfor KITLG

Proteinsfor KITLG

Protein Domains/Familiesfor KITLG

Gene Functionfor KITLG

Pathways & Interactionsfor KITLG

Drugs & Compoundsfor KITLG

Transcriptsfor KITLG

Expression for KITLG

Orthologsfor KITLG

Paralogsfor KITLG

SNPs/Variantsfor KITLG

Disorders & Mutationsfor KITLG

Medical Newsfor KITLG

Publicationsfor KITLG

Search for KITLG

Genome Databases showing KITLG

Other Databases showing KITLG

Specialized Databases showing KITLG

Licensable Technologiesfor KITLG

Servicesfor KITLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KITLG

Summaries
for KITLG

Genomic Location
for KITLG

Proteins
for KITLG

Protein Domains/
Families
for KITLG

Gene Function
for KITLG

Pathways & Interactions
for KITLG

Drugs & Compounds
for KITLG

Transcripts
for KITLG

Expression
for KITLG

Orthologs
for KITLG

Paralogs
for KITLG

SNPs/Variants
for KITLG

Disorders & Mutations
for KITLG

Medical News
for KITLG

Publications
for KITLG

Licensable Technologies
for KITLG

Services
for KITLG