Aliases for MGEA5 Gene
- Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3 5
- Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
- N-Acetyl-Beta-D-Glucosaminidase 3 4
- Meningioma-Expressed Antigen 5 3 4
- N-Acetyl-Beta-Glucosaminidase 3 4
- Beta-N-Acetylglucosaminidase 3 4
- Beta-N-Acetylhexosaminidase 3 4
- Beta-Hexosaminidase 3 4
- NCOAT 3 4
- MEA5 3 4
External Ids for MGEA5 Gene
Previous GeneCards Identifiers for MGEA5 Gene
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
GeneCards Summary for MGEA5 Gene
MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase)) is a Protein Coding gene. Diseases associated with MGEA5 include Gangliosidosis Gm2 and Sandhoff Disease, Infantile, Juvenile, And Adult Forms. Among its related pathways are Insulin resistance. GO annotations related to this gene include histone acetyltransferase activity and beta-N-acetylglucosaminidase activity.
UniProtKB/Swiss-Prot for MGEA5 Gene
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.