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Aliases for MGEA5 Gene

Aliases for MGEA5 Gene

  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Beta-Hexosaminidase 3 4
  • NCOAT 3 4
  • MEA5 3 4
  • OGA 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • Protein O-GlcNAcase 3
  • EC 3.2.1.169 4
  • O-GlcNAcase 3
  • EC 3.2.1.- 4
  • KIAA0679 4
  • HEXC 4

External Ids for MGEA5 Gene

Previous GeneCards Identifiers for MGEA5 Gene

  • GC10M102437
  • GC10M102777
  • GC10M103675
  • GC10M103208
  • GC10M103534
  • GC10M097174

Summaries for MGEA5 Gene

Entrez Gene Summary for MGEA5 Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MGEA5 Gene

MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase)) is a Protein Coding gene. GO annotations related to this gene include histone acetyltransferase activity and hyalurononglucosaminidase activity.

UniProtKB/Swiss-Prot for MGEA5 Gene

  • Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

  • Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for MGEA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGEA5 Gene

Genomics for MGEA5 Gene

Regulatory Elements for MGEA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGEA5 Gene

Start:
101,784,443 bp from pter
End:
101,818,709 bp from pter
Size:
34,267 bases
Orientation:
Minus strand

Genomic View for MGEA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGEA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGEA5 Gene

Proteins for MGEA5 Gene

  • Protein details for MGEA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for MGEA5 Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MGEA5 Gene

    Alternative splice isoforms for MGEA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGEA5 Gene

Proteomics data for MGEA5 Gene at MOPED

Post-translational modifications for MGEA5 Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Ubiquitination at Lys87, Lys240, Lys297, Lys723, Lys858, and Lys869
  • Glycosylation at Ser405
  • Modification sites at PhosphoSitePlus

Other Protein References for MGEA5 Gene

No data available for DME Specific Peptides for MGEA5 Gene

Domains for MGEA5 Gene

Protein Domains for MGEA5 Gene

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • O60502
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with MGEA5: view

No data available for Gene Families for MGEA5 Gene

Function for MGEA5 Gene

Molecular function for MGEA5 Gene

GENATLAS Biochemistry: meningioma expressed antigen (MEA5) highly homolog to C elegans hyaluronidase with two alternative forms,expressed in many tissues
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};
UniProtKB/Swiss-Prot CatalyticActivity: [Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity: [Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
UniProtKB/Swiss-Prot Function: Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function: Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Enzyme Numbers (IUBMB) for MGEA5 Gene

Gene Ontology (GO) - Molecular Function for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 histone acetyltransferase activity IEA --
GO:0004415 hyalurononglucosaminidase activity TAS 9811929
GO:0016231 beta-N-acetylglucosaminidase activity IDA 11148210
genes like me logo Genes that share ontologies with MGEA5: view

Animal Model Products

CRISPR Products

miRNA for MGEA5 Gene

miRTarBase miRNAs that target MGEA5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MGEA5 Gene

Localization for MGEA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGEA5 Gene

Isoform 3: Nucleus.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGEA5 Gene COMPARTMENTS Subcellular localization image for MGEA5 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 11148210
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MGEA5: view

Pathways for MGEA5 Gene

SuperPathways for MGEA5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IDA 11148210
GO:0006516 glycoprotein catabolic process TAS 9811929
GO:0006517 protein deglycosylation IDA 11148210
GO:0006612 protein targeting to membrane IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with MGEA5: view

No data available for Pathways by source for MGEA5 Gene

Compounds for MGEA5 Gene

No Compound Related Data Available

Transcripts for MGEA5 Gene

Unigene Clusters for MGEA5 Gene

Meningioma expressed antigen 5 (hyaluronidase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGEA5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MGEA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGEA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:

ExUns: 16c · 16d · 16e ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - -
SP2: - - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for MGEA5 Gene

GeneLoc Exon Structure for
MGEA5
ECgene alternative splicing isoforms for
MGEA5

Expression for MGEA5 Gene

mRNA expression in normal human tissues for MGEA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGEA5 Gene

SOURCE GeneReport for Unigene cluster for MGEA5 Gene Hs.500842

mRNA Expression by UniProt/SwissProt for MGEA5 Gene

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
genes like me logo Genes that share expressions with MGEA5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MGEA5 Gene

Orthologs for MGEA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGEA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGEA5 35
  • 99.71 (n)
  • 99.89 (a)
MGEA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGEA5 35
  • 94.43 (n)
  • 99.02 (a)
MGEA5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGEA5 35
  • 94.98 (n)
  • 99.24 (a)
MGEA5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgea5 35
  • 90.83 (n)
  • 97.27 (a)
Mgea5 16
Mgea5 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGEA5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mgea5 35
  • 91.01 (n)
  • 97.38 (a)
chicken
(Gallus gallus)
Aves MGEA5 35
  • 81.21 (n)
  • 89.51 (a)
MGEA5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGEA5 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17870 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mgea5 35
  • 74.4 (n)
  • 82.8 (a)
Str.17607 35
zebrafish
(Danio rerio)
Actinopterygii mgea5 35
  • 74.44 (n)
  • 81.35 (a)
mgea5 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002287 35
  • 52.42 (n)
  • 47.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oga 35
  • 52.81 (n)
  • 47.47 (a)
Oga 36
  • 34 (a)
OneToOne
CG5871 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea oga-1 35
  • 45.28 (n)
  • 34.44 (a)
oga-1 36
  • 29 (a)
OneToOne
T20B5.3 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for MGEA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGEA5 Gene

ENSEMBL:
Gene Tree for MGEA5 (if available)
TreeFam:
Gene Tree for MGEA5 (if available)

Paralogs for MGEA5 Gene

No data available for Paralogs for MGEA5 Gene

Variants for MGEA5 Gene

Sequence variations from dbSNP and Humsavar for MGEA5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14591 -- 101,797,236(+) TATAA(G/T)TCCAT intron-variant
rs1008013 -- 101,789,109(+) TAGTG(A/T)CAGTG intron-variant
rs1043250 -- 101,785,902(-) GTAAA(A/G)CCGTG utr-variant-3-prime, nc-transcript-variant
rs1124714 -- 101,790,847(-) TATTT(A/G)TTTAT intron-variant
rs1900384 -- 101,816,254(-) acgga(C/G)tctcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGEA5 Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV Gain 20364138
esv1006576 CNV Deletion 20482838

Relevant External Links for MGEA5 Gene

HapMap Linkage Disequilibrium report
MGEA5
Human Gene Mutation Database (HGMD)
MGEA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGEA5 Gene

Disorders for MGEA5 Gene

(1) Novoseek inferred disease relationships for MGEA5 Gene

Disease -log(P) Hits PubMed IDs
meningioma 56.9 3

Relevant External Links for MGEA5

Genetic Association Database (GAD)
MGEA5
Human Genome Epidemiology (HuGE) Navigator
MGEA5
genes like me logo Genes that share disorders with MGEA5: view

No data available for UniProtKB/Swiss-Prot for MGEA5 Gene

Publications for MGEA5 Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D. … Meese E. (Hum. Mol. Genet. 1998) 2 3 4 23
  2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N. … Meese E. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. (PMID: 16356930) Toleman C.A. … Kudlow J.E. (J. Biol. Chem. 2006) 2 3
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  5. Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N- acetylglucosaminidase from human brain. (PMID: 11148210) Gao Y. … Hart G.W. (J. Biol. Chem. 2001) 3 4

Products for MGEA5 Gene

Sources for MGEA5 Gene

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