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MGEA5 Gene

protein-coding   GIFtS: 59
GCID: GC10M103534

Meningioma Expressed Antigen 5 (Hyaluronidase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meningioma Expressed Antigen 5 (Hyaluronidase)1 2     OGA2
Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase1 2 3     Bifunctional Protein NCOAT2
Meningioma-Expressed Antigen 52 3     Hyaluronidase In Meningioma2
MEA52 3     HEXC3
NCOAT2     KIAA06793
O-GlcNAcase2     

External Ids:    HGNC: 70561   Entrez Gene: 107242   Ensembl: ENSG000001984087   OMIM: 6040395   UniProtKB: O605023   

Export aliases for MGEA5 gene to outside databases

Previous GC identifers: GC10M102437 GC10M102777 GC10M103675 GC10M103208 GC10M097174


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGEA5 Gene:
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition
and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a
glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 (PubMed 11148210)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MGEA5 Gene:
MGEA5 (meningioma expressed antigen 5 (hyaluronidase)) is a protein-coding gene. Diseases associated with MGEA5 include meningioma, and thyroid cancer. GO annotations related to this gene include hyalurononglucosaminidase activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot: NCOAT_HUMAN, O60502
Function: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not
p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of
histone H4 and 'Lys-14' of histone H3

Gene Wiki entry for MGEA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGEA5 gene promoter:
         GATA-3   Sp1   c-Myb   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGEA5 promoter sequence
   Search Chromatin IP Primers for MGEA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGEA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1-q24.3   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.1-q24.3

MGEA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGEA5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103534:  view genomic region     (about GC identifiers)

Start:
103,544,200 bp from pter      End:
103,578,696 bp from pter
Size:
34,497 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCOAT_HUMAN, O60502 (See protein sequence)
Recommended Name: Bifunctional protein NCOAT  
Size: 916 amino acids; 102915 Da
Subunit: Monomer. Binds both acetylated and unacetylated histone H4 tail but acetylation on 'Lys-8' of histone H4
abolishes binding (By similarity)
Sequence caution: Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA31654.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for MGEA5:
2YDQ (3D)    
Secondary accessions: B7WPB9 D3DR79 O75166 Q86WV0 Q8IV98 Q9BVA5 Q9HAR0
Alternative splicing: 3 isoforms:  O60502-1   O60502-2   O60502-3   

Explore the universe of human proteins at neXtProt for MGEA5: NX_O60502

Explore proteomics data for MGEA5 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspase-31
  • Ubiquitination2 at Lys87, Lys240, Lys297, Lys723, Lys858, Lys869
  • Glycosylation2 at Ser405
  • Modification sites at PhosphoSitePlus

  • See MGEA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135906.1  NP_036347.1  

    ENSEMBL proteins: 
     ENSP00000354850   ENSP00000350445   ENSP00000359112   ENSP00000414235   ENSP00000409973  
     ENSP00000407081  

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011496 Beta-N-acetylglucosaminidase
     IPR017853 Glycoside_hydrolase_SF
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry O60502

    ProtoNet protein and cluster: O60502


    MGEA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCOAT_HUMAN, O60502
    Function: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not
    p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of
    histone H4 and 'Lys-14' of histone H3
    Catalytic activity: [Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine +
    N-acetyl-D-glucosamine
    Catalytic activity: [Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine +
    N-acetyl-D-glucosamine
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
    Enzyme regulation: Inhibited by N-acetylglucosamine and not N-acetylgalactosamine
    Biophysicochemical properties: Kinetic parameters: KM=1.1 mM for pNP-GlcNAc; Vmax=652 umol/min/mg enzyme with
    pNP-GLcNAc as substrate; pH dependence: Optimum pH is 5.7-7;

         Genatlas biochemistry entry for MGEA5:
    meningioma expressed antigen (MEA5) highly homolog to C elegans hyaluronidase with two alternative forms,expressed
    in many tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004402histone acetyltransferase activity IEA--
    GO:0004415hyalurononglucosaminidase activity TAS9811929
         
    MGEA5 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    Block miRNA regulation of human, mouse, rat MGEA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MGEA5 (see all 10):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-582-5p hsa-miR-93 hsa-miR-520g hsa-miR-20b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCOAT_HUMAN, O60502: Isoform 3: Nucleus
    NCOAT_HUMAN, O60502: Isoform 1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    MGEA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MGEA5: 
              Necrosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGEA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for MGEA5 (O605022, 3 ENSP000003548504) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253418 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253418 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253418 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253418 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253418 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006044N-acetylglucosamine metabolic process IEA--
    GO:0006516glycoprotein catabolic process TAS9811929
    GO:0006612protein targeting to membrane IEA--
    GO:0007568aging IEA--
    GO:0010524positive regulation of calcium ion transport into cytosol IEA--

    MGEA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MGEA5
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGEA5 (NCOAT)



    MGEA5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MGEA5 gene (2 alternative transcripts): 
    NM_001142434.1  NM_012215.3  

    Unigene Cluster for MGEA5:

    Meningioma expressed antigen 5 (hyaluronidase)
    Hs.500842  [show with all ESTs]
    Unigene Representative Sequence: NM_012215
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361464(uc001ktv.2) ENST00000462994 ENST00000482611 ENST00000357797
    ENST00000494347 ENST00000479811 ENST00000461645 ENST00000492204 ENST00000370094(uc001ktw.2 uc009xwt.2)
    ENST00000429860 ENST00000439817(uc001ktu.2 uc010qqe.1 uc009xws.2)
    ENST00000419011(uc010qqf.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MGEA5 (see all 10):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-582-5p hsa-miR-93 hsa-miR-520g hsa-miR-20b
    SwitchGear 3'UTR luciferase reporter plasmidMGEA5 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MGEA5

    Additional mRNA sequence: 

    AB014579.2 AF036144.2 AF086223.1 AF307332.1 AK000988.1 AK002091.1 AK027008.1 AK302626.1 
    BC001343.1 BC014201.2 BC032591.1 BC039583.2 BC047877.1 

    Selected DOTS entries (see all 36):

    DT.95174202  DT.319455  DT.95174195  DT.100810106  DT.121266742  DT.121266760  DT.314943  DT.95357244 
    DT.100810108  DT.100030148  DT.92458496  DT.121266802  DT.121266806  DT.95174192  DT.427999  DT.95211846 
    DT.100688704  DT.121266729  DT.121266733  DT.121266739  DT.100644272  DT.100651251  DT.121266738  DT.121266805 

    Selected AceView cDNA sequences (see all 692):

    BX498735 BQ723571 BE219693 AA609176 BU069206 BE263478 BQ004516 AA047705 
    AI678525 BG777263 AA626105 AI792762 BG058688 BE879485 BP375781 BE218821 
    BM746579 BU630160 AA333551 AI015532 BF439051 AA235110 AA332077 AA418233 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGEA5 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
    SP1:                          -                                               -                                   -     -     -     -           -     -     -   
    SP2:                          -                                         -     -                                   -     -     -     -           -     -     -   
    SP3:                          -                                               -                                                                                 
    SP4:                                                                                                              -     -     -     -     -     -     -     -   
    SP5:                          -     -                       -     -           -                                                                                 

    ExUns: 16c · 16d · 16e ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
    SP1:              -           -                       -                                                   
    SP2:  -           -           -                       -                                                   
    SP3:                                                                                                      
    SP4:              -           -                       -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MGEA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MGEA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGAGGCAA
    MGEA5 Expression
    About this image


    MGEA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
    MGEA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGEA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500842

    UniProtKB/Swiss-Prot: NCOAT_HUMAN, O60502
    Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including MGEA5: 
              Necrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGEA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MGEA5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgea51 , 5 meningioma expressed antigen 5 (hyaluronidase)1, 5 90.83(n)1
    97.27(a)1
      19 (38.75 cM)5
    760551  NM_023799.31  NP_076288.11 
     457502595 
    chicken
    (Gallus gallus)
    Aves MGEA51 meningioma expressed antigen 5 (hyaluronidase) 81.21(n)
    89.51(a)
      423851  NM_001039305.2  NP_001034394.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGEA56
    meningioma expressed antigen 5 (hyaluronidase)
    87(a)
    1 ↔ 1
    GL343239.1(1320190-1345980)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178702 Xenopus laevis transcribed sequence with moderate similarity more 77.17(n)    BG812119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgea51 meningioma expressed antigen 5 (hyaluronidase) 74.44(n)
    81.35(a)
      324487  XM_002664139.3  XP_002664185.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58713
    Oga1
    hyaluronoglucosaminidase3
    O-GlcNAcase1
    30(a)3
    52.81(n)1
    47.47(a)1
      93C73
    425181  NM_142699.31  NP_650956.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T20B5.33
    oga-11
    oga-11 30(a)3
    45.28(n)1
    34.44(a)1
      X(9378981-9382615)3
    1811641  NM_001129712.11  NP_001123184.11 


    ENSEMBL Gene Tree for MGEA5 (if available)
    TreeFam Gene Tree for MGEA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MGEA5 (see all 613)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs43324541,2
    C,A--103575720(+) AGAGAA/GAAAAA 2 -- int1 trp31Minor allele frequency- G:0.00CSA 1
    rs1145825581,2
    F--103905850(+) GTTAGC/TTCATG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1868156731,2
    --103905853(+) AGCTCA/GTGTGT 2 -- int10--------
    rs13744721,2
    C--103905925(-) CGGCGC/TAAAGA 2 -- int15Minor allele frequency- T:0.03EA NA WA 262
    rs70917011,2
    C,F--103906057(+) AGGTTA/GTAACT 2 -- int11Minor allele frequency- G:0.01WA 118
    rs37585581,2
    C,F,H--103906073(-) CCCACC/TCTCTT 2 -- int16Minor allele frequency- T:0.00MN EA NS 878
    rs174359111,2
    F--103906120(-) ATTAA-/GGACAA 2 -- int12Minor allele frequency- G:0.02MN EA 376
    rs1812162011,2
    --103906135(+) ATCTGC/GAAGTC 2 -- int10--------
    rs772319961,2
    F--103906256(+) AAAGGG/TAGGGG 2 -- int11Minor allele frequency- T:0.05WA 118
    rs1860840791,2
    --103906344(+) TTTACA/GGTTCG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MGEA5 (103544200 - 103578696 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MGEA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006576CNV Deletion20482838
    dgv171n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): MGEA5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGEA5
    DNA2.0 Custom Variant and Variant Library Synthesis for MGEA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604039    OMIM disorders: --

    9 diseases for MGEA5:    
    About MalaCards
    meningioma    thyroid cancer    diabetes mellitus    thyroiditis
    sarcoma    alzheimer's disease    colorectal cancer    malaria
    breast cancer


    MGEA5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MGEA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningioma 56.9 3 9811929 (2), 11341771 (1)

    Genetic Association Database (GAD): MGEA5
    Human Genome Epidemiology (HuGE) Navigator: MGEA5 (6 documents)

    Export disorders for MGEA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGEA5 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with MGEA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PubMed id 9811929)1, 2, 3, 9 Heckel D.... Meese E. (Hum. Mol. Genet. 1998)
    2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PubMed id 11341771)1, 2, 9 Comtesse N.... Meese E. (Biochem. Biophys. Res. Commun. 2001)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. MGEA5-14 polymorphism and type 2 diabetes in Mexico City. (PubMed id 17546623)1, 4 Cameron E.A....Parra E.J. (Am. J. Hum. Biol. 2007)
    5. The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. (PubMed id 16356930)1, 3 Toleman C.A....Kudlow J.E. (J. Biol. Chem. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N- acetylglucosaminidase, O-GlcNAcase. (PubMed id 11788610)1, 2 Wells L....Hart G.W. (J. Biol. Chem. 2002)
    8. Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. (PubMed id 12359146)1, 4 Farook V.S....Prochazka M. (Mol. Genet. Metab. 2002)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    10. Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N- acetylglucosaminidase from human brain. (PubMed id 11148210)1, 2 Gao Y.... Hart G.W. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10724 HGNC: 7056 AceView: MGEA5 Ensembl:ENSG00000198408 euGenes: HUgn10724
    ECgene: MGEA5 H-InvDB: MGEA5

    (According to HUGE)
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    HUGE: KIAA0679

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MGEA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGEA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGEA5 gene:
    Search GeneIP for patents involving MGEA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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