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Aliases for MGEA5 Gene

Aliases for MGEA5 Gene

  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3 5
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Beta-Hexosaminidase 3 4
  • NCOAT 3 4
  • MEA5 3 4
  • OGA 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • EC 3.2.1.169 4
  • O-GlcNAcase 3
  • EC 3.2.1.- 4
  • KIAA0679 4
  • HEXC 4

External Ids for MGEA5 Gene

Previous GeneCards Identifiers for MGEA5 Gene

  • GC10M102437
  • GC10M102777
  • GC10M103675
  • GC10M103208
  • GC10M103534
  • GC10M097174

Summaries for MGEA5 Gene

Entrez Gene Summary for MGEA5 Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MGEA5 Gene

MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase)) is a Protein Coding gene. Diseases associated with MGEA5 include gastric cardia carcinoma and meningioma, familial. Among its related pathways are Translation Insulin regulation of translation. GO annotations related to this gene include histone acetyltransferase activity and beta-N-acetylglucosaminidase activity.

UniProtKB/Swiss-Prot for MGEA5 Gene

  • Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

  • Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for MGEA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGEA5 Gene

Genomics for MGEA5 Gene

Regulatory Elements for MGEA5 Gene

Promoters for MGEA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGEA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGEA5 Gene

Chromosome:
10
Start:
101,784,443 bp from pter
End:
101,818,709 bp from pter
Size:
34,267 bases
Orientation:
Minus strand

Genomic View for MGEA5 Gene

Genes around MGEA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGEA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGEA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGEA5 Gene

Proteins for MGEA5 Gene

  • Protein details for MGEA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for MGEA5 Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MGEA5 Gene

    Alternative splice isoforms for MGEA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGEA5 Gene

Proteomics data for MGEA5 Gene at MOPED

Post-translational modifications for MGEA5 Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Ubiquitination at Lys 87, Lys 240, Lys 297, Lys 723, Lys 858, and Lys 869
  • Glycosylation at Ser 405
  • Modification sites at PhosphoSitePlus

Other Protein References for MGEA5 Gene

Antibody Products

No data available for DME Specific Peptides for MGEA5 Gene

Domains & Families for MGEA5 Gene

Protein Domains for MGEA5 Gene

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • Belongs to the glycosyl hydrolase 84 family.
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with MGEA5: view

No data available for Gene Families for MGEA5 Gene

Function for MGEA5 Gene

Molecular function for MGEA5 Gene

GENATLAS Biochemistry:
meningioma expressed antigen (MEA5) highly homolog to C elegans hyaluronidase with two alternative forms,expressed in many tissues
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
UniProtKB/Swiss-Prot Function:
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function:
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Enzyme Numbers (IUBMB) for MGEA5 Gene

genes like me logo Genes that share phenotypes with MGEA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MGEA5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGEA5 Gene

Localization for MGEA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGEA5 Gene

Isoform 3: Nucleus.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGEA5 Gene COMPARTMENTS Subcellular localization image for MGEA5 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 11148210
genes like me logo Genes that share ontologies with MGEA5: view

Pathways & Interactions for MGEA5 Gene

genes like me logo Genes that share pathways with MGEA5: view

Pathways by source for MGEA5 Gene

1 BioSystems pathway for MGEA5 Gene
1 KEGG pathway for MGEA5 Gene

Gene Ontology (GO) - Biological Process for MGEA5 Gene

None

No data available for SIGNOR curated interactions for MGEA5 Gene

Drugs & Compounds for MGEA5 Gene

(3) Drugs for MGEA5 Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra 0
Thiamet G Pharma 0
Coenzyme A Nutra 0

(2) Additional Compounds for MGEA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MGEA5: view

Drug Products

Transcripts for MGEA5 Gene

Unigene Clusters for MGEA5 Gene

Meningioma expressed antigen 5 (hyaluronidase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGEA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:

ExUns: 16c · 16d · 16e ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - -
SP2: - - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for MGEA5 Gene

GeneLoc Exon Structure for
MGEA5
ECgene alternative splicing isoforms for
MGEA5

Expression for MGEA5 Gene

mRNA expression in normal human tissues for MGEA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGEA5 Gene

This gene is overexpressed in Fetal Brain (12.7), Lymph node (8.2), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGEA5 Gene



SOURCE GeneReport for Unigene cluster for MGEA5 Gene Hs.500842

mRNA Expression by UniProt/SwissProt for MGEA5 Gene

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
genes like me logo Genes that share expression patterns with MGEA5: view

Protein tissue co-expression partners for MGEA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MGEA5 Gene

Orthologs for MGEA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGEA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGEA5 36
  • 100 (a)
OneToOne
MGEA5 35
  • 99.71 (n)
  • 99.89 (a)
cow
(Bos Taurus)
Mammalia MGEA5 35
  • 94.43 (n)
  • 99.02 (a)
MGEA5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGEA5 36
  • 99 (a)
OneToOne
MGEA5 35
  • 94.98 (n)
  • 99.24 (a)
mouse
(Mus musculus)
Mammalia Mgea5 16
Mgea5 36
  • 97 (a)
OneToOne
Mgea5 35
  • 90.83 (n)
  • 97.27 (a)
oppossum
(Monodelphis domestica)
Mammalia MGEA5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mgea5 35
  • 91.01 (n)
  • 97.38 (a)
chicken
(Gallus gallus)
Aves MGEA5 35
  • 81.21 (n)
  • 89.51 (a)
MGEA5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGEA5 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17870 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mgea5 35
  • 74.4 (n)
  • 82.8 (a)
Str.17607 35
zebrafish
(Danio rerio)
Actinopterygii mgea5 36
  • 78 (a)
OneToOne
mgea5 35
  • 74.44 (n)
  • 81.35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002287 35
  • 52.42 (n)
  • 47.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oga 36
  • 34 (a)
OneToOne
CG5871 37
  • 30 (a)
Oga 35
  • 52.81 (n)
  • 47.47 (a)
worm
(Caenorhabditis elegans)
Secernentea oga-1 35
  • 45.28 (n)
  • 34.44 (a)
oga-1 36
  • 29 (a)
OneToOne
T20B5.3 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for MGEA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGEA5 Gene

ENSEMBL:
Gene Tree for MGEA5 (if available)
TreeFam:
Gene Tree for MGEA5 (if available)

Paralogs for MGEA5 Gene

No data available for Paralogs for MGEA5 Gene

Variants for MGEA5 Gene

Sequence variations from dbSNP and Humsavar for MGEA5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs14591 -- 101,797,236(+) TATAA(G/T)TCCAT intron-variant
rs1043250 -- 101,785,902(-) GTAAA(A/G)CCGTG nc-transcript-variant, utr-variant-3-prime
rs1124714 -- 101,790,847(-) TATTT(A/G)TTTAT intron-variant, downstream-variant-500B
rs1900384 -- 101,816,254(-) acgga(C/G)tctcg intron-variant
rs2305191 -- 101,800,576(-) ATGAA(A/G)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGEA5 Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV Gain 20364138
esv1006576 CNV Deletion 20482838

Variation tolerance for MGEA5 Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGEA5 Gene

HapMap Linkage Disequilibrium report
MGEA5
Human Gene Mutation Database (HGMD)
MGEA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGEA5 Gene

Disorders for MGEA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MGEA5 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gastric cardia carcinoma
  • carcinoma of cardia of stomach
meningioma, familial
  • meningioma
gangliosidosis gm2
  • gm>2< gangliosidosis
tay-sachs disease
  • gm2-gangliosidosis, several forms
- elite association - COSMIC cancer census association via MalaCards
Search MGEA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGEA5

Genetic Association Database (GAD)
MGEA5
Human Genome Epidemiology (HuGE) Navigator
MGEA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGEA5
genes like me logo Genes that share disorders with MGEA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGEA5 Gene

Publications for MGEA5 Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D. … Meese E. (Hum. Mol. Genet. 1998) 2 3 4 23 67
  2. The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. (PMID: 16356930) Toleman C.A. … Kudlow J.E. (J. Biol. Chem. 2006) 2 3
  3. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N. … Meese E. (Biochem. Biophys. Res. Commun. 2001) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MGEA5 Gene

Sources for MGEA5 Gene

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