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MGC16025 Gene

RNA gene   GIFtS: 19
GCID: GC02M240115

Uncharacterized LOC85009


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 1

Aliases
Uncharacterized LOC850092

External Ids:    Entrez Gene: 850092   UniProtKB: Q53SB44   UniProtKB: Q53SM24   
ORGUL members:         

Export aliases for MGC16025 gene to outside databases

Previous GC identifers: GC02M238057 GC02M238688 GC02M240030 GC02M240327 GC02U900722 GC02M239781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MGC16025 Gene:
MGC16025 is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MGC16025 include huntington's disease, and melanoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MGC16025 gene promoter:
         Max1   NF-1   NF-1/L   XBP-1   Nkx5-1   Roaz   HEN1   E2F-1   E2F   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MGC16025

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGC16025


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   

MGC16025 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGC16025 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M240115:  view genomic region     (about GC identifiers)

Start:
240,115,027 bp from pter      End:
240,117,153 bp from pter
Size:
2,127 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/TrEMBL: Q53SB4 (See protein sequence)
Recommended Name: Putative uncharacterized protein MGC16025  
Size: 31 amino acids; 3359 Da

UniProtKB/TrEMBL: Q53SM2 (See protein sequence)

Recommended Name: Putative uncharacterized protein MGC16025  
Size: 1052 amino acids; 115600 Da


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR019154 Arb2_domain
 IPR023801 His_deacetylse_dom
 IPR024643 Hist_deacetylase_Gln_rich_N
 IPR017320 Histone_deAcase_II_euk
 IPR000286 His_deacetylse

Graphical View of Domain Structure for InterPro Entry Q53SB4
Graphical View of Domain Structure for InterPro Entry Q53SM2

ProtoNet protein and cluster: Q53SB4


MGC16025 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGC16025
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MGC16025 About   (see all 13)  
See pathways by source

SuperPathContained pathways About
1Cyclins and Cell Cycle Regulation
Cyclins and Cell Cycle Regulation0.67
G1-S Phase Transition0.67
2Macrophage Differentiation and Growth Inhibition by METS
Macrophage Differentiation and Growth Inhibition by METS0.30
DNA Methylation and Transcriptional Repression0.30
3Phospholipase-C Pathway
Phospholipase-C Pathway0.56
4GPCR Pathway
Estrogen Pathway0.55
5Assembly of RNA Polymerase-II Initiation Complex
Protein Acetylation and Deacetylation0.51

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MGC16025 (see all 15)
    DNA Methylation and Transcriptional Repression
Protein Acetylation and Deacetylation
BRCA1 Pathway
Glucocorticoid Receptor Signaling
Intracellular Calcium Signaling


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Interactions:

    Search GeneGlobe Interaction Network for MGC16025

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MGC16025



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MGC16025 gene: 
NM_032923.1  

miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MGC16025:none

MGC16025 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTTGAAGT
MGC16025 Expression
About this image

MGC16025 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MGC16025
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGC16025

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MGC16025 gene
6 SIMAP similar genes for MGC16025 using alignment to 2 protein entries:     Q53SB4_HUMAN (see all proteins):
HDAC4    KIAA0600    HDAC5    HDAC9    HDAC7    DKFZp779K1053

MGC16025 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 10 variations for MGC16025:    About this table    
Variant IDTypeSubtypePubMed ID
dgv4464n71CNV Loss21882294
dgv4465n71CNV Loss21882294
nsv876090CNV Loss21882294
dgv4462n71CNV Loss21882294
dgv4463n71CNV Loss21882294
nsv834582CNV Loss17160897
nsv876071CNV Loss21882294
nsv876081CNV Loss21882294
nsv834579CNV Loss17160897
nsv428409CNV Gain18775914

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MGC16025
DNA2.0 Custom Variant and Variant Library Synthesis for MGC16025

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for MGC16025:    
About MalaCards
huntington's disease    melanoma


MGC16025 for disorders           About GeneDecksing

Genetic Association Database (GAD): MGC16025

Export disorders for MGC16025 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MGC16025 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MGC16025)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
  2. Genomewide association study of movement-related adverse antipsychotic effects. (PubMed id 19875103)4 Aberg K....van den Oord E.J. (Biol. Psychiatry 2010)
  3. Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy. (PubMed id 20217862)1 Godet Y....LabarriA"re N. (Eur. J. Immunol. 2010)
  4. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency. (PubMed id 18936238)1 Godet Y....Labarriere N. (J. Exp. Med. 2008)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85009 euGenes: HUgn85009

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MGC16025 gene:
Search GeneIP for patents involving MGC16025

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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