Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT5B Gene

protein-coding   GIFtS: 52
GCID: GC17P074864

Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase,...

(Previous names: mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosyl (Alpha-1,6-)-Glycoprotein
Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isozyme B1 2
     GnT-VB2
Mannosyl (Alpha-1,6-)-Glycoprotein
Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isoenzyme B1 2
     Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase B2
Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase B2 3     Beta(1,6)-N-Acetylglucosaminyltransferase V2
GlcNAc-T Vb2 3     EC 2.4.1.-3
Mannoside Acetylglucosaminyltransferase 5B2 3     EC 2.4.1.1553
hGnTVb2 3     GNT-IX3
N-Acetylglucosaminyl-Transferase Vb2 3     GNT-Vb3
N-Acetylglucosaminyltransferase IX2 3     KIAA20083
GnT-IX2     

External Ids:    HGNC: 241401   Entrez Gene: 1466642   Ensembl: ENSG000001678897   OMIM: 6124415   UniProtKB: Q3V5L53   

Export aliases for MGAT5B gene to outside databases

Previous GC identifers: GC17P075461 GC17P072376 GC17P070291


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGAT5B Gene:
The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis
of complex cell surface N-glycans (Kaneko et al., 2003 (PubMed 14623122)).(supplied by OMIM, Nov 2008)

GeneCards Summary for MGAT5B Gene: 
MGAT5B (mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B) is a protein-coding gene. Diseases associated with MGAT5B include fukuyama congenital muscular dystrophy, and walker-warburg syndrome, and among its related super-pathways are Asparagine N-linked glycosylation and Metabolism. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity and metal ion binding. An important paralog of this gene is MGAT5.

UniProtKB/Swiss-Prot: MGT5B_HUMAN, Q3V5L5
Function: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the
transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha
on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the
GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an
active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its
activity in the O-mannosyl glycan pathway

Gene Wiki entry for MGAT5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT5B gene promoter:
         Elk-1   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGAT5B promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.2   Ensembl cytogenetic band:  17q25.2   HGNC cytogenetic band: 17q25.3

MGAT5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT5B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P074864:  view genomic region     (about GC identifiers)

Start:
74,864,538 bp from pter      End:
74,946,475 bp from pter
Size:
81,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGT5B_HUMAN, Q3V5L5 (See protein sequence)
Recommended Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B  
Size: 792 amino acids; 89535 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=AAH62354.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAH63862.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAB71598.1;
Type=Miscellaneous discrepancy; Note=Chimeric sequence; Sequence=BAD02406.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAE44474.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Secondary accessions: Q6P3S8 Q6P6B3 Q766X5 Q76D04 Q96LS2
Alternative splicing: 3 isoforms:  Q3V5L5-1   Q3V5L5-2   Q3V5L5-5   

Explore the universe of human proteins at neXtProt for MGAT5B: NX_Q3V5L5

Explore proteomics data for MGAT5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3V5L5

  • MGAT5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MGAT5B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186101.1  NP_653278.2  NP_945193.1  

    ENSEMBL proteins: 
     ENSP00000301618   ENSP00000456037   ENSP00000457614   ENSP00000391227   ENSP00000455631  

    Human Recombinant Protein Products for MGAT5B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MGAT5B
    GenScript Custom Purified and Recombinant Proteins Services for MGAT5B
    Novus Biologicals MGAT5B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGAT5B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--

    MGAT5B for ontologies           About GeneDecksing



    MGAT5B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MGAT5B
    GenScript Custom Superior Antibodies Services for MGAT5B
    Abcam antibodies for MGAT5B
    Cloud-Clone Corp. Antibodies for MGAT5B 
    Search ThermoFisher Antibodies for MGAT5B
    Search LSBio for Antibodies for MGAT5B 

    Assay Products for MGAT5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MGAT5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MGAT5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MGAT5B 
    Cloud-Clone Corp. CLIAs for MGAT5B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026116 GlyclTrfase_18

    Graphical View of Domain Structure for InterPro Entry Q3V5L5

    ProtoNet protein and cluster: Q3V5L5

    UniProtKB/Swiss-Prot: MGT5B_HUMAN, Q3V5L5
    Similarity: Belongs to the glycosyltransferase 18 family


    MGAT5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGT5B_HUMAN, Q3V5L5
    Function: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the
    transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha
    on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the
    GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an
    active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its
    activity in the O-mannosyl glycan pathway
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

         Enzyme Numbers (IUBMB): EC 2.4.1.1551 EC 2.4.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0030144alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    MGAT5B for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mgat5b):
     homeostasis/metabolism  nervous system  no phenotypic analysis 

    MGAT5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MGAT5B: Mgat5btm1.1Itl Mgat5btm1.1Cfg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MGAT5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MGAT5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGAT5B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGAT5B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGAT5B
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MGAT5B (see all 15):
    hsa-miR-3163 hsa-miR-498 hsa-miR-3679-3p hsa-miR-485-5p hsa-miR-4311 hsa-miR-34c-5p hsa-miR-137 hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidMGAT5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MGAT5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MGAT5B
    Sirion Biotech Customized adenovirus for overexpression of MGAT5B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MGAT5B (see all 7)
    OriGene ORF clones in mouse, rat for MGAT5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MGAT5B (NM_001199172)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGAT5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT5B
    Sirion Biotech Customized lentivirus for stable overexpression of MGAT5B 
                         Customized lentivirus expression plasmids for stable overexpression of MGAT5B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MGAT5B
    Search LifeMap BioReagents cell lines for MGAT5B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MGAT5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    N-Glycan biosynthesis0.52
    2Metabolism
    Metabolic pathways0.40
    3Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for MGAT5B):
        N-Glycan biosynthesis
    Other types of O-glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT5B_HUMAN, Q3V5L5
    Pathway: Protein modification; protein glycosylation


    MGAT5B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT5B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for MGAT5B (Q3V5L51, 3 ENSP000003912274) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930623I2D: score=1 
    MGAT4AENSP000002649684STRING: ENSP00000264968
    MGAT4BENSP000003384874STRING: ENSP00000338487
    MGAT4CENSP000003316644STRING: ENSP00000331664
    Hoxa1P090221EBI-3957727,EBI-3957603
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation IEA--

    MGAT5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT5B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGAT5B (MGT5B)

    1 Novoseek inferred chemical compound relationship for MGAT5B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 58.7 4 14617637 (1), 9020137 (1), 16413118 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT5B / MGT5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MGAT5B gene (3 alternative transcripts): 
    NM_001199172.1  NM_144677.2  NM_198955.1  

    Unigene Cluster for MGAT5B:

    Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
    Hs.144531  [show with all ESTs]
    Unigene Representative Sequence: AB235153
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301618(uc002jth.3) ENST00000569840 ENST00000565675(uc002jtg.4)
    ENST00000374998 ENST00000428789(uc002jti.3) ENST00000565043 ENST00000563627
    ENST00000563153 ENST00000568598(uc002jtj.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGAT5B
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MGAT5B (see all 15):
    hsa-miR-3163 hsa-miR-498 hsa-miR-3679-3p hsa-miR-485-5p hsa-miR-4311 hsa-miR-34c-5p hsa-miR-137 hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidMGAT5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MGAT5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT5B
    Clone
    Products:
         
    OriGene clones in human, mouse for MGAT5B (see all 7)
    OriGene ORF clones in mouse, rat for MGAT5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MGAT5B (NM_001199172)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGAT5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT5B
    Sirion Biotech Customized lentivirus for stable overexpression of MGAT5B 
                         Customized lentivirus expression plasmids for stable overexpression of MGAT5B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MGAT5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGAT5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT5B

    Additional mRNA sequence: 

    AB109185.1 AB114297.1 AB235153.1 AK123189.1 BC036948.1 BC041577.1 BC063862.1 BC144361.1 

    7 DOTS entries:

    DT.91834464  DT.92065151  DT.99960244  DT.97820706  DT.100001392  DT.120993936  DT.95268697 

    24/51 AceView cDNA sequences (see all 51):

    BC063862 AB114297 BC062354 BC041577 NM_144677 AW191036 AB109185 NM_198955 
    BX281532 AL524151 BG745494 BE276066 BE789945 AW673010 BG489574 BE730360 
    BM467203 AW675179 BI758105 D81122 BC036948 BU192639 AK123189 BG478724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGAGCCC
    MGAT5B Expression
    About this image


    See MGAT5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT5B

    SOURCE GeneReport for Unigene cluster: Hs.144531

    UniProtKB/Swiss-Prot: MGT5B_HUMAN, Q3V5L5
    Tissue specificity: Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also
    expressed at much lower level in testis, spleen and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including MGAT5B: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MGAT5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGAT5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MGAT5B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat5b1 , 5 mannoside acetylglucosaminyltransferase 5, isoenzyme more1, 5 87.67(n)1
    91.29(a)1
      11 (81.49 cM)5
    2685101  NM_172948.31  NP_766536.21 
     1169188635 
    chicken
    (Gallus gallus)
    Aves MGAT5B1 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, more 79.41(n)
    80.51(a)
      427801  XM_003642334.1  XP_003642382.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    78(a)
    77(a)
    many → 1
    many → 1
    2(111246902-111347749)
    GL344778.1(38-18723)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123142 Xenopus laevis transcribed sequence with weak similarity more 75.4(n)    BJ067477.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MGAT5B (1 of 2)6
    MGAT5B (2 of 2)6
    mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acet...
    mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acet...
    70(a)
    57(a)
    many → 1
    many → 1
    3(59755563-59805990)
    9(51926664-52019629)
    worm
    (Caenorhabditis elegans)
    Secernentea gly-26
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylgluc...
    32(a)
    1 → many
    I(6507894-6511616)


    ENSEMBL Gene Tree for MGAT5B (if available)
    TreeFam Gene Tree for MGAT5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT5B gene
    MGAT52  
    1 SIMAP similar gene for MGAT5B using alignment to 3 protein entries:     MGT5B_HUMAN (see all proteins):
    MGAT5

    MGAT5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2201 SNPs in MGAT5B are shown (see all 2201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447184591,2
    C--74862883(+) GAGGCC/TTTCCC 2 -- us2k10--------
    rs1928090261,2
    --74862889(+) TTCCCG/TCTCCA 2 -- us2k10--------
    rs1821105831,2
    --74862949(+) ACCTTC/TCCCTA 2 -- us2k10--------
    rs1481901751,2
    --74862980(+) GTGGAG/TGGTAG 2 -- us2k10--------
    rs72118461,2
    C,F,A,H--74863117(+) CCTACT/CCAATC 2 -- us2k119Minor allele frequency- C:0.15NS EA NA CSA WA 2341
    rs1151742891,2
    F--74863320(+) CCACCA/GTTCAT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1872216631,2
    --74863408(+) ATCTGC/TTAACA 2 -- us2k10--------
    rs1170833481,2
    C,F--74863585(+) AAGGGG/CCCTGG 2 -- us2k11Minor allele frequency- C:0.05EA 120
    rs757707561,2
    C--74863653(+) CATAA-/GCCAG 
     GCTGCAG
    CATCG
    4 -- us2k1 cds10--------
    rs1421266921,2
    C--74863653(+) CATAA-/GCCAG 
     GCTGCAG
    CATCG
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MGAT5B (74864538 - 74946475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MGAT5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2546238CNV Insertion19546169
    nsv524066CNV Loss19592680
    dgv3273n71CNV Loss21882294
    nsv510443CNV Loss20534489
    nsv833550CNV Loss17160897
    nsv908837CNV Loss21882294
    nsv457912CNV Loss19166990
    nsv521914CNV Loss19592680
    dgv3272n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MGAT5B
    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612441    OMIM disorders: --

    7 diseases for MGAT5B:    About MalaCards
    fukuyama congenital muscular dystrophy    walker-warburg syndrome    congenital muscular dystrophy    muscular dystrophy
    neuroblastoma    melanoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MGAT5B:
    Fukuyama congenital muscular dystrophy     Walker-Warburg syndrome

    MGAT5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MGAT5B
    Human Genome Epidemiology (HuGE) Navigator: MGAT5B (4 documents)

    Export disorders for MGAT5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT5B gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with MGAT5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB). (PubMed id 14623122)1, 2, 3, 9 Kaneko M.... Pierce M. (2003)
    2. N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O- mannosyl glycan. (PubMed id 14617637)1, 2, 3, 9 Inamori K.... Taniguchi N. (2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O- mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb. (PubMed id 16857188)1, 2 Abbott K.L.... Pierce M. (2006)
    6. N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. (PubMed id 16606368)1, 2 Lee I.... Pierce M. (2006)
    7. Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain. (PubMed id 12941944)1, 2 Inamori K.... Taniguchi N. (2003)
    8. Comparison of the substrate specificities and catalyt ic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). (PubMed id 19846580)1, 9 Alvarez-Manilla G....Pierce M. (2010)
    9. Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. (PubMed id 16413118)1, 9 Inamori K....Taniguchi N. (2006)
    10. A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern. (PubMed id 22683750)1 Sinner M.F....Salomaa V. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146664 HGNC: 24140 AceView: MGAT5B Ensembl:ENSG00000167889 euGenes: HUgn146664
    ECgene: MGAT5B Kegg: 146664 H-InvDB: MGAT5B

    (According to HUGE)
    About This Section
    HUGE: KIAA2008

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT5B Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT5B

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MGAT5B gene:
    Search GeneIP for patents involving MGAT5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MGAT5B  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MGAT5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for MGAT5B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MGAT5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MGAT5B   OriGene Custom Protein Services for MGAT5B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MGAT5B
     QIAGEN SeqTarget long-range PCR primers for resequencing MGAT5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT5B
     GenScript Custom Purified and Recombinant Proteins Services for MGAT5B GenScript cDNA clones with any tag delivered in your preferred vector for MGAT5B
     GenScript Custom Assay Services for MGAT5B GenScript Custom Superior Antibodies Services for MGAT5B
     GenScript Custom overexpressing Cell Line Services for MGAT5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MGAT5B promoter
     Search Chromatin IP Primers for MGAT5B
     RT2 qPCR Primer Assay in human, mouse, rat MGAT5B
     Search GNC Networks for MGAT5B
     SABiosciences PCR Arrays including human, mouse, rat MGAT5B
     Search Tocris compounds for MGAT5B (MGT5B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MGAT5B proteins
     Antibodies for MGAT5B
     See all of Abcam's Antibodies, Kits and Proteins for MGAT5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MGAT5B
     Antibodies for MGAT5B
     ELISAs for MGAT5B
     CLIAs for MGAT5B
     Search LifeMap BioReagents cell lines for MGAT5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT5B
     SwitchGear 3'UTR luciferase reporter plasmids for MGAT5B
     SwitchGear Promoter luciferase reporter plasmids for MGAT5B
     Search ThermoFisher Antibodies for MGAT5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT5B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MGAT5B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MGAT5B
    Customized:
     lentivirus for stable overexpression of MGAT5B
     lentivirus expression plasmids for stable overexpression of MGAT5B
     adenovirus for overexpression of MGAT5B
     Search LSBio for Antibodies for MGAT5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MGAT5B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4