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Aliases for MGAT5B Gene

Aliases for MGAT5B Gene

  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isozyme B 2 3
  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isoenzyme B 2 3
  • Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase B 3 4
  • Mannoside Acetylglucosaminyltransferase 5B 3 4
  • N-Acetylglucosaminyl-Transferase Vb 3 4
  • N-Acetylglucosaminyltransferase IX 3 4
  • GlcNAc-T Vb 3 4
  • GnT-IX 3 4
  • GnT-VB 3 4
  • HGnTVb 3 4
  • Beta(1,6)-N-Acetylglucosaminyltransferase V 3
  • EC 2.4.1.155 4
  • EC 2.4.1.- 4
  • KIAA2008 4

External Ids for MGAT5B Gene

Previous GeneCards Identifiers for MGAT5B Gene

  • GC17P075461
  • GC17P072376
  • GC17P074864
  • GC17P070291

Summaries for MGAT5B Gene

Entrez Gene Summary for MGAT5B Gene

  • The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]

GeneCards Summary for MGAT5B Gene

MGAT5B (Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isozyme B) is a Protein Coding gene. Diseases associated with MGAT5B include walker-warburg syndrome. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is CCDC126.

UniProtKB/Swiss-Prot for MGAT5B Gene

  • Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

Gene Wiki entry for MGAT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT5B Gene

Genomics for MGAT5B Gene

Regulatory Elements for MGAT5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGAT5B Gene

Chromosome:
17
Start:
76,850,503 bp from pter
End:
76,950,393 bp from pter
Size:
99,891 bases
Orientation:
Plus strand

Genomic View for MGAT5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT5B Gene

Proteins for MGAT5B Gene

  • Protein details for MGAT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3V5L5-MGT5B_HUMAN
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
    Protein Accession:
    Q3V5L5
    Secondary Accessions:
    • Q6P3S8
    • Q6P6B3
    • Q766X5
    • Q76D04
    • Q96LS2

    Protein attributes for MGAT5B Gene

    Size:
    792 amino acids
    Molecular mass:
    89535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62354.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH63862.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB71598.1; Type=Miscellaneous discrepancy; Note=Chimeric sequence.; Evidence={ECO:0000305}; Sequence=BAD02406.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE44474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MGAT5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT5B Gene

Proteomics data for MGAT5B Gene at MOPED

Post-translational modifications for MGAT5B Gene

  • Glycosylation at Asn 127
  • Modification sites at PhosphoSitePlus

Other Protein References for MGAT5B Gene

No data available for DME Specific Peptides for MGAT5B Gene

Domains & Families for MGAT5B Gene

Protein Domains for MGAT5B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MGAT5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3V5L5

UniProtKB/Swiss-Prot:

MGT5B_HUMAN :
  • Belongs to the glycosyltransferase 18 family.
Family:
  • Belongs to the glycosyltransferase 18 family.
genes like me logo Genes that share domains with MGAT5B: view

Function for MGAT5B Gene

Molecular function for MGAT5B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

Enzyme Numbers (IUBMB) for MGAT5B Gene

Gene Ontology (GO) - Molecular Function for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT5B: view
genes like me logo Genes that share phenotypes with MGAT5B: view

Animal Models for MGAT5B Gene

MGI Knock Outs for MGAT5B:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for MGAT5B Gene

Localization for MGAT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT5B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT5B Gene COMPARTMENTS Subcellular localization image for MGAT5B gene
Compartment Confidence
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGAT5B: view

Pathways & Interactions for MGAT5B Gene

genes like me logo Genes that share pathways with MGAT5B: view

Pathways by source for MGAT5B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q3V5L5-MGT5B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation IEA --
genes like me logo Genes that share ontologies with MGAT5B: view

No data available for SIGNOR curated interactions for MGAT5B Gene

Drugs & Compounds for MGAT5B Gene

(1) Drugs for MGAT5B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0

(2) Additional Compounds for MGAT5B Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
mannose
genes like me logo Genes that share compounds with MGAT5B: view

Transcripts for MGAT5B Gene

Unigene Clusters for MGAT5B Gene

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT5B Gene

No ASD Table

Relevant External Links for MGAT5B Gene

GeneLoc Exon Structure for
MGAT5B
ECgene alternative splicing isoforms for
MGAT5B

Expression for MGAT5B Gene

mRNA expression in normal human tissues for MGAT5B Gene

mRNA differential expression in normal tissues according to GTEx for MGAT5B Gene

This gene is overexpressed in Brain - Cortex (x10.9), Brain - Frontal Cortex (BA9) (x8.5), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Putamen (basal ganglia) (x5.5), Brain - Amygdala (x4.2), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for MGAT5B Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MGAT5B Gene



SOURCE GeneReport for Unigene cluster for MGAT5B Gene Hs.144531

mRNA Expression by UniProt/SwissProt for MGAT5B Gene

Q3V5L5-MGT5B_HUMAN
Tissue specificity: Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus.
genes like me logo Genes that share expression patterns with MGAT5B: view

Protein tissue co-expression partners for MGAT5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MGAT5B Gene

Orthologs for MGAT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGAT5B 35
  • 91.11 (n)
  • 93.5 (a)
MGAT5B 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT5B 35
  • 91.46 (n)
  • 93.94 (a)
MGAT5B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat5b 35
  • 87.67 (n)
  • 91.29 (a)
Mgat5b 16
Mgat5b 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGAT5B 35
  • 96.37 (n)
  • 95.73 (a)
MGAT5B 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat5b 35
  • 86.96 (n)
  • 90.42 (a)
oppossum
(Monodelphis domestica)
Mammalia MGAT5B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT5B 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGAT5B 35
  • 79.41 (n)
  • 80.51 (a)
MGAT5B 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT5B 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat5b 35
  • 70.06 (n)
  • 73.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12314 35
zebrafish
(Danio rerio)
Actinopterygii LOC101884072 35
  • 71.41 (n)
  • 72.67 (a)
MGAT5B 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-2 36
  • 33 (a)
OneToMany
Species with no ortholog for MGAT5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT5B Gene

ENSEMBL:
Gene Tree for MGAT5B (if available)
TreeFam:
Gene Tree for MGAT5B (if available)

Paralogs for MGAT5B Gene

Paralogs for MGAT5B Gene

(1) SIMAP similar genes for MGAT5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MGAT5B: view

Variants for MGAT5B Gene

Sequence variations from dbSNP and Humsavar for MGAT5B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs76936 -- 76,903,881(+) TGGCC(A/G)CCTTG intron-variant
rs472078 -- 76,862,119(-) ccctc(A/T)tgctg intron-variant, upstream-variant-2KB
rs474589 -- 76,889,054(-) TTTCT(C/T)ACTCG intron-variant
rs485153 -- 76,902,516(-) CCGGC(C/T)GGGGT intron-variant
rs485262 -- 76,902,475(-) CCCAC(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT5B Gene

Variant ID Type Subtype PubMed ID
nsv833550 CNV Loss 17160897
nsv457912 CNV Loss 19166990
dgv3272n71 CNV Gain 21882294
nsv908837 CNV Loss 21882294
dgv3273n71 CNV Loss 21882294
nsv510443 CNV Loss 20534489
esv2546238 CNV Insertion 19546169
nsv521914 CNV Loss 19592680
nsv524066 CNV Loss 19592680

Variation tolerance for MGAT5B Gene

Residual Variation Intolerance Score: 13.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT5B Gene

HapMap Linkage Disequilibrium report
MGAT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT5B Gene

Disorders for MGAT5B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGAT5B Gene - From: DISEASES

Disorder Aliases PubMed IDs
walker-warburg syndrome
  • cerebroocular dysplasia-muscular dystrophy syndrome
- elite association

Relevant External Links for MGAT5B

Genetic Association Database (GAD)
MGAT5B
Human Genome Epidemiology (HuGE) Navigator
MGAT5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT5B
genes like me logo Genes that share disorders with MGAT5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT5B Gene

Publications for MGAT5B Gene

  1. N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O- mannosyl glycan. (PMID: 14617637) Inamori K. … Taniguchi N. (J. Biol. Chem. 2004) 2 23 67
  2. A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB). (PMID: 14623122) Kaneko M. … Pierce M. (FEBS Lett. 2003) 2 23 67
  3. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). (PMID: 19846580) Alvarez-Manilla G. … Pierce M. (Glycobiology 2010) 23 67
  4. Expression of fucosyltransferases contributes to melanoma invasive phenotype. (PMID: 17897065) CioA8czyk-Wierzbicka D. … Laidler P. (Med Chem 2007) 23 67
  5. High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis. (PMID: 16406367) Inamori K. … Taniguchi N. (FEBS Lett. 2006) 23 67

Products for MGAT5B Gene

Sources for MGAT5B Gene

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