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Aliases for MGAT5B Gene

Aliases for MGAT5B Gene

  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isozyme B 2 3
  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isoenzyme B 2 3
  • Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase B 3 4
  • Mannoside Acetylglucosaminyltransferase 5B 3 4
  • N-Acetylglucosaminyl-Transferase Vb 3 4
  • N-Acetylglucosaminyltransferase IX 3 4
  • GlcNAc-T Vb 3 4
  • GnT-IX 3 4
  • GnT-VB 3 4
  • HGnTVb 3 4
  • Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase B 3
  • Beta(1,6)-N-Acetylglucosaminyltransferase V 3
  • EC 2.4.1.155 4
  • EC 2.4.1.- 4
  • KIAA2008 4

External Ids for MGAT5B Gene

Summaries for MGAT5B Gene

Entrez Gene Summary for MGAT5B Gene

  • The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]

GeneCards Summary for MGAT5B Gene

MGAT5B (Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase, Isozyme B) is a Protein Coding gene. Diseases associated with MGAT5B include walker-warburg syndrome. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is CCDC126.

UniProtKB/Swiss-Prot for MGAT5B Gene

  • Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

Gene Wiki entry for MGAT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT5B Gene

Genomics for MGAT5B Gene

Genomic Location for MGAT5B Gene

Start:
76,868,456 bp from pter
End:
76,950,393 bp from pter
Size:
81,938 bases
Orientation:
Plus strand

Genomic View for MGAT5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT5B Gene

Regulatory Elements for MGAT5B Gene

Proteins for MGAT5B Gene

  • Protein details for MGAT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3V5L5-MGT5B_HUMAN
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
    Protein Accession:
    Q3V5L5
    Secondary Accessions:
    • Q6P3S8
    • Q6P6B3
    • Q766X5
    • Q76D04
    • Q96LS2

    Protein attributes for MGAT5B Gene

    Size:
    792 amino acids
    Molecular mass:
    89535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62354.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH63862.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB71598.1; Type=Miscellaneous discrepancy; Note=Chimeric sequence.; Evidence={ECO:0000305}; Sequence=BAD02406.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE44474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MGAT5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT5B Gene

Proteomics data for MGAT5B Gene at MOPED

Post-translational modifications for MGAT5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MGAT5B Gene

No data available for DME Specific Peptides for MGAT5B Gene

Domains for MGAT5B Gene

Protein Domains for MGAT5B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MGT5B_HUMAN
Family:
  • Belongs to the glycosyltransferase 18 family.:
    • Q3V5L5
genes like me logo Genes that share domains with MGAT5B: view

No data available for Gene Families for MGAT5B Gene

Function for MGAT5B Gene

Molecular function for MGAT5B Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.

Enzyme Numbers (IUBMB) for MGAT5B Gene

Gene Ontology (GO) - Molecular Function for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT5B: view
genes like me logo Genes that share phenotypes with MGAT5B: view

Animal Models for MGAT5B Gene

MGI Knock Outs for MGAT5B:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MGAT5B Gene

Localization for MGAT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT5B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT5B Gene COMPARTMENTS Subcellular localization image for MGAT5B gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGAT5B: view

Pathways for MGAT5B Gene

genes like me logo Genes that share pathways with MGAT5B: view

Pathways by source for MGAT5B Gene

UniProtKB/Swiss-Prot Q3V5L5-MGT5B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for MGAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation IEA --
genes like me logo Genes that share ontologies with MGAT5B: view

Compounds for MGAT5B Gene

(1) Novoseek inferred chemical compound relationships for MGAT5B Gene

Compound -log(P) Hits PubMed IDs
mannose 58.7 3
genes like me logo Genes that share compounds with MGAT5B: view

Transcripts for MGAT5B Gene

Unigene Clusters for MGAT5B Gene

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT5B Gene

No ASD Table

Relevant External Links for MGAT5B Gene

GeneLoc Exon Structure for
MGAT5B
ECgene alternative splicing isoforms for
MGAT5B

Expression for MGAT5B Gene

mRNA expression in normal human tissues for MGAT5B Gene

mRNA differential expression in normal tissues according to GTEx for MGAT5B Gene

This gene is overexpressed in Brain - Cortex (10.9), Brain - Frontal Cortex (BA9) (8.5), Brain - Anterior cingulate cortex (BA24) (5.8), Brain - Putamen (basal ganglia) (5.5), Brain - Amygdala (4.2), and Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MGAT5B Gene

SOURCE GeneReport for Unigene cluster for MGAT5B Gene Hs.144531

mRNA Expression by UniProt/SwissProt for MGAT5B Gene

Q3V5L5-MGT5B_HUMAN
Tissue specificity: Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus.
genes like me logo Genes that share expressions with MGAT5B: view

Orthologs for MGAT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT5B 36
  • 96.37 (n)
  • 95.73 (a)
MGAT5B 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT5B 36
  • 91.11 (n)
  • 93.5 (a)
MGAT5B 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT5B 36
  • 91.46 (n)
  • 93.94 (a)
MGAT5B 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat5b 36
  • 87.67 (n)
  • 91.29 (a)
Mgat5b 16
Mgat5b 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT5B 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT5B 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat5b 36
  • 86.96 (n)
  • 90.42 (a)
chicken
(Gallus gallus)
Aves MGAT5B 36
  • 79.41 (n)
  • 80.51 (a)
MGAT5B 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT5B 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12314 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat5b 36
  • 70.06 (n)
  • 73.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884072 36
  • 71.41 (n)
  • 72.67 (a)
MGAT5B 37
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-2 37
  • 33 (a)
OneToMany
Species with no ortholog for MGAT5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT5B Gene

ENSEMBL:
Gene Tree for MGAT5B (if available)
TreeFam:
Gene Tree for MGAT5B (if available)

Paralogs for MGAT5B Gene

Paralogs for MGAT5B Gene

Selected SIMAP similar genes for MGAT5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MGAT5B: view

Variants for MGAT5B Gene

Sequence variations from dbSNP and Humsavar for MGAT5B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs76936 -- 76,903,881(+) TGGCC(A/G)CCTTG intron-variant
rs474589 -- 76,889,054(-) TTTCT(C/T)ACTCG intron-variant
rs485153 -- 76,902,516(-) CCGGC(C/T)GGGGT intron-variant
rs485262 -- 76,902,475(-) CCCAC(A/G)GGCAA intron-variant
rs487598 -- 76,874,969(-) gtaca(C/T)gcaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT5B Gene

Variant ID Type Subtype PubMed ID
nsv833550 CNV Loss 17160897
nsv457912 CNV Loss 19166990
dgv3272n71 CNV Gain 21882294
nsv908837 CNV Loss 21882294
dgv3273n71 CNV Loss 21882294
nsv510443 CNV Loss 20534489
esv2546238 CNV Insertion 19546169
nsv521914 CNV Loss 19592680
nsv524066 CNV Loss 19592680

Relevant External Links for MGAT5B Gene

HapMap Linkage Disequilibrium report
MGAT5B

Disorders for MGAT5B Gene

(1) MalaCards Diseases for MGAT5B Gene

Search for MGAT5B Gene in MalaCards »

(2) University of Copenhagen DISEASES for MGAT5B Gene

Relevant External Links for MGAT5B

Genetic Association Database (GAD)
MGAT5B
Human Genome Epidemiology (HuGE) Navigator
MGAT5B
genes like me logo Genes that share disorders with MGAT5B: view

No data available for UniProtKB/Swiss-Prot for MGAT5B Gene

Publications for MGAT5B Gene

  1. N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O- mannosyl glycan. (PMID: 14617637) Inamori K. … Taniguchi N. (J. Biol. Chem. 2004) 2 3 4 23
  2. A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB). (PMID: 14623122) Kaneko M. … Pierce M. (FEBS Lett. 2003) 2 3 4 23
  3. Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain. (PMID: 16413118) Inamori K. … Taniguchi N. (Biochim. Biophys. Acta 2006) 3 23
  4. Molecular cloning and characterization of human GnT-IX, a novel beta1,6-N-acetylglucosaminyltransferase that is specifically expressed in the brain. (PMID: 12941944) Inamori K. … Taniguchi N. (J. Biol. Chem. 2003) 3 4
  5. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). (PMID: 19846580) Alvarez-Manilla G. … Pierce M. (Glycobiology 2010) 3 23

Products for MGAT5B Gene

Sources for MGAT5B Gene

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