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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT5 Gene

protein-coding   GIFtS: 60
GCID: GC02P134842

Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosyl (Alpha-1,6-)-Glycoprotein
Beta-1,6-N-Acetyl-Glucosaminyltransferase1 2
     N-Acetylglucosaminyl-Transferase V2 3
Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase2 3     EC 2.4.1.1553 8
GlcNAc-T V2 3     GNT-VA2
Mannoside Acetylglucosaminyltransferase 52 3     Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A2
GNT-V2 3     GGNT53

External Ids:    HGNC: 70491   Entrez Gene: 42492   Ensembl: ENSG000001521277   OMIM: 6017745   UniProtKB: Q093283   

Export aliases for MGAT5 gene to outside databases

Previous GC identifers: GC02P132654 GC02P133296 GC02P135031 GC02P135219 GC02P134725 GC02P134594 GC02P127004


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGAT5 Gene:
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of
beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the
newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the
biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins
cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this
enzyme has been correlated with the progression of invasive malignancies. (provided by RefSeq, Oct 2011)

GeneCards Summary for MGAT5 Gene: 
MGAT5 (mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase) is a protein-coding gene. Diseases associated with MGAT5 include bile duct carcinoma, and congenital dyserythropoietic anemia, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT5B.

UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
Function: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of
biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the
biosynthesis of glycoprotein oligosaccharides

Gene Wiki entry for MGAT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT5 gene promoter:
         c-Fos   AP-1   AML1a   POU2F1   POU2F1a   c-Jun   MIF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGAT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.2   HGNC cytogenetic band: 2q21

MGAT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P134842:  view genomic region     (about GC identifiers)

Start:
134,877,554 bp from pter      End:
135,212,192 bp from pter
Size:
334,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328 (See protein sequence)
Recommended Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A  
Size: 741 amino acids; 84543 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Secondary accessions: D3DP70

Explore the universe of human proteins at neXtProt for MGAT5: NX_Q09328

Explore proteomics data for MGAT5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q09328

  • 4/5 DME Specific Peptides for MGAT5 (Q09328) (see all 5)
     KDILVPSF  NSTNSTTAVPSLV  CSFFIYLSEVENWCP  QEKCVLPPMDGYPHCEGKIKWMKDMWRSDPCYADYGVDG 

    MGAT5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MGAT5 Protein Expression
    REFSEQ proteins: NP_002401.1  
    ENSEMBL proteins: 
     ENSP00000386377   ENSP00000281923  
    Reactome Protein details: Q09328
    Human Recombinant Protein Products for MGAT5: 
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    Cloud-Clone Corp. Proteins for MGAT5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane NAS--

    MGAT5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026116 GlyclTrfase_18

    Graphical View of Domain Structure for InterPro Entry Q09328

    ProtoNet protein and cluster: Q09328

    UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
    Similarity: Belongs to the glycosyltransferase 18 family


    MGAT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGT5A_HUMAN, Q09328
    Function: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of
    biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the
    biosynthesis of glycoprotein oligosaccharides
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT5:
    mannosyl (alpha-1,6-) glycoprotein beta-1,6-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex
    Asn-linked (N) glycans

         Enzyme Number (IUBMB): EC 2.4.1.1551 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008375acetylglucosaminyltransferase activity ----
    GO:0030144alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity NAS8292036
         
    MGAT5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MGAT5:
     Increased gamma-H2AX phosphory  Large cells 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mgat5):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  renal/urinary system 
     tumorigenesis 

    MGAT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MGAT5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGAT5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MGAT5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for MGAT5 (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    N-Glycan antennae elongation


    2         Kegg Pathways  (Kegg details for MGAT5):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
    Pathway: Protein modification; protein glycosylation


    MGAT5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MGAT5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MGAT5 (ENSP000002819234) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MGAT4AENSP000002649684STRING: ENSP00000264968
    MGAT4BENSP000003384874STRING: ENSP00000338487
    MGAT4CENSP000003316644STRING: ENSP00000331664
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation NAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MGAT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGAT5 (MGT5A)

    2 HMDB Compounds for MGAT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    10/16 Novoseek inferred chemical compound relationships for MGAT5 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-d-mannoside 83.7 1 15189346 (1)
    n-acetylglucosamine 72.6 21 10815896 (2), 19787216 (1), 8393437 (1), 8900148 (1) (see all 10)
    polysaccharide 65.8 19 15809094 (3), 19846557 (2), 11315257 (2), 11501752 (1) (see all 10)
    ebdc 64.8 4 15238704 (2), 15138129 (1)
    polylactosamine 54 3 8900148 (1), 15840653 (1)
    n-acetyllactosamine 51.4 1 11511814 (1)
    mannose 50.9 2 8428922 (1), 16413118 (1)
    udp-n-acetylglucosamine 46.9 3 8393437 (1), 8900148 (1)
    matrigel 44.2 3 10972975 (1), 11315257 (1), 12460896 (1)
    retinoic acid 40 36 17031849 (3), 19960509 (2), 10699467 (2), 16411021 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about MGAT5 / MGT5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MGAT5 gene: 
    NM_002410.4  

    Unigene Cluster for MGAT5:

    Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
    Hs.4988  [show with all ESTs]
    Unigene Representative Sequence: NM_002410
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481801 ENST00000468758 ENST00000409645(uc002ttw.4) ENST00000488365
    ENST00000281923
    miRNA
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    Additional mRNA sequence: 

    AF055029.1 AF113921.1 AK056461.1 AK125207.1 BC041917.1 BX647087.1 D17716.1 

    8 DOTS entries:

    DT.97808004  DT.445584  DT.75129808  DT.101962674  DT.100658584  DT.95117248  DT.95172280  DT.99950244 

    24/309 AceView cDNA sequences (see all 309):

    F12010 BM456973 AI379211 AA588223 AA295202 AW054888 AA371887 AW007543 
    AI061299 AA331865 AA706407 AW502708 BQ929928 BQ221864 AW449002 AA150977 
    CF142470 BX647087 BU161242 AI375333 BG314931 BU191961 BF589867 AA721306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT5 expression in normal human tissues (normalized intensities)      MGAT5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAATGTT
    MGAT5 Expression
    About this image


    MGAT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See MGAT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT5

    SOURCE GeneReport for Unigene cluster: Hs.4988
        SABiosciences Expression via Pathway-Focused PCR Arrays including MGAT5: 
              Glycosylation in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MGAT5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat51 , 5 mannoside acetylglucosaminyltransferase 51, 5 88.92(n)1
    97.3(a)1
      1 (55.71 cM)5
    1078951  NM_145128.31  NP_660110.21 
     1272049865 
    chicken
    (Gallus gallus)
    Aves MGAT51 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 79.9(n)
    87.26(a)
      424286  XM_422131.2  XP_422131.2 
    lizard
    (Anolis carolinensis)
    Reptilia MGAT56
    Uncharacterized protein
    87(a)
    1 ↔ 1
    1(96169445-96248843)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19262 Xenopus laevis transcribed sequence with moderate similarity more 81.86(n)    BJ069098.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120832 Transcribed sequence with moderate similarity to protein more 77.09(n)    CK024434.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gly-21 Protein GLY-2 49.49(n)
    39.9(a)
      172360  NM_059473.5  NP_491874.1 


    ENSEMBL Gene Tree for MGAT5 (if available)
    TreeFam Gene Tree for MGAT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT5 gene
    MGAT5B2  
    2 SIMAP similar genes for MGAT5 using alignment to 4 protein entries:     MGT5A_HUMAN (see all proteins):
    CCDC126    MGAT5B

    MGAT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4212 SNPs in MGAT5 are shown (see all 4212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37912701,2
    C,A,H--127015093(+) TTGCCA/GGTTTC 1 -- int10--------
    rs106547801,2
    C--127022667(+) TTTTG-/T/TT  
            
    TTTTT
    1 -- int1 trp31CSA 2
    rs722331871,2
    C--127033286(+) AACCG-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs1394855701,2
    C--127034880(+) AGAGC-/AAAAAA 1 -- int10--------
    rs38413871,2
    C--127040710(-) ATCAT-/TCAGTCCC 1 -- int10--------
    rs1395072141,2
    C--127055367(+) CTTTT-/ATAC  
      ATTCTC
    TCTGT
    1 -- int10--------
    rs1477454091,2
    C--127056564(+) CAGAG-/TTTTGC 1 -- int10--------
    rs114389441,2
    C--127075287(+) AAGAA-/TTTTAA 1 -- int10--------
    rs3728226361,2
    C--127076318(+) CTCTT-/TCTC  
            
    TCTCT
    1 -- int10--------
    rs1406723441,2
    C--127084315(+) AAGAT-/GTTCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MGAT5 (134877554 - 135127554 bp, first 250kb of MGAT5)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MGAT5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268736CNV Insertion20981092
    nsv508107CNV Loss20534489
    dgv667n67CNV Loss20364138
    nsv834385CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601774    OMIM disorders: --

    20/32 diseases for MGAT5 (see all 32):    About MalaCards
    bile duct carcinoma    congenital dyserythropoietic anemia    conduct disorder    congenital muscular dystrophy
    congenital disorder of glycosylation    fibrosarcoma    liver cirrhosis    wiskott-aldrich syndrome
    hepatoblastoma    noma    muscular dystrophy    diffuse large b-cell lymphoma
    anemia    b-cell lymphomas    thyroid cancer    melanoma
    colon cancer    hepatocellular carcinoma    esophageal cancer    nasopharyngitis

    1 disease from the University of Copenhagen DISEASES database for MGAT5:
    Cancer

    MGAT5 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for MGAT5 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma cloudman s91 75.6 1 14760865 (1)
    hepatocellular carcinoma 58.4 33 11903748 (2), 19960509 (2), 10699467 (2), 17031849 (2) (see all 19)
    metastatic cancer 58.3 8 17878270 (1), 19645485 (1), 10972975 (1)
    metastasis 52.5 57 15452379 (4), 10815896 (4), 11751457 (3), 18931531 (3) (see all 26)
    tumors 40.4 72 11903748 (6), 15014031 (4), 16638859 (3), 16406879 (3) (see all 25)
    melanoma 35.5 8 11751457 (3), 17235237 (2), 17897065 (2), 10571019 (1)
    cancer 33.3 38 10438459 (4), 19787216 (2), 10815896 (2), 10571019 (2) (see all 23)
    sarcoma rous 32.7 2 9235963 (1), 2160776 (1)
    colon cancer 31.9 16 15452379 (6), 17878270 (2), 16404719 (2), 20462175 (1) (see all 5)
    fibrosarcoma 24.3 5 19846557 (1), 12460896 (1), 14561752 (1)

    Genetic Association Database (GAD): MGAT5
    Human Genome Epidemiology (HuGE) Navigator: MGAT5 (4 documents)

    Export disorders for MGAT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT5 gene, integrated from 9 sources (see all 167):
    (articles sorted by number of sources associating them with MGAT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal mapping of human N- acetylglucosaminyltransferase V+. (PubMed id 8292036)1, 2, 3, 9 Nishikawa A.... Taniguchi N. (1994)
    2. MGAT5 and disease severity in progressive multiple sc lerosis. (PubMed id 21115203)1, 4 Esposito F....Boneschi F.M. (2011)
    3. Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. (2010)
    4. MGAT5 alters the severity of multiple sclerosis. (PubMed id 20117844)1, 4 Brynedal B....Abderrahim H. (2010)
    5. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (2010)
    6. Characterization of UDP-N-acetylglucosamine: alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B. (PubMed id 10395745)1, 2 Park C.... Kim C.H. (1999)
    7. Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. (PubMed id 15014031)1, 9 Dosaka-Akita H....Taniguchi N. (2004)
    8. N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer. (PubMed id 16638859)1, 9 Ishimura H....Ohyama C. (2006)
    9. The implication of N-acetylglucosaminyltransferase V expression in gastric cancer. (PubMed id 18931531)1, 9 Tian H....Matsuura N. (2008)
    10. Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. (PubMed id 17971775)1, 9 Yamamoto E....Kikkawa F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4249 HGNC: 7049 AceView: MGAT5 Ensembl:ENSG00000152127 euGenes: HUgn4249
    ECgene: MGAT5 Kegg: 4249 H-InvDB: MGAT5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGAT5 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_533

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MGAT5 gene:
    Search GeneIP for patents involving MGAT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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