Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGAT5 Gene

Aliases for MGAT5 Gene

  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase 2 3
  • Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase 3 4
  • Mannoside Acetylglucosaminyltransferase 5 3 4
  • N-Acetylglucosaminyl-Transferase V 3 4
  • EC 2.4.1.155 4 64
  • GlcNAc-T V 3 4
  • GNT-V 3 4
  • Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A 3
  • GNT-VA 3
  • GGNT5 4

External Ids for MGAT5 Gene

Summaries for MGAT5 Gene

Entrez Gene Summary for MGAT5 Gene

  • The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

GeneCards Summary for MGAT5 Gene

MGAT5 (Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is CCDC126.

UniProtKB/Swiss-Prot for MGAT5 Gene

  • Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides

Gene Wiki entry for MGAT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT5 Gene

Genomics for MGAT5 Gene

Genomic Location for MGAT5 Gene

Start:
134,119,935 bp from pter
End:
134,454,621 bp from pter
Size:
334,687 bases
Orientation:
Plus strand

Genomic View for MGAT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT5 Gene

Regulatory Elements for MGAT5 Gene

Proteins for MGAT5 Gene

  • Protein details for MGAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09328-MGT5A_HUMAN
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
    Protein Accession:
    Q09328
    Secondary Accessions:
    • D3DP70

    Protein attributes for MGAT5 Gene

    Size:
    741 amino acids
    Molecular mass:
    84543 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT5 Gene

Proteomics data for MGAT5 Gene at MOPED

Post-translational modifications for MGAT5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn110, Asn115, Asn118, Asn334, Asn433, and Asn447

Other Protein References for MGAT5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MGAT5 Gene

Protein Domains for MGAT5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MGT5A_HUMAN
Family:
  • Belongs to the glycosyltransferase 18 family.:
    • Q09328
genes like me logo Genes that share domains with MGAT5: view

No data available for Gene Families for MGAT5 Gene

Function for MGAT5 Gene

Molecular function for MGAT5 Gene

GENATLAS Biochemistry: mannosyl (alpha-1,6-) glycoprotein beta-1,6-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides

Enzyme Numbers (IUBMB) for MGAT5 Gene

Gene Ontology (GO) - Molecular Function for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity --
GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity NAS 8292036
genes like me logo Genes that share ontologies with MGAT5: view
genes like me logo Genes that share phenotypes with MGAT5: view

miRNA for MGAT5 Gene

miRTarBase miRNAs that target MGAT5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MGAT5 Gene

Localization for MGAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT5 Gene COMPARTMENTS Subcellular localization image for MGAT5 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MGAT5: view

Pathways for MGAT5 Gene

genes like me logo Genes that share pathways with MGAT5: view

UniProtKB/Swiss-Prot Q09328-MGT5A_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281923%0d%0a9606.ENSP00000264968%0d%0a9606.ENSP00000338487%0d%0a9606.ENSP00000331664%0d%0a
Selected Interacting proteins: ENSP00000281923 for MGAT5 Gene via STRING

Gene Ontology (GO) - Biological Process for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MGAT5: view

Compounds for MGAT5 Gene

(2) HMDB Compounds for MGAT5 Gene

Compound Synonyms Cas Number PubMed IDs
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
528-04-1

(16) Novoseek inferred chemical compound relationships for MGAT5 Gene

Compound -log(P) Hits PubMed IDs
beta-d-mannoside 83.7 1
n-acetylglucosamine 72.6 11
polysaccharide 65.8 14
ebdc 64.8 3
polylactosamine 54 2
genes like me logo Genes that share compounds with MGAT5: view

Transcripts for MGAT5 Gene

Unigene Clusters for MGAT5 Gene

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT5 Gene

No ASD Table

Relevant External Links for MGAT5 Gene

GeneLoc Exon Structure for
MGAT5
ECgene alternative splicing isoforms for
MGAT5

Expression for MGAT5 Gene

mRNA expression in normal human tissues for MGAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MGAT5 Gene

SOURCE GeneReport for Unigene cluster for MGAT5 Gene Hs.4988

genes like me logo Genes that share expressions with MGAT5: view

Orthologs for MGAT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT5 36
  • 99.87 (n)
  • 100 (a)
MGAT5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT5 36
  • 90.66 (n)
  • 96.21 (a)
MGAT5 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT5 36
  • 93.3 (n)
  • 98.79 (a)
MGAT5 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat5 36
  • 88.92 (n)
  • 97.3 (a)
Mgat5 16
Mgat5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT5 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT5 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat5 36
  • 88.78 (n)
  • 97.3 (a)
chicken
(Gallus gallus)
Aves MGAT5 36
  • 79.9 (n)
  • 87.26 (a)
MGAT5 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT5 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1926 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat5 36
  • 77.06 (n)
  • 86.5 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12083 36
mgat5 36
  • 71.97 (n)
  • 79.59 (a)
mgat5 37
  • 79 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-2 36
  • 49.54 (n)
  • 39.55 (a)
gly-2 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for MGAT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT5 Gene

ENSEMBL:
Gene Tree for MGAT5 (if available)
TreeFam:
Gene Tree for MGAT5 (if available)

Paralogs for MGAT5 Gene

Paralogs for MGAT5 Gene

Selected SIMAP similar genes for MGAT5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MGAT5: view

Variants for MGAT5 Gene

Sequence variations from dbSNP and Humsavar for MGAT5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7841 -- 134,454,290(+) GGGAG(C/T)GAACT utr-variant-3-prime
rs499582 -- 134,433,794(-) TTGGG(C/T)CCCGT intron-variant
rs500657 -- 134,417,750(-) cagga(A/T)attct intron-variant
rs503059 -- 134,443,602(-) GGTGC(C/T)GCCCC intron-variant
rs509429 -- 134,437,734(-) cAGCC(C/T)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT5 Gene

Variant ID Type Subtype PubMed ID
dgv667n67 CNV Loss 20364138
nsv834385 CNV Gain 17160897
nsv508107 CNV Loss 20534489
esv268736 CNV Insertion 20981092

Relevant External Links for MGAT5 Gene

HapMap Linkage Disequilibrium report
MGAT5

Disorders for MGAT5 Gene

(1) University of Copenhagen DISEASES for MGAT5 Gene

(21) Novoseek inferred disease relationships for MGAT5 Gene

Disease -log(P) Hits PubMed IDs
melanoma cloudman s91 75.6 1
hepatocellular carcinoma 58.4 26
metastatic cancer 58.3 3
metastasis 52.5 41
tumors 40.4 42

Relevant External Links for MGAT5

Genetic Association Database (GAD)
MGAT5
Human Genome Epidemiology (HuGE) Navigator
MGAT5
genes like me logo Genes that share disorders with MGAT5: view

No data available for UniProtKB/Swiss-Prot for MGAT5 Gene

Publications for MGAT5 Gene

  1. cDNA cloning and chromosomal mapping of human N- acetylglucosaminyltransferase V+. (PMID: 8292036) Nishikawa A. … Taniguchi N. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. (PMID: 11872751) Saito T. … Taniguchi N. (J. Biol. Chem. 2002) 3 23
  3. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene. (PMID: 9235963) Buckhaults P. … Pierce M. (J. Biol. Chem. 1997) 3 23
  4. Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. (PMID: 15014031) Dosaka-Akita H. … Taniguchi N. (Clin. Cancer Res. 2004) 3 23
  5. Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases. (PMID: 15044007) Guo P. … Chen H.L. (FEBS Lett. 2004) 3 23

Products for MGAT5 Gene

Sources for MGAT5 Gene

Back to Top

Content