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Aliases for MGAT5 Gene

Aliases for MGAT5 Gene

  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase 2 3 5
  • Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase 3 4
  • Mannoside Acetylglucosaminyltransferase 5 3 4
  • N-Acetylglucosaminyl-Transferase V 3 4
  • EC 2.4.1.155 4 63
  • GlcNAc-T V 3 4
  • GNT-V 3 4
  • GNT-VA 3
  • GGNT5 4

External Ids for MGAT5 Gene

Previous GeneCards Identifiers for MGAT5 Gene

  • GC02P132654
  • GC02P133296
  • GC02P135031
  • GC02P135219
  • GC02P134842
  • GC02P134725
  • GC02P134594
  • GC02P127004

Summaries for MGAT5 Gene

Entrez Gene Summary for MGAT5 Gene

  • The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

GeneCards Summary for MGAT5 Gene

MGAT5 (Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT5 include Hepatocellular Carcinoma and Bile Duct Carcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT5B.

UniProtKB/Swiss-Prot for MGAT5 Gene

  • Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Gene Wiki entry for MGAT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT5 Gene

Genomics for MGAT5 Gene

Regulatory Elements for MGAT5 Gene

Enhancers for MGAT5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MGAT5 on UCSC Golden Path with GeneCards custom track

Promoters for MGAT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGAT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGAT5 Gene

Chromosome:
2
Start:
134,119,930 bp from pter
End:
134,454,621 bp from pter
Size:
334,692 bases
Orientation:
Plus strand

Genomic View for MGAT5 Gene

Genes around MGAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT5 Gene

Proteins for MGAT5 Gene

  • Protein details for MGAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09328-MGT5A_HUMAN
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
    Protein Accession:
    Q09328
    Secondary Accessions:
    • D3DP70

    Protein attributes for MGAT5 Gene

    Size:
    741 amino acids
    Molecular mass:
    84543 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT5 Gene

Proteomics data for MGAT5 Gene at MOPED

Post-translational modifications for MGAT5 Gene

  • Glycosylation at Asn 110, Asn 115, Asn 118, Asn 334, Asn 433, and Asn 447
  • Modification sites at PhosphoSitePlus

Other Protein References for MGAT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MGAT5 (N-Acetylglucosaminyltransferase V/MGAT5)
  • Abcam antibodies for MGAT5

Domains & Families for MGAT5 Gene

Protein Domains for MGAT5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MGAT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q09328

UniProtKB/Swiss-Prot:

MGT5A_HUMAN :
  • Belongs to the glycosyltransferase 18 family.
Family:
  • Belongs to the glycosyltransferase 18 family.
genes like me logo Genes that share domains with MGAT5: view

Function for MGAT5 Gene

Molecular function for MGAT5 Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,6-) glycoprotein beta-1,6-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Enzyme Numbers (IUBMB) for MGAT5 Gene

Gene Ontology (GO) - Molecular Function for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with MGAT5: view
genes like me logo Genes that share phenotypes with MGAT5: view

Animal Models for MGAT5 Gene

MGI Knock Outs for MGAT5:

Animal Model Products

miRNA for MGAT5 Gene

miRTarBase miRNAs that target MGAT5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT5 Gene

Localization for MGAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT5 Gene COMPARTMENTS Subcellular localization image for MGAT5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2
plasma membrane 2
cytoskeleton 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with MGAT5: view

Pathways & Interactions for MGAT5 Gene

genes like me logo Genes that share pathways with MGAT5: view

UniProtKB/Swiss-Prot Q09328-MGT5A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MGAT5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281923%0d%0a9606.ENSP00000264968%0d%0a9606.ENSP00000338487%0d%0a9606.ENSP00000331664%0d%0a
Selected Interacting proteins: ENSP00000281923 for MGAT5 Gene via STRING

Gene Ontology (GO) - Biological Process for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MGAT5: view

No data available for SIGNOR curated interactions for MGAT5 Gene

Drugs & Compounds for MGAT5 Gene

(3) Drugs for MGAT5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(15) Additional Compounds for MGAT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with MGAT5: view

Transcripts for MGAT5 Gene

Unigene Clusters for MGAT5 Gene

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT5 Gene

No ASD Table

Relevant External Links for MGAT5 Gene

GeneLoc Exon Structure for
MGAT5
ECgene alternative splicing isoforms for
MGAT5

Expression for MGAT5 Gene

mRNA expression in normal human tissues for MGAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGAT5 Gene

This gene is overexpressed in Testis (13.2), Heart (11.5), Placenta (11.1), Vitreous humor (10.8), and Urine (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT5 Gene



SOURCE GeneReport for Unigene cluster for MGAT5 Gene Hs.4988

genes like me logo Genes that share expression patterns with MGAT5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MGAT5 Gene

Orthologs for MGAT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGAT5 35
  • 90.66 (n)
  • 96.21 (a)
MGAT5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT5 35
  • 93.3 (n)
  • 98.79 (a)
MGAT5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat5 35
  • 88.92 (n)
  • 97.3 (a)
Mgat5 16
Mgat5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGAT5 35
  • 99.87 (n)
  • 100 (a)
MGAT5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat5 35
  • 88.78 (n)
  • 97.3 (a)
oppossum
(Monodelphis domestica)
Mammalia MGAT5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT5 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGAT5 35
  • 79.9 (n)
  • 87.26 (a)
MGAT5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat5 35
  • 77.06 (n)
  • 86.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1926 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12083 35
mgat5 35
  • 71.97 (n)
  • 79.59 (a)
mgat5 36
  • 79 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-2 35
  • 49.54 (n)
  • 39.55 (a)
gly-2 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for MGAT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT5 Gene

ENSEMBL:
Gene Tree for MGAT5 (if available)
TreeFam:
Gene Tree for MGAT5 (if available)

Paralogs for MGAT5 Gene

Paralogs for MGAT5 Gene

(2) SIMAP similar genes for MGAT5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MGAT5: view

Variants for MGAT5 Gene

Sequence variations from dbSNP and Humsavar for MGAT5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs499582 -- 134,433,794(-) TTGGG(C/T)CCCGT intron-variant
rs500657 -- 134,417,750(-) cagga(A/T)attct intron-variant
rs503059 -- 134,443,602(-) GGTGC(C/T)GCCCC intron-variant
rs509429 -- 134,437,734(-) cAGCC(C/T)GCTCA intron-variant
rs519054 -- 134,448,190(-) GGGAG(G/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT5 Gene

Variant ID Type Subtype PubMed ID
dgv667n67 CNV Loss 20364138
nsv834385 CNV Gain 17160897
nsv508107 CNV Loss 20534489
esv268736 CNV Insertion 20981092

Variation tolerance for MGAT5 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MGAT5 Gene

Disorders for MGAT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MGAT5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
- elite association - COSMIC cancer census association via MalaCards
Search MGAT5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGAT5

Genetic Association Database (GAD)
MGAT5
Human Genome Epidemiology (HuGE) Navigator
MGAT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT5
genes like me logo Genes that share disorders with MGAT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT5 Gene

Publications for MGAT5 Gene

  1. cDNA cloning and chromosomal mapping of human N- acetylglucosaminyltransferase V+. (PMID: 8292036) Nishikawa A. … Taniguchi N. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23 67
  2. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). (PMID: 19846580) Alvarez-Manilla G. … Pierce M. (Glycobiology 2010) 3 23
  3. The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V. (PMID: 19911372) Wang C. … Zha X. (J. Cell. Biochem. 2010) 3 23
  4. N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin. (PMID: 18845630) Yamamoto E. … Kikkawa F. (Endocrinology 2009) 3 23
  5. EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa. (PMID: 19236842) Wang C. … Zha X. (Arch. Biochem. Biophys. 2009) 3 23

Products for MGAT5 Gene

Sources for MGAT5 Gene

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