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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT5 Gene

protein-coding   GIFtS: 56
GCID: GC02P134842

mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 Explore 40 diseases affiliated with
MGAT5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MGAT5    

Aliases
for MGAT5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mannosyl (Alpha-1,6-)-Glycoprotein
Beta-1,6-N-Acetyl-Glucosaminyltransferase1 2
     N-Acetylglucosaminyl-Transferase V2 3
GNT-V1 2 3     EC 2.4.1.1553 8
Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase2 3     GNT-VA2
GlcNAc-T V2 3     Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A2
Mannoside Acetylglucosaminyltransferase 52 3     GGNT53

External Ids:    HGNC: 70491   Entrez Gene: 42492   Ensembl: ENSG000001521277   OMIM: 6017745   UniProtKB: Q093283   

Export aliases for MGAT5 gene to outside databases

Previous GC identifers: GC02P132654 GC02P133296 GC02P135031 GC02P135219 GC02P134725 GC02P134594 GC02P127004


Summaries
for MGAT5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGAT5:
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of
beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly
synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of
glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant
changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated
with the progression of invasive malignancies. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
Function: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary
N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of
glycoprotein oligosaccharides

Gene Wiki entry for MGAT5


Genomic Views
for MGAT5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT5 gene promoter:
         c-Fos   AP-1   AML1a   POU2F1   POU2F1a   c-Jun   MIF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGAT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.2   HGNC cytogenetic band: 2q21

MGAT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P134842:  view genomic region     (about GC identifiers)

Start:
 134,877,554 bp from pter      End:
 135,212,192 bp from pter
Size:
 334,639 bases      Orientation:
 plus strand

Proteins
for MGAT5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328 (See protein sequence)
Recommended Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A  
Size: 741 amino acids; 84543 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Secondary accessions: D3DP70

Explore the universe of human proteins at neXtProt for MGAT5: NX_Q09328

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q09328

    • 4/5 DME Specific Peptides for MGAT5 (Q09328) (see all 5)
     KDILVPSF  NSTNSTTAVPSLV  CSFFIYLSEVENWCP  QEKCVLPPMDGYPHCEGKIKWMKDMWRSDPCYADYGVDG 

    MGAT5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002401.1  
    ENSEMBL proteins: 
     ENSP00000386377   ENSP00000281923  
    Reactome Protein details: Q09328
    Human Recombinant Protein Products: 
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    Uscn Proteins for MGAT5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane NAS--


    MGAT5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MGAT5

    Protein Domains /
    Families
    for MGAT5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGAT5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026116 GlyclTrfase_18

    Graphical View of Domain Structure for InterPro Entry Q09328

    ProtoNet protein and cluster: Q09328

    UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
    Similarity: Belongs to the glycosyltransferase 18 family


    Function
    for MGAT5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
    Function: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary
    N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of
    glycoprotein oligosaccharides
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT5:
    mannosyl (alpha-1,6-) glycoprotein beta-1,6-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked
    (N) glycans

    Enzyme Number (IUBMB): EC 2.4.1.1551 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008375acetylglucosaminyltransferase activity ----
    GO:0030144alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity NAS8292036


    MGAT5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MGAT5:
     Increased gamma-H2AX phosphory  Large cells 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mgat5):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  renal/urinary system 
     tumorigenesis 

    MGAT5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MGAT5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    		N-Glycan antennae elongation0.75
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for MGAT5 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    N-Glycan antennae elongation
    Metabolism of proteins


    2         Kegg Pathways  (Kegg details for MGAT5):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT5A_HUMAN, Q09328
    Pathway: Protein modification; protein glycosylation


    MGAT5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MGAT5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MGAT5 (ENSP000002819234) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MGAT4AENSP000002649684STRING: ENSP00000264968
    MGAT4BENSP000003384874STRING: ENSP00000338487
    MGAT4CENSP000003316644STRING: ENSP00000331664
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation NAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MGAT5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGAT5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGAT5

    2 HMDB Compounds for MGAT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--
    10/16 Novoseek chemical compound relationships for MGAT5 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-d-mannoside 83.7 1 15189346 (1)
    n-acetylglucosamine 72.6 21 10815896 (2), 19787216 (1), 8393437 (1), 8900148 (1) (see all 10)
    polysaccharide 65.8 19 15809094 (3), 19846557 (2), 11315257 (2), 11501752 (1) (see all 10)
    ebdc 64.8 4 15238704 (2), 15138129 (1)
    polylactosamine 54 3 8900148 (1), 15840653 (1)
    n-acetyllactosamine 51.4 1 11511814 (1)
    mannose 50.9 2 8428922 (1), 16413118 (1)
    udp-n-acetylglucosamine 46.9 3 8393437 (1), 8900148 (1)
    matrigel 44.2 3 10972975 (1), 11315257 (1), 12460896 (1)
    retinoic acid 40 36 17031849 (3), 19960509 (2), 10699467 (2), 16411021 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about MGAT5 / MGT5A 

    Transcripts
    for MGAT5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGAT5 gene: 
    NM_002410.4  

    Unigene Cluster for MGAT5:

    Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
    Hs.4988  [show with all ESTs]
    Unigene Representative Sequence: NM_002410
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481801 ENST00000468758 ENST00000409645(uc002ttw.4) ENST00000488365
    ENST00000281923

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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGAT5 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AF055029.1 AF113921.1 AK056461.1 AK125207.1 BC041917.1 BX647087.1 D17716.1 

    8 DOTS entries:

    DT.97808004  DT.445584  DT.75129808  DT.101962674  DT.100658584  DT.95117248  DT.95172280  DT.99950244 

    24/309 AceView cDNA sequences (see all 309):

    F09656 BX103343 CF136139 BF589867 AI129353 BM853776 BM787503 AA721306 
    BM842023 D17716 AA337355 AW500199 BU428594 AI986179 BM844897 Z38698 
    AU125276 BU628863 BM687834 BQ773562 AA769725 AU140909 BU431458 F10546 

    GeneLoc Exon Structure


    Expression
    for MGAT5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGAATGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MGAT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT5

    SOURCE GeneReport for Unigene cluster: Hs.4988
        SABiosciences Expression via Pathway-Focused PCR Arrays including MGAT5: 
              Glycosylation in human mouse rat
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for MGAT5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MGAT5 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MGAT51 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 79.9(n)
    87.26(a)    		   424286  XM_422131.2  XP_422131.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MGAT56
    		 --
    		 87(a)
    		 1 ↔ 1
    		 1(96169601-96248843)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.19262 Xenopus laevis transcribed sequence with moderate similarity more 81.86(n)    BJ069098.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.120832 Transcribed sequence with moderate similarity to protein more 77.09(n)    CK024434.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea gly-21 Protein GLY-2 49.49(n)
    39.9(a)    		   172360  NM_059473.5  NP_491874.1 


    ENSEMBL Gene Tree for MGAT5 (if available)
    TreeFam Gene Tree for MGAT5 (if available) 

    Paralogs
    for MGAT5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT5 gene
    MGAT5B2  
    2 SIMAP similar genes for MGAT5 using alignment to 4 protein entries:     MGT5A_HUMAN (see all proteins):
    CCDC126    MGAT5B

    MGAT5 for paralogs           About GeneDecksing



    Genomic Variants
    for MGAT5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3651 NCBI SNPs in MGAT5 are shown (see all 3651)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs729761241,2
    		C,F,--127002660(+) CTTACG/ATTATG 1 -- us2k13Minor allele frequency- A:0.08WA 122
    rs758821951,2
    		F,--127002734(+) GGAATG/ATATGG 1 -- us2k11Minor allele frequency- A:0.11EA 120
    rs1113588601,2
    		--127002865(+) TGGGTG/AGGGCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs27339501,2
    		H--127002887(+) atttcT/Ccactg 1 -- us2k1 ese34Minor allele frequency- C:0.00NS EA 406
    rs768406121,2
    		F,--127003255(+) AGAGAC/TGATAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs752994131,2
    		--127003278(+) TTACCA/GTATAG 1 -- us2k10--------
    rs786311911,2
    		F,--127003321(+) AAGATG/TGTATG 1 -- us2k12Minor allele frequency- T:0.02NA EA 240
    rs67328671,2
    		H--127003323(+) GATGGT/GATGTC 1 -- us2k1 ese34Minor allele frequency- G:0.00NS EA 416
    rs1121399731,2
    		--127003333(+) CACAAC/TATCTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1131970341,2
    		--127003460(+) TACCAG/TTTTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for MGAT5 (134877554 - 135127554 bp, first 250kb of MGAT5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MGAT5: --

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    Disorders / Diseases
    for MGAT5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGAT5 for disorders           About GeneDecksing

    OMIM gene information: 601774    OMIM disorders: --

    20/40 diseases for MGAT5 (see all 40):    About MalaCards
    diffuse large b-cell lymphoma    wiskott-aldrich syndrome    b-cell lymphomas    congenital dyserythropoietic anemia
    bile duct carcinoma    congenital muscular dystrophy    dyserythropoietic anemia    congenital disorder of glycosylation
    liver cirrhosis    conduct disorder    muscular dystrophy    fibrosarcoma
    hepatocellular carcinoma    colon cancer    multiple sclerosis    breast carcinoma
    colorectal cancer    carcinoma    hepatoblastoma    breast cancer

    10/21 Novoseek disease relationships for MGAT5 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma cloudman s91 75.6 1 14760865 (1)
    hepatocellular carcinoma 58.4 33 11903748 (2), 19960509 (2), 10699467 (2), 17031849 (2) (see all 19)
    metastatic cancer 58.3 8 17878270 (1), 19645485 (1), 10972975 (1)
    metastasis 52.5 57 15452379 (4), 10815896 (4), 11751457 (3), 18931531 (3) (see all 26)
    tumors 40.4 72 11903748 (6), 15014031 (4), 16638859 (3), 16406879 (3) (see all 25)
    melanoma 35.5 8 11751457 (3), 17235237 (2), 17897065 (2), 10571019 (1)
    cancer 33.3 38 10438459 (4), 19787216 (2), 10815896 (2), 10571019 (2) (see all 23)
    sarcoma rous 32.7 2 9235963 (1), 2160776 (1)
    colon cancer 31.9 16 15452379 (6), 17878270 (2), 16404719 (2), 20462175 (1) (see all 5)
    fibrosarcoma 24.3 5 19846557 (1), 12460896 (1), 14561752 (1)

    Human Genome Epidemiology (HuGE) Navigator: MGAT5 (4 documents)

    Export disorders for MGAT5 gene to outside databases

    Publications
    for MGAT5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT5 gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with MGAT5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal mapping of human N- acetylglucosaminyltransferase V+. (PubMed id 8292036)1, 2, 3, 9 Nishikawa A.... Taniguchi N. (1994)
    2. Characterization of UDP-N-acetylglucosamine: alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B. (PubMed id 10395745)1, 2 Park C.... Kim C.H. (1999)
    3. Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. (PubMed id 15014031)1, 9 Dosaka-Akita H....Taniguchi N. (2004)
    4. N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer. (PubMed id 16638859)1, 9 Ishimura H....Ohyama C. (2006)
    5. The implication of N-acetylglucosaminyltransferase V expression in gastric cancer. (PubMed id 18931531)1, 9 Tian H....Matsuura N. (2008)
    6. Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. (PubMed id 17971775)1, 9 Yamamoto E....Kikkawa F. (2007)
    7. The effect of receptor protein tyrosine phosphatase k appa on the change of cell adhesion and proliferation induced by N-acetylglucos aminyltransferase V. (PubMed id 19911372)1, 9 Wang C....Zha X. (2010)
    8. High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary. (PubMed id 19787216)1, 9 Takahashi N....Kikkawa F. (2009)
    9. N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin. (PubMed id 18845630)1, 9 Yamamoto E....Kikkawa F. (2009)
    10. Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1. (PubMed id 17451637)1, 9 Li J....Shen Z.H. (2007)

    External Searches for MGAT5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MGAT5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4249 HGNC: 7049 AceView: MGAT5 Ensembl:ENSG00000152127 euGenes: HUgn4249
    ECgene: MGAT5 Kegg: 4249 H-InvDB: MGAT5

    Other Databases showing MGAT5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGAT5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MGAT5 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_533

    Intellectual Property
    for MGAT5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGAT5 gene:
    Search GeneIP for patents involving MGAT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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