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Aliases for MGAT5 Gene

Aliases for MGAT5 Gene

  • Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase 2 3 5
  • Alpha-Mannoside Beta-1,6-N-Acetylglucosaminyltransferase 3 4
  • Mannoside Acetylglucosaminyltransferase 5 3 4
  • N-Acetylglucosaminyl-Transferase V 3 4
  • EC 4 58
  • GlcNAc-T V 3 4
  • GNT-V 3 4
  • Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A 3
  • GNT-VA 3
  • GGNT5 4

External Ids for MGAT5 Gene

Previous GeneCards Identifiers for MGAT5 Gene

  • GC02P132654
  • GC02P133296
  • GC02P135031
  • GC02P135219
  • GC02P134842
  • GC02P134725
  • GC02P134594
  • GC02P127004

Summaries for MGAT5 Gene

Entrez Gene Summary for MGAT5 Gene

  • The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

GeneCards Summary for MGAT5 Gene

MGAT5 (Mannosyl (Alpha-1,6-)-Glycoprotein Beta-1,6-N-Acetyl-Glucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT5 include Hepatocellular Carcinoma and Bile Duct Carcinoma. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Transport to the Golgi and subsequent modification. GO annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT5B.

UniProtKB/Swiss-Prot for MGAT5 Gene

  • Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Gene Wiki entry for MGAT5 Gene

Additional gene information for MGAT5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT5 Gene

Genomics for MGAT5 Gene

Regulatory Elements for MGAT5 Gene

Enhancers for MGAT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H134256 1.5 FANTOM5 Ensembl ENCODE dbSUPER 30.6 +140.4 140381 6.8 ELF1 EBF1 NR2F2 RELA ZNF316 POLR2A IKZF1 HNF4A RUNX3 IKZF2 MGAT5 RNA5SP104 GC02M134321
GH02H134231 1.3 Ensembl ENCODE dbSUPER 19.9 +113.8 113840 5.3 HDGF SOX13 FOXA2 CEBPG EBF1 BATF EED RCOR1 ATF7 ETV6 MGAT5 RNA5SP104 GC02M134321
GH02H134205 1.2 Ensembl ENCODE dbSUPER 19.6 +86.5 86471 2 CTCF JUNB ZEB2 BATF ZNF843 OSR2 HIC1 NFIC ZNF366 ZBTB48 MGAT5 RNA5SP104 PIR46678
GH02H134148 1.4 Ensembl ENCODE dbSUPER 12.7 +29.7 29743 1.5 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 MGAT5 PIR46678 RNA5SP104
GH02H134410 1.5 Ensembl ENCODE dbSUPER 11.6 +292.2 292230 2.8 PKNOX1 FOXA2 ATF1 MLX SIN3A ARID4B DMAP1 ZNF143 ATF7 RUNX3 MGAT5 GC02P134449 GC02P134364
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGAT5 on UCSC Golden Path with GeneCards custom track

Promoters for MGAT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123379 870 2001 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Locations for MGAT5 Gene

Genomic Locations for MGAT5 Gene
334,692 bases
Plus strand

Genomic View for MGAT5 Gene

Genes around MGAT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT5 Gene

Proteins for MGAT5 Gene

  • Protein details for MGAT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
    Protein Accession:
    Secondary Accessions:
    • D3DP70

    Protein attributes for MGAT5 Gene

    741 amino acids
    Molecular mass:
    84543 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT5 Gene

Selected DME Specific Peptides for MGAT5 Gene


Post-translational modifications for MGAT5 Gene

  • Glycosylation at Asn110, posLast=115115, Asn118, Asn334, Asn433, and Asn447
  • Modification sites at PhosphoSitePlus

Domains & Families for MGAT5 Gene

Gene Families for MGAT5 Gene

Protein Domains for MGAT5 Gene


Suggested Antigen Peptide Sequences for MGAT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 18 family.
  • Belongs to the glycosyltransferase 18 family.
genes like me logo Genes that share domains with MGAT5: view

Function for MGAT5 Gene

Molecular function for MGAT5 Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,6-) glycoprotein beta-1,6-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Enzyme Numbers (IUBMB) for MGAT5 Gene

Phenotypes From GWAS Catalog for MGAT5 Gene

Gene Ontology (GO) - Molecular Function for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity TAS --
genes like me logo Genes that share ontologies with MGAT5: view
genes like me logo Genes that share phenotypes with MGAT5: view

Animal Models for MGAT5 Gene

MGI Knock Outs for MGAT5:

miRNA for MGAT5 Gene

miRTarBase miRNAs that target MGAT5

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT5 Gene

Localization for MGAT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGAT5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MGAT5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MGAT5 Gene

Pathways & Interactions for MGAT5 Gene

genes like me logo Genes that share pathways with MGAT5: view

UniProtKB/Swiss-Prot Q09328-MGT5A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MGAT5 Gene

Gene Ontology (GO) - Biological Process for MGAT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation IBA --
genes like me logo Genes that share ontologies with MGAT5: view

No data available for SIGNOR curated interactions for MGAT5 Gene

Drugs & Compounds for MGAT5 Gene

(5) Drugs for MGAT5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(13) Additional Compounds for MGAT5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
genes like me logo Genes that share compounds with MGAT5: view

Transcripts for MGAT5 Gene

Unigene Clusters for MGAT5 Gene

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT5 Gene

No ASD Table

Relevant External Links for MGAT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MGAT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGAT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGAT5 Gene

This gene is overexpressed in Testis (13.2), Heart (11.5), Placenta (11.1), Vitreous humor (10.8), and Urine (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGAT5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MGAT5 Gene:


SOURCE GeneReport for Unigene cluster for MGAT5 Gene:


Evidence on tissue expression from TISSUES for MGAT5 Gene

  • Liver(4.2)
  • Nervous system(3.9)
  • Intestine(3.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MGAT5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGAT5 Gene

Orthologs for MGAT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MGAT5 33 34
  • 99.87 (n)
(Canis familiaris)
Mammalia MGAT5 33 34
  • 93.3 (n)
(Monodelphis domestica)
Mammalia MGAT5 34
  • 92 (a)
(Bos Taurus)
Mammalia MGAT5 33 34
  • 90.66 (n)
(Mus musculus)
Mammalia Mgat5 33 16 34
  • 88.92 (n)
(Rattus norvegicus)
Mammalia Mgat5 33
  • 88.78 (n)
(Ornithorhynchus anatinus)
Mammalia MGAT5 34
  • 81 (a)
(Gallus gallus)
Aves MGAT5 33 34
  • 79.9 (n)
(Anolis carolinensis)
Reptilia MGAT5 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat5 33
  • 77.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1926 33
(Danio rerio)
Actinopterygii mgat5 33 34
  • 71.97 (n)
Dr.12083 33
(Caenorhabditis elegans)
Secernentea gly-2 33 34
  • 49.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for MGAT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT5 Gene

Gene Tree for MGAT5 (if available)
Gene Tree for MGAT5 (if available)

Paralogs for MGAT5 Gene

Paralogs for MGAT5 Gene

(2) SIMAP similar genes for MGAT5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MGAT5: view

Variants for MGAT5 Gene

Sequence variations from dbSNP and Humsavar for MGAT5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000016396 -- 134,453,289(+) GCACT(C/G)GTTTG utr-variant-3-prime
rs1000019798 -- 134,137,703(+) TTAAA(A/G)AAATA intron-variant
rs1000038728 -- 134,229,971(+) ATGAA(A/G)TAGCA intron-variant
rs1000040704 -- 134,265,292(+) CCAGC(A/G)GGGCC intron-variant
rs1000042449 -- 134,321,622(+) GGAAC(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT5 Gene

Variant ID Type Subtype PubMed ID
nsv834385 CNV gain 17160897
nsv508107 OTHER sequence alteration 20534489
nsv478303 CNV novel sequence insertion 20440878
nsv1142286 CNV tandem duplication 24896259
nsv1009691 CNV gain 25217958
nsv1008965 CNV loss 25217958
nsv1004843 CNV gain 25217958
nsv1004271 CNV loss 25217958
esv3592553 CNV loss 21293372
esv3368288 CNV insertion 20981092
dgv667n67 CNV loss 20364138

Variation tolerance for MGAT5 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT5 Gene

Disorders for MGAT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MGAT5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
bile duct carcinoma
  • bile duct cancer
- elite association - COSMIC cancer census association via MalaCards
Search MGAT5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGAT5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MGAT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT5 Gene

Publications for MGAT5 Gene

  1. cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+. (PMID: 8292036) Saito H … Taniguchi N (Biochemical and biophysical research communications 1994) 2 3 4 22 60
  2. MGAT5 and disease severity in progressive multiple sclerosis. (PMID: 21115203) Esposito F … Martinelli Boneschi F (Journal of neuroimmunology 2011) 3 45 60
  3. Comparison of the substrate specificities and catalytic properties of the sister N-acetylglucosaminyltransferases, GnT-V and GnT-Vb (IX). (PMID: 19846580) Alvarez-Manilla G … Pierce M (Glycobiology 2010) 3 22 60
  4. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H … Wang DW (Stroke 2010) 3 45 60
  5. The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V. (PMID: 19911372) Wang C … Zha X (Journal of cellular biochemistry 2010) 3 22 60

Products for MGAT5 Gene

Sources for MGAT5 Gene

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