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Aliases for MGAT4C Gene

Aliases for MGAT4C Gene

  • MGAT4 Family, Member C 2 3
  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme C (Putative) 2 3
  • UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVc 3 4
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVc 3 4
  • N-Acetylglucosaminyltransferase IV Homolog 3 4
  • N-Acetylglucosaminyltransferase IVc 3 4
  • GlcNAc-T IVc 3 4
  • EC 2.4.1.145 4 63
  • HGNT-IV-H 3 4
  • GnT-IVc 3 4
  • GNTIVH 3 6
  • UDP-N-Acetylglucosamine:A-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IV-Homolog 3
  • UDP-N-Acetylglucosamine:A-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IV 3
  • Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C 3

External Ids for MGAT4C Gene

Previous GeneCards Identifiers for MGAT4C Gene

  • GC12M084876
  • GC12M086372
  • GC12M083429

Summaries for MGAT4C Gene

GeneCards Summary for MGAT4C Gene

MGAT4C (MGAT4 Family, Member C) is a Protein Coding gene. Diseases associated with MGAT4C include mannosidosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT4D.

UniProtKB/Swiss-Prot for MGAT4C Gene

  • Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (GnT-VI activity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT4C Gene

Genomics for MGAT4C Gene

Regulatory Elements for MGAT4C Gene

Genomic Location for MGAT4C Gene

Start:
85,955,666 bp from pter
End:
86,838,904 bp from pter
Size:
883,239 bases
Orientation:
Minus strand

Genomic View for MGAT4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT4C Gene

Proteins for MGAT4C Gene

  • Protein details for MGAT4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBM8-MGT4C_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
    Protein Accession:
    Q9UBM8
    Secondary Accessions:
    • B4DRH2
    • Q4G199
    • Q9UIU5

    Protein attributes for MGAT4C Gene

    Size:
    478 amino acids
    Molecular mass:
    56061 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26068.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MGAT4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT4C Gene

Proteomics data for MGAT4C Gene at MOPED

Selected DME Specific Peptides for MGAT4C Gene

Post-translational modifications for MGAT4C Gene

  • Glycosylation at Asn84 and Asn215
  • Modification sites at PhosphoSitePlus

Other Protein References for MGAT4C Gene

Domains for MGAT4C Gene

Protein Domains for MGAT4C Gene

Suggested Antigen Peptide Sequences for MGAT4C Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBM8

UniProtKB/Swiss-Prot:

MGT4C_HUMAN :
  • Q9UBM8
Family:
  • Belongs to the glycosyltransferase 54 family.
genes like me logo Genes that share domains with MGAT4C: view

No data available for Gene Families for MGAT4C Gene

Function for MGAT4C Gene

Molecular function for MGAT4C Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (GnT-VI activity).

Enzyme Numbers (IUBMB) for MGAT4C Gene

Gene Ontology (GO) - Molecular Function for MGAT4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT4C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT4C

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MGAT4C Gene

Localization for MGAT4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT4C Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT4C Gene COMPARTMENTS Subcellular localization image for MGAT4C gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGAT4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGAT4C: view

Pathways for MGAT4C Gene

genes like me logo Genes that share pathways with MGAT4C: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UBM8-MGT4C_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT4C Gene

Gene Ontology (GO) - Biological Process for MGAT4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MGAT4C: view

Transcripts for MGAT4C Gene

Unigene Clusters for MGAT4C Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT4C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT4C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: - - - -
SP3: - - - -
SP4: - - - - -

Relevant External Links for MGAT4C Gene

GeneLoc Exon Structure for
MGAT4C
ECgene alternative splicing isoforms for
MGAT4C

Expression for MGAT4C Gene

mRNA expression in normal human tissues for MGAT4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT4C Gene

This gene is overexpressed in Thyroid (5.4), Brain - Nucleus accumbens (basal ganglia) (4.6), Testis (4.4), and Brain - Caudate (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MGAT4C Gene

SOURCE GeneReport for Unigene cluster for MGAT4C Gene Hs.589093

mRNA Expression by UniProt/SwissProt for MGAT4C Gene

Q9UBM8-MGT4C_HUMAN
Tissue specificity: Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas.
genes like me logo Genes that share expressions with MGAT4C: view

In Situ Assay Products

Orthologs for MGAT4C Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT4C 35
  • 99.79 (n)
  • 100 (a)
MGAT4C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT4C 35
  • 90.52 (n)
  • 90.38 (a)
MGAT4C 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT4C 35
  • 93.86 (n)
  • 96.23 (a)
MGAT4C 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat4c 35
  • 88.98 (n)
  • 94.77 (a)
Mgat4c 16
Mgat4c 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT4C 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT4C 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat4c 35
  • 90.24 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves MGAT4C 35
  • 79.04 (n)
  • 85.12 (a)
MGAT4C 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT4C 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat4c 35
  • 74.5 (n)
  • 77.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333333 35
  • 69.49 (n)
  • 78.39 (a)
mgat4c 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17173 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
CSA.589 36
  • 25 (a)
ManyToMany
Species with no ortholog for MGAT4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT4C Gene

ENSEMBL:
Gene Tree for MGAT4C (if available)
TreeFam:
Gene Tree for MGAT4C (if available)

Paralogs for MGAT4C Gene

Paralogs for MGAT4C Gene

Selected SIMAP similar genes for MGAT4C Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MGAT4C Gene

genes like me logo Genes that share paralogs with MGAT4C: view

Variants for MGAT4C Gene

Sequence variations from dbSNP and Humsavar for MGAT4C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs709812 -- 86,214,272(+) CTCAG(A/G)TCAAA intron-variant
rs717681 -- 86,719,734(-) CAGTA(A/C/T)AAATT intron-variant
rs721829 -- 85,976,005(+) AAATA(C/T)TGACA downstream-variant-500B
rs767898 -- 86,267,642(-) TTATT(A/C)CCCCC intron-variant
rs839091 -- 86,096,775(+) CAATA(C/T)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT4C Gene

Variant ID Type Subtype PubMed ID
nsv797 CNV Insertion 18451855
nsv832476 CNV Loss 17160897
nsv798 CNV Loss 18451855
nsv518059 CNV Loss 19592680
nsv820997 CNV Deletion 20802225
esv27128 CNV Gain+Loss 19812545
esv2746154 CNV Deletion 23290073
esv2657591 CNV Deletion 23128226
nsv470311 CNV Loss 18288195
esv2671336 CNV Deletion 23128226
esv2604566 CNV Deletion 19546169
esv3395 CNV Deletion 18987735
esv2746155 CNV Deletion 23290073
esv5822 CNV Loss 19470904
esv1509471 CNV Deletion 17803354
esv2539626 CNV Deletion 19546169
nsv510606 CNV Loss 20534489
nsv800 CNV Loss 18451855
esv21585 CNV Gain 19812545
nsv801 CNV Insertion 18451855
nsv509473 CNV Insertion 20534489
esv2625711 CNV Loss 19546169
esv994139 CNV Insertion 20482838
esv2746156 CNV Deletion 23290073
nsv802 CNV Loss 18451855
esv2529439 CNV Loss 19546169
esv2471686 CNV Deletion 19546169
nsv819565 CNV Loss 19587683
esv2131445 CNV Deletion 18987734
dgv301n67 CNV Loss 20364138
nsv514678 CNV Loss 21397061
esv2746157 CNV Deletion 23290073
esv2670492 CNV Deletion 23128226
nsv498801 CNV Loss 21111241
esv25339 CNV Loss 19812545
esv2421908 CNV Deletion 20811451
nsv442652 CNV CNV 18776908
esv2676787 CNV Deletion 23128226
dgv1473n71 CNV Loss 21882294
esv997184 CNV Insertion 20482838
nsv803 CNV Insertion 18451855
nsv899397 CNV Loss 21882294
esv988216 CNV Insertion 20482838
esv1653091 CNV Insertion 17803354
nsv899398 CNV Loss 21882294
esv275003 CNV Gain+Loss 21479260
esv2746158 CNV Deletion 23290073
esv2746159 CNV Deletion 23290073
esv2667990 CNV Deletion 23128226
nsv520577 CNV Gain 19592680
nsv899400 CNV Loss 21882294
nsv455681 CNV Loss 19166990
nsv804 CNV Insertion 18451855
esv269823 CNV Insertion 20981092
nsv455682 CNV Loss 19166990
nsv7233 OTHER Inversion 18451855
esv2746160 CNV Deletion 23290073
esv7837 CNV Loss 19470904
esv1048546 CNV Insertion 17803354
dgv212e201 CNV Deletion 23290073
esv2746161 CNV Deletion 23290073
esv2746162 CNV Deletion 23290073
esv1455826 CNV Deletion 17803354
dgv1474n71 CNV Loss 21882294
dgv1475n71 CNV Loss 21882294

Relevant External Links for MGAT4C Gene

HapMap Linkage Disequilibrium report
MGAT4C
Human Gene Mutation Database (HGMD)
MGAT4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT4C Gene

Disorders for MGAT4C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MGAT4C Gene including...

Search for MGAT4C Gene in MalaCards »

(2) University of Copenhagen DISEASES for MGAT4C Gene

Relevant External Links for MGAT4C

Genetic Association Database (GAD)
MGAT4C
Human Genome Epidemiology (HuGE) Navigator
MGAT4C
genes like me logo Genes that share disorders with MGAT4C: view

No data available for UniProtKB/Swiss-Prot for MGAT4C Gene

Publications for MGAT4C Gene

  1. Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV- homologue (hGnT-IV-H) gene. (PMID: 10570912) Furukawa T. … Horii A. (J. Hum. Genet. 1999) 2 3 4 23
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MGAT4C Gene

Sources for MGAT4C Gene

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