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MGAT4B Gene

protein-coding   GIFtS: 62
GCID: GC05M179224

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase,...

(Previous names: mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,...)
  Search for MGAT4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mannosyl (Alpha-1,3-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme B1 2
     GNT-IV2
Mannosyl (Alpha-1,3-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme B1 2
     GNT-IVB2
GlcNAc-T IVb2 3     Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase B2
N-Acetylglucosaminyltransferase IVb2 3     Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase2
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase
IVb2 3
     aminyltransferase2
UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside
Beta-1,4-N-Acetylglucosaminyltransferase IVb2 3
     UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside
Beta-1,4-N-Acetylglucosaminyltransferase IV2
EC 2.4.1.1453 8     GnT-IVb3

External Ids:    HGNC: 70481   Entrez Gene: 112822   Ensembl: ENSG000001610137   OMIM: 6045615   UniProtKB: Q9UQ533   

Export aliases for MGAT4B gene to outside databases

Previous GC identifers: GC05M179336 GC05M180168 GC05M179334 GC05M179157 GC05M173950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGAT4B Gene:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching
structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the
transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the
Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of
R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein
may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MGAT4B Gene:
MGAT4B (mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B) is a protein-coding gene. GO annotations related to this gene include alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LOC152586.

UniProtKB/Swiss-Prot: MGT4B_HUMAN, Q9UQ53
Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core
mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the
GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and
tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that,
under physiological conditions, it is not the main contributor in N-glycan biosynthesis

Gene Wiki entry for MGAT4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGAT4B gene promoter:
         Sp1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGAT4B promoter sequence
   Search Chromatin IP Primers for MGAT4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGAT4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

MGAT4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT4B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179224:  view genomic region     (about GC identifiers)

Start:
179,224,597 bp from pter      End:
179,233,952 bp from pter
Size:
9,356 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MGT4B_HUMAN, Q9UQ53 (See protein sequence)
Recommended Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B  
Size: 548 amino acids; 63198 Da
Cofactor: Divalent metal cations (By similarity)
Secondary accessions: A8MPR0 Q86TF1 Q96GH4 Q9NSK6
Alternative splicing: 3 isoforms:  Q9UQ53-1   Q9UQ53-2   Q9UQ53-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGAT4B: NX_Q9UQ53

Explore proteomics data for MGAT4B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn87, Asn103, Thr490
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MGAT4B (Q9UQ53) (see all 6)
     FLSLSWY  KPSLFQH  KPIDWLLDHI  HVNPPAEVSTSLK 


    See MGAT4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055090.1  NP_463459.1  

    ENSEMBL proteins: 
     ENSP00000428906   ENSP00000338487   ENSP00000292591   ENSP00000430721   ENSP00000428960  
     ENSP00000431093   ENSP00000430723   ENSP00000428764   ENSP00000427995   ENSP00000430376  
     ENSP00000430964  
    Reactome Protein details: Q9UQ53

    MGAT4B Human Recombinant Protein Products:

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    Novus Biologicals MGAT4B Proteins
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    Cloud-Clone Corp. Proteins for MGAT4B

     
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    Cloud-Clone Corp. ELISAs for MGAT4B
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    Search eBioscience for ELISAs for MGAT4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006759 Glyco_transf_54

    Graphical View of Domain Structure for InterPro Entry Q9UQ53

    ProtoNet protein and cluster: Q9UQ53

    UniProtKB/Swiss-Prot: MGT4B_HUMAN, Q9UQ53
    Similarity: Belongs to the glycosyltransferase 54 family


    Find genes that share domains with MGAT4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGT4B_HUMAN, Q9UQ53
    Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core
    mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the
    GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and
    tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that,
    under physiological conditions, it is not the main contributor in N-glycan biosynthesis
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
    Biophysicochemical properties: Kinetic parameters: KM=0.242 mM for UDP-GlcNAc;

         Genatlas biochemistry entry for MGAT4B:
    mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme B

         Enzyme Number (IUBMB): EC 2.4.1.1451 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008454alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MGAT4B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MGAT4B:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mgat4b):
     normal 

    Find genes that share phenotypes with MGAT4B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MGAT4B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MGAT4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MGAT4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MGAT4B

    miRNA
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    miRTarBase miRNAs that target MGAT4B:
    hsa-mir-222-3p (MIRT046626), hsa-mir-484 (MIRT042146)

    Block miRNA regulation of human, mouse, rat MGAT4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MGAT4B (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-548k hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-105 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMGAT4B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MGAT4B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MGAT4B (NM_014275)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGT4B_HUMAN, Q9UQ53: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MGAT4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGAT4B About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Post-translational protein modification0.43
    N-Glycan antennae elongation0.00
    Transport to the Golgi and subsequent modification0.40
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with MGAT4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MGAT4B
        N-Glycan antennae elongation


    2 Kegg Pathways  (Kegg details for MGAT4B):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT4B_HUMAN, Q9UQ53
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including MGAT4B: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGAT4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MGAT4B (Q9UQ532, 3 ENSP000003384874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRSAM1Q6UWE02, 3MINT-64689 I2D: score=4 
    FUT8ENSP000003539104STRING: ENSP00000353910
    MGAT2ENSP000003074234STRING: ENSP00000307423
    MGAT3ENSP000003452704STRING: ENSP00000345270
    MGAT5ENSP000002819234STRING: ENSP00000281923
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006491N-glycan processing TAS10372966
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with MGAT4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGAT4B (MGT4B)

    2 HMDB Compounds for MGAT4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    1 PharmGKB related drug/compound annotation for MGAT4B gene    About this table
    Drug/compound PharmGKB Annotation
    montelukastCA  



    Find genes that share compounds with MGAT4B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGAT4B gene (2 alternative transcripts): 
    NM_014275.4  NM_054013.3  

    Unigene Cluster for MGAT4B:

    Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
    Hs.567419  [show with all ESTs]
    Unigene Representative Sequence: NM_054013
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000518778 ENST00000337755(uc003mkr.3) ENST00000292591(uc003mkp.3 uc003mkq.3 uc003mks.3)
    ENST00000519836 ENST00000520969 ENST00000522293 ENST00000518980 ENST00000522451
    ENST00000520875 ENST00000523382 ENST00000518867 ENST00000518702 ENST00000520822
    ENST00000523108 ENST00000521855 ENST00000520918 ENST00000521305 ENST00000523329

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MGAT4B (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-548k hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-105 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMGAT4B 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MGAT4B
      QuantiFast Probe-based Assays in human, mouse, rat MGAT4B

    Additional mRNA sequence: 

    AB000624.1 AK023137.1 AK225490.1 AK225492.1 AL162067.1 AY358984.1 BC009464.1 BC051835.1 
    BC131814.1 

    Selected DOTS entries (see all 42):

    DT.92383355  DT.100818878  DT.100060035  DT.99960486  DT.102839201  DT.100818885  DT.414516  DT.95175019 
    DT.120832782  DT.100060037  DT.100041677  DT.100818875  DT.100818883  DT.100051892  DT.97796178  DT.100818881 
    DT.100818891  DT.100818893  DT.92019271  DT.92467610  DT.95128550  DT.100818876  DT.100818888  DT.120832794 

    13 AceView cDNA sequences:

    CB153099 BM763398 BE394298 BM910395 BV170608 BV198437 BI199370 BM845936 
    BM841970 BG674199 BE616452 BU169170 BF879632 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGAT4B (see all 20)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ·
    SP1:              -     -     -     -     -     -     -     -                 -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -     -                 -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
    SP1:                          -           -                 -                 -                           
    SP2:                          -           -                 -                 -                           
    SP3:                          -           -     -           -                 -                           
    SP4:                                                                                                      
    SP5:                          -           -                                                               


    ECgene alternative splicing isoforms for MGAT4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MGAT4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACCCGCC
    MGAT4B Expression
    About this image


    MGAT4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Lung (Respiratory System)
    MGAT4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGAT4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567419

    UniProtKB/Swiss-Prot: MGT4B_HUMAN, Q9UQ53
    Tissue specificity: Widely expressed. Strongly overexpressed in pancreatic cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including MGAT4B: 
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MGAT4B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat4b1 , 5 mannoside acetylglucosaminyltransferase 4, isoenzyme more1, 5 90.51(n)1
    98.54(a)1
      11 (30.37 cM)5
    1035341  NM_145926.31  NP_666038.31 
     502108905 
    chicken
    (Gallus gallus)
    Aves MGAT4B1 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, more 81.78(n)
    88.91(a)
      416285  XM_414605.4  XP_414605.4 
    lizard
    (Anolis carolinensis)
    Reptilia MGAT4B6
    mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acet...
    82(a)
    1 ↔ 1
    2(140171727-140278159)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45692 Xenopus laevis transcribed sequence with moderate similarity more 75.98(n)    BX851573.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d022 Transcribed sequence with weak similarity to protein more 76.88(n)    BI864738.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93843 alpha-1,3-mannosylglycoprotein
    beta-1,4-N-acetylglucosaminyltransferase
    46(a)
    (best of 2)
      70F4   --


    ENSEMBL Gene Tree for MGAT4B (if available)
    TreeFam Gene Tree for MGAT4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGAT4B gene
    LOC1525862  LOC6415152  MGAT4C2  MGAT4A2  
    3 SIMAP similar genes for MGAT4B using alignment to 10 protein entries:     MGT4B_HUMAN (see all proteins):
    MGAT4A    LOC152586    MGAT4C

    Find genes that share paralogs with MGAT4B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MGAT4B
    PGOHUM00000261138


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGAT4B (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019290301,2
    C--179224098(+) CGGAGA/GAAGGA 2 -- ds50010--------
    rs1481474611,2
    C--179224285(+) GGCCT-/TGGACA
            
    TGGGG
    2 -- ds50010--------
    rs1908445301,2
    --179224296(+) TGGGGA/GAGACA 2 -- ds50010--------
    rs1148584541,2
    C,F--179224297(+) GGGGGA/TGACAT 2 -- ds50011Minor allele frequency- T:0.11WA 118
    rs1136470381,2
    F--179224305(+) CATTCC/GGGGGA 2 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1397309991,2
    C--179224387(+) GGAAGA/GGGGGT 2 -- ds50010--------
    rs1858680021,2
    --179224400(+) GCTGGC/TGCCGA 2 -- ds50010--------
    rs1436046891,2
    --179224401(+) CTGGCA/GCCGAG 2 -- ds50010--------
    rs610764421,2
    C--179224566(+) CAGGGG/-CAGAG 2 -- ds50012Minor allele frequency- -:0.00NA CSA 4
    rs2007634811,2
    C--179224566(-) TGCCCC/TGCGGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for MGAT4B (179224597 - 179233952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MGAT4B (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988291CNV Deletion20482838
    nsv823361CNV Loss20364138
    nsv883270CNV Loss21882294
    nsv469579CNV Loss16826518
    nsv883278CNV Loss21882294
    nsv483062CNV Loss15286789
    dgv6403n71CNV Loss21882294
    nsv518964CNV Loss19592680
    dgv6401n71CNV Loss21882294
    dgv6402n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGAT4B
    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604561    OMIM disorders: --


    Find genes that share disorders with MGAT4B           About GenesLikeMe

    1 Novoseek inferred disease relationship for MGAT4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 17006639 (1)

    Genetic Association Database (GAD): MGAT4B
    Human Genome Epidemiology (HuGE) Navigator: MGAT4B (3 documents)

    Export disorders for MGAT4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGAT4B gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with MGAT4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel second isoenzyme of the human UDP-N- acetylglucosamine:alpha1,3-D-mannoside beta1,4-N- acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment. (PubMed id 10372966)1, 2, 3 Yoshida A....Takeuchi M. (Glycoconj. J. 1998)
    2. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PubMed id 17006639)1, 2, 9 Oguri S.... Takeuchi M. (Glycoconj. J. 2006)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (PubMed id 16434023)1, 2 Ide Y.... Taniguchi N. (Biochem. Biophys. Res. Commun. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. (PubMed id 17488527)1, 9 Kudo T....Todo S. (Mol. Cancer 2007)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11282 HGNC: 7048 AceView: MGAT4B Ensembl:ENSG00000161013 euGenes: HUgn11282
    ECgene: MGAT4B Kegg: 11282 H-InvDB: MGAT4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGAT4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGAT4B gene:
    Search GeneIP for patents involving MGAT4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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