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Aliases for MGAT4B Gene

Aliases for MGAT4B Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme B 2 3 5
  • UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVb 3 4
  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme B 2 3
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVb 3 4
  • N-Acetylglucosaminyltransferase IVb 3 4
  • GlcNAc-T IVb 3 4
  • EC 2.4.1.145 4 63
  • GNT-IVB 3 4
  • UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IV 3
  • Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase 3
  • Aminyltransferase 3
  • GNT-IV 3

External Ids for MGAT4B Gene

Previous GeneCards Identifiers for MGAT4B Gene

  • GC05M179336
  • GC05M180168
  • GC05M179334
  • GC05M179157
  • GC05M173950
  • GC05M179224

Summaries for MGAT4B Gene

Entrez Gene Summary for MGAT4B Gene

  • This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT4B Gene

MGAT4B (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme B) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include transferase activity, transferring hexosyl groups and alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT4A.

UniProtKB/Swiss-Prot for MGAT4B Gene

  • Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.

Gene Wiki entry for MGAT4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT4B Gene

Genomics for MGAT4B Gene

Regulatory Elements for MGAT4B Gene

Enhancers for MGAT4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MGAT4B on UCSC Golden Path with GeneCards custom track

Promoters for MGAT4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGAT4B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MGAT4B gene promoter:

Genomic Location for MGAT4B Gene

Chromosome:
5
Start:
179,797,597 bp from pter
End:
179,806,952 bp from pter
Size:
9,356 bases
Orientation:
Minus strand

Genomic View for MGAT4B Gene

Genes around MGAT4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT4B Gene

Proteins for MGAT4B Gene

  • Protein details for MGAT4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ53-MGT4B_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
    Protein Accession:
    Q9UQ53
    Secondary Accessions:
    • A8MPR0
    • Q86TF1
    • Q96GH4
    • Q9NSK6

    Protein attributes for MGAT4B Gene

    Size:
    548 amino acids
    Molecular mass:
    63198 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGAT4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT4B Gene

Proteomics data for MGAT4B Gene at MOPED

Selected DME Specific Peptides for MGAT4B Gene

Post-translational modifications for MGAT4B Gene

  • Glycosylation at Asn 87, Asn 103, and Thr 490
  • Modification sites at PhosphoSitePlus

Domains & Families for MGAT4B Gene

Protein Domains for MGAT4B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UQ53

UniProtKB/Swiss-Prot:

MGT4B_HUMAN :
  • Belongs to the glycosyltransferase 54 family.
Family:
  • Belongs to the glycosyltransferase 54 family.
genes like me logo Genes that share domains with MGAT4B: view

Function for MGAT4B Gene

Molecular function for MGAT4B Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme B
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.242 mM for UDP-GlcNAc {ECO:0000269 PubMed:17006639};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.

Enzyme Numbers (IUBMB) for MGAT4B Gene

Gene Ontology (GO) - Molecular Function for MGAT4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with MGAT4B: view
genes like me logo Genes that share phenotypes with MGAT4B: view

Animal Models for MGAT4B Gene

MGI Knock Outs for MGAT4B:

Animal Model Products

  • Taconic Biosciences Mouse Models for MGAT4B

miRNA for MGAT4B Gene

miRTarBase miRNAs that target MGAT4B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT4B Gene

Localization for MGAT4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT4B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT4B Gene COMPARTMENTS Subcellular localization image for MGAT4B gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MGAT4B Gene

Pathways & Interactions for MGAT4B Gene

genes like me logo Genes that share pathways with MGAT4B: view

UniProtKB/Swiss-Prot Q9UQ53-MGT4B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MGAT4B Gene

Gene Ontology (GO) - Biological Process for MGAT4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MGAT4B: view

No data available for SIGNOR curated interactions for MGAT4B Gene

Drugs & Compounds for MGAT4B Gene

(2) Drugs for MGAT4B Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Montelukast Approved Pharma Antagonist 265
Uridine-5'-Diphosphate Experimental Pharma 0

(1) Additional Compounds for MGAT4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with MGAT4B: view

Transcripts for MGAT4B Gene

mRNA/cDNA for MGAT4B Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MGAT4B Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT4B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ·
SP1: - - - - - - - - -
SP2: -
SP3:
SP4: - - - - - - -
SP5:
SP6:
SP7: - -
SP8: - - -
SP9:
SP10: - - - - - - - - - - -
SP11:
SP12: - -
SP13: - - - -
SP14:
SP15: - - -
SP16:
SP17: - - - - -
SP18:
SP19: -
SP20:

ExUns: 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10:
SP11: - - -
SP12:
SP13:
SP14: - -
SP15: - -
SP16: - -
SP17:
SP18: -
SP19:
SP20:

Relevant External Links for MGAT4B Gene

GeneLoc Exon Structure for
MGAT4B
ECgene alternative splicing isoforms for
MGAT4B

Expression for MGAT4B Gene

mRNA expression in normal human tissues for MGAT4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT4B Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for MGAT4B Gene

This gene is overexpressed in Plasma (25.2), Heart (21.4), and Bone (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT4B Gene



SOURCE GeneReport for Unigene cluster for MGAT4B Gene Hs.567419

mRNA Expression by UniProt/SwissProt for MGAT4B Gene

Q9UQ53-MGT4B_HUMAN
Tissue specificity: Widely expressed. Strongly overexpressed in pancreatic cancer.
genes like me logo Genes that share expression patterns with MGAT4B: view

Protein tissue co-expression partners for MGAT4B Gene

Primer Products

Orthologs for MGAT4B Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGAT4B 35
  • 91.69 (n)
  • 95.61 (a)
MGAT4B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT4B 35
  • 92.94 (n)
  • 97.99 (a)
MGAT4B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat4b 35
  • 90.51 (n)
  • 98.54 (a)
Mgat4b 16
Mgat4b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGAT4B 35
  • 99.33 (n)
  • 99.82 (a)
MGAT4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat4b 35
  • 90.57 (n)
  • 98.54 (a)
oppossum
(Monodelphis domestica)
Mammalia MGAT4B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT4B 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGAT4B 35
  • 81.78 (n)
  • 88.91 (a)
MGAT4B 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT4B 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489322 35
  • 76.8 (n)
  • 85.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4569 35
zebrafish
(Danio rerio)
Actinopterygii mgat4b 35
  • 74.79 (n)
  • 80.59 (a)
wufb01d02 35
mgat4b 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17173 37
  • 37 (a)
CG9384 37
  • 46 (a)
CG9384 36
  • 37 (a)
OneToMany
Species with no ortholog for MGAT4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT4B Gene

ENSEMBL:
Gene Tree for MGAT4B (if available)
TreeFam:
Gene Tree for MGAT4B (if available)

Paralogs for MGAT4B Gene

Paralogs for MGAT4B Gene

Pseudogenes.org Pseudogenes for MGAT4B Gene

genes like me logo Genes that share paralogs with MGAT4B: view

Variants for MGAT4B Gene

Sequence variations from dbSNP and Humsavar for MGAT4B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_032446 -
VAR_053913 -
rs1043193 -- 179,797,747(-) CGCCC(C/G)CCGTC utr-variant-3-prime
rs190629 -- 179,802,557(+) TCAAG(C/G)ACAGT intron-variant, utr-variant-5-prime
rs190630 -- 179,800,640(+) AGGGG(A/C)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT4B Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv483062 CNV Loss 15286789
nsv469579 CNV Loss 16826518
dgv6400n71 CNV Loss 21882294
nsv518964 CNV Loss 19592680
nsv883275 CNV Loss 21882294
nsv823361 CNV Loss 20364138
nsv883278 CNV Loss 21882294
dgv6401n71 CNV Loss 21882294
dgv6402n71 CNV Loss 21882294
dgv6403n71 CNV Loss 21882294
esv988291 CNV Deletion 20482838

Variation tolerance for MGAT4B Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MGAT4B Gene

Disorders for MGAT4B Gene

Relevant External Links for MGAT4B

Genetic Association Database (GAD)
MGAT4B
Human Genome Epidemiology (HuGE) Navigator
MGAT4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT4B

No disorders were found for MGAT4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGAT4B Gene

Publications for MGAT4B Gene

  1. A novel second isoenzyme of the human UDP-N- acetylglucosamine:alpha1,3-D-mannoside beta1,4-N- acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment. (PMID: 10372966) Yoshida A. … Takeuchi M. (Glycoconj. J. 1998) 2 3 4 67
  2. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. (PMID: 17488527) Kudo T. … Todo S. (Mol. Cancer 2007) 3 23
  3. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PMID: 17006639) Oguri S. … Takeuchi M. (Glycoconj. J. 2006) 3 23
  4. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). (PMID: 25944901) Maszczak-Seneczko D. … Olczak M. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MGAT4B Gene

Sources for MGAT4B Gene

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