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Aliases for MGAT4A Gene

Aliases for MGAT4A Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A 2 3
  • UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVa 3 4
  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme A 2 3
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVa 3 4
  • N-Acetylglucosaminyltransferase IVa 3 4
  • GlcNAc-T IVa 3 4
  • EC 2.4.1.145 4 64
  • GNT-IVA 3 4
  • UDP-N-Acetylglucosamine:Alpha1,3-D-Mannoside Beta1,4-N-Acetylglucosaminyltransferase 3
  • Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A 3
  • Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase 3
  • UDP-GlcNAc:A-1,3-D-Mannoside B-1,4-Acetylglucosaminyltransferase IV 3
  • GNT-IV 3
  • GnT-4a 3

External Ids for MGAT4A Gene

Summaries for MGAT4A Gene

Entrez Gene Summary for MGAT4A Gene

  • This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT4A Gene

MGAT4A (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT4D.

UniProtKB/Swiss-Prot for MGAT4A Gene

  • Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT4A Gene

Genomics for MGAT4A Gene

Genomic Location for MGAT4A Gene

Start:
98,619,106 bp from pter
End:
98,731,126 bp from pter
Size:
112,021 bases
Orientation:
Minus strand

Genomic View for MGAT4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT4A Gene

Regulatory Elements for MGAT4A Gene

Proteins for MGAT4A Gene

  • Protein details for MGAT4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM21-MGT4A_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
    Protein Accession:
    Q9UM21
    Secondary Accessions:
    • B4E2R6
    • D3DVH6
    • E9PEN2
    • Q53S97
    • Q86Z15

    Protein attributes for MGAT4A Gene

    Size:
    535 amino acids
    Molecular mass:
    61544 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGAT4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT4A Gene

Proteomics data for MGAT4A Gene at MOPED

Post-translational modifications for MGAT4A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser59, Ser60, Thr64, Asn77, Thr376, and Asn458

Other Protein References for MGAT4A Gene

Domains for MGAT4A Gene

Protein Domains for MGAT4A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MGT4A_HUMAN
Family:
  • Belongs to the glycosyltransferase 54 family.:
    • Q9UM21
genes like me logo Genes that share domains with MGAT4A: view

No data available for Gene Families for MGAT4A Gene

Function for MGAT4A Gene

Molecular function for MGAT4A Gene

GENATLAS Biochemistry: mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme A
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.118 mM for UDP-GlcNAc {ECO:0000269 PubMed:17006639};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells

Enzyme Numbers (IUBMB) for MGAT4A Gene

Gene Ontology (GO) - Molecular Function for MGAT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity --
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT4A: view
genes like me logo Genes that share phenotypes with MGAT4A: view

Animal Models for MGAT4A Gene

MGI Knock Outs for MGAT4A:

miRNA for MGAT4A Gene

miRTarBase miRNAs that target MGAT4A

No data available for Transcription Factor Targeting and HOMER Transcription for MGAT4A Gene

Localization for MGAT4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT4A Gene

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A: Golgi apparatus membrane; Single-pass type II membrane protein.
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT4A Gene COMPARTMENTS Subcellular localization image for MGAT4A gene
Compartment Confidence
golgi apparatus 5
cytosol 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MGAT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MGAT4A: view

Pathways for MGAT4A Gene

genes like me logo Genes that share pathways with MGAT4A: view

UniProtKB/Swiss-Prot Q9UM21-MGT4A_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT4A Gene

Gene Ontology (GO) - Biological Process for MGAT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006487 protein N-linked glycosylation --
GO:0006491 N-glycan processing TAS 10024668
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MGAT4A: view

Compounds for MGAT4A Gene

(2) HMDB Compounds for MGAT4A Gene

Compound Synonyms Cas Number PubMed IDs
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
528-04-1

(1) Novoseek inferred chemical compound relationships for MGAT4A Gene

Compound -log(P) Hits PubMed IDs
polysaccharide 32.5 1
genes like me logo Genes that share compounds with MGAT4A: view

Transcripts for MGAT4A Gene

Unigene Clusters for MGAT4A Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT4A Gene

No ASD Table

Relevant External Links for MGAT4A Gene

GeneLoc Exon Structure for
MGAT4A
ECgene alternative splicing isoforms for
MGAT4A

Expression for MGAT4A Gene

mRNA expression in normal human tissues for MGAT4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT4A Gene

SOURCE GeneReport for Unigene cluster for MGAT4A Gene Hs.177576

mRNA Expression by UniProt/SwissProt for MGAT4A Gene

Q9UM21-MGT4A_HUMAN
Tissue specificity: Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer.
genes like me logo Genes that share expressions with MGAT4A: view

Orthologs for MGAT4A Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT4A 36
  • 99.69 (n)
  • 100 (a)
MGAT4A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT4A 36
  • 91.03 (n)
  • 96.07 (a)
MGAT4A 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT4A 36
  • 93.4 (n)
  • 97.57 (a)
MGAT4A 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat4a 36
  • 85.98 (n)
  • 93.64 (a)
Mgat4a 16
Mgat4a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT4A 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT4A 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat4a 36
  • 86.54 (n)
  • 94.58 (a)
chicken
(Gallus gallus)
Aves MGAT4A 36
  • 81.68 (n)
  • 88.6 (a)
MGAT4A 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT4A 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat4b 36
  • 77.01 (n)
  • 82.52 (a)
zebrafish
(Danio rerio)
Actinopterygii mgat4a 36
  • 70.94 (n)
  • 78.11 (a)
mgat4a 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9384 37
  • 36 (a)
OneToMany
CG17173 38
  • 37 (a)
CG9384 38
  • 43 (a)
Species with no ortholog for MGAT4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT4A Gene

ENSEMBL:
Gene Tree for MGAT4A (if available)
TreeFam:
Gene Tree for MGAT4A (if available)

Paralogs for MGAT4A Gene

Paralogs for MGAT4A Gene

Selected SIMAP similar genes for MGAT4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MGAT4A: view

Variants for MGAT4A Gene

Sequence variations from dbSNP and Humsavar for MGAT4A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13427 -- 98,625,571(+) TCAGT(C/T)GGTGG intron-variant, reference, missense
rs882164 -- 98,701,226(+) GTTCA(C/T)TGGTA intron-variant
rs885036 -- 98,688,331(-) gcttg(C/T)gacag intron-variant
rs955701 -- 98,721,657(-) ATGTA(A/G)GTCTG intron-variant
rs955702 -- 98,721,271(-) TATAA(A/G)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT4A Gene

Variant ID Type Subtype PubMed ID
esv988416 CNV Insertion 20482838
esv2450775 CNV Insertion 19546169
nsv2841 CNV Loss 18451855

Relevant External Links for MGAT4A Gene

HapMap Linkage Disequilibrium report
MGAT4A

Disorders for MGAT4A Gene

(3) Novoseek inferred disease relationships for MGAT4A Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 60.6 5
tumors 0 1
cancer 0 2

Relevant External Links for MGAT4A

Genetic Association Database (GAD)
MGAT4A
genes like me logo Genes that share disorders with MGAT4A: view

No data available for UniProtKB/Swiss-Prot for MGAT4A Gene

Publications for MGAT4A Gene

  1. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (PMID: 16434023) Ide Y. … Taniguchi N. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PMID: 17006639) Oguri S. … Takeuchi M. (Glycoconj. J. 2006) 3 4 23
  3. Tissue specific expression and chromosomal mapping of a human UDP-N- acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N- acetylglucosaminyltransferase. (PMID: 10024668) Yoshida A. … Takeuchi M. (Glycobiology 1999) 2 3 4
  4. Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. (PMID: 15688387) D'Arrigo A. … Lise M. (Int. J. Cancer 2005) 3 23
  5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PMID: 21738484) Smith E.N. … Kelsoe J.R. (PLoS Genet. 2011) 3 49

Products for MGAT4A Gene

  • antibodies-online proteins for MGAT4A
  • antibodies-online antibodies for MGAT4A
  • antibodies-online kits for MGAT4A

Sources for MGAT4A Gene

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