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Aliases for MGAT4A Gene

Aliases for MGAT4A Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A 2 3 5
  • UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVa 3 4
  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme A 2 3
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVa 3 4
  • N-Acetylglucosaminyltransferase IVa 3 4
  • GlcNAc-T IVa 3 4
  • EC 2.4.1.145 4 63
  • GNT-IVA 3 4
  • UDP-N-Acetylglucosamine:Alpha1,3-D-Mannoside Beta1,4-N-Acetylglucosaminyltransferase 3
  • Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase 3
  • UDP-GlcNAc:A-1,3-D-Mannoside B-1,4-Acetylglucosaminyltransferase IV 3
  • GNT-IV 3
  • GnT-4a 3

External Ids for MGAT4A Gene

Previous GeneCards Identifiers for MGAT4A Gene

  • GC02M097123
  • GC02M097694
  • GC02M098842
  • GC02M098863
  • GC02M099236
  • GC02M093000

Summaries for MGAT4A Gene

Entrez Gene Summary for MGAT4A Gene

  • This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT4A Gene

MGAT4A (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A) is a Protein Coding gene. Diseases associated with MGAT4A include choriocarcinoma. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring hexosyl groups and alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT4D.

UniProtKB/Swiss-Prot for MGAT4A Gene

  • Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT4A Gene

Genomics for MGAT4A Gene

Regulatory Elements for MGAT4A Gene

Promoters for MGAT4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGAT4A on UCSC Golden Path with GeneCards custom track

Genomic Location for MGAT4A Gene

Chromosome:
2
Start:
98,619,106 bp from pter
End:
98,731,126 bp from pter
Size:
112,021 bases
Orientation:
Minus strand

Genomic View for MGAT4A Gene

Genes around MGAT4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT4A Gene

Proteins for MGAT4A Gene

  • Protein details for MGAT4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM21-MGT4A_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
    Protein Accession:
    Q9UM21
    Secondary Accessions:
    • B4E2R6
    • D3DVH6
    • E9PEN2
    • Q53S97
    • Q86Z15

    Protein attributes for MGAT4A Gene

    Size:
    535 amino acids
    Molecular mass:
    61544 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGAT4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGAT4A Gene

Proteomics data for MGAT4A Gene at MOPED

Post-translational modifications for MGAT4A Gene

  • Glycosylation at Ser 60, Asn 77, Thr 376, and Asn 458
  • Modification sites at PhosphoSitePlus

Other Protein References for MGAT4A Gene

Domains & Families for MGAT4A Gene

Protein Domains for MGAT4A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MGAT4A Gene

Graphical View of Domain Structure for InterPro Entry

Q9UM21

UniProtKB/Swiss-Prot:

MGT4A_HUMAN :
  • Belongs to the glycosyltransferase 54 family.
Family:
  • Belongs to the glycosyltransferase 54 family.
genes like me logo Genes that share domains with MGAT4A: view

Function for MGAT4A Gene

Molecular function for MGAT4A Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.118 mM for UDP-GlcNAc {ECO:0000269 PubMed:17006639};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.

Enzyme Numbers (IUBMB) for MGAT4A Gene

Gene Ontology (GO) - Molecular Function for MGAT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with MGAT4A: view
genes like me logo Genes that share phenotypes with MGAT4A: view

Animal Models for MGAT4A Gene

MGI Knock Outs for MGAT4A:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT4A Gene

Localization for MGAT4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT4A Gene

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A: Golgi apparatus membrane; Single-pass type II membrane protein.
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT4A Gene COMPARTMENTS Subcellular localization image for MGAT4A gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for MGAT4A Gene

Pathways & Interactions for MGAT4A Gene

genes like me logo Genes that share pathways with MGAT4A: view

UniProtKB/Swiss-Prot Q9UM21-MGT4A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MGAT4A Gene

Gene Ontology (GO) - Biological Process for MGAT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MGAT4A: view

No data available for SIGNOR curated interactions for MGAT4A Gene

Drugs & Compounds for MGAT4A Gene

(1) Drugs for MGAT4A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(2) Additional Compounds for MGAT4A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with MGAT4A: view

Transcripts for MGAT4A Gene

Unigene Clusters for MGAT4A Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT4A Gene

No ASD Table

Relevant External Links for MGAT4A Gene

GeneLoc Exon Structure for
MGAT4A
ECgene alternative splicing isoforms for
MGAT4A

Expression for MGAT4A Gene

mRNA expression in normal human tissues for MGAT4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGAT4A Gene

This gene is overexpressed in Liver (26.3), Placenta (18.2), CD8 Tcells (15.6), and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT4A Gene



SOURCE GeneReport for Unigene cluster for MGAT4A Gene Hs.177576

mRNA Expression by UniProt/SwissProt for MGAT4A Gene

Q9UM21-MGT4A_HUMAN
Tissue specificity: Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer.
genes like me logo Genes that share expression patterns with MGAT4A: view

Protein tissue co-expression partners for MGAT4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MGAT4A Gene

Orthologs for MGAT4A Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT4A 35
  • 99.69 (n)
  • 100 (a)
MGAT4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT4A 36
  • 96 (a)
OneToOne
MGAT4A 35
  • 91.03 (n)
  • 96.07 (a)
dog
(Canis familiaris)
Mammalia MGAT4A 35
  • 93.4 (n)
  • 97.57 (a)
MGAT4A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat4a 16
Mgat4a 35
  • 85.98 (n)
  • 93.64 (a)
Mgat4a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT4A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT4A 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat4a 35
  • 86.54 (n)
  • 94.58 (a)
chicken
(Gallus gallus)
Aves MGAT4A 35
  • 81.68 (n)
  • 88.6 (a)
MGAT4A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT4A 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat4b 35
  • 77.01 (n)
  • 82.52 (a)
zebrafish
(Danio rerio)
Actinopterygii mgat4a 36
  • 75 (a)
OneToOne
mgat4a 35
  • 70.94 (n)
  • 78.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17173 37
  • 37 (a)
CG9384 37
  • 43 (a)
CG9384 36
  • 36 (a)
OneToMany
Species with no ortholog for MGAT4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT4A Gene

ENSEMBL:
Gene Tree for MGAT4A (if available)
TreeFam:
Gene Tree for MGAT4A (if available)

Paralogs for MGAT4A Gene

Paralogs for MGAT4A Gene

(3) SIMAP similar genes for MGAT4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MGAT4A: view

Variants for MGAT4A Gene

Sequence variations from dbSNP and Humsavar for MGAT4A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13427 -- 98,625,571(+) TCAGT(C/T)GGTGG intron-variant, reference, missense
rs885036 -- 98,688,331(-) gcttg(C/T)gacag intron-variant
rs1059072 -- 98,624,434(-) CCAAG(A/T)GACTG intron-variant, utr-variant-3-prime
rs1307117 -- 98,665,261(+) gaggc(A/G)gaggt intron-variant, upstream-variant-2KB
rs1599827 -- 98,661,152(-) ttttc(A/G)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT4A Gene

Variant ID Type Subtype PubMed ID
esv988416 CNV Insertion 20482838
esv2450775 CNV Insertion 19546169
nsv2841 CNV Loss 18451855

Variation tolerance for MGAT4A Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT4A Gene

HapMap Linkage Disequilibrium report
MGAT4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT4A Gene

Disorders for MGAT4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGAT4A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma
  • choriocarcinoma, no icd-o subtype
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MGAT4A

Genetic Association Database (GAD)
MGAT4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT4A
genes like me logo Genes that share disorders with MGAT4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT4A Gene

Publications for MGAT4A Gene

  1. Tissue specific expression and chromosomal mapping of a human UDP-N- acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N- acetylglucosaminyltransferase. (PMID: 10024668) Yoshida A. … Takeuchi M. (Glycobiology 1999) 2 3 4 67
  2. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. (PMID: 17488527) Kudo T. … Todo S. (Mol. Cancer 2007) 3 23
  3. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (PMID: 16434023) Ide Y. … Taniguchi N. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PMID: 17006639) Oguri S. … Takeuchi M. (Glycoconj. J. 2006) 3 23
  5. Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. (PMID: 15688387) D'Arrigo A. … Lise M. (Int. J. Cancer 2005) 3 23

Products for MGAT4A Gene

Sources for MGAT4A Gene

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