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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT4A Gene

protein-coding   GIFtS: 53
GCID: GC02M099236

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,...

(Previous names: mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,...)
 Explore 14 diseases affiliated with
MGAT4A via
MalaCards
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 Human Malady Compendium 
Biological research products
for MGAT4A    

Aliases
for MGAT4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase,
Isozyme A1 2
     GnT-Iva1
GnT-4a1 2     GNT-IV2
Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase,
Isoenzyme A1 2
     GNT-IVA2
GlcNAc-T IVa2 3     Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A2
N-Acetylglucosaminyltransferase IVa2 3     Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase2
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVa2 3     UDP-GlcNAc:A-1,3-D-Mannoside B-1,4-Acetylglucosaminyltransferase IV2
UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside
Beta-1,4-N-Acetylglucosaminyltransferase IVa2 3
     UDP-N-Acetylglucosamine:Alpha1,3-D-Mannoside
Beta1,4-N-Acetylglucosaminyltransferase2
EC 2.4.1.1453 8     GnT-IVa3

External Ids:    HGNC: 70471   Entrez Gene: 113202   Ensembl: ENSG000000710737   OMIM: 6046235   UniProtKB: Q9UM213   
ORGUL members:         
NONCODE:n338918    

Export aliases for MGAT4A gene to outside databases

Previous GC identifers: GC02M097123 GC02M097694 GC02M098842 GC02M098863 GC02M098700 GC02M093000


Summaries
for MGAT4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGAT4A:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching
structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer
of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of
R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may
play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose
residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm
of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar
chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface
expression of SLC2A2 in pancreatic beta cells




Genomic Views
for MGAT4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT4A gene promoter:
         RP58   C/EBPbeta   Pax-5   MEF-2   HNF-1A   c-Ets-1   MEF-2A   FAC1   HNF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGAT4A promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

MGAT4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT4A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M099236:  view genomic region     (about GC identifiers)

Start:
 99,235,569 bp from pter      End:
 99,347,589 bp from pter
Size:
 112,021 bases      Orientation:
 minus strand

Proteins
for MGAT4A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21 (See protein sequence)
Recommended Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A  
Size: 535 amino acids; 61544 Da
Cofactor: Divalent metal cations (By similarity)
Subcellular location: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A: Golgi apparatus
membrane; Single-pass type II membrane protein (By similarity)
Subcellular location: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form: Secreted
(By similarity)
Secondary accessions: B4E2R6 D3DVH6 E9PEN2 Q53S97 Q86Z15
Alternative splicing: 2 isoforms:  Q9UM21-1   Q9UM21-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGAT4A: NX_Q9UM21

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UM21

    • 4/25 DME Specific Peptides for MGAT4A (Q9UM21) (see all 25)
     VFIGETD  NKFSDNT  YLFHSGN  ETLHSLID 

    MGAT4A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153626.1  NP_036346.1  

    ENSEMBL proteins: 
     ENSP00000264968   ENSP00000386841   ENSP00000404889   ENSP00000377127  
    Reactome Protein details: Q9UM21
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    MGAT4A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MGAT4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGAT4A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006759 Glyco_transf_54

    Graphical View of Domain Structure for InterPro Entry Q9UM21

    ProtoNet protein and cluster: Q9UM21

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Similarity: Belongs to the glycosyltransferase 54 family


    Function
    for MGAT4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose
    residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm
    of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar
    chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface
    expression of SLC2A2 in pancreatic beta cells
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
    Biophysicochemical properties: Kinetic parameters: KM=0.118 mM for UDP-GlcNAc;

         Genatlas biochemistry entry for MGAT4A:
    mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme A

    Enzyme Number (IUBMB): EC 2.4.1.1451 2

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    hsa-miR-124* hsa-miR-411* hsa-miR-361-5p hsa-miR-509-3-5p hsa-miR-374b* hsa-miR-34c-5p hsa-miR-4255 hsa-miR-548y
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    Inhib. RNA
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    OriGene shRNA RFP: MGAT4A
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008454alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--


    MGAT4A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mgat4atm1.1Jxm for MGAT4A
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mgat4a):
     cellular  growth/size  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    MGAT4A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MGAT4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    		N-Glycan antennae elongation0.75
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for MGAT4A (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    N-Glycan antennae elongation
    Metabolism of proteins


    2         Kegg Pathways  (Kegg details for MGAT4A):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Pathway: Protein modification; protein glycosylation


    MGAT4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MGAT4A (ENSP000002649684) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUT8ENSP000003539104STRING: ENSP00000353910
    MGAT2ENSP000003074234STRING: ENSP00000307423
    MGAT3ENSP000003452704STRING: ENSP00000345270
    MGAT5ENSP000002819234STRING: ENSP00000281923
    MGAT5BENSP000003912274STRING: ENSP00000391227
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006491N-glycan processing TAS10024668
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MGAT4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGAT4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT4A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MGAT4A

    2 HMDB Compounds for MGAT4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--
    1 Novoseek chemical compound relationship for MGAT4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysaccharide 32.5 1 18309288 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT4A / MGT4A 

    Transcripts
    for MGAT4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGAT4A gene (2 alternative transcripts): 
    NM_001160154.1  NM_012214.2  

    Unigene Cluster for MGAT4A:

    Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
    Hs.177576  [show with all ESTs]
    Unigene Representative Sequence: NM_012214
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264968 ENST00000409391 ENST00000492163 ENST00000461884(uc010fim.1)
    ENST00000484936 ENST00000460768 ENST00000495056 ENST00000414521(uc010yvm.2)
    ENST00000393487(uc002sze.3 uc010fil.3)

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    hsa-miR-124* hsa-miR-411* hsa-miR-361-5p hsa-miR-509-3-5p hsa-miR-374b* hsa-miR-34c-5p hsa-miR-4255 hsa-miR-548y
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB000616.1 AK092952.1 AK128366.1 AK291533.1 AK304393.1 AK309852.1 AK314024.1 BC031487.2 
    BC127107.1 BC127108.1 

    9 DOTS entries:

    DT.207365  DT.100717783  DT.408750  DT.91687283  DT.120936044  DT.433154  DT.120936049  DT.95148958 
    DT.91921358 

    24/381 AceView cDNA sequences (see all 381):

    BX442577 BC031487 BM854981 NM_012214 AA904940 BF055252 Z44422 BX356076 
    CK904870 AI335894 AA164687 BM128755 BE327041 AI431875 CR590322 CA435557 
    CA429372 BM052763 AI867151 BF195431 AW138839 AW005666 AL599612 AA830445 

    GeneLoc Exon Structure


    Expression
    for MGAT4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATTTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MGAT4A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPodocytesKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MGAT4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT4A

    SOURCE GeneReport for Unigene cluster: Hs.177576

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Tissue specificity: Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and
    lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer

        SABiosciences Expression via Pathway-Focused PCR Array including MGAT4A: 
              Glycosylation in human mouse rat

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    In Situ
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    Orthologs
    for MGAT4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MGAT4A gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MGAT4A1 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, more 81.68(n)
    88.6(a)    		   418692  NM_001012824.1  NP_001012842.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MGAT4A6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 3(109102685-109141335)
    zebrafish
    (Danio rerio)    		 Actinopterygii mgat4a1 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, more 70.94(n)
    78.11(a)    		   563038  XM_686404.4  XP_691496.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG93843 alpha-1,3-mannosylglycoprotein
    beta-1,4-N-acetylglucosaminyltransferase    		 43(a)
    (best of 2)    		   70F4   --


    ENSEMBL Gene Tree for MGAT4A (if available)
    TreeFam Gene Tree for MGAT4A (if available) 

    Paralogs
    for MGAT4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT4A gene
    ENSG000002053012  LOC6415152  MGAT4C2  MGAT4B2  
    3 SIMAP similar genes for MGAT4A using alignment to 1 protein entry:     MGT4A_HUMAN:
    MGAT4B    LOC152586    MGAT4C

    MGAT4A for paralogs           About GeneDecksing



    Genomic Variants
    for MGAT4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1653 NCBI SNPs in MGAT4A are shown (see all 1653)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1493145681,2
    		C,unknown99310096(+) AGCCTC/TAGAGG 1 -- int10--------
    rs133824041,2
    		C,H,--93110480(+) TGTTTG/ATCTCC 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs779711641,2
    		C,F,--93110701(+) TATGTT/CTATAC 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs739624241,2
    		C,--93110909(+) ATTGAA/GCTTAT 1 -- us2k12Minor allele frequency- G:0.15WA 120
    rs1925281451,2
    		--99235132(+) TCGCTC/TTCCTA 3 -- ds5001 int10--------
    rs175134681,2
    		C,F,H,--99235169(+) CTAATT/GAGCTG 3 -- ds5001 int122Minor allele frequency- G:0.26NA NS EA CSA WA 2479
    rs1512414971,2
    		--99235222(+) ACCTTC/TGGAAT 3 -- int1 ds50010--------
    rs1398910801,2
    		--99235320(+) TTACTC/TATAGC 3 -- int1 ds50010--------
    rs1456208331,2
    		--99235442(+) AGTAGA/GGCTTT 3 -- ds5001 int10--------
    rs134097311,2
    		C,F,H,--99235561(+) AAAATA/GCTACT 2 -- ds50016Minor allele frequency- G:0.06NS NA WA 908

    HapMap Linkage Disequilibrium report for MGAT4A (99235569 - 99347589 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MGAT4A: --

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    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT4A

    Disorders / Diseases
    for MGAT4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGAT4A for disorders           About GeneDecksing

    OMIM gene information: 604623    OMIM disorders: --

    14 diseases for MGAT4A:    About MalaCards
    extrahepatic bile duct carcinoma    bile duct carcinoma    renal cell carcinoma    choriocarcinoma
    bipolar disorder    hepatoblastoma    hepatocellular carcinoma    carcinoma
    pancreatitis    pancreatic carcinoma    gastric cancer    pancreatic cancer
    immunodeficiency    prostatitis

    3 Novoseek disease relationships for MGAT4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 60.6 6 10463590 (3), 10571021 (2)
    tumors 0 1 15688387 (1)
    cancer 0 4 10463590 (1), 17006639 (1)


    Export disorders for MGAT4A gene to outside databases

    Publications
    for MGAT4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT4A gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with MGAT4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tissue specific expression and chromosomal mapping of a human UDP-N- acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N- acetylglucosaminyltransferase. (PubMed id 10024668)1, 2, 3 Yoshida A....Takeuchi M. (1999)
    2. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PubMed id 17006639)1, 2, 9 Oguri S.... Takeuchi M. (2006)
    3. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (PubMed id 16434023)1, 2, 9 Ide Y.... Taniguchi N. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain. (PubMed id 10463590)2, 9 Takamatsu S.... Kobata A. (1999)
    6. Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. (PubMed id 15688387)1, 9 D'Arrigo A....Lise M. (2005)
    7. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. (PubMed id 17488527)1, 9 Kudo T....Todo S. (2007)
    8. High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. (PubMed id 23169300)1 Niimi K....Kikkawa F. (2012)
    9. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    10. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)1 Smith E.N....Kelsoe J.R. (2011)

    External Searches for MGAT4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MGAT4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11320 HGNC: 7047 AceView: MGAT4A Ensembl:ENSG00000071073 euGenes: HUgn11320
    ECgene: MGAT4A Kegg: 11320 H-InvDB: MGAT4A

    Other Databases showing MGAT4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGAT4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT4A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MGAT4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGAT4A gene:
    Search GeneIP for patents involving MGAT4A

    GeneCards and IP:
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