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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT4A Gene

protein-coding   GIFtS: 55
GCID: GC02M099236

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase,...

(Previous names: mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
Mannosyl (Alpha-1,3-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A1 2
     GNT-IVA2
Mannosyl (Alpha-1,3-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme A1 2
     GnT-4a2
GlcNAc-T IVa2 3     Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A2
N-Acetylglucosaminyltransferase IVa2 3     Alpha-1,3-Mannosyl-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase2
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase
IVa2 3
     UDP-GlcNAc:A-1,3-D-Mannoside B-1,4-Acetylglucosaminyltransferase IV2
UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside
Beta-1,4-N-Acetylglucosaminyltransferase IVa2 3
     UDP-N-Acetylglucosamine:Alpha1,3-D-Mannoside
Beta1,4-N-Acetylglucosaminyltransferase2
EC 2.4.1.1453 8     GnT-IVa3
GNT-IV2     

External Ids:    HGNC: 70471   Entrez Gene: 113202   Ensembl: ENSG000000710737   OMIM: 6046235   UniProtKB: Q9UM213   
ORGUL members:    fRNAdb10:FR059453      
NONCODE14:n338918      
RNAdb15:EVF41921    

Export aliases for MGAT4A gene to outside databases

Previous GC identifers: GC02M097123 GC02M097694 GC02M098842 GC02M098863 GC02M098700 GC02M093000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGAT4A Gene:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching
structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the
transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the
Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of
R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein
may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MGAT4A Gene: 
MGAT4A (mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MGAT4A include bile duct carcinoma, and choriocarcinoma, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity and metal ion binding. An important paralog of this gene is LOC152586.

UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core
mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the
GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and
tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation,
thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells



fRNAdb sequence ontology for MGAT4A:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MGAT4A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT4A gene promoter:
         RP58   C/EBPbeta   Pax-5   MEF-2   HNF-1A   c-Ets-1   MEF-2A   FAC1   HNF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGAT4A promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

MGAT4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT4A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M099236:  view genomic region     (about GC identifiers)

Start:
99,235,569 bp from pter      End:
99,347,589 bp from pter
Size:
112,021 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MGAT4A

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21 (See protein sequence)
Recommended Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A  
Size: 535 amino acids; 61544 Da
Cofactor: Divalent metal cations (By similarity)
Subcellular location: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A: Golgi apparatus
membrane; Single-pass type II membrane protein (By similarity)
Subcellular location: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form:
Secreted (By similarity)
Secondary accessions: B4E2R6 D3DVH6 E9PEN2 Q53S97 Q86Z15
Alternative splicing: 2 isoforms:  Q9UM21-1   Q9UM21-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MGAT4A: NX_Q9UM21

Explore proteomics data for MGAT4A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UM21

  • 4/25 DME Specific Peptides for MGAT4A (Q9UM21) (see all 25)
     VFIGETD  NKFSDNT  YLFHSGN  ETLHSLID 

    MGAT4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MGAT4A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153626.1  NP_036346.1  

    ENSEMBL proteins: 
     ENSP00000264968   ENSP00000386841   ENSP00000475198   ENSP00000404889   ENSP00000377127  
    Reactome Protein details: Q9UM21
    Human Recombinant Protein Products for MGAT4A: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    MGAT4A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006759 Glyco_transf_54

    Graphical View of Domain Structure for InterPro Entry Q9UM21

    ProtoNet protein and cluster: Q9UM21

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Similarity: Belongs to the glycosyltransferase 54 family


    MGAT4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGT4A_HUMAN, Q9UM21
    Function: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core
    mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the
    GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and
    tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation,
    thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells
    Catalytic activity: UDP-N-acetyl-D-glucosamine +
    3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
    Biophysicochemical properties: Kinetic parameters: KM=0.118 mM for UDP-GlcNAc;

         Genatlas biochemistry entry for MGAT4A:
    mannosyl (alpha-1,3-)glycoprotein beta,4-N acetylglucosaminyltransferase,isoenzyme A

         Enzyme Number (IUBMB): EC 2.4.1.1451 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008454alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--
         
    MGAT4A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mgat4a):
     cellular  growth/size  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    MGAT4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mgat4atm1.1Jxm for MGAT4A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MGAT4A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MGAT4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9        Reactome Pathways for MGAT4A (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    N-Glycan antennae elongation


    2         Kegg Pathways  (Kegg details for MGAT4A):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Pathway: Protein modification; protein glycosylation


    MGAT4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MGAT4A (ENSP000002649684) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUT8ENSP000003539104STRING: ENSP00000353910
    MGAT2ENSP000003074234STRING: ENSP00000307423
    MGAT3ENSP000003452704STRING: ENSP00000345270
    MGAT5ENSP000002819234STRING: ENSP00000281923
    MGAT5BENSP000003912274STRING: ENSP00000391227
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006491N-glycan processing TAS10024668
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MGAT4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT4A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    2 HMDB Compounds for MGAT4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    1 Novoseek inferred chemical compound relationship for MGAT4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysaccharide 32.5 1 18309288 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT4A / MGT4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for MGAT4A gene (2 alternative transcripts): 
    NM_001160154.1  NM_012214.2  

    Unigene Cluster for MGAT4A:

    Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
    Hs.177576  [show with all ESTs]
    Unigene Representative Sequence: NM_012214
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264968 ENST00000409391 ENST00000492163 ENST00000461884(uc010fim.1)
    ENST00000484936 ENST00000460768 ENST00000495056 ENST00000414521(uc010yvm.2)
    ENST00000393487(uc002sze.3 uc010fil.3)
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    Additional mRNA sequence: 

    AB000616.1 AK092952.1 AK128366.1 AK291533.1 AK304393.1 AK309852.1 AK314024.1 BC031487.2 
    BC127107.1 BC127108.1 

    9 DOTS entries:

    DT.207365  DT.100717783  DT.408750  DT.91687283  DT.120936044  DT.433154  DT.120936049  DT.95148958 
    DT.91921358 

    24/381 AceView cDNA sequences (see all 381):

    AW052057 AA904940 BF593267 AL699814 BC031487 BM854981 AA910254 AI655609 
    AI016763 CR611133 CD251409 AI075116 BM976098 AA322013 BF058911 CB242453 
    N75443 BM053057 H14910 AI805668 CR599320 BX641585 AI888998 BM795260 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT4A expression in normal human tissues (normalized intensities)      MGAT4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTGAA
    MGAT4A Expression
    About this image


    MGAT4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood Pan-T Cells   
             cd8+ t cell   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood Pan-T Cells   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See MGAT4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT4A

    SOURCE GeneReport for Unigene cluster: Hs.177576

    UniProtKB/Swiss-Prot: MGT4A_HUMAN, Q9UM21
    Tissue specificity: Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes
    and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer

        SABiosciences Expression via Pathway-Focused PCR Array including MGAT4A: 
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MGAT4A gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat4a1 , 5 mannoside acetylglucosaminyltransferase 4, isoenzyme more1, 5 85.98(n)1
    93.64(a)1
      1 (15.46 cM)5
    2691811  NM_173870.21  NP_776295.11 
     374393405 
    chicken
    (Gallus gallus)
    Aves MGAT4A1 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, more 81.68(n)
    88.6(a)
      418692  NM_001012824.1  NP_001012842.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGAT4A6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    3(109102685-109141336)
    zebrafish
    (Danio rerio)
    Actinopterygii mgat4a1 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, more 70.94(n)
    78.11(a)
      563038  XM_686404.4  XP_691496.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93843 alpha-1,3-mannosylglycoprotein
    beta-1,4-N-acetylglucosaminyltransferase
    43(a)
    (best of 2)
      70F4   --


    ENSEMBL Gene Tree for MGAT4A (if available)
    TreeFam Gene Tree for MGAT4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT4A gene
    LOC1525862  LOC6415152  MGAT4C2  MGAT4B2  
    3 SIMAP similar genes for MGAT4A using alignment to 1 protein entry:     MGT4A_HUMAN:
    MGAT4B    LOC152586    MGAT4C

    MGAT4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1963 SNPs in MGAT4A are shown (see all 1963)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493145681,2
    Cuntested199310096(+) AGCCTC/TAGAGG 1 -- int10--------
    rs134097311,2
    C,F,H--99235561(+) AAAATA/GCTACT 2 -- ds50016Minor allele frequency- G:0.06NS NA WA 908
    rs791802111,2
    C,F--99235564(+) ATACTA/GCTCAT 2 -- ds50011Minor allele frequency- G:0.04EA 120
    rs1858401431,2
    --99235670(+) GAAACA/GGTGAT 2 -- ut310--------
    rs1903634671,2
    --99235899(+) CTAAGC/GGATGC 2 -- ut310--------
    rs1125175441,2
    C,F--99235960(+) GGACAG/CTTCAG 2 -- ut311Minor allele frequency- C:0.50CSA 2
    rs1502560201,2
    C--99235973(+) TTTCCA/GTTCCA 2 -- ut310--------
    rs1449392661,2
    C--99236021(+) AATCTA/TTCTTA 2 -- ut310--------
    rs1931797111,2
    --99236068(+) AAATCA/TACTGG 2 -- ut310--------
    rs1850475541,2
    --99236208(+) AAAAGG/TACCAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MGAT4A (99235569 - 99347589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MGAT4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2450775CNV Insertion19546169
    esv988416CNV Insertion20482838
    nsv2841CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604623OMIM information: 604119    
    10 diseases for MGAT4A:    About MalaCards
    bile duct carcinoma    choriocarcinoma    hepatoblastoma    bipolar disorder
    pancreatitis    renal cell carcinoma    pancreatic cancer    gastric cancer
    hepatocellular carcinoma    prostatitis


    MGAT4A for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MGAT4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 60.6 6 10463590 (3), 10571021 (2)
    tumors 0 1 15688387 (1)
    cancer 0 4 10463590 (1), 17006639 (1)

    Genetic Association Database (GAD): MGAT4A

    Export disorders for MGAT4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT4A gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with MGAT4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tissue specific expression and chromosomal mapping of a human UDP-N- acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N- acetylglucosaminyltransferase. (PubMed id 10024668)1, 2, 3 Yoshida A....Takeuchi M. (1999)
    2. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes. (PubMed id 17006639)1, 2, 9 Oguri S.... Takeuchi M. (2006)
    3. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. (PubMed id 16434023)1, 2, 9 Ide Y.... Taniguchi N. (2006)
    4. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)1, 4 Smith E.N....Kelsoe J.R. (2011)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain. (PubMed id 10463590)2, 9 Takamatsu S.... Kobata A. (1999)
    7. Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. (PubMed id 15688387)1, 9 D'Arrigo A....Lise M. (2005)
    8. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. (PubMed id 17488527)1, 9 Kudo T....Todo S. (2007)
    9. High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. (PubMed id 23169300)1 Niimi K....Kikkawa F. (2012)
    10. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11320 HGNC: 7047 AceView: MGAT4A Ensembl:ENSG00000071073 euGenes: HUgn11320
    ECgene: MGAT4A Kegg: 11320 H-InvDB: MGAT4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MGAT4A gene:
    Search GeneIP for patents involving MGAT4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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