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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT3 Gene

protein-coding   GIFtS: 56
GCID: GC22P039853

Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosyl (Beta-1,4-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase1 2
     GNT32 5
GNT-III2 3     Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase2
GlcNAc-T III2 3     EC 2.4.1.1443
N-Acetylglucosaminyltransferase III2 3     GGNT33
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase
III2 3
     

External Ids:    HGNC: 70461   Entrez Gene: 42482   Ensembl: ENSG000001282687   OMIM: 6046215   UniProtKB: Q093273   

Export aliases for MGAT3 gene to outside databases

Previous GC identifers: GC22P036467 GC22P038096 GC22P038177 GC22P038183 GC22P022847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGAT3 Gene:
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and
lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked
mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple
alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for MGAT3 Gene: 
MGAT3 (mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase) is a protein-coding gene. Diseases associated with MGAT3 include bile duct carcinoma, and hepatoblastoma, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
Function: It is involved in the regulation of the biosynthesis and biological function of glycoprotein
oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of
the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation
of the biosynthesis of glycoprotein oligosaccharides

Gene Wiki entry for MGAT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT3 gene promoter:
         Spz1   MAZR   AP-1   ATF-2   Nkx2-5   HEN1   PPAR-alpha   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MGAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039853:  view genomic region     (about GC identifiers)

Start:
39,853,325 bp from pter      End:
39,888,199 bp from pter
Size:
34,875 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327 (See protein sequence)
Recommended Name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase  
Size: 533 amino acids; 61313 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAA02937.1; Type=Erroneous initiation;
Secondary accessions: A6NGD0 Q14CK5 Q6IC49 Q9UH32

Explore the universe of human proteins at neXtProt for MGAT3: NX_Q09327

Explore proteomics data for MGAT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q09327

  • MGAT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MGAT3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091740.1  NP_002400.3  

    ENSEMBL proteins: 
     ENSP00000345270   ENSP00000416226   ENSP00000408075  
    Reactome Protein details: Q09327
    Human Recombinant Protein Products for MGAT3: 
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    Cloud-Clone Corp. Proteins for MGAT3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    MGAT3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006813 Glyco_trans_17

    Graphical View of Domain Structure for InterPro Entry Q09327

    ProtoNet protein and cluster: Q09327

    1 Blocks protein domain: IPB006813 Glycosyl transferase

    UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
    Similarity: Belongs to the glycosyltransferase 17 family


    MGAT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGAT3_HUMAN, Q09327
    Function: It is involved in the regulation of the biosynthesis and biological function of glycoprotein
    oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of
    the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation
    of the biosynthesis of glycoprotein oligosaccharides
    Catalytic activity: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP +
    4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT3:
    mannosyl (beta-1,4-) glycoprotein beta-1,4-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex
    Asn-linked (N) glycans

         Enzyme Number (IUBMB): EC 2.4.1.1441

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003830beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA--
         
    MGAT3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mgat3):
     cellular  homeostasis/metabolism  liver/biliary system  normal  tumorigenesis 

    MGAT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MGAT3: Mgat3tm1Jxm Mgat3tm1Pst

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MGAT3 
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    SwitchGear 3'UTR luciferase reporter plasmidMGAT3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MGAT3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40
    5Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MGAT3
        Stabilization and expansion of the E-cadherin adherens junction


    5/9        Reactome Pathways for MGAT3 (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Reactions specific to the hybrid N-glycan synthesis pathway
    N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification


    2         Kegg Pathways  (Kegg details for MGAT3):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
    Pathway: Protein modification; protein glycosylation


    MGAT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for MGAT3 (ENSP000003452704) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNA1ENSP000003046694STRING: ENSP00000304669
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    CTNND1ENSP000003820044STRING: ENSP00000382004
    FUT8ENSP000003539104STRING: ENSP00000353910
    MGAT2ENSP000003074234STRING: ENSP00000307423
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MGAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MGAT3

    2 HMDB Compounds for MGAT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--

    7 Novoseek inferred chemical compound relationships for MGAT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-d-mannoside 95.8 6 9199197 (1), 15189346 (1), 11486004 (1), 7499330 (1) (see all 6)
    n-acetylglucosamine 78.5 18 8893165 (2), 14707488 (1), 12427758 (1), 10640395 (1) (see all 13)
    polysaccharide 55.2 11 18778316 (2), 16435400 (1), 11501752 (1), 9715405 (1) (see all 7)
    mannose 50.5 8 14707488 (1), 8370666 (1), 8893165 (1), 7499330 (1) (see all 6)
    con a 45 1 8893165 (1)
    carbohydrates 30.8 1 7590346 (1)
    retinoic acid 10.4 3 10699467 (1), 10452822 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MGAT3 gene (2 alternative transcripts): 
    NM_001098270.1  NM_002409.4  

    Unigene Cluster for MGAT3:

    Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
    Hs.276808  [show with all ESTs]
    Unigene Representative Sequence: NM_002409
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341184(uc003axv.4) ENST00000429402 ENST00000418314

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    Additional mRNA sequence: 

    AK125361.1 AK313664.1 BC075025.2 BC075026.2 BC113383.1 BC113718.1 CR456519.1 D13789.1 
    L48489.1 

    4 DOTS entries:

    DT.110228  DT.120647328  DT.101978657  DT.75187087 

    24/116 AceView cDNA sequences (see all 116):

    BC075026 AK125361 AA421504 CB155629 BG683192 BM799578 BC075025 BM714558 
    AW501353 CA438617 AI090769 CD614755 BE675503 AI914746 AI953235 AI524129 
    BX114859 NM_002409 CB044643 CR456519 AI367012 BE466759 AI571173 AI439025 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MGAT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
    SP1:                              
    SP2:        -     -               


    ECgene alternative splicing isoforms for MGAT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT3 expression in normal human tissues (normalized intensities)      MGAT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGATCTTT
    MGAT3 Expression
    About this image


    MGAT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Intestine (Gastrointestinal Tract)
             ileum   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Spinal Cord (Nervous System)
             motor neurons   
     
     Ear (Sensory Organs)
             cochlea   
     
     Ovary (Reproductive System)

    See MGAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT3

    SOURCE GeneReport for Unigene cluster: Hs.276808
        SABiosciences Expression via Pathway-Focused PCR Array including MGAT3: 
              Glycosylation in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MGAT3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat31 , 5 mannoside acetylglucosaminyltransferase 31, 5 86.59(n)1
    93.42(a)1
      15 (37.85 cM)5
    173091  NM_010795.31  NP_034925.21 
     801737215 
    chicken
    (Gallus gallus)
    Aves MGAT31 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 82.44(n)
    89.72(a)
      418013  NM_001012693.1  NP_001012711.1 
    lizard
    (Anolis carolinensis)
    Reptilia MGAT36
    Uncharacterized protein
    87(a)
    1 ↔ 1
    5(24861022-24863521)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65332 Xenopus laevis transcribed sequence with moderate similarity more 76.42(n)    BG513330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cxcl12a2 chemokine (C-X-C motif) ligand 12a (stromal cell-derived more 74.99(n)    BQ480675.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG318496
    --
    22(a)
    1 ↔ 1
    2L(13180398-13182596)


    ENSEMBL Gene Tree for MGAT3 (if available)
    TreeFam Gene Tree for MGAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 SNPs in MGAT3 are shown (see all 772)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883533851,2
    --39851428(+) CAGGCG/TTGTGC 1 -- us2k10--------
    rs1406691131,2
    --39851518(+) CTTCTG/TATCCA 1 -- us2k10--------
    rs57576841,2
    C,F,A,H--39851584(+) CCATGA/GAGATG 1 -- us2k110Minor allele frequency- G:0.22NA WA CSA EA 372
    rs1458508581,2
    --39851621(+) AGGAAA/CTAGGA 1 -- us2k10--------
    rs1150380681,2
    C,F--39851681(+) GGACAC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1383255951,2
    --39851688(+) TGAAAA/GTGACA 1 -- us2k10--------
    rs1917035191,2
    --39851807(+) TTGGGA/GCAGAG 1 -- us2k10--------
    rs1181400521,2
    C,F--39851968(+) TGTGCC/GCCGCC 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs15575411,2
    C,F,A,H--39851970(+) TGCCCA/CGCCCA 1 -- us2k124Minor allele frequency- C:0.27MN NS EA NA WA CSA 2504
    rs1174181121,2
    C,F--39852024(+) GCAGGC/AAGGAG 1 -- us2k11Minor allele frequency- A:0.04EA 120

    HapMap Linkage Disequilibrium report for MGAT3 (39853325 - 39888199 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MGAT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667824CNV Deletion23128226
    nsv3628CNV Insertion18451855
    nsv915099CNV Loss21882294
    nsv834199CNV Loss17160897
    nsv915098CNV Loss21882294
    nsv471200CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604621    OMIM disorders: --

    17 diseases for MGAT3:    About MalaCards
    bile duct carcinoma    hepatoblastoma    liver cirrhosis    hepatitis b
    hepatocellular carcinoma    choriocarcinoma    renal cell carcinoma    myeloma
    hepatitis    neuroblastoma    obesity    alzheimer's disease
    colon cancer    endotheliitis    pancreatitis    ovarian cancer
    leukemia


    MGAT3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for MGAT3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 46.1 4 8137300 (3), 1373706 (1)
    hepatocellular carcinoma 38.4 6 10699467 (1), 14707488 (1), 11768033 (1), 9715405 (1) (see all 5)
    blast crisis 35.9 3 7829256 (2), 7496137 (1)
    liver cirrhosis 18 1 9715405 (1)
    hepatitis chronic 14.5 1 9715405 (1)
    metastasis 12.1 10 10571019 (3), 19262156 (1), 16940045 (1), 19403558 (1)
    myeloma 9.41 2 2386941 (1)
    cancer 2.01 9 10571019 (3), 15189346 (1), 9762355 (1), 15238704 (1) (see all 5)
    leukemia 1.99 4 7496137 (2), 14708522 (1)
    hepatitis b 0.577 7 8137300 (4), 15610311 (1), 7499330 (1)


    Export disorders for MGAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT3 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with MGAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression, and chromosomal localization of human N- acetylglucosaminyltransferase III (GnT-III). (PubMed id 8370666)1, 2, 3, 9 Ihara Y.... Taniguchi N. (1993)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. (PubMed id 19403558)1, 9 Pinho S.S....Seruca R. (2009)
    6. Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. (PubMed id 12716887)1, 9 Sasai K....Taniguchi N. (2003)
    7. Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. (PubMed id 12427758)1, 9 Shibukawa Y....Taniguchi N. (2003)
    8. Protective effect of N-glycan bisecting GlcNAc residu es on beta-amyloid production in Alzheimer's disease. (PubMed id 19776078)1, 9 Akasaka-Manya K....Endo T. (2010)
    9. Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. (PubMed id 14998999)1, 9 Isaji T....Taniguchi N. (2004)
    10. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. (PubMed id 19276077)1, 9 Sato Y....Gu J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4248 HGNC: 7046 AceView: MGAT3 Ensembl:ENSG00000128268 euGenes: HUgn4248
    ECgene: MGAT3 Kegg: 4248 H-InvDB: MGAT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_540

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MGAT3 gene:
    Search GeneIP for patents involving MGAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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