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Aliases for MGAT3 Gene

Aliases for MGAT3 Gene

  • Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase 2 3 5
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase III 3 4
  • N-Acetylglucosaminyltransferase III 3 4
  • GlcNAc-T III 3 4
  • GNT-III 3 4
  • Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase 3
  • EC 2.4.1.144 4
  • GGNT3 4
  • GNT3 3

External Ids for MGAT3 Gene

Previous GeneCards Identifiers for MGAT3 Gene

  • GC22P036467
  • GC22P038096
  • GC22P038177
  • GC22P038183
  • GC22P039853
  • GC22P022847

Summaries for MGAT3 Gene

Entrez Gene Summary for MGAT3 Gene

  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT3 Gene

MGAT3 (Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and N-glycan antennae elongation in the medial/trans-Golgi. GO annotations related to this gene include beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot for MGAT3 Gene

  • It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Gene Wiki entry for MGAT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT3 Gene

Genomics for MGAT3 Gene

Regulatory Elements for MGAT3 Gene

Enhancers for MGAT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F039462 1.6 FANTOM5 Ensembl ENCODE 27.1 +22.1 22058 14.5 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 ZNF143 ZNF207 SP5 ENSG00000272834 SNORD83B TAB1 ENSG00000228274 PRDX3P1 MGAT3 ENSG00000227413 CBY1 SYNGR1 SNORD83A
GH22F039500 1.1 ENCODE 19.9 +55.3 55254 3.8 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 SLC30A9 ATF4 MGAT3 RPS19BP1 MGAT3-AS1 GC22P039504 GC22P039507 GC22P039509 LOC105373035
GH22F039388 1.5 FANTOM5 Ensembl ENCODE 13.4 -58.3 -58318 1.7 HDAC1 ATF1 PKNOX1 DMAP1 KLF7 CREM EGR2 ZNF362 SP3 SP5 SYNGR1 MGAT3 RPL3 MIEF1 CACNA1I CBX7 APOBEC3G APOBEC3D GC22P039386 PIR49666
GH22F039404 1.4 FANTOM5 Ensembl ENCODE 11.3 -41.6 -41585 1.8 HDAC1 TBL1XR1 FEZF1 ZNF335 GATA2 ZNF302 EGR2 CEBPB ZNF488 TSHZ1 SYNGR1 MGAT3 RPL3 MIEF1 GC22M041396 TAB1
GH22F039488 1.2 Ensembl ENCODE 11.9 +42.6 42600 2.0 HDGF CREB3L1 ZNF76 ZBTB40 ETS1 YY1 ZNF143 FOS CREM KLF13 ATF4 MGAT3 CBY1 SYNGR1 GC22P039491 PIR38876 PIR45261
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGAT3 Gene

Chromosome:
22
Start:
39,447,182 bp from pter
End:
39,492,194 bp from pter
Size:
45,013 bases
Orientation:
Plus strand

Genomic View for MGAT3 Gene

Genes around MGAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT3 Gene

Proteins for MGAT3 Gene

  • Protein details for MGAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09327-MGAT3_HUMAN
    Recommended name:
    Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
    Protein Accession:
    Q09327
    Secondary Accessions:
    • A6NGD0
    • Q14CK5
    • Q6IC49
    • Q9UH32

    Protein attributes for MGAT3 Gene

    Size:
    533 amino acids
    Molecular mass:
    61313 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MGAT3 Gene

Post-translational modifications for MGAT3 Gene

  • Glycosylation at Asn 141, Asn 241, Asn 259, and Asn 397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MGAT3 Gene

Domains & Families for MGAT3 Gene

Protein Domains for MGAT3 Gene

Suggested Antigen Peptide Sequences for MGAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q09327

UniProtKB/Swiss-Prot:

MGAT3_HUMAN :
  • Belongs to the glycosyltransferase 17 family.
Family:
  • Belongs to the glycosyltransferase 17 family.
genes like me logo Genes that share domains with MGAT3: view

Function for MGAT3 Gene

Molecular function for MGAT3 Gene

GENATLAS Biochemistry:
mannosyl (beta-1,4-) glycoprotein beta-1,4-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Enzyme Numbers (IUBMB) for MGAT3 Gene

Gene Ontology (GO) - Molecular Function for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA,TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with MGAT3: view
genes like me logo Genes that share phenotypes with MGAT3: view

Animal Models for MGAT3 Gene

MGI Knock Outs for MGAT3:

Animal Model Products

miRNA for MGAT3 Gene

miRTarBase miRNAs that target MGAT3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT3 Gene

Localization for MGAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGAT3 gene
Compartment Confidence
golgi apparatus 5
lysosome 2
extracellular 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGAT3: view

Pathways & Interactions for MGAT3 Gene

genes like me logo Genes that share pathways with MGAT3: view

UniProtKB/Swiss-Prot Q09327-MGAT3_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation IEA --
genes like me logo Genes that share ontologies with MGAT3: view

No data available for SIGNOR curated interactions for MGAT3 Gene

Drugs & Compounds for MGAT3 Gene

(1) Drugs for MGAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(8) Additional Compounds for MGAT3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with MGAT3: view

Transcripts for MGAT3 Gene

Unigene Clusters for MGAT3 Gene

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: - -

Relevant External Links for MGAT3 Gene

GeneLoc Exon Structure for
MGAT3
ECgene alternative splicing isoforms for
MGAT3

Expression for MGAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT3 Gene

This gene is overexpressed in Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for MGAT3 Gene

This gene is overexpressed in Heart (58.9) and Pancreas (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MGAT3 Gene



Protein tissue co-expression partners for MGAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MGAT3 Gene:

MGAT3

SOURCE GeneReport for Unigene cluster for MGAT3 Gene:

Hs.276808
genes like me logo Genes that share expression patterns with MGAT3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MGAT3 Gene

Orthologs for MGAT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT3 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia MGAT3 34 35
  • 92.54 (n)
cow
(Bos Taurus)
Mammalia MGAT3 34 35
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Mgat3 34 16 35
  • 86.59 (n)
rat
(Rattus norvegicus)
Mammalia Mgat3 34
  • 86.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT3 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT3 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGAT3 34 35
  • 82.44 (n)
lizard
(Anolis carolinensis)
Reptilia MGAT3 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat3 34
  • 66.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6533 34
zebrafish
(Danio rerio)
Actinopterygii LOC570828 34
  • 66.08 (n)
CABZ01084569.1 35
  • 66 (a)
OneToMany
mgat3a 35
  • 55 (a)
OneToMany
cxcl12a 34
fruit fly
(Drosophila melanogaster)
Insecta CG31849 35
  • 22 (a)
OneToOne
Species where no ortholog for MGAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT3 Gene

ENSEMBL:
Gene Tree for MGAT3 (if available)
TreeFam:
Gene Tree for MGAT3 (if available)

Paralogs for MGAT3 Gene

No data available for Paralogs for MGAT3 Gene

Variants for MGAT3 Gene

Sequence variations from dbSNP and Humsavar for MGAT3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1003538 -- 39,476,702(+) TTTCC(A/G)TCTGT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1005522 -- 39,449,893(+) CCTGG(A/C)CCTCA intron-variant
rs111240108 -- 39,477,502(+) ATTCA(A/C/G)GGGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111242127 -- 39,465,533(+) TCACC(C/T)GTCAG intron-variant, upstream-variant-2KB
rs111475792 -- 39,450,324(+) CTGGG(C/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT3 Gene

Variant ID Type Subtype PubMed ID
nsv955158 CNV deletion 24416366
nsv834199 CNV loss 17160897
nsv471200 CNV loss 18288195
nsv3628 CNV insertion 18451855
nsv1144973 CNV deletion 24896259
nsv1072211 CNV deletion 25765185
esv3647766 CNV loss 21293372
esv3647765 CNV loss 21293372
esv2667824 CNV deletion 23128226

Variation tolerance for MGAT3 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT3 Gene

Disorders for MGAT3 Gene

Relevant External Links for MGAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT3

No disorders were found for MGAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGAT3 Gene

Publications for MGAT3 Gene

  1. cDNA cloning, expression, and chromosomal localization of human N- acetylglucosaminyltransferase III (GnT-III). (PMID: 8370666) Ihara Y. … Taniguchi N. (J. Biochem. 1993) 2 3 4 22 64
  2. Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease. (PMID: 19776078) Akasaka-Manya K. … Endo T. (Glycobiology 2010) 3 22 64
  3. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. (PMID: 19276077) Sato Y. … Gu J. (J. Biol. Chem. 2009) 3 22 64
  4. The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. (PMID: 19403558) Pinho S.S. … Seruca R. (Hum. Mol. Genet. 2009) 3 22 64
  5. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. (PMID: 17652175) Fiala M. … Cashman J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 22 64

Products for MGAT3 Gene

Sources for MGAT3 Gene

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