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Aliases for MGAT3 Gene

Aliases for MGAT3 Gene

  • Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase 2 3
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase III 3 4
  • N-Acetylglucosaminyltransferase III 3 4
  • GlcNAc-T III 3 4
  • GNT-III 3 4
  • EC 2.4.1.144 4
  • GGNT3 4
  • GNT3 3

External Ids for MGAT3 Gene

Previous GeneCards Identifiers for MGAT3 Gene

  • GC22P036467
  • GC22P038096
  • GC22P038177
  • GC22P038183
  • GC22P039853
  • GC22P022847

Summaries for MGAT3 Gene

Entrez Gene Summary for MGAT3 Gene

  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT3 Gene

MGAT3 (Mannosyl (Beta-1,4-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity.

UniProtKB/Swiss-Prot for MGAT3 Gene

  • It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides

Gene Wiki entry for MGAT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT3 Gene

Genomics for MGAT3 Gene

Regulatory Elements for MGAT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGAT3 Gene

Chromosome:
22
Start:
39,447,182 bp from pter
End:
39,492,194 bp from pter
Size:
45,013 bases
Orientation:
Plus strand

Genomic View for MGAT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT3 Gene

Proteins for MGAT3 Gene

  • Protein details for MGAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q09327-MGAT3_HUMAN
    Recommended name:
    Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
    Protein Accession:
    Q09327
    Secondary Accessions:
    • A6NGD0
    • Q14CK5
    • Q6IC49
    • Q9UH32

    Protein attributes for MGAT3 Gene

    Size:
    533 amino acids
    Molecular mass:
    61313 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MGAT3 Gene

Proteomics data for MGAT3 Gene at MOPED

Post-translational modifications for MGAT3 Gene

  • Glycosylation at Asn 141, Asn 241, Asn 259, and Asn 397
  • Modification sites at PhosphoSitePlus

Other Protein References for MGAT3 Gene

Antibody Products

No data available for DME Specific Peptides for MGAT3 Gene

Domains & Families for MGAT3 Gene

Protein Domains for MGAT3 Gene

Suggested Antigen Peptide Sequences for MGAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q09327

UniProtKB/Swiss-Prot:

MGAT3_HUMAN :
  • Belongs to the glycosyltransferase 17 family.
Family:
  • Belongs to the glycosyltransferase 17 family.
genes like me logo Genes that share domains with MGAT3: view

Function for MGAT3 Gene

Molecular function for MGAT3 Gene

GENATLAS Biochemistry:
mannosyl (beta-1,4-) glycoprotein beta-1,4-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function:
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides

Enzyme Numbers (IUBMB) for MGAT3 Gene

Gene Ontology (GO) - Molecular Function for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with MGAT3: view

Phenotypes for MGAT3 Gene

genes like me logo Genes that share phenotypes with MGAT3: view

Animal Models for MGAT3 Gene

MGI Knock Outs for MGAT3:

Animal Model Products

miRNA for MGAT3 Gene

miRTarBase miRNAs that target MGAT3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MGAT3 Gene

Localization for MGAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT3 Gene COMPARTMENTS Subcellular localization image for MGAT3 gene
Compartment Confidence
golgi apparatus 5
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGAT3: view

Pathways & Interactions for MGAT3 Gene

genes like me logo Genes that share pathways with MGAT3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q09327-MGAT3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT3 Gene

Gene Ontology (GO) - Biological Process for MGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MGAT3: view

No data available for SIGNOR curated interactions for MGAT3 Gene

Drugs & Compounds for MGAT3 Gene

(1) Drugs for MGAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0

(8) Additional Compounds for MGAT3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
beta-D-Mannoside
Carbohydrates
CON A
mannose
genes like me logo Genes that share compounds with MGAT3: view

Transcripts for MGAT3 Gene

Unigene Clusters for MGAT3 Gene

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: - -

Relevant External Links for MGAT3 Gene

GeneLoc Exon Structure for
MGAT3
ECgene alternative splicing isoforms for
MGAT3

Expression for MGAT3 Gene

mRNA expression in normal human tissues for MGAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT3 Gene

This gene is overexpressed in Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for MGAT3 Gene

This gene is overexpressed in Heart (58.9) and Pancreas (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MGAT3 Gene



SOURCE GeneReport for Unigene cluster for MGAT3 Gene Hs.276808

genes like me logo Genes that share expression patterns with MGAT3: view

Protein tissue co-expression partners for MGAT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MGAT3 Gene

Orthologs for MGAT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGAT3 35
  • 90.91 (n)
  • 94.17 (a)
MGAT3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT3 35
  • 92.54 (n)
  • 94.55 (a)
MGAT3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat3 35
  • 86.59 (n)
  • 93.42 (a)
Mgat3 16
Mgat3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGAT3 35
  • 99.31 (n)
  • 99.44 (a)
MGAT3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat3 35
  • 86.59 (n)
  • 93.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MGAT3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGAT3 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGAT3 35
  • 82.44 (n)
  • 89.72 (a)
MGAT3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat3 35
  • 66.26 (n)
  • 73.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6533 35
zebrafish
(Danio rerio)
Actinopterygii cxcl12a 35
LOC570828 35
  • 66.08 (n)
  • 65.05 (a)
CABZ01084569.1 36
  • 66 (a)
OneToMany
mgat3a 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31849 36
  • 22 (a)
OneToOne
Species with no ortholog for MGAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGAT3 Gene

ENSEMBL:
Gene Tree for MGAT3 (if available)
TreeFam:
Gene Tree for MGAT3 (if available)

Paralogs for MGAT3 Gene

No data available for Paralogs for MGAT3 Gene

Variants for MGAT3 Gene

Sequence variations from dbSNP and Humsavar for MGAT3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738285 -- 39,460,351(+) ACCTA(C/G)CCCTG intron-variant
rs738286 -- 39,459,570(+) gggat(A/C)cttct intron-variant
rs738287 -- 39,459,723(+) TCTAT(C/G)TCCCA intron-variant
rs738289 -- 39,459,878(+) GAAAA(C/T)GAGGA intron-variant
rs738290 -- 39,460,027(+) ACATA(A/C)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT3 Gene

Variant ID Type Subtype PubMed ID
nsv834199 CNV Loss 17160897
nsv915098 CNV Loss 21882294
nsv915099 CNV Loss 21882294
nsv471200 CNV Loss 18288195
nsv3628 CNV Insertion 18451855
esv2667824 CNV Deletion 23128226

Variation tolerance for MGAT3 Gene

Residual Variation Intolerance Score: 52.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT3 Gene

HapMap Linkage Disequilibrium report
MGAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT3 Gene

Disorders for MGAT3 Gene

Relevant External Links for MGAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT3
genes like me logo Genes that share disorders with MGAT3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGAT3 Gene

Publications for MGAT3 Gene

  1. cDNA cloning, expression, and chromosomal localization of human N- acetylglucosaminyltransferase III (GnT-III). (PMID: 8370666) Ihara Y. … Taniguchi N. (J. Biochem. 1993) 2 23 67
  2. Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility. (PMID: 19940114) Kariya Y. … Gu J. (J. Biol. Chem. 2010) 23 67
  3. Survey of glycoantigens in cells from alpha1-3galactosyltransferase knockout pig using a lectin microarray. (PMID: 20149189) Miyagawa S. … Nagashima H. (Xenotransplantation 2010) 23 67
  4. Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease. (PMID: 19776078) Akasaka-Manya K. … Endo T. (Glycobiology 2010) 23 67
  5. A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions. (PMID: 19053837) Gu J. … Fukuda T. (J. Proteome Res. 2009) 23 67

Products for MGAT3 Gene

Sources for MGAT3 Gene

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