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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT3 Gene

protein-coding   GIFtS: 56
GCID: GC22P039853

mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
 Explore 20 diseases affiliated with
MGAT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MGAT3    

Aliases
for MGAT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mannosyl (Beta-1,4-)-Glycoprotein
Beta-1,4-N-Acetylglucosaminyltransferase1 2
     GNT32 5
GNT-III1 2 3     Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase2
GlcNAc-T III2 3     EC 2.4.1.1443
N-Acetylglucosaminyltransferase III2 3     GGNT33
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase III2 3     

External Ids:    HGNC: 70461   Entrez Gene: 42482   Ensembl: ENSG000001282687   OMIM: 6046215   UniProtKB: Q093273   

Export aliases for MGAT3 gene to outside databases

Previous GC identifers: GC22P036467 GC22P038096 GC22P038177 GC22P038183 GC22P022847


Summaries
for MGAT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGAT3:
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and
lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of
the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced
variants, encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
Function: It is involved in the regulation of the biosynthesis and biological function of glycoprotein
oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the
trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the
biosynthesis of glycoprotein oligosaccharides

Gene Wiki entry for MGAT3


Genomic Views
for MGAT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT3 gene promoter:
         Spz1   MAZR   AP-1   ATF-2   Nkx2-5   HEN1   PPAR-alpha   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MGAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039853:  view genomic region     (about GC identifiers)

Start:
 39,853,325 bp from pter      End:
 39,888,199 bp from pter
Size:
 34,875 bases      Orientation:
 plus strand

Proteins
for MGAT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327 (See protein sequence)
Recommended Name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase  
Size: 533 amino acids; 61313 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAA02937.1; Type=Erroneous initiation;
Secondary accessions: A6NGD0 Q14CK5 Q6IC49 Q9UH32

Explore the universe of human proteins at neXtProt for MGAT3: NX_Q09327

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q09327

    • MGAT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091740.1  NP_002400.3  

    ENSEMBL proteins: 
     ENSP00000345270   ENSP00000416226   ENSP00000408075  
    Reactome Protein details: Q09327
    Human Recombinant Protein Products: 
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    Novus Biologicals MGAT3 Proteins
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    Uscn Proteins for MGAT3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    MGAT3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MGAT3

    Protein Domains /
    Families
    for MGAT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGAT3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006813 Glyco_trans_17

    Graphical View of Domain Structure for InterPro Entry Q09327

    ProtoNet protein and cluster: Q09327

    1 Blocks protein family: IPB006813 Glycosyl transferase

    UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
    Similarity: Belongs to the glycosyltransferase 17 family


    Function
    for MGAT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
    Function: It is involved in the regulation of the biosynthesis and biological function of glycoprotein
    oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the
    trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the
    biosynthesis of glycoprotein oligosaccharides
    Catalytic activity: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP +
    4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT3:
    mannosyl (beta-1,4-) glycoprotein beta-1,4-N-acetylglucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N)
    glycans

    Enzyme Number (IUBMB): EC 2.4.1.1441

    miRNA
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    hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-429 hsa-let-7d hsa-miR-502-3p hsa-let-7g hsa-let-7a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: MGAT3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003830beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA--


    MGAT3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MGAT3: Mgat3tm1Jxm Mgat3tm1Pst
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mgat3):
     cellular  homeostasis/metabolism  liver/biliary system  normal  tumorigenesis 

    MGAT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MGAT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    3Reactions specific to the hybrid N-glycan synthesis pathway
    		Reactions specific to the hybrid N-glycan synthesis pathway1.00
    4Stabilization and expansion of the E-cadherin adherens junction
    		Stabilization and expansion of the E-cadherin adherens junction1.00
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MGAT3 
        Stabilization and expansion of the E-cadherin adherens junction

    5/6        Reactome Pathways for MGAT3 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for MGAT3):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGAT3_HUMAN, Q09327
    Pathway: Protein modification; protein glycosylation


    MGAT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for MGAT3 (ENSP000003452704) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNA1ENSP000003046694STRING: ENSP00000304669
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    CTNND1ENSP000003820044STRING: ENSP00000382004
    FUT8ENSP000003539104STRING: ENSP00000353910
    MGAT2ENSP000003074234STRING: ENSP00000307423
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation ----
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MGAT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGAT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MGAT3

    2 HMDB Compounds for MGAT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--
    7 Novoseek chemical compound relationships for MGAT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-d-mannoside 95.8 6 9199197 (1), 15189346 (1), 11486004 (1), 7499330 (1) (see all 6)
    n-acetylglucosamine 78.5 18 8893165 (2), 14707488 (1), 12427758 (1), 10640395 (1) (see all 13)
    polysaccharide 55.2 11 18778316 (2), 16435400 (1), 11501752 (1), 9715405 (1) (see all 7)
    mannose 50.5 8 14707488 (1), 8370666 (1), 8893165 (1), 7499330 (1) (see all 6)
    con a 45 1 8893165 (1)
    carbohydrates 30.8 1 7590346 (1)
    retinoic acid 10.4 3 10699467 (1), 10452822 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT3 

    Transcripts
    for MGAT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGAT3 gene (2 alternative transcripts): 
    NM_001098270.1  NM_002409.4  

    Unigene Cluster for MGAT3:

    Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
    Hs.276808  [show with all ESTs]
    Unigene Representative Sequence: NM_002409
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341184(uc003axv.4) ENST00000429402 ENST00000418314

    miRNA
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    hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-429 hsa-let-7d hsa-miR-502-3p hsa-let-7g hsa-let-7a hsa-miR-889
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK125361.1 AK313664.1 BC075025.2 BC075026.2 BC113383.1 BC113718.1 CR456519.1 D13789.1 
    L48489.1 

    4 DOTS entries:

    DT.110228  DT.120647328  DT.101978657  DT.75187087 

    24/116 AceView cDNA sequences (see all 116):

    BM676981 AK125361 AI571173 BC075025 CA438617 BE466759 AI524129 AI914746 
    NM_002409 BE675503 AI367012 CB155629 BM799578 AA421504 AI439025 AI090769 
    BC075026 AA876086 AA345131 AI075278 CB044643 BM714558 CD614755 BG683192 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MGAT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
    SP1:                              
    SP2:        -     -               


    ECgene alternative splicing isoforms for MGAT3

    Expression
    for MGAT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGATCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MGAT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MGAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT3

    SOURCE GeneReport for Unigene cluster: Hs.276808
        SABiosciences Expression via Pathway-Focused PCR Array including MGAT3: 
              Glycosylation in human mouse rat

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    In Situ
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    Orthologs
    for MGAT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGAT3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mgat31 , 5 mannoside acetylglucosaminyltransferase 31, 5 86.59(n)1
    93.42(a)1    		   15 (37.85 cM)5
    173091  NM_010795.31  NP_034925.21 
     801737215 
    chicken
    (Gallus gallus)    		 Aves MGAT31 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 82.44(n)
    89.72(a)    		   418013  NM_001012693.1  NP_001012711.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MGAT36
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(24862016-24863509)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.65332 Xenopus laevis transcribed sequence with moderate similarity more 76.42(n)    BG513330.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cxcl12a2 chemokine (C-X-C motif) ligand 12a (stromal cell-derived more 74.99(n)    BQ480675.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG318496
    		 --
    		 18(a)
    		 1 ↔ 1
    		 2L(13180398-13182596)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G144806
    AT3G275406
    (see all 7)    		 beta-1,4-mannosyl-glycoprotein
    (see all 7)    		 25(a)
    25(a)
    (see all 7)    		 many → 1
    many → 1
    (see all 7)    		 5(4667774-4670106)
    3(10205308-10207306)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 glycosyl transferase family 17 protein, putative, ...
    glycosyl transferase family 17 protein, putative, ...
    (see all 4)    		 25(a)
    24(a)
    (see all 4)    		 many → 1
    many → 1
    (see all 4)    		 4(23707541-23711334)
    2(23077237-23080573)


    ENSEMBL Gene Tree for MGAT3 (if available)
    TreeFam Gene Tree for MGAT3 (if available) 

    Paralogs
    for MGAT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MGAT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 NCBI SNPs in MGAT3 are shown (see all 646)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1883533851,2
    		--39851428(+) CAGGCG/TTGTGC 1 -- us2k10--------
    rs1406691131,2
    		--39851518(+) CTTCTG/TATCCA 1 -- us2k10--------
    rs57576841,2
    		C,F,A,H,--39851584(+) CCATGA/GAGATG 1 -- us2k110Minor allele frequency- G:0.22NA WA CSA EA 372
    rs1458508581,2
    		--39851621(+) AGGAAA/CTAGGA 1 -- us2k10--------
    rs1150380681,2
    		F,--39851681(+) GGACAC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1383255951,2
    		--39851688(+) TGAAAA/GTGACA 1 -- us2k10--------
    rs1917035191,2
    		--39851807(+) TTGGGA/GCAGAG 1 -- us2k10--------
    rs1181400521,2
    		F,--39851968(+) TGTGCC/GCCGCC 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs15575411,2
    		C,F,A,H,--39851970(+) TGCCCA/CGCCCA 1 -- us2k124Minor allele frequency- C:0.27MN NS EA NA WA CSA 2504
    rs1174181121,2
    		F,--39852024(+) GCAGGC/AAGGAG 1 -- us2k11Minor allele frequency- A:0.04EA 120

    HapMap Linkage Disequilibrium report for MGAT3 (39853325 - 39888199 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MGAT3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGAT3
    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT3

    Disorders / Diseases
    for MGAT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGAT3 for disorders           About GeneDecksing

    OMIM gene information: 604621    OMIM disorders: --

    20 diseases for MGAT3:    About MalaCards
    bile duct carcinoma    liver cirrhosis    hepatitis b    hepatoblastoma
    renal cell carcinoma    hepatocellular carcinoma    vaginitis    myeloma
    carcinoma    choriocarcinoma    hepatitis    alzheimer's disease
    pancreatic carcinoma    colon cancer    ovarian cancer    pancreatitis
    obesity    leukemia    neuroblastoma    extrahepatic bile duct carcinoma

    10/12 Novoseek disease relationships for MGAT3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 46.1 4 8137300 (3), 1373706 (1)
    hepatocellular carcinoma 38.4 6 10699467 (1), 14707488 (1), 11768033 (1), 9715405 (1) (see all 5)
    blast crisis 35.9 3 7829256 (2), 7496137 (1)
    liver cirrhosis 18 1 9715405 (1)
    hepatitis chronic 14.5 1 9715405 (1)
    metastasis 12.1 10 10571019 (3), 19262156 (1), 16940045 (1), 19403558 (1)
    myeloma 9.41 2 2386941 (1)
    cancer 2.01 9 10571019 (3), 15189346 (1), 9762355 (1), 15238704 (1) (see all 5)
    leukemia 1.99 4 7496137 (2), 14708522 (1)
    hepatitis b 0.577 7 8137300 (4), 15610311 (1), 7499330 (1)


    Export disorders for MGAT3 gene to outside databases

    Publications
    for MGAT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT3 gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with MGAT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression, and chromosomal localization of human N- acetylglucosaminyltransferase III (GnT-III). (PubMed id 8370666)1, 2, 3, 9 Ihara Y.... Taniguchi N. (1993)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. (PubMed id 19403558)1, 9 Pinho S.S....Seruca R. (2009)
    6. Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. (PubMed id 12716887)1, 9 Sasai K....Taniguchi N. (2003)
    7. Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. (PubMed id 12427758)1, 9 Shibukawa Y....Taniguchi N. (2003)
    8. Protective effect of N-glycan bisecting GlcNAc residu es on beta-amyloid production in Alzheimer's disease. (PubMed id 19776078)1, 9 Akasaka-Manya K....Endo T. (2010)
    9. Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. (PubMed id 14998999)1, 9 Isaji T....Taniguchi N. (2004)
    10. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. (PubMed id 19276077)1, 9 Sato Y....Gu J. (2009)

    External Searches for MGAT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing MGAT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4248 HGNC: 7046 AceView: MGAT3 Ensembl:ENSG00000128268 euGenes: HUgn4248
    ECgene: MGAT3 Kegg: 4248 H-InvDB: MGAT3

    Other Databases showing MGAT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGAT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_540

    Intellectual Property
    for MGAT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGAT3 gene:
    Search GeneIP for patents involving MGAT3

    GeneCards and IP:
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