Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MGAT2 Gene

protein-coding   GIFtS: 61
GCID: GC14P050087

mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
 Explore 8 diseases affiliated with
MGAT2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MGAT2    

Aliases
for MGAT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mannosyl (Alpha-1,6-)-Glycoprotein
Beta-1,2-N-Acetylglucosaminyltransferase1 2
     CDG2A2 5
GNT-II1 2 3     CDGS22 5
GlcNAc-T II2 3     GLCNACTII2
Mannoside Acetylglucosaminyltransferase 22 3     GNT22
Beta-1,2-N-Acetylglucosaminyltransferase II2 3     Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase2
N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase II2 3     UDP-N-Acetylglucosamine:Alpha-6-D-Mannoside
Beta-1,2-N-Acetylglucosaminyltransferase II2
EC 2.4.1.1433 8     

External Ids:    HGNC: 70451   Entrez Gene: 42472   Ensembl: ENSG000001682827   OMIM: 6026165   UniProtKB: Q104693   

Export aliases for MGAT2 gene to outside databases

Previous GC identifers: GC14P047409 GC14P043883 GC14P048077 GC14P049157 GC14P030204


Summaries
for MGAT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MGAT2:
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex
N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a
hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to
carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript
variants with a spliced 5' UTR may exist, but their biological validity has not been determined. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: MGAT2_HUMAN, Q10469
Function: Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans

Gene Wiki entry for MGAT2


Genomic Views
for MGAT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MGAT2 gene promoter:
         TBP   Elk-1   Pax-5   LCR-F1   C/EBPalpha   CREB   NRF-2   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MGAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MGAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21

MGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P050087:  view genomic region     (about GC identifiers)

Start:
 50,087,489 bp from pter      End:
 50,090,199 bp from pter
Size:
 2,711 bases      Orientation:
 plus strand

Proteins
for MGAT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MGAT2_HUMAN, Q10469 (See protein sequence)
Recommended Name: Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase  
Size: 447 amino acids; 51550 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Secondary accessions: B3KPC5

Explore the universe of human proteins at neXtProt for MGAT2: NX_Q10469

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q10469

    • 3 DME Specific Peptides for MGAT2 (Q10469)
     DPRDCPRDL  APDFYHVFKKMW  ADKVDVKTWKSTEHNMGLALTR 

    MGAT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002399.1  
    ENSEMBL proteins: 
     ENSP00000307423  
    Reactome Protein details: Q10469
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): MGAT2
    OriGene Custom Protein Services for MGAT2 
    GenScript Custom Purified and Recombinant Proteins Services for MGAT2
    Novus Biologicals MGAT2 Protein
    Novus Biologicals MGAT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MGAT2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005624membrane fraction ----
    GO:0005795Golgi stack IEA--
    GO:0016020membrane TAS7797505
    GO:0016021integral to membrane IEA--


    MGAT2 for ontologies           About GeneDecksing



    MGAT2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MGAT2 
    GenScript Custom Superior Antibodies Services for MGAT2
    Novus Biologicals MGAT2 Antibodies
    Search for Antibodies for MGAT2 at Abcam  
    Uscn Antibodies for MGAT2
    Search ThermoFisher Antibodies for MGAT2

    Assay Products for MGAT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MGAT2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MGAT2

    Protein Domains /
    Families
    for MGAT2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MGAT2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007754 GlcNAc_II

    Graphical View of Domain Structure for InterPro Entry Q10469

    ProtoNet protein and cluster: Q10469

    1 Blocks protein family: IPB007754 N-acetylglucosaminyltransferase II


    Function
    for MGAT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MGAT2_HUMAN, Q10469
    Function: Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT2:
    mannosyl (alpha-1,6-) glycoprotein beta -1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked
    (N) glycans

    Enzyme Number (IUBMB): EC 2.4.1.1431 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MGAT2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGAT2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MGAT2 (see all 14):
    hsa-miR-374b* hsa-miR-3671 hsa-miR-577 hsa-miR-495 hsa-miR-429 hsa-miR-496 hsa-miR-491-3p hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MGAT2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGAT2 (see all 7)
    OriGene shRNA RFP: MGAT2
    OriGene siRNA: MGAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MGAT2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MGAT2 (NM_002408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MGAT2
    Search LifeMap BioReagents cell lines for MGAT2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008455alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0030246carbohydrate binding IEA--


    MGAT2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MGAT2:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Mgat2tm1.1Jxm for MGAT2
         15/17 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mgat2) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  no phenotypic analysis  renal/urinary system 

    MGAT2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MGAT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    3Reactions specific to the complex N-glycan synthesis pathway
    		Reactions specific to the complex N-glycan synthesis pathway1.00
    4Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for MGAT2 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Reactions specific to the complex N-glycan synthesis pathway
    Asparagine N-linked glycosylation
    Metabolism of proteins


    2         Kegg Pathways  (Kegg details for MGAT2):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGAT2_HUMAN, Q10469
    Pathway: Protein modification; protein glycosylation


    MGAT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for MGAT2 (ENSP000003074234) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUT8ENSP000003539104STRING: ENSP00000353910
    MAN2A1ENSP000002614834STRING: ENSP00000261483
    MAN2A2ENSP000003536554STRING: ENSP00000353655
    MGAT3ENSP000003452704STRING: ENSP00000345270
    MGAT4AENSP000002649684STRING: ENSP00000264968
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation TAS7635144
    GO:0009311oligosaccharide metabolic process TAS7635144
    GO:0009312oligosaccharide biosynthetic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--


    MGAT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MGAT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MGAT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MGAT2

    2 HMDB Compounds for MGAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylglucosamineN-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide (see all 30)528-04-1--
    2 Novoseek chemical compound relationships for MGAT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysaccharide 57.6 6 12417409 (1), 9579808 (1), 10571011 (1), 8808595 (1) (see all 5)
    mannose 41.7 1 7797505 (1)

    Search CenterWatch for drugs/clinical trials and news about MGAT2 

    Transcripts
    for MGAT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MGAT2 gene (2 alternative transcripts): 
    NM_002408.3  NM_001015883.1  

    Unigene Cluster for MGAT2:

    Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    Hs.93338  [show with all ESTs]
    Unigene Representative Sequence: NM_002408
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305386(uc001wwr.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MGAT2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MGAT2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MGAT2 (see all 14):
    hsa-miR-374b* hsa-miR-3671 hsa-miR-577 hsa-miR-495 hsa-miR-429 hsa-miR-496 hsa-miR-491-3p hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MGAT2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGAT2 (see all 7)
    OriGene shRNA RFP: MGAT2
    OriGene siRNA: MGAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MGAT2 (NM_002408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MGAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGAT2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGAT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT2

    Additional cDNA sequence: 

    AK056167.1 AK075051.1 AK075199.1 AK293231.1 BC006390.2 BC018912.2 

    8 DOTS entries:

    DT.417467  DT.97801629  DT.102824166  DT.95280094  DT.120729906  DT.120730041  DT.95280092  DT.87046992 

    24/149 AceView cDNA sequences (see all 149):

    NM_002408 BP380227 AI343517 BF002289 AI264638 CK819492 CB143376 AI138634 
    CK819491 BQ011809 AI342414 AI927456 BC006390 AI344112 BI764270 BM838604 
    BC018912 BU072944 AW450719 AI087857 AI739101 AI566907 CB125715 AI216315 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MGAT2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for MGAT2

    Expression
    for MGAT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MGAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTCTGTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MGAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MGAT2

    SOURCE GeneReport for Unigene cluster: Hs.93338
        SABiosciences Expression via Pathway-Focused PCR Arrays including MGAT2: 
              Glycosylation in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGAT2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGAT2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT2

    Orthologs
    for MGAT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGAT2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mgat21 , 5 mannoside acetylglucosaminyltransferase 21, 5 88.16(n)1
    89.59(a)1    		   12 (28.73 cM)5
    2176641  NM_146035.21  NP_666147.11 
     691841575 
    chicken
    (Gallus gallus)    		 Aves LOC4289251 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase-like 70.36(n)
    75.41(a)    		   428925  XM_003641449.1  XP_003641497.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.64032 Xenopus laevis transcribed sequence with moderate similarity more 76.51(n)    48020624 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.145472 Transcribed sequence with moderate similarity to protein more 78(n)    BI673989.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mgat21 , 3 terminal N-glycosylation
    alpha-1,6-mannosylglycoprotein
    more3
    CG7921-PA1    		 44(a)3
    51.51(n)1
    44.41(a)1    		   99D13
    435631  NM_143506.31  NP_651763.41 
    worm
    (Caenorhabditis elegans)    		 Secernentea C03E10.43
    gly-201    		 UDP-GlcNAc:a-6-D-mannoside
    b1,2-N-acetylglucosaminyltransferase more3
    Protein GLY-201    		 35(a)3
    46.74(n)1
    36.98(a)1    		   V(11285248-11288301)3
    1795621  NM_073463.51  NP_505864.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G053206
    		 beta-1,2-N-acetylglucosaminyltransferase II
    		 24(a)
    		 1 ↔ 1
    		 2(1936016-1937464)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglu...
    		 27(a)
    		 1 ↔ 1
    		 2(33965501-33966817)


    ENSEMBL Gene Tree for MGAT2 (if available)
    TreeFam Gene Tree for MGAT2 (if available) 

    Paralogs
    for MGAT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MGAT2 gene

    MGAT2 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for MGAT2 (see all 7)
    PGOHUM00000241564 PGOHUM00000241565 PGOHUM00000241566 PGOHUM00000241567 PGOHUM00000242034


    Genomic Variants
    for MGAT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 NCBI SNPs in MGAT2 are shown (see all 124)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048944471,2
    		Cpathogenic30205902(+) GGATCA/GCTACT 2 H R mis10--------
    rs1048944461,2
    		Cpathogenic30205986(+) TCTCTC/TCCTGG 2 S F mis10--------
    rs1048944481,2
    		Cpathogenic30206069(+) AGCACA/GATATG 2 N D mis10--------
    rs1048944491,2
    		Cpathogenic30206134(+) TTCTGA/TACTTA 2 * C stg10--------
    rs18044011,2
    		C--30202855(-) TCTTTG/TTATGC 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs171216141,2
    		C,F,H,--30203031(+) AAACAT/GTCCGA 1 -- us2k115Minor allele frequency- G:0.04NA NS EA CSA WA 1454
    rs732657011,2
    		C,--30203111(+) ACGTAC/GTCTTT 1 -- us2k13Minor allele frequency- G:0.02WA NS 264
    rs30070401,2
    		C,F,--30203407(+) GGGAGG/AGGCGG 1 -- us2k1 tfbs39Minor allele frequency- A:0.17NA WA CSA EA 370
    rs347898581,2
    		C--30203484(+) AAAAAC/-AAAAA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs80188491,2
    		C,F,H,--30204379(+) TCCTAT/CTGGAG 1 -- us2k110Minor allele frequency- C:0.17NS NA CSA WA 1239

    HapMap Linkage Disequilibrium report for MGAT2 (50087489 - 50090199 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MGAT2
         1 CNV: 66642
    Human Gene Mutation Database (HGMD): MGAT2

    Locus Specific Mutation Databases (LSDB): MGAT2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT2

    Disorders / Diseases
    for MGAT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MGAT2 for disorders           About GeneDecksing

    OMIM gene information: 602616   
    OMIM disorders: 212066  
    UniProtKB/Swiss-Prot: MGAT2_HUMAN, Q10469
  • Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A (CDG2A) [MIM:212066]; also
    • known as carbohydrate-deficient glycoprotein syndrome type II. CDGs are a family of severe inherited diseases caused
    by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem
    disorders present with a wide variety of clinical features, such as disorders of the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and
    maintenance of cell functions

    8 diseases for MGAT2:    About MalaCards
    congenital disorder of glycosylation    congenital disorder of glycosylation type 2a    dyserythropoietic anemia    congenital dyserythropoietic anemia
    autosomal recessive disease    anemia    hypotonia    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for MGAT2:
    Congenital disorder of glycosylation

    2 Novoseek disease relationships for MGAT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbohydrate-deficient glycoprotein syndrome, type ii 97 1 8808595 (1)
    congenital disorders 68.6 1 12417412 (1)

    GeneTests: MGAT2
    Congenital Disorders of Glycosylation


    Export disorders for MGAT2 gene to outside databases

    Publications
    for MGAT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MGAT2 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with MGAT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2-N- acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein. (PubMed id 7635144)1, 2, 3, 9 Tan J.... Schachter H. (1995)
    2. Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development. (PubMed id 8808595)1, 2, 9 Tan J.... Schachter H. (1996)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism. (PubMed id 11228641)1, 2 Cormier-Daire V.... Seta N. (2000)
    6. Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II. (PubMed id 7797505)1, 9 D'Agostaro G.A....Bendiak B. (1995)
    7. Transcriptional regulation of the human UDP-GlcNAc:alpha-6-D-mannoside beta-1-2-N-acetylglucosaminyltransferase II gene (MGAT2) which controls complex N-glycan synthesis. (PubMed id 9579808)1, 9 Chen S.H....Schachter H. (1998)
    8. Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. (PubMed id 11805078)1, 9 Wang Y....Marth J.D. (2001)
    9. Golgi N-glycosyltransferases form both homo- and hete rodimeric enzyme complexes in live cells. (PubMed id 20378551)1 Hassinen A....Kellokumpu S. (2010)
    10. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)

    External Searches for MGAT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MGAT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4247 HGNC: 7045 AceView: MGAT2 Ensembl:ENSG00000168282 euGenes: HUgn4247
    ECgene: MGAT2 Kegg: 4247 H-InvDB: MGAT2

    Other Databases showing MGAT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MGAT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MGAT2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MGAT2
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_534

    Intellectual Property
    for MGAT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MGAT2 gene:
    Search GeneIP for patents involving MGAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MGAT2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MGAT2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGAT2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGAT2  
     OriGene Protein Over-expression Lysate for MGAT2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MGAT2   OriGene 3'-UTR Clone for MGAT2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MGAT2   OriGene Custom Protein Services for MGAT2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MGAT2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGAT2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGAT2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT2
     GenScript Custom Purified and Recombinant Proteins Services for MGAT2 GenScript cDNA clones with any tag delivered in your preferred vector for MGAT2
     GenScript Custom Assay Services for MGAT2 GenScript Custom Superior Antibodies Services for MGAT2
     GenScript Custom overexpressing Cell Line Services for MGAT2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MGAT2 promoter
     Search Chromatin IP Primers for MGAT2
     RT2 qPCR Primer Assay in human, mouse, rat MGAT2
     Search GNC Networks for MGAT2
     SABiosciences PCR Arrays including human, mouse, rat MGAT2
     Search Tocris compounds for MGAT2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MGAT2 antibodies
     MGAT2 proteins
     MGAT2 lysates
     Search for Antibodies for MGAT2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MGAT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MGAT2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MGAT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT2
     SwitchGear 3'UTR luciferase reporter plasmids for MGAT2
     SwitchGear Promoter luciferase reporter plasmids for MGAT2
     Search ThermoFisher Antibodies for MGAT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MGAT2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4