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Aliases for MGAT1 Gene

Aliases for MGAT1 Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase 2 3
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase I 3 4
  • EC 2.4.1.101 4 63
  • GlcNAc-T I 3 4
  • GLYT1 3 4
  • GLCT1 3 4
  • GNT-I 3 4
  • MGAT 3 4
  • Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase 2
  • GLCNAC-TI 3
  • GNT-1 3
  • GGNT1 4

External Ids for MGAT1 Gene

Previous HGNC Symbols for MGAT1 Gene

  • MGAT
  • GLYT1

Previous GeneCards Identifiers for MGAT1 Gene

  • GC05M180347
  • GC05M181203
  • GC05M180281
  • GC05M180327
  • GC05M180150
  • GC05M180218
  • GC05M174942

Summaries for MGAT1 Gene

Entrez Gene Summary for MGAT1 Gene

  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT1 Gene

MGAT1 (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT1 include plague and muscle eye brain disease. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is POMGNT1.

UniProtKB/Swiss-Prot for MGAT1 Gene

  • Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans

Gene Wiki entry for MGAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT1 Gene

Genomics for MGAT1 Gene

Regulatory Elements for MGAT1 Gene

Transcription factor binding sites by QIAGEN in the MGAT1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MGAT1 Gene

Chromosome:
5
Start:
180,790,541 bp from pter
End:
180,815,652 bp from pter
Size:
25,112 bases
Orientation:
Minus strand

Genomic View for MGAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT1 Gene

Proteins for MGAT1 Gene

  • Protein details for MGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26572-MGAT1_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Protein Accession:
    P26572
    Secondary Accessions:
    • A8K404
    • B3KRU8
    • D3DWR1
    • Q6IBE3

    Protein attributes for MGAT1 Gene

    Size:
    445 amino acids
    Molecular mass:
    50878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=The cofactor is mostly bound to the substrate.;
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT1 Gene

Proteomics data for MGAT1 Gene at MOPED

Selected DME Specific Peptides for MGAT1 Gene

Post-translational modifications for MGAT1 Gene

  • Glycosylation at Thr 88 and Ser 320
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MGAT1

Domains & Families for MGAT1 Gene

Protein Domains for MGAT1 Gene

Suggested Antigen Peptide Sequences for MGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

P26572

UniProtKB/Swiss-Prot:

MGAT1_HUMAN :
  • Belongs to the glycosyltransferase 13 family.
Family:
  • Belongs to the glycosyltransferase 13 family.
genes like me logo Genes that share domains with MGAT1: view

Function for MGAT1 Gene

Molecular function for MGAT1 Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,3-) glycoprotein beta-1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans

Enzyme Numbers (IUBMB) for MGAT1 Gene

Gene Ontology (GO) - Molecular Function for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0008375 acetylglucosaminyltransferase activity TAS 1702225
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT1: view
genes like me logo Genes that share phenotypes with MGAT1: view

Animal Models for MGAT1 Gene

MGI Knock Outs for MGAT1:

Animal Model Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for MGAT1 Gene

Localization for MGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT1 Gene COMPARTMENTS Subcellular localization image for MGAT1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
GO:1903561 extracellular vesicle IDA 24769233
genes like me logo Genes that share ontologies with MGAT1: view

Pathways & Interactions for MGAT1 Gene

genes like me logo Genes that share pathways with MGAT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P26572-MGAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT1 Gene

Gene Ontology (GO) - Biological Process for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0005975 carbohydrate metabolic process TAS 1702225
GO:0006049 UDP-N-acetylglucosamine catabolic process IEA --
GO:0006486 protein glycosylation TAS 1702225
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MGAT1: view

No data available for SIGNOR curated interactions for MGAT1 Gene

Drugs & Compounds for MGAT1 Gene

(6) Drugs for MGAT1 Gene - From: NovoSeek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyl Mercury Ion Experimental Pharma Target 0
Uridine-Diphosphate-N-Acetylglucosamine Experimental Pharma Target 0
Uridine 5'-diphosphate Experimental Pharma 0
cholesterol Experimental Pharma Agonist 0
oleic acid Experimental Pharma Activation, Activator 0

(11) Additional Compounds for MGAT1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
alpha-D-Mannoside
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
LIPID
Man5GlcNAc2
genes like me logo Genes that share compounds with MGAT1: view

Transcripts for MGAT1 Gene

Unigene Clusters for MGAT1 Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGAT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - -
SP14: - - - -
SP15: - - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - -
SP26:

ExUns: 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h · 16i · 16j · 16k · 16l · 16m · 16n · 16o ^ 17 ^ 18
SP1: - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - -
SP19:
SP20:
SP21: - - - - - - -
SP22: -
SP23: - - - - - - -
SP24:
SP25:
SP26:

Relevant External Links for MGAT1 Gene

GeneLoc Exon Structure for
MGAT1
ECgene alternative splicing isoforms for
MGAT1

Expression for MGAT1 Gene

mRNA expression in normal human tissues for MGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for MGAT1 Gene

This gene is overexpressed in Serum (12.8), Peripheral blood mononuclear cells (12.1), Liver (9.2), and Plasma (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT1 Gene



SOURCE GeneReport for Unigene cluster for MGAT1 Gene Hs.519818

mRNA Expression by UniProt/SwissProt for MGAT1 Gene

P26572-MGAT1_HUMAN
Tissue specificity: Appears to be present in all tissues
genes like me logo Genes that share expression patterns with MGAT1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MGAT1 Gene

Orthologs for MGAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGAT1 35
  • 87.79 (n)
  • 90.56 (a)
MGAT1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT1 35
  • 88.24 (n)
  • 90.79 (a)
MGAT1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat1 35
  • 84.64 (n)
  • 90.34 (a)
Mgat1 16
Mgat1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGAT1 35
  • 99.18 (n)
  • 99.1 (a)
MGAT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat1 35
  • 85.54 (n)
  • 91.46 (a)
oppossum
(Monodelphis domestica)
Mammalia MGAT1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat1 35
  • 60.81 (n)
  • 66.03 (a)
Str.5502 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52514 35
zebrafish
(Danio rerio)
Actinopterygii mgat1b 35
  • 65.32 (n)
  • 70.32 (a)
zgc66030 35
mgat1a 36
  • 52 (a)
OneToMany
mgat1b 36
  • 52 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3816 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005347 35
  • 62.06 (n)
  • 57.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mgat1 35
  • 59.5 (n)
  • 57.51 (a)
Mgat1 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-12 37
  • 36 (a)
gly-14 35
  • 48.34 (n)
  • 43.48 (a)
gly-13 36
  • 36 (a)
OneToMany
gly-14 36
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CGL1 35
  • 47.46 (n)
  • 40.72 (a)
rice
(Oryza sativa)
Liliopsida Os02g0832800 35
  • 48.53 (n)
  • 41.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1484 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8479 36
  • 39 (a)
OneToOne
Species with no ortholog for MGAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT1 Gene

ENSEMBL:
Gene Tree for MGAT1 (if available)
TreeFam:
Gene Tree for MGAT1 (if available)

Paralogs for MGAT1 Gene

Paralogs for MGAT1 Gene

genes like me logo Genes that share paralogs with MGAT1: view

Variants for MGAT1 Gene

Sequence variations from dbSNP and Humsavar for MGAT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_028272 -
VAR_028273 -

Structural Variations from Database of Genomic Variants (DGV) for MGAT1 Gene

Variant ID Type Subtype PubMed ID
dgv1882e1 CNV Complex 17122850
nsv462587 CNV Gain 19166990
dgv6n29 CNV Loss 16826518
nsv428133 CNV Gain 18775914

Variation tolerance for MGAT1 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT1 Gene

HapMap Linkage Disequilibrium report
MGAT1
Human Gene Mutation Database (HGMD)
MGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT1 Gene

Disorders for MGAT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MGAT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
plague
  • yersiniosis
muscle eye brain disease
  • meb
- elite association
Search MGAT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGAT1

Genetic Association Database (GAD)
MGAT1
Human Genome Epidemiology (HuGE) Navigator
MGAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT1
genes like me logo Genes that share disorders with MGAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT1 Gene

Publications for MGAT1 Gene

  1. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 23 67
  2. Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function. (PMID: 20304457) Eggink D. … Sanders R.W. (Virology 2010) 23 67
  3. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PMID: 20374941) Holmes R.S. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2010) 23 67
  4. Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization. (PMID: 20335257) Binley J.M. … Sanders R.W. (J. Virol. 2010) 23 67
  5. Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span. (PMID: 20457894) Sarkar M. … Boulianne G.L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67

Products for MGAT1 Gene

Sources for MGAT1 Gene

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