Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGAT1 Gene

Aliases for MGAT1 Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase 2 3
  • GLYT1 3 4 6
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase I 3 4
  • Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase 2 3
  • EC 2.4.1.101 4 63
  • GlcNAc-T I 3 4
  • GLCT1 3 4
  • GNT-I 3 4
  • MGAT 3 4
  • GLCNAC-TI 3
  • GNT-1 3
  • GGNT1 4

External Ids for MGAT1 Gene

Previous HGNC Symbols for MGAT1 Gene

  • MGAT
  • GLYT1

Previous GeneCards Identifiers for MGAT1 Gene

  • GC05M180347
  • GC05M181203
  • GC05M180281
  • GC05M180327
  • GC05M180150
  • GC05M180218
  • GC05M174942

Summaries for MGAT1 Gene

Entrez Gene Summary for MGAT1 Gene

  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT1 Gene

MGAT1 (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT1 include plague and brain disease. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is POMGNT1.

UniProtKB/Swiss-Prot for MGAT1 Gene

  • Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans

Gene Wiki entry for MGAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT1 Gene

Genomics for MGAT1 Gene

Regulatory Elements for MGAT1 Gene

Transcription factor binding sites by QIAGEN in the MGAT1 gene promoter:

Genomic Location for MGAT1 Gene

Start:
180,790,541 bp from pter
End:
180,815,652 bp from pter
Size:
25,112 bases
Orientation:
Minus strand

Genomic View for MGAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT1 Gene

Proteins for MGAT1 Gene

  • Protein details for MGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26572-MGAT1_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Protein Accession:
    P26572
    Secondary Accessions:
    • A8K404
    • B3KRU8
    • D3DWR1
    • Q6IBE3

    Protein attributes for MGAT1 Gene

    Size:
    445 amino acids
    Molecular mass:
    50878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=The cofactor is mostly bound to the substrate.;
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT1 Gene

Proteomics data for MGAT1 Gene at MOPED

Selected DME Specific Peptides for MGAT1 Gene

Post-translational modifications for MGAT1 Gene

  • Glycosylation at Thr88 and Ser320
  • Modification sites at PhosphoSitePlus

Domains for MGAT1 Gene

Protein Domains for MGAT1 Gene

Suggested Antigen Peptide Sequences for MGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

P26572

UniProtKB/Swiss-Prot:

MGAT1_HUMAN :
  • P26572
Family:
  • Belongs to the glycosyltransferase 13 family.
genes like me logo Genes that share domains with MGAT1: view

No data available for Gene Families for MGAT1 Gene

Function for MGAT1 Gene

Molecular function for MGAT1 Gene

GENATLAS Biochemistry: mannosyl (alpha-1,3-) glycoprotein beta-1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
UniProtKB/Swiss-Prot Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans

Enzyme Numbers (IUBMB) for MGAT1 Gene

Gene Ontology (GO) - Molecular Function for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0008375 acetylglucosaminyltransferase activity TAS 1702225
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT1: view
genes like me logo Genes that share phenotypes with MGAT1: view

Animal Models for MGAT1 Gene

MGI Knock Outs for MGAT1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MGAT1 Gene

Localization for MGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAT1 Gene COMPARTMENTS Subcellular localization image for MGAT1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IDA 24769233
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MGAT1: view

Pathways for MGAT1 Gene

genes like me logo Genes that share pathways with MGAT1: view

UniProtKB/Swiss-Prot P26572-MGAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MGAT1 Gene

Gene Ontology (GO) - Biological Process for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0005975 carbohydrate metabolic process TAS 1702225
GO:0006049 UDP-N-acetylglucosamine catabolic process IEA --
GO:0006486 protein glycosylation TAS 1702225
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MGAT1: view

Compounds for MGAT1 Gene

(2) Drugbank Compounds for MGAT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Methyl Mercury Ion
target
Uridine-Diphosphate-N-Acetylglucosamine
target

(13) Novoseek inferred chemical compound relationships for MGAT1 Gene

Compound -log(P) Hits PubMed IDs
alpha-d-mannoside 90.5 1
man5glcnac2 80.9 2
monoacylglycerol 80.7 8
n-acetylglucosamine 60 5
mannose 53.4 7
genes like me logo Genes that share compounds with MGAT1: view

Transcripts for MGAT1 Gene

Unigene Clusters for MGAT1 Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - -
SP14: - - - -
SP15: - - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - -
SP26:

ExUns: 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h · 16i · 16j · 16k · 16l · 16m · 16n · 16o ^ 17 ^ 18
SP1: - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - -
SP19:
SP20:
SP21: - - - - - - -
SP22: -
SP23: - - - - - - -
SP24:
SP25:
SP26:

Relevant External Links for MGAT1 Gene

GeneLoc Exon Structure for
MGAT1
ECgene alternative splicing isoforms for
MGAT1

Expression for MGAT1 Gene

mRNA expression in normal human tissues for MGAT1 Gene

mRNA differential expression in normal tissues according to GTEx for MGAT1 Gene

This gene is overexpressed in Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGAT1 Gene

SOURCE GeneReport for Unigene cluster for MGAT1 Gene Hs.519818

mRNA Expression by UniProt/SwissProt for MGAT1 Gene

P26572-MGAT1_HUMAN
Tissue specificity: Appears to be present in all tissues
genes like me logo Genes that share expressions with MGAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MGAT1 Gene

Orthologs for MGAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT1 35
  • 99.18 (n)
  • 99.1 (a)
MGAT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAT1 35
  • 87.79 (n)
  • 90.56 (a)
MGAT1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAT1 35
  • 88.24 (n)
  • 90.79 (a)
MGAT1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgat1 35
  • 84.64 (n)
  • 90.34 (a)
Mgat1 16
Mgat1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGAT1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgat1 35
  • 85.54 (n)
  • 91.46 (a)
lizard
(Anolis carolinensis)
Reptilia MGAT1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52514 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat1 35
  • 60.81 (n)
  • 66.03 (a)
Str.5502 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3816 35
zebrafish
(Danio rerio)
Actinopterygii mgat1a 36
  • 52 (a)
OneToMany
mgat1b 35
  • 65.32 (n)
  • 70.32 (a)
mgat1b 36
  • 52 (a)
OneToMany
zgc66030 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005347 35
  • 62.06 (n)
  • 57.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mgat1 35
  • 59.5 (n)
  • 57.51 (a)
Mgat1 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-13 36
  • 36 (a)
OneToMany
gly-14 35
  • 48.34 (n)
  • 43.48 (a)
gly-14 36
  • 37 (a)
OneToMany
gly-12 37
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CGL1 35
  • 47.46 (n)
  • 40.72 (a)
rice
(Oryza sativa)
Liliopsida Os02g0832800 35
  • 48.53 (n)
  • 41.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1484 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8479 36
  • 39 (a)
OneToOne
Species with no ortholog for MGAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT1 Gene

ENSEMBL:
Gene Tree for MGAT1 (if available)
TreeFam:
Gene Tree for MGAT1 (if available)

Paralogs for MGAT1 Gene

Paralogs for MGAT1 Gene

genes like me logo Genes that share paralogs with MGAT1: view

Variants for MGAT1 Gene

Sequence variations from dbSNP and Humsavar for MGAT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9387 -- 180,790,626(-) TTTTT(G/T)TTTCT utr-variant-3-prime
rs14995 -- 180,790,619(-) TTCTT(G/T)CCTGA utr-variant-3-prime
rs634501 - 180,791,668(+) ACGTC(A/G)GTGGG missense, reference
rs678529 -- 180,794,191(-) gtgct(G/T)cccag intron-variant
rs1064247 -- 180,790,887(-) CCTTT(C/T)TGAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MGAT1 Gene

Variant ID Type Subtype PubMed ID
dgv1882e1 CNV Complex 17122850
nsv462587 CNV Gain 19166990
dgv6n29 CNV Loss 16826518
nsv428133 CNV Gain 18775914

Relevant External Links for MGAT1 Gene

HapMap Linkage Disequilibrium report
MGAT1
Human Gene Mutation Database (HGMD)
MGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT1 Gene

Disorders for MGAT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MGAT1 Gene including...

Search for MGAT1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for MGAT1 Gene

Disease -log(P) Hits PubMed IDs
obesity 0 1

Relevant External Links for MGAT1

Genetic Association Database (GAD)
MGAT1
Human Genome Epidemiology (HuGE) Navigator
MGAT1
genes like me logo Genes that share disorders with MGAT1: view

No data available for UniProtKB/Swiss-Prot for MGAT1 Gene

Publications for MGAT1 Gene

  1. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 3 23 48
  2. Organization and localization to chromosome 5 of the human UDP-N- acetylglucosamine:alpha-3-D-mannoside beta-1,2-N- acetylglucosaminyltransferase I gene. (PMID: 1827260) Hull E. … Schachter H. (Biochem. Biophys. Res. Commun. 1991) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman C.A. … Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. (PMID: 1421759) Kumar R. … Stanley P. (Glycobiology 1992) 3 23

Products for MGAT1 Gene

Sources for MGAT1 Gene

Back to Top

Content