Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGAT1 Gene

Aliases for MGAT1 Gene

  • Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase 2 3 5
  • N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase I 3 4
  • Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase 2 3
  • EC 2.4.1.101 4 61
  • GlcNAc-T I 3 4
  • GLYT1 3 4
  • GLCT1 3 4
  • GNT-I 3 4
  • MGAT 3 4
  • GLCNAC-TI 3
  • GNT-1 3
  • GGNT1 4
  • GnTI 3

External Ids for MGAT1 Gene

Previous HGNC Symbols for MGAT1 Gene

  • MGAT
  • GLYT1

Previous GeneCards Identifiers for MGAT1 Gene

  • GC05M180347
  • GC05M181203
  • GC05M180281
  • GC05M180327
  • GC05M180150
  • GC05M180218
  • GC05M174942

Summaries for MGAT1 Gene

Entrez Gene Summary for MGAT1 Gene

  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAT1 Gene

MGAT1 (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT1 include Plague and Muscle Eye Brain Disease. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is POMGNT1.

UniProtKB/Swiss-Prot for MGAT1 Gene

  • Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

Gene Wiki entry for MGAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAT1 Gene

Genomics for MGAT1 Gene

Regulatory Elements for MGAT1 Gene

Enhancers for MGAT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F180784 1.1 Ensembl ENCODE 17.9 +28.8 28766 5.8 PLRG1 RAD21 RFX5 CHAMP1 ZNF335 ZNF143 ZNF207 EGR2 ZNF263 ZNF654 ZFP62 MGAT1 LOC100996419 OR2V2 OR2Y1 ENSG00000250900 CNOT6 TBC1D9B RN7SKP150 TRIM7
GH05F180820 1.4 FANTOM5 Ensembl ENCODE 9.3 -5.4 -5378 2.1 BCOR SMARCA5 PKNOX1 MTA2 ZMYM3 CEBPB TBX21 NR2F2 RAD51 HDAC2 MGAT1 LINC00847 ZFP62 LOC105377766
GH05F180828 1.4 FANTOM5 ENCODE 8.9 -15.6 -15564 4.5 HDGF CREB3L1 WRNIP1 SIN3A YY1 CBX5 ZNF143 KLF13 REST ZNF592 LINC00847 MGAT1 ZFP62 GC05M180831
GH05F180865 1.1 ENCODE 11.1 -50.7 -50688 2.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS OR2V2 ZFP62 ENSG00000233937 LOC100128762 LOC100419853 LOC646227 OR2AI1P LOC100420514 ENSG00000250765 LOC646058
GH05F180814 1.3 FANTOM5 ENCODE 9.2 -0.8 -830 5.4 HDGF PKNOX1 ZNF76 EGR1 ZNF366 CREM CBFB JUNB TBX21 NR2F2 TRIM52-AS1 ENSG00000233937 MGAT1 ZFP62 LOC105377766
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGAT1 Gene

Chromosome:
5
Start:
180,784,782 bp from pter
End:
180,815,652 bp from pter
Size:
30,871 bases
Orientation:
Minus strand

Genomic View for MGAT1 Gene

Genes around MGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAT1 Gene

Proteins for MGAT1 Gene

  • Protein details for MGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26572-MGAT1_HUMAN
    Recommended name:
    Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Protein Accession:
    P26572
    Secondary Accessions:
    • A8K404
    • B3KRU8
    • D3DWR1
    • Q6IBE3

    Protein attributes for MGAT1 Gene

    Size:
    445 amino acids
    Molecular mass:
    50878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for MGAT1 Gene

Selected DME Specific Peptides for MGAT1 Gene

P26572:
  • DFFPGLGW
  • FWDDWMR
  • YYKIARHY
  • ELEPKWP
  • IPILVIACDRSTVRRCLDKLLHYRPSAE

Post-translational modifications for MGAT1 Gene

  • Glycosylation at Thr 88 and Ser 320
  • Modification sites at PhosphoSitePlus

Domains & Families for MGAT1 Gene

Protein Domains for MGAT1 Gene

Suggested Antigen Peptide Sequences for MGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

P26572

UniProtKB/Swiss-Prot:

MGAT1_HUMAN :
  • Belongs to the glycosyltransferase 13 family.
Family:
  • Belongs to the glycosyltransferase 13 family.
genes like me logo Genes that share domains with MGAT1: view

Function for MGAT1 Gene

Molecular function for MGAT1 Gene

GENATLAS Biochemistry:
mannosyl (alpha-1,3-) glycoprotein beta-1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
UniProtKB/Swiss-Prot Function:
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

Enzyme Numbers (IUBMB) for MGAT1 Gene

Gene Ontology (GO) - Molecular Function for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity TAS --
GO:0008375 acetylglucosaminyltransferase activity TAS 1702225
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MGAT1: view
genes like me logo Genes that share phenotypes with MGAT1: view

Animal Models for MGAT1 Gene

MGI Knock Outs for MGAT1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MGAT1

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MGAT1 Gene

Localization for MGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAT1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGAT1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA,TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MGAT1: view

Pathways & Interactions for MGAT1 Gene

genes like me logo Genes that share pathways with MGAT1: view

UniProtKB/Swiss-Prot P26572-MGAT1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for MGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0005975 carbohydrate metabolic process TAS 1702225
GO:0006049 UDP-N-acetylglucosamine catabolic process IEA --
GO:0006486 protein glycosylation IEA,TAS --
genes like me logo Genes that share ontologies with MGAT1: view

No data available for SIGNOR curated interactions for MGAT1 Gene

Drugs & Compounds for MGAT1 Gene

(5) Drugs for MGAT1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-Diphosphate-N-Acetylglucosamine Experimental Pharma Target 0
Uridine-5'-Diphosphate Experimental Pharma 0

(11) Additional Compounds for MGAT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with MGAT1: view

Transcripts for MGAT1 Gene

Unigene Clusters for MGAT1 Gene

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MGAT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGAT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - -
SP14: - - - -
SP15: - - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - -
SP26:

ExUns: 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h · 16i · 16j · 16k · 16l · 16m · 16n · 16o ^ 17 ^ 18
SP1: - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - -
SP19:
SP20:
SP21: - - - - - - -
SP22: -
SP23: - - - - - - -
SP24:
SP25:
SP26:

Relevant External Links for MGAT1 Gene

GeneLoc Exon Structure for
MGAT1
ECgene alternative splicing isoforms for
MGAT1

Expression for MGAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAT1 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for MGAT1 Gene

This gene is overexpressed in Serum (12.8), Peripheral blood mononuclear cells (12.1), Liver (9.2), and Plasma (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGAT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MGAT1 Gene:

MGAT1

SOURCE GeneReport for Unigene cluster for MGAT1 Gene:

Hs.519818

mRNA Expression by UniProt/SwissProt for MGAT1 Gene:

P26572-MGAT1_HUMAN
Tissue specificity: Appears to be present in all tissues.
genes like me logo Genes that share expression patterns with MGAT1: view

Primer Products

No data available for Protein tissue co-expression partners for MGAT1 Gene

Orthologs for MGAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAT1 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia MGAT1 34 35
  • 88.24 (n)
cow
(Bos Taurus)
Mammalia MGAT1 34 35
  • 87.79 (n)
rat
(Rattus norvegicus)
Mammalia Mgat1 34
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Mgat1 34 16 35
  • 84.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MGAT1 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGAT1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgat1 34
  • 60.81 (n)
Str.5502 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52514 34
zebrafish
(Danio rerio)
Actinopterygii mgat1b 34 35
  • 65.32 (n)
mgat1a 35
  • 52 (a)
OneToMany
zgc66030 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3816 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005347 34
  • 62.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mgat1 35 34
  • 59.5 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-14 34 35
  • 48.34 (n)
gly-12 36
  • 36 (a)
gly-13 35
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CGL1 34
  • 47.46 (n)
rice
(Oryza sativa)
Liliopsida Os02g0832800 34
  • 48.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8479 35
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1484 34
Species where no ortholog for MGAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAT1 Gene

ENSEMBL:
Gene Tree for MGAT1 (if available)
TreeFam:
Gene Tree for MGAT1 (if available)

Paralogs for MGAT1 Gene

Paralogs for MGAT1 Gene

genes like me logo Genes that share paralogs with MGAT1: view

Variants for MGAT1 Gene

Sequence variations from dbSNP and Humsavar for MGAT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10040542 -- 180,815,178(+) cctct(C/T)ttata intron-variant, upstream-variant-2KB
rs10042479 -- 180,813,236(+) ccatt(A/T)tttgt intron-variant
rs10059104 -- 180,812,583(+) acaca(C/T)acata intron-variant, upstream-variant-2KB
rs10464106 -- 180,796,261(+) ACTTC(A/C)CCAGC intron-variant
rs10464107 -- 180,796,596(+) GCACA(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAT1 Gene

Variant ID Type Subtype PubMed ID
nsv600678 CNV gain 21841781
nsv462587 CNV gain 19166990
nsv428133 CNV gain 18775914
nsv1161322 CNV duplication 26073780
nsv1026417 CNV gain 25217958
esv3607794 CNV gain 21293372
esv3607793 CNV gain 21293372
esv3607791 CNV gain 21293372
esv2759399 CNV gain 17122850
dgv9n29 CNV loss 16826518
dgv5849n100 CNV gain 25217958

Variation tolerance for MGAT1 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGAT1 Gene

Human Gene Mutation Database (HGMD)
MGAT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT1 Gene

Disorders for MGAT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MGAT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
plague
  • yersiniosis
muscle eye brain disease
  • meb
- elite association - COSMIC cancer census association via MalaCards
Search MGAT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGAT1

Genetic Association Database (GAD)
MGAT1
Human Genome Epidemiology (HuGE) Navigator
MGAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGAT1
genes like me logo Genes that share disorders with MGAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT1 Gene

Publications for MGAT1 Gene

  1. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 3 22 46 64
  2. Organization and localization to chromosome 5 of the human UDP-N- acetylglucosamine:alpha-3-D-mannoside beta-1,2-N- acetylglucosaminyltransferase I gene. (PMID: 1827260) Hull E. … Schachter H. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 64
  3. Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization. (PMID: 20335257) Binley J.M. … Sanders R.W. (J. Virol. 2010) 3 22 64
  4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 46 64
  5. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman C.A. … Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for MGAT1 Gene

Sources for MGAT1 Gene

Content
Loading form....