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MGAT1 Gene

protein-coding   GIFtS: 66
GCID: GC05M180218

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase


(Previous symbols: MGAT, GLYT1)
  See MGAT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mannosyl (Alpha-1,3-)-Glycoprotein
Beta-1,2-N-Acetylglucosaminyltransferase1 2
     N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase I2 3
GLYT11 2 3 5     EC 2.4.1.1013 8
MGAT1 2 3     GLCNAC-TI2
GlcNAc-T I2 3     GNT-12
GLCT12 3     Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase2
GNT-I2 3     GGNT13

External Ids:    HGNC: 70441   Entrez Gene: 42452   Ensembl: ENSG000001314467   OMIM: 1609955   UniProtKB: P265723   
ORGUL members:         

Export aliases for MGAT1 gene to outside databases

Previous GC identifers: GC05M180347 GC05M181203 GC05M180281 GC05M180327 GC05M180150 GC05M174942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MGAT1 Gene:
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and
lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside
beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and
complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane
protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same
protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MGAT1 Gene:
MGAT1 (mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase) is a protein-coding gene. Diseases associated with MGAT1 include plague, and brain disease. GO annotations related to this gene include alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity and acetylglucosaminyltransferase activity. An important paralog of this gene is POMGNT1.

UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572
Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to
hybrid and complex N-glycans

Gene Wiki entry for MGAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MGAT1 gene promoter:
         AREB6   Sp1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMGAT1 promoter sequence
   Search Chromatin IP Primers for MGAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MGAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

MGAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAT1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M180218:  view genomic region     (about GC identifiers)

Start:
180,217,541 bp from pter      End:
180,242,652 bp from pter
Size:
25,112 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572 (See protein sequence)
Recommended Name: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase  
Size: 445 amino acids; 50878 Da
Cofactor: Manganese. The cofactor is mostly bound to the substrate (By similarity)
Secondary accessions: A8K404 B3KRU8 D3DWR1 Q6IBE3

Explore the universe of human proteins at neXtProt for MGAT1: NX_P26572

Explore proteomics data for MGAT1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr88, Ser320
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MGAT1 (P26572) (see all 5)
     ELEPKWP  FWDDWMR  DFFPGLGW  YYKIARHY 


    See MGAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001108089.1  NP_001108090.1  NP_001108091.1  NP_001108092.1  NP_002397.2  

    ENSEMBL proteins: 
     ENSP00000332073   ENSP00000311888   ENSP00000404718   ENSP00000402838   ENSP00000424891  
     ENSP00000425988   ENSP00000424382   ENSP00000427116   ENSP00000422906   ENSP00000421738  
     ENSP00000422588   ENSP00000423401   ENSP00000427433   ENSP00000377010  
    Reactome Protein details: P26572

    MGAT1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MGAT1

     
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    antibodies-online proteins for MGAT1 (7 products) 

     
    antibodies-online peptides for MGAT1

    MGAT1 Antibody Products:

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    antibodies-online antibodies for MGAT1 (37 products) 

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    antibodies-online kits for MGAT1 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004139 Glyco_trans_13

    Graphical View of Domain Structure for InterPro Entry P26572

    ProtoNet protein and cluster: P26572

    1 Blocks protein domain: IPB004139 Glycosyl transferase

    UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572
    Similarity: Belongs to the glycosyltransferase 13 family


    Find genes that share domains with MGAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGAT1_HUMAN, P26572
    Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to
    hybrid and complex N-glycans
    Catalytic activity: UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +
    3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R

         Genatlas biochemistry entry for MGAT1:
    mannosyl (alpha-1,3-) glycoprotein beta-1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex
    Asn-linked (N) glycans

         Enzyme Number (IUBMB): EC 2.4.1.1011 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003827alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0008375acetylglucosaminyltransferase activity TAS1702225
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MGAT1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MGAT1:
     Decreased Tat-dependent transc  Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mgat1):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     integument  limbs/digits/tail  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with MGAT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MGAT1: Mgat1tm1Jxm Mgat1tm1Pst

       genOway: Develop your customized and physiologically relevant rodent model for MGAT1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MGAT1 (see all 11):
    hsa-miR-140-5p hsa-miR-588 hsa-miR-1324 hsa-miR-128 hsa-miR-3681* hsa-miR-3921 hsa-miR-20b* hsa-miR-3137
    SwitchGear 3'UTR luciferase reporter plasmidMGAT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MGAT1
    Predesigned siRNA for gene silencing in human, mouse, rat MGAT1

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for MGAT1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGAT1_HUMAN, P26572: Golgi apparatus membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with MGAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MGAT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Transport to the Golgi and subsequent modification0.40
    N-Glycan biosynthesis0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan trimming and elongation in the cis-Golgi0.00
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with MGAT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MGAT1
        N-glycan trimming and elongation in the cis-Golgi


    2 Kegg Pathways  (Kegg details for MGAT1):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGAT1: 

              Glycosylation in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MGAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MGAT1 (P265722, 3 ENSP000003118884) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62145 I2D: score=3 
    MAPK6Q166592, 3MINT-8261461 I2D: score=2 
    MAN1A1ENSP000003574534STRING: ENSP00000357453
    MAN1A2ENSP000003489594STRING: ENSP00000348959
    MAN1B1ENSP000003606454STRING: ENSP00000360645
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0005975carbohydrate metabolic process TAS1702225
    GO:0006049UDP-N-acetylglucosamine catabolic process IEA--
    GO:0006486protein glycosylation TAS1702225
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    Find genes that share ontologies with MGAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MGAT1

    2 DrugBank Compounds for MGAT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Methyl Mercury Ion-- --target--17139284 17016423 10592235
    Uridine-Diphosphate-N-Acetylglucosamine-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for MGAT1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-d-mannoside 90.5 1 12417411 (1)
    man5glcnac2 80.9 3 16233148 (2)
    monoacylglycerol 80.7 9 8175745 (2), 17170429 (2), 20374941 (1), 8418888 (1) (see all 6)
    n-acetylglucosamine 60 5 16233148 (1), 20335257 (1), 19706602 (1), 16672288 (1) (see all 5)
    mannose 53.4 11 16233148 (3), 16756569 (1), 17920136 (1), 12672701 (1) (see all 5)
    polysaccharide 47.4 10 16233148 (2), 12417409 (1), 17920136 (1), 10441510 (1) (see all 6)
    triacylglycerol 46.3 2 16214399 (1), 20493784 (1)
    oleic acid 34.9 3 9558325 (2), 8175745 (1)
    sphingosine 34.3 2 8175745 (2)
    lipid 19.9 9 8175745 (2), 10820520 (1), 12730219 (1), 9558325 (1) (see all 5)



    Find genes that share compounds with MGAT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MGAT1 gene (5 alternative transcripts): 
    NM_001114617.1  NM_001114618.1  NM_001114619.1  NM_001114620.1  NM_002406.3  

    Unigene Cluster for MGAT1:

    Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    Hs.519818  [show with all ESTs]
    Unigene Representative Sequence: NM_001114618
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000333055(uc010jlf.3 uc010jlg.3 uc003mmi.4) ENST00000307826(uc003mmg.4)
    ENST00000446023(uc003mmh.4 uc010jlh.3) ENST00000427865 ENST00000504671
    ENST00000506889 ENST00000514283 ENST00000512695 ENST00000506269 ENST00000514438
    ENST00000502678 ENST00000513431 ENST00000507384 ENST00000504385 ENST00000514760
    ENST00000505682 ENST00000512080 ENST00000510341
    miRNA
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    hsa-miR-140-5p hsa-miR-588 hsa-miR-1324 hsa-miR-128 hsa-miR-3681* hsa-miR-3921 hsa-miR-20b* hsa-miR-3137
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    Additional mRNA sequence: 

    AB209239.1 AF289558.1 AK057194.1 AK075429.1 AK090523.1 AK092256.1 AK094130.1 AK124428.1 
    AK290769.1 BC003575.1 BC104045.1 BC128250.1 CR456861.1 M55621.1 

    Selected DOTS entries (see all 48):

    DT.101966301  DT.100778240  DT.454143  DT.100641543  DT.100758269  DT.99971147  DT.100031246  DT.95266662 
    DT.100821578  DT.102833288  DT.100821574  DT.86855743  DT.100821570  DT.100821575  DT.40301852  DT.95266665 
    DT.97813634  DT.120831197  DT.100704656  DT.120831141  DT.120831184  DT.97854919  DT.100031248  DT.120831152 

    Selected AceView cDNA sequences (see all 543):

    BQ278676 BM757833 AI884915 BU783509 BU177358 CA431323 CA307332 BF002917 
    BQ671941 AI148879 CB268970 AU104716 C18510 BU165886 AU104713 CR599363 
    BQ000906 BM982821 AI188769 AK057194 N78777 BM750320 BE018668 AA295967 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MGAT1 (see all 26)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ·
    SP1:                                                  -     -     -     -     -                       -     -           -     -     -     -     -     -     -   
    SP2:                                                                    -     -                       -     -           -     -     -     -     -     -     -   
    SP3:                                -     -     -     -     -     -     -     -                 -     -           -     -     -     -     -     -     -     -   
    SP4:                                      -     -     -     -     -     -     -                       -     -           -     -     -     -     -     -     -   
    SP5:                                                  -     -     -     -     -                 -     -           -     -     -     -     -     -     -     -   

    ExUns: 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f · 16g · 16h · 16i · 16j · 16k · 16l · 16m · 16n · 16o ^ 17 ^ 18
    SP1:  -     -     -     -     -     -     -                                                                                                         
    SP2:  -     -     -     -     -     -     -                                                                                                         
    SP3:  -                                                                                                                                             
    SP4:  -     -     -     -     -     -     -                                                                                                         
    SP5:  -     -     -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for MGAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MGAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAAGTG
    MGAT1 Expression
    About this image

    MGAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MGAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519818

    UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572
    Tissue specificity: Appears to be present in all tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MGAT1: 
              Glycosylation in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MGAT1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mgat11 , 5 mannoside acetylglucosaminyltransferase 11, 5 84.64(n)1
    90.34(a)1
      11 (29.27 cM)5
    173081  NM_001110150.11  NP_001103620.11 
     492442465 
    lizard
    (Anolis carolinensis)
    Reptilia MGAT16
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acet...
    71(a)
    1 ↔ 1
    2(192812758-192814110)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525142 similar to mannoside acetylglucosaminyltransferase more 74.98(n)    BC041180.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660302 hypothetical protein MGC66030 77.15(n)   393649  BC058297.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mgat11 UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase more 59.5(n)
    57.51(a)
      37323  NM_080378.3  NP_525117.2 
    worm
    (Caenorhabditis elegans)
    Secernentea gly-123
    gly-141
    Expression: head ganglia, hypodermis,
    intestine, more3
    gly-141
    36(a)3
    48.34(n)1
    43.48(a)1
      X(7518728-7519906)3
    1754531  NM_065318.31  NP_497719.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CGL11 CGL1 47.46(n)
    40.72(a)
      829981  NM_119986.3  NP_195537.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g08328001 Os02g0832800 48.53(n)
    41.64(a)
      4331263  NM_001055166.1  NP_001048631.1 


    ENSEMBL Gene Tree for MGAT1 (if available)
    TreeFam Gene Tree for MGAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MGAT1 gene
    POMGNT12  

    Find genes that share paralogs with MGAT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MGAT1 (see all 607)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360601831,2
    C--180221224(+) ACAAT-/TTAAAA 5 -- int10--------
    rs746352341,2
    C--180221689(+) GGTGG-/TGCTGCCG 5 -- int10--------
    rs579893471,2
    C--180224441(+) GGGGC-/CCAGAGG 5 -- int10--------
    rs355576461,2
    C--180231312(+) CCCCC-/CAACAC 5 -- us2k1 int10--------
    rs30295261,2
    C--180238657(+) TCCCT-/GCC   
      CTCCCT
    ACCCT
    2 -- cds10--------
    rs1890534941,2
    --180437145(+) GGTTGC/TGTTTG 5 -- ds50010--------
    rs1496114271,2
    --180437416(+) GAGCAA/CAGTCC 5 -- ds50010--------
    rs1918626561,2
    C--180437576(+) TCTCCC/TTTTTC 5 -- ds50010--------
    rs1491661411,2
    C--180437582(+) TTTTC-/CTTT  
            
    CTTTC
    5 -- ds50010--------
    rs1144943571,2
    C,F--180437708(+) GTCAGG/ACAAGA 5 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for MGAT1 (180217541 - 180242652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MGAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6n29CNV Loss16826518
    nsv428133CNV Gain18775914
    nsv462587CNV Gain19166990
    dgv1882e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MGAT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MGAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MGAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160995    OMIM disorders: --

    2 diseases for MGAT1:    
    About MalaCards
    plague    brain disease


    Find genes that share disorders with MGAT1           About GenesLikeMe

    1 Novoseek inferred disease relationship for MGAT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 0 1 14966132 (1)

    Genetic Association Database (GAD): MGAT1
    Human Genome Epidemiology (HuGE) Navigator: MGAT1 (4 documents)

    Export disorders for MGAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MGAT1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with MGAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and localization to chromosome 5 of the human UDP-N- acetylglucosamine:alpha-3-D-mannoside beta-1,2-N- acetylglucosaminyltransferase I gene. (PubMed id 1827260)1, 2, 3 Hull E....Schachter H. (Biochem. Biophys. Res. Commun. 1991)
    2. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)1, 4, 9 Johansson A....Gyllensten U. (Obesity (Silver Spring) 2010)
    3. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    4. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PubMed id 19219857)1, 4 Bousman C.A....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. (PubMed id 1702225)1, 2 Kumar R.... Stanley P. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    8. Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. (PubMed id 9020882)1, 9 Yip B....Schachter H. (Biochem. J. 1997)
    9. Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. (PubMed id 1421759)1, 9 Kumar R....Stanley P. (Glycobiology 1992)
    10. Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization. (PubMed id 20335257)1, 9 Binley J.M....Sanders R.W. (J. Virol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4245 HGNC: 7044 AceView: MGAT1 Ensembl:ENSG00000131446 euGenes: HUgn4245
    ECgene: MGAT1 Kegg: 4245 H-InvDB: MGAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MGAT1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT1
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_535

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MGAT1 gene:
    Search GeneIP for patents involving MGAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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