MGAT1 Gene
protein-coding GIFtS: 62
GCID: GC05M180218
|
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
(Previous symbols: MGAT, GLYT1)
| |
Aliases
for MGAT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mannosyl (Alpha-1,3-)-GlycoproteinBeta-1,2-N-Acetylglucosaminyltransferase1 2 | | GLCT12 3 | | GLYT11 2 3 5 | | GNT-I2 3 | | MGAT1 2 3 | | N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase I2 3 | | GLCNAC-TI1 2 | | EC 2.4.1.1013 8 | | GNT-11 2 | | Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase2 | | GlcNAc-T I2 3 | | GGNT13 |
Export aliases for MGAT1 gene to outside databasesPrevious GC identifers: GC05M180347 GC05M181203 GC05M180281 GC05M180327 GC05M180150 GC05M174942 |
Summaries
for MGAT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MGAT1:
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound andlipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase Iis a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a singleexon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normalembryogenesis. Several variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid andcomplex N-glycans
Gene Wiki entry for MGAT1
|
Genomic Views
for MGAT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MGAT1 gene promoter:
AREB6 Sp1 HFH-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MGAT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3MGAT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M180218: view genomic region
(about GC identifiers)
Start:
|
180,217,541 bp from pter |
End:
|
180,242,652 bp from pter |
Size:
|
25,112 bases |
Orientation:
|
minus strand |
|
Proteins
for MGAT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572 (See
protein sequence)Recommended Name: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Size: 445 amino acids; 50878 Da
Cofactor: Manganese. The cofactor is mostly bound to the substrate (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Secondary accessions: A8K404 D3DWR1 Q6IBE3Explore the universe of human proteins at neXtProt for MGAT1: NX_P26572
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P26572
4/5 DME Specific Peptides for MGAT1 (P26572) (see all 5)
MGAT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001108089.1 NP_001108090.1 NP_001108091.1 NP_001108092.1 NP_002397.2
ENSEMBL proteins: ENSP00000332073 ENSP00000311888 ENSP00000404718 ENSP00000402838 ENSP00000424891 ENSP00000425988 ENSP00000424382 ENSP00000427116 ENSP00000422906 ENSP00000421738 ENSP00000422588 ENSP00000423401 ENSP00000427433 ENSP00000377010 Reactome Protein details: P26572
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MGAT1 for ontologies About GeneDecksing
MGAT1 Antibody Products:
Assay Products for MGAT1: |
Protein
Domains /
Families
for MGAT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MGAT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P26572ProtoNet protein and cluster: P26572 1 Blocks protein family: IPB004139 Glycosyl transferase
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572Similarity: Belongs to the glycosyltransferase 13 family |
Function
for MGAT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid andcomplex N-glycansCatalytic activity: UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP +3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R Genatlas biochemistry entry for MGAT1:mannosyl (alpha-1,3-) glycoprotein beta-1,2-N-acetyl-glucosaminyltransferase,Golgi,biosynthesis of complex Asn-linked(N) glycans
Enzyme Number (IUBMB): EC 2.4.1.1011 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): MGAT1 (NM_001114618) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MGAT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity |
IEA | -- | | GO:0008375 | acetylglucosaminyltransferase activity |
TAS | 1702225 | | GO:0046872 | metal ion binding |
IEA | -- |
MGAT1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MGAT1:
Animal Models:
Mouse knock-outs for MGAT1: Mgat1tm1Jxm Mgat1tm1Pst
10 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mgat1):
MGAT1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MGAT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | N-glycan trimming and elongation in the cis-Golgi | | | 3 | N-glycan antennae elongation in the medial/trans-Golgi | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for MGAT1
2 
Kegg Pathways (Kegg details for MGAT1):
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572Pathway: Protein modification; protein glycosylation
MGAT1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGAT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for MGAT1 (P265722, 3 ENSP000003118884) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
MGAT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MGAT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MGAT1 for compounds About GeneDecksing
 Browse Tocris compounds for MGAT1
2 DrugBank Compounds for MGAT1 About this table
10/13 Novoseek chemical compound relationships for MGAT1 gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alpha-d-mannoside |
90.5 |
1 |
12417411 (1) |
| man5glcnac2 |
80.9 |
3 |
16233148 (2) |
| monoacylglycerol |
80.7 |
9 |
8175745 (2), 17170429 (2), 20374941 (1), 8418888 (1) (see all 6) |
| n-acetylglucosamine |
60 |
5 |
16233148 (1), 20335257 (1), 19706602 (1), 16672288 (1) (see all 5) |
| mannose |
53.4 |
11 |
16233148 (3), 16756569 (1), 17920136 (1), 12672701 (1) (see all 5) |
| polysaccharide |
47.4 |
10 |
16233148 (2), 12417409 (1), 17920136 (1), 10441510 (1) (see all 6) |
| triacylglycerol |
46.3 |
2 |
16214399 (1), 20493784 (1) |
| oleic acid |
34.9 |
3 |
9558325 (2), 8175745 (1) |
| sphingosine |
34.3 |
2 |
8175745 (2) |
| lipid |
19.9 |
9 |
8175745 (2), 10820520 (1), 12730219 (1), 9558325 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about MGAT1
|
Transcripts
for MGAT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MGAT1 gene (5 alternative transcripts): NM_001114617.1 NM_001114618.1 NM_001114619.1 NM_001114620.1 NM_002406.3 Unigene Cluster for MGAT1: Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Hs.519818 [show with all ESTs]Unigene Representative Sequence: NM_00111461818/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000333055(uc010jlf.3 uc010jlg.3 uc003mmi.4) ENST00000307826(uc003mmg.4)
ENST00000446023(uc003mmh.4 uc010jlh.3) ENST00000427865 ENST00000504671
ENST00000506889 ENST00000514283 ENST00000512695 ENST00000506269 ENST00000514438
ENST00000502678 ENST00000513431 ENST00000507384 ENST00000504385 ENST00000514760
ENST00000505682 ENST00000512080 ENST00000510341
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): MGAT1 (NM_001114618) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MGAT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT1 |
Additional cDNA sequence: AB209239.1 AF289558.1 AK057194.1 AK075429.1 AK090523.1 AK092256.1 AK094130.1 AK124428.1 AK290769.1 BC003575.1 BC104045.1 BC128250.1 CR456861.1 M55621.1 24/48 DOTS entries (see all 48): DT.101966301 DT.100778240 DT.454143 DT.100641543 DT.100758269 DT.99971147 DT.100031246 DT.95266662 DT.100821578 DT.102833288 DT.100821574 DT.86855743 DT.100821570 DT.100821575 DT.40301852 DT.95266665 DT.97813634 DT.120831197 DT.100704656 DT.120831141 DT.120831184 DT.97854919 DT.100031248 DT.120831152 24/543 AceView cDNA sequences (see all 543): CB267367 C18510 AA350085 AI884915 CA749020 BU168490 AI521731 AW664378 BU177358 BM477220 CA307768 CA422836 BQ448414 AU104711 BU859015 AI363186 BQ941275 AI825238 AW453057 BE645440 BE885481 AI083952 AI674239 BE739828
GeneLoc Exon Structure
5/26 Alternative Splicing Database (ASD) splice patterns (SP) for MGAT1 (see all 26) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 13c | ^ | 14a | · | 14b | · | 14c | · | 14d | · | 14e | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e | · | 16f | · | 16g | · | 16h | · | 16i | · | 16j | · | 16k | · | 16l | · | 16m | · | 16n | · | 16o | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MGAT1
|
Expression
for MGAT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MGAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAAAGTG
About this image
See MGAT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGAT1
SOURCE GeneReport for Unigene cluster: Hs.519818
UniProtKB/Swiss-Prot: MGAT1_HUMAN, P26572Tissue specificity: Appears to be present in all tissues
SABiosciences Expression via Pathway-Focused PCR Arrays including MGAT1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGAT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGAT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGAT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAT1 |
Orthologs
for MGAT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MGAT1 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mgat11 , 5 |
mannoside acetylglucosaminyltransferase 11, 5 |
84.64(n)1
90.34(a)1 |
|
11 (29.27 cM)5
173081 NM_010794.31 NP_034924.31
492442465 |
lizard
(Anolis carolinensis) |
Reptilia |
MGAT16 |
-- |
75(a) |
1 ↔ 1 |
2(192812758-192814110) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC525142 |
similar to mannoside acetylglucosaminyltransferase more |
74.98(n) |
|
BC041180.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc660302 |
hypothetical protein MGC66030 |
77.15(n) |
|
393649 BC058297.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mgat11 |
UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase more |
59.33(n)
57.25(a) |
|
37323 NM_080378.3 NP_525117.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
gly-123
gly-141 |
Expression: head ganglia, hypodermis,
intestine, more3
Protein GLY-141 |
36(a)3
50.1(n)1
46.78(a)1 |
|
X(7518728-7519906)3
1754531 NM_065318.21 NP_497719.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CGL11 |
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
47.65(n)
40.72(a) |
|
829981 NM_179186.1 NP_849517.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g08328001 |
hypothetical protein |
48.13(n)
41.64(a) |
|
4331263 NM_001055166.1 NP_001048631.1 |
ENSEMBL Gene Tree for MGAT1 (if available)
TreeFam Gene Tree for MGAT1 (if available) |
Paralogs
for MGAT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MGAT1 gene
- POMGNT12
MGAT1 for paralogs About GeneDecksing
|
Genomic Variants
for MGAT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MGAT1 (180217541 - 180242652 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MGAT1
5 CNVs: 3592 2612 2094 2093 34493
Human Gene Mutation Database (HGMD): MGAT1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGAT1 |
|
Disorders
/ Diseases
for MGAT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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MGAT1 for disorders About GeneDecksing
OMIM gene information: 160995
OMIM disorders: --
10  diseases for MGAT1: About MalaCardsmuscle-eye-brain disease congenital muscular dystrophy muscular dystrophy plague
insulin resistance brain disease cholesterol hepatitis
neuronitis alcoholism
1 Novoseek disease relationship for MGAT1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| obesity |
0 |
1 |
14966132 (1) |
Human Genome Epidemiology (HuGE) Navigator: MGAT1 (4 documents)
Export disorders for MGAT1 gene to outside databases
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Publications
for MGAT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for MGAT1 gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with MGAT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Organization and localization to chromosome 5 of the human UDP-N- acetylglucosamine:alpha-3-D-mannoside beta-1,2-N- acetylglucosaminyltransferase I gene. (PubMed id 1827260)1, 2, 3 Hull E....Schachter H. (1991)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. (PubMed id 1702225)1, 2 Kumar R.... Stanley P. (1990)
- Linkage and genome-wide association analysis of obesi ty-related phenotypes: association of weight with the MGAT1 gene. (PubMed id 19851299)1, 9 Johansson A....Gyllensten U. (2010)
- Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. (PubMed id 9020882)1, 9 Yip B....Schachter H. (1997)
- Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. (PubMed id 1421759)1, 9 Kumar R....Stanley P. (1992)
- Role of complex carbohydrates in human immunodeficien cy virus type 1 infection and resistance to antibody neutralization. (PubMed id 20335257)1, 9 Binley J.M....Sanders R.W. (2010)
- The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2-N- acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein. (PubMed id 7635144)1, 9 Tan J.... Schachter H. (1995)
- Genetic variants near the MGAT1 gene are associated wi th body weight, BMI and fatty acid metabolism among adults and children. (PubMed id 21304485)1 Jacobsson J.A....Fredriksson R. (2012)
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External Searches for MGAT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing MGAT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing MGAT1 gene
(According to HUGE)
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| -- |
Specialized Databases showing MGAT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for MGAT1 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT1 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_535 |
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About This Section
| Patent Information for MGAT1 gene:
Search GeneIP for patents involving MGAT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MGAT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MGAT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGAT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGAT1 | | | OriGene Protein Over-expression Lysate for MGAT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MGAT1 | | OriGene 3'-UTR Clone for MGAT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGAT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGAT1 |
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