Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGAM Gene

Aliases for MGAM Gene

  • Maltase-Glucoamylase 2 3
  • MGA 3 4 6
  • Maltase-Glucoamylase (Alpha-Glucosidase) 3
  • Maltase-Glucoamylase, Intestinal 3
  • Brush Border Hydrolase 3
  • Alpha-Glucosidase 2
  • EC 3.2.1.20 64
  • MGAML 4
  • MG 3

External Ids for MGAM Gene

Summaries for MGAM Gene

Entrez Gene Summary for MGAM Gene

  • This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAM Gene

MGAM (Maltase-Glucoamylase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include carbohydrate binding and maltose alpha-glucosidase activity. An important paralog of this gene is GAA.

UniProtKB/Swiss-Prot for MGAM Gene

  • May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing

Gene Wiki entry for MGAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAM Gene

Genomics for MGAM Gene

Genomic Location for MGAM Gene

Start:
141,907,813 bp from pter
End:
142,106,747 bp from pter
Size:
198,935 bases
Orientation:
Plus strand

Genomic View for MGAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAM Gene

Regulatory Elements for MGAM Gene

Proteins for MGAM Gene

  • Protein details for MGAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43451-MGA_HUMAN
    Recommended name:
    Maltase-glucoamylase, intestinal
    Protein Accession:
    O43451
    Secondary Accessions:
    • Q0VAX6
    • Q75ME7
    • Q86UM5

    Protein attributes for MGAM Gene

    Size:
    1857 amino acids
    Molecular mass:
    209852 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for MGAM Gene

neXtProt entry for MGAM Gene

Proteomics data for MGAM Gene at MOPED

Selected DME Specific Peptides for MGAM Gene

Post-translational modifications for MGAM Gene

  • Does not undergo intracellular or extracellular proteolytic cleavage
  • N- and O-glycosylated.
  • Sulfated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn135, Asn295, Asn457, Asn458, Asn479, Asn707, Asn749, Asn827, Asn885, Asn912, Asn977, Asn989, Asn1255, Asn1323, Asn1364, Asn1388, Asn1603, Asn1672, Asn1842, and Asn1847

Other Protein References for MGAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MGAM Gene

UniProtKB/Swiss-Prot:

MGA_HUMAN
Domain:
  • Contains 2 P-type (trefoil) domains.:
    • O43451
Family:
  • Belongs to the glycosyl hydrolase 31 family.:
    • O43451
genes like me logo Genes that share domains with MGAM: view

No data available for Gene Families for MGAM Gene

Function for MGAM Gene

Molecular function for MGAM Gene

GENATLAS Biochemistry: maltase-glucoamylase,alpha-glucosidase,expressed in the small intestine,member of the glucosyl hydrolase family 31,playing a unique role in the digestion of malted dietary oligosaccharides
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose
UniProtKB/Swiss-Prot Function: May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing

Enzyme Numbers (IUBMB) for MGAM Gene

Gene Ontology (GO) - Molecular Function for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 9446624
GO:0004339 glucan 1,4-alpha-glucosidase activity IEA --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004558 alpha-1,4-glucosidase activity TAS --
GO:0016160 amylase activity IEA --
genes like me logo Genes that share ontologies with MGAM: view

Phenotypes for MGAM Gene

genes like me logo Genes that share phenotypes with MGAM: view

miRNA for MGAM Gene

miRTarBase miRNAs that target MGAM

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MGAM Gene

Localization for MGAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAM Gene

Apical cell membrane; Single-pass type II membrane protein. Note=Brush border.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGAM Gene COMPARTMENTS Subcellular localization image for MGAM gene
Compartment Confidence
plasma membrane 5
chloroplast 3
cytoskeleton 3
endoplasmic reticulum 3
extracellular 3
mitochondrion 3
nucleus 3
cytosol 2
golgi apparatus 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MGAM: view

Pathways for MGAM Gene

genes like me logo Genes that share pathways with MGAM: view

Gene Ontology (GO) - Biological Process for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005983 starch catabolic process TAS 9446624
GO:0044245 polysaccharide digestion TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with MGAM: view

Compounds for MGAM Gene

(10) HMDB Compounds for MGAM Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-D-Glucose
  • Hexopyranose
492-62-6
Beta-D-Glucose
  • b-D-Glucopyranose
492-61-5
Dextrin
  • Caloreen
9004-53-9
D-Galactose
  • (+)-Galactose
59-23-4
D-Glucose
  • (+)-Glucose
50-99-7

(3) Drugbank Compounds for MGAM Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acarbose
56180-94-0 target inhibitor
Miglitol
72432-03-2 target antagonist inhibitor
Voglibose
83480-29-9 target inhibitor

(67) Novoseek inferred chemical compound relationships for MGAM Gene

Compound -log(P) Hits PubMed IDs
salacinol 94.6 12
starch 80.5 58
acarbose 80.4 19
maltose 80.2 28
isomaltose 74.5 7
genes like me logo Genes that share compounds with MGAM: view

Transcripts for MGAM Gene

Unigene Clusters for MGAM Gene

Maltase-glucoamylase (alpha-glucosidase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGAM Gene

No ASD Table

Relevant External Links for MGAM Gene

GeneLoc Exon Structure for
MGAM
ECgene alternative splicing isoforms for
MGAM

Expression for MGAM Gene

mRNA expression in normal human tissues for MGAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAM Gene

This gene is overexpressed in Whole Blood (36.5) and Small Intestine - Terminal Ileum (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MGAM Gene

SOURCE GeneReport for Unigene cluster for MGAM Gene Hs.122785

mRNA Expression by UniProt/SwissProt for MGAM Gene

O43451-MGA_HUMAN
Tissue specificity: Expressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas
genes like me logo Genes that share expressions with MGAM: view

Orthologs for MGAM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGAM 37
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGAM 36
  • 86.93 (n)
  • 85.94 (a)
MGAM 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGAM 36
  • 87.44 (n)
  • 87.06 (a)
MGAM 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgam 36
  • 81.92 (n)
  • 80.3 (a)
Mgam 16
Mgam 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC679818 36
  • 81.47 (n)
  • 80.27 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
SI 36
  • 65.31 (n)
  • 64.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mgam 36
  • 63.73 (n)
  • 62.25 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01079192.1 37
  • 55 (a)
OneToMany
si 36
  • 61.14 (n)
  • 58.71 (a)
worm
(Caenorhabditis elegans)
Secernentea aagr-2 36
  • 50.99 (n)
  • 45.83 (a)
R05F9.12 38
  • 38 (a)
F53F4.8 38
  • 36 (a)
D2096.3 38
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 37
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11720 36
  • 48.78 (n)
  • 41.35 (a)
rice
(Oryza sativa)
Liliopsida Os.19761 36
Os06g0676700 36
  • 47.95 (n)
  • 40.73 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04674 36
  • 47.44 (n)
  • 38.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1518 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToMany
Species with no ortholog for MGAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAM Gene

ENSEMBL:
Gene Tree for MGAM (if available)
TreeFam:
Gene Tree for MGAM (if available)

Paralogs for MGAM Gene

Paralogs for MGAM Gene

Selected SIMAP similar genes for MGAM Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MGAM: view

Variants for MGAM Gene

Sequence variations from dbSNP and Humsavar for MGAM Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs745162 -- 141,916,706(+) GGGCC(A/G)GGGCT intron-variant
rs941254 -- 142,007,218(+) aatat(A/T)tgaaa intron-variant
rs994808 -- 141,911,091(+) ACATA(A/C)ATGAG upstream-variant-2KB
rs994809 -- 141,911,485(+) TGGTG(C/T)TACTG upstream-variant-2KB
rs1159908 -- 142,006,140(+) aagaa(A/C)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGAM Gene

Variant ID Type Subtype PubMed ID
nsv831161 CNV Loss 17160897
dgv2142e1 CNV Complex 17122850
esv270979 CNV Insertion 20981092
nsv515542 CNV Loss 19592680
nsv8217 CNV Loss 18304495
nsv889249 CNV Loss 21882294
nsv464740 CNV Loss 19166990
nsv824323 CNV Loss 20364138
esv25886 CNV Gain+Loss 19812545
esv1318675 CNV Insertion 17803354
esv1556929 CNV Deletion 17803354
esv2735254 CNV Deletion 23290073
dgv7499n71 CNV Gain 21882294
esv2735255 CNV Deletion 23290073
nsv525756 CNV Loss 19592680
nsv889251 CNV Loss 21882294
nsv464741 CNV Loss 19166990
dgv832n27 CNV Gain 19166990
nsv8218 CNV Gain+Loss 18304495
nsv824324 CNV Gain 20364138
dgv833n27 CNV Gain 19166990
dgv7500n71 CNV Loss 21882294
dgv1242e199 CNV Deletion 23128226
nsv470395 CNV Loss 18288195
dgv834n27 CNV Loss 19166990
nsv818558 CNV Gain+Loss 17921354
nsv433393 CNV Gain 18776910
dgv835n27 CNV Loss 19166990
nsv464790 CNV Gain 19166990
dgv836n27 CNV Loss 19166990
nsv516285 CNV Gain+Loss 19592680
esv33962 CNV Gain+Loss 17666407
nsv5975 CNV Insertion 18451855
dgv7501n71 CNV Loss 21882294
nsv818559 CNV Loss 17921354
nsv889264 CNV Gain+Loss 21882294
dgv1136n67 CNV Loss 20364138
dgv1163e201 CNV Deletion 23290073
nsv820289 CNV Loss 19587683
esv2421934 CNV Deletion 20811451
nsv433239 CNV Loss 18776910
esv1780125 CNV Insertion 17803354
nsv514453 CNV Complex 21397061
nsv442187 CNV CNV 18776908
dgv837n27 CNV Loss 19166990
nsv818560 CNV Loss 17921354
nsv438007 CNV Loss 16468122
nsv465105 CNV Gain 19166990
dgv7502n71 CNV Loss 21882294
dgv838n27 CNV Loss 19166990
nsv5976 CNV Insertion 18451855
nsv824329 CNV Loss 20364138
dgv1164e201 CNV Deletion 23290073
nsv824330 CNV Loss 20364138

Relevant External Links for MGAM Gene

HapMap Linkage Disequilibrium report
MGAM

Disorders for MGAM Gene

(17) Novoseek inferred disease relationships for MGAM Gene

Disease -log(P) Hits PubMed IDs
disaccharidase deficiencies 79.7 1
pompe disease 61.5 3
lactase deficiency 61.4 1
enzyme deficiency 45.6 1
diarrhea chronic 36.1 4

Genatlas disease for MGAM Gene

diarrhea in children associated with starch malabsorption and small intestinal glucoamylase deficiency

Relevant External Links for MGAM

Genetic Association Database (GAD)
MGAM
Human Genome Epidemiology (HuGE) Navigator
MGAM
genes like me logo Genes that share disorders with MGAM: view

No data available for UniProtKB/Swiss-Prot for MGAM Gene

Publications for MGAM Gene

  1. Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. (PMID: 9446624) Nichols B.L. … Sterchi E.E. (J. Biol. Chem. 1998) 2 3 4 23
  2. Human intestinal maltase-glucoamylase: crystal structure of the N- terminal catalytic subunit and basis of inhibition and substrate specificity. (PMID: 18036614) Sim L. … Rose D.R. (J. Mol. Biol. 2008) 3 4 23
  3. Structural basis for substrate selectivity in human maltase- glucoamylase and sucrase-isomaltase N-terminal domains. (PMID: 20356844) Sim L. … Rose D.R. (J. Biol. Chem. 2010) 3 23
  4. Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte. (PMID: 3121301) Danielsen E.M. (EMBO J. 1987) 3 4
  5. Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase. (PMID: 3143729) Naim H.Y. … Lentze M.J. (J. Biol. Chem. 1988) 3 4

Products for MGAM Gene

Sources for MGAM Gene

Back to Top

Content