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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MGAM Gene

protein-coding GIFtS: 59
GCID: GC07P141607

maltase-glucoamylase (alpha-glucosidase)

Explore 18 diseases affiliated with
MGAM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Maltase-Glucoamylase (Alpha-Glucosidase)¹ ²		Brush Border Hydrolase²
MGA¹ ² ³ ⁵		Maltase-Glucoamylase, Intestinal²
MG²		MGAML³
Alpha-Glucosidase¹		EC 3.2.1.20⁸

External Ids:	HGNC: 7043¹	Entrez Gene: 8972²	Ensembl: ENSG00000257335⁷	OMIM: 154360⁵	UniProtKB: O43451³

Export aliases for MGAM gene to outside databases

Previous GC identifers: GC07P139967 GC07P140976 GC07P141102 GC07P141148 GC07P141342 GC07P135992

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MGAM:

This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of

digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins

are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate

specificities. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MGA_HUMAN, O43451

Function: May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because

of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food

manufacturing

Gene Wiki entry for MGAM (Maltase-glucoamylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MGAM gene promoter:
AML1a ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MGAM promoter sequence

Search SABiosciences Chromatin IP Primers for MGAM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGAM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34

MGAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MGAM gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P141607: view genomic region (about GC identifiers)

Start:	141,607,613 bp from pter	End:	141,806,547 bp from pter
Size:	198,935 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 141,033,874-141,144,746

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGA_HUMAN, O43451 (See protein sequence)

Recommended Name: Maltase-glucoamylase, intestinal

Size: 1857 amino acids; 209852 Da

Subunit: Monomer

Subcellular location: Apical cell membrane; Single-pass type II membrane protein. Note=Brush border

6/12 PDB 3D structures from and Proteopedia for MGAM (see all 12):

2QLY (3D)

2QMJ (3D)

3CTT (3D)

3L4T (3D)

3L4U (3D)

3L4V (3D)

Secondary accessions: Q0VAX6 Q75ME7 Q86UM5

Explore the universe of human proteins at neXtProt for MGAM: NX_O43451

Post-translational modifications:

N- and O-glycosylated¹

Does not undergo intracellular or extracellular proteolytic cleavage¹

Sulfated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43451

2 DME Specific Peptides for MGAM (O43451)

GADICGF

LLPYLYTL

MGAM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004659.2

ENSEMBL proteins:

ENSP00000419372 ENSP00000447378 ENSP00000417103 ENSP00000417515

Reactome Protein details: O43451
Human Recombinant Protein Products:

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	Uscn Proteins for MGAM

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--

MGAM for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MGAM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MGAM for domains About GeneDecksing

5 InterPro domains/families:

IPR000519 P_trefoil

IPR017853 Glycoside_hydrolase_SF

IPR017957 P_trefoil_CS

IPR000322 Glyco_hydro_31

IPR011013 Gal_mutarotase_SF_dom

Graphical View of Domain Structure for InterPro Entry O43451

ProtoNet protein and cluster: O43451

1 Blocks protein family: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: MGA_HUMAN, O43451

Similarity: Belongs to the glycosyl hydrolase 31 family

Similarity: Contains 2 P-type (trefoil) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MGA_HUMAN, O43451

Function: May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because

of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food

manufacturing

Catalytic activity: Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of

alpha-D-glucose

Catalytic activity: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends

of the chains with release of beta-D-glucose

Genatlas biochemistry entry for MGAM:

maltase-glucoamylase,alpha-glucosidase,expressed in the small intestine,member of the glucosyl hydrolase family

31,playing a unique role in the digestion of malted dietary oligosaccharides

Enzyme Number (IUBMB): EC 3.2.1.20²

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		hsa-miR-466 hsa-miR-330-3p hsa-miR-216a hsa-miR-3692
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAM

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	TAS	9446624
GO:0004339	glucan 1,4-alpha-glucosidase activity	IEA	--
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	--	--
GO:0004558	alpha-glucosidase activity	TAS	--
GO:0016160	amylase activity	IEA	--

MGAM for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MGAM:

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Mgam):

homeostasis/metabolism

MGAM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Digestion of dietary carbohydrate

Digestion of dietary carbohydrate

1.00

Carbohydrate digestion and absorption

Carbohydrate digestion and absorption

1.00

MPS IIIC - Sanfilippo syndrome C

Metabolism of carbohydrates

0.47

Galactose metabolism

Galactose metabolism

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for MGAM

	Metabolism of carbohydrates
	Digestion of dietary carbohydrate
	Metabolism

4 Kegg Pathways (Kegg details for MGAM):

	Galactose metabolism
	Starch and sucrose metabolism
	Metabolic pathways
	Carbohydrate digestion and absorption

MGAM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MGAM

1 Interacting protein for MGAM (O43451³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCF1	P14598³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0005983	starch catabolic process	TAS	9446624
GO:0044245	polysaccharide digestion	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

MGAM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MGAM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MGAM

10 HMDB Compounds for MGAM About this table

Compound	Synonyms	CAS #	PubMed Ids
Alpha-D-Glucose	Hexopyranose (see all 11)	492-62-6	--
Beta-D-Glucose	b-D-Glucopyranose (see all 8)	492-61-5	--
D-Galactose	(+)-Galactose (see all 14)	59-23-4	--
D-Glucose	(+)-Glucose (see all 23)	50-99-7	--
D-Maltose	alpha-Malt sugar (see all 40)	69-79-4	--
Dextrin	Caloreen (see all 10)	9004-53-9	--
Glycogen	Animal starch (see all 5)	9005-79-2	--
Melibiose	6-(D-galactosido)-D-glucose (see all 17)	585-99-9	--
Sucrose	(+)-Sucrose (see all 11)	57-50-1	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 DrugBank Compounds for MGAM About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Voglibose	--	83480-29-9	target	inhibitor	20351564 20025554 16713439 19281809 11752352 19568704
Acarbose	--	56180-94-0	target	inhibitor	16763908 16359900 11752352 19275550 16702880
Miglitol	--	72432-03-2	target	antagonist inhibitor	19818342 16817895 11752352 9951949

10/67 Novoseek chemical compound relationships for MGAM gene (see all 67) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
salacinol	94.6	14	18295754 (3), 16438529 (1), 17194097 (1), 16817895 (1) (see all 10)
starch	80.5	77	10942292 (5), 7706213 (2), 7765970 (2), 1368209 (2) (see all 45)
acarbose	80.4	22	16702880 (3), 16359900 (2), 11890888 (2), 7821430 (2) (see all 14)
maltose	80.2	32	16702880 (3), 9336980 (2), 9680991 (1), 1525871 (1) (see all 25)
isomaltose	74.5	8	9605546 (3), 9605547 (2), 1970434 (1), 7716159 (1)
1-deoxynojirimycin	72.4	3	11275559 (1), 16611383 (1), 8611585 (1)
maltodextrin	70.8	8	9605546 (2), 11400108 (2), 11890888 (1), 18356321 (1) (see all 6)
miglitol	67.8	2	9825953 (1)
maltotetraose	65.4	2	1295602 (1), 9099629 (1)
cyclomaltodextrin	59.5	1	15178396 (1)

Search CenterWatch for drugs/clinical trials and news about MGAM / MGA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MGAM gene:

NM_004668.2

Unigene Cluster for MGAM:

Maltase-glucoamylase (alpha-glucosidase)

Hs.122785 [show with all ESTs]

Unigene Representative Sequence: NM_004668

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465654 ENST00000497554 ENST00000549489(uc003vwy.3) ENST00000497673

ENST00000475668 ENST00000495045 ENST00000490593 ENST00000479289 ENST00000485078

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		hsa-miR-466 hsa-miR-330-3p hsa-miR-216a hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: MGAM 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGAM

Additional cDNA sequence:

AF016833.2 AK127838.1 BC120872.1

2 DOTS entries:

DT.105116 DT.101976434

24/36 AceView cDNA sequences (see all 36):

AA411968 CK301106 AI733054 AF016833 AW468532 AI474873 BE501751 AA894763

BU684758 AI249749 AA412675 BE501913 BX099576 BE501528 AL698344 BP383005

NM_004668 AI791544 BG721366 AA412737 AW612430 AA846103 BX645594 AK127838

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MGAM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGGAAAA

About this image

MGAM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MGAM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGAM

SOURCE GeneReport for Unigene cluster: Hs.122785

UniProtKB/Swiss-Prot: MGA_HUMAN, O43451

Tissue specificity: Expressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas

SABiosciences Custom PCR Arrays for MGAM

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGAM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAM gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SI¹	sucrase-isomaltase (alpha-glucosidase)	65.07(n) 63.84(a)		425007 XM_422811.3 XP_422811.2
lizard (Anolis carolinensis)	Reptilia	SI⁶	--	61(a)	1 ↔ 1	3(10755679-10858144)
zebrafish (Danio rerio)	Actinopterygii	wu:fd44a09¹	wu:fd44a09	61.43(n) 58.97(a)		100148922 XM_001919100.3 XP_001919135.3
honey bee (Apis mellifera)	Insecta	--	--	22(a)	possible ortholog	GroupUn.6815(10-1068)
worm (Caenorhabditis elegans)	Secernentea	D2096.3³	--	39(a) (best of 3)		IV(8363651-8375533) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G11720⁶ AT3G45940⁶ (see all 4)	alpha-glucosidase (see all 4)	32(a) 30(a) (see all 4)	possible ortholog possible ortholog (see all 4)	5(3776814-3780146) 3(16886226-16889171)
rice (Oryza sativa)	Liliopsida	Os.19761²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	72.88(n)		AK102309.1

ENSEMBL Gene Tree for MGAM (if available)
TreeFam Gene Tree for MGAM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MGAM gene

SI² GAA² GANC² GANAB² LOC93432²

2 SIMAP similar genes for MGAM using alignment to 6 protein entries: MGA_HUMAN (see all proteins):

SI GAA

MGAM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10601773^1,2	C	--	141058069(+)	`GTCTC-/AAAAAAA`	1	--	int¹		1		NA	2
rs148033172^1,2		--	141693761(+)	`ACCTCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs141802297^1,2	C,	--	141693816(+)	`GATTAC/TAGGCA`	1	--	us2k¹		0	--	--	--	--
rs150162137^1,2		--	141693828(+)	`GCACCA/GCCATG`	1	--	us2k¹		0	--	--	--	--
rs115691103^1,2	C,	--	141693848(+)	`TTTTCA/GTACTT`	1	--	us2k¹		0	--	--	--	--
rs185191390^1,2		--	141693994(+)	`TAAGAA/GGGGTT`	1	--	us2k¹		0	--	--	--	--
rs13437780^1,2	C,F,H,	--	141694222(+)	`TTGATT/AGGCAG`	1	--	us2k¹		21		NS EA NA WA	2756
rs141926590^1,2		--	141694248(+)	`GAGCAC/TCTAAA`	1	--	us2k¹		0	--	--	--	--
rs1609100^1,2	C,F,A,H,	--	141694268(+)	`GTGCAA/GCTGAG`	1	--	us2k¹		11		NA WA CSA EA	372
rs146333588^1,2		--	141694285(+)	`CCCAGA/GAGGGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MGAM (141607613 - 141806547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 45 variations for MGAM
15/44 CNVs (see all 44): 64965 30265 54002 10211 32953 53904 36627 36626 9586 32952 54016 53845 37566 52119 52110
1 Indel: 28473

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MGAM for disorders           About GeneDecksing

OMIM gene information: 154360    OMIM disorders: --

18 diseases for MGAM:    About MalaCards

protein-energy malnutrition glycogen storage disease glycogen storage disease ii cystic fibrosis

coronary heart disease insulin resistance colon adenocarcinoma diarrhea

hyperglycemia apnea fibrosis noma

duodenitis adenocarcinoma colorectal cancer asthma

obesity alcoholism

13 diseases from the University of Copenhagen DISEASES database for MGAM:

Hypertension Hypokalemia Kidney disease Heart disease

Calcinosis Osteoporosis Diabetes mellitus Metabolic acidosis

Hyperparathyroidism Toxic encephalopathy Hypophosphatemia Cerebrovascular accident

Neurodegenerative disease

10/17 Novoseek disease relationships for MGAM gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
disaccharidase deficiencies	79.7	1	8151467 (1)
pompe disease	61.5	4	16702880 (2), 16763908 (1)
lactase deficiency	61.4	1	12394387 (1)
enzyme deficiency	45.6	1	12394387 (1)
diarrhea chronic	36.1	4	12519224 (2), 12394383 (1), 8151467 (1)
atrophy	24.5	4	11346204 (2), 10817278 (1)
colon adenocarcinoma	20.2	1	9438518 (1)
malnutrition	16.5	5	7896332 (2), 8125391 (1), 9446624 (1)
bowel disease	3.68	1	17671629 (1)
cancer	0.597	3	1281900 (1), 1515557 (1)

Genatlas disease: MGAM

diarrhea in children associated with starch malabsorption and small intestinal glucoamylase deficiency

Human Genome Epidemiology (HuGE) Navigator: MGAM (3 documents)

Export disorders for MGAM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MGAM gene, integrated from 9 sources (see all 305):
(articles sorted by number of sources associating them with MGAM)

Utopia: connect your pdf to the dynamic
world of online information

Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. (PubMed id 9446624)^{1, 2, 3, 9} Nichols B.L....Sterchi E.E. (1998)
Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. (PubMed id 18036614)^{1, 2, 9} Sim L....Rose D.R. (2008)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase. (PubMed id 3143729)^{1, 2} Naim H.Y.... Lentze M.J. (1988)
Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte. (PubMed id 3121301)^{1, 2} Danielsen E.M. (1987)
Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives. (PubMed id 16817895)^{7, 9} Rossi E.J....Rose D.R. (2006)
Structural basis for substrate selectivity in human m altase-glucoamylase and sucrase-isomaltase N-terminal domains. (PubMed id 20356844)^{1, 9} Sim L....Rose D.R. (2010)
Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease. (PubMed id 16702880)^{7, 9} Zhang H....Bali D. (2006)
Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders. (PubMed id 16763908)^{7, 9} Gelb M.H....Chamoles N.A. (2006)
A new diagnostic assay for glycogen storage disease type II in mixed leukocytes. (PubMed id 16359900)^{7, 9} Okumiya T....Reuser A.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8972	HGNC: 7043	AceView: MGAM	Ensembl:ENSG00000257335	euGenes: HUgn8972
ECgene: MGAM	Kegg: 8972	H-InvDB: MGAM

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MGAM	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MGAM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MGAM gene:
Search GeneIP for patents involving MGAM

GeneCards and IP:
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maltase-glucoamylase (alpha-glucosidase)

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maltase-glucoamylase (alpha-glucosidase)

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