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Aliases for MGA Gene

Aliases for MGA Gene

  • MGA, MAX Dimerization Protein 2 3 5
  • MAX Dimerization Protein 5 3 4
  • MAD5 3 4
  • MAX Gene Associated 2
  • KIAA0518 4
  • MXD5 3

External Ids for MGA Gene

Previous GeneCards Identifiers for MGA Gene

  • GC15P037399
  • GC15P034928
  • GC15P039612
  • GC15P039677
  • GC15P039749
  • GC15P041952
  • GC15P018801

Summaries for MGA Gene

GeneCards Summary for MGA Gene

MGA (MGA, MAX Dimerization Protein) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot for MGA Gene

  • Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGA Gene

Genomics for MGA Gene

Regulatory Elements for MGA Gene

Enhancers for MGA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MGA on UCSC Golden Path with GeneCards custom track

Promoters for MGA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGA on UCSC Golden Path with GeneCards custom track

Genomic Location for MGA Gene

Chromosome:
15
Start:
41,621,224 bp from pter
End:
41,773,081 bp from pter
Size:
151,858 bases
Orientation:
Plus strand

Genomic View for MGA Gene

Genes around MGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGA Gene

Proteins for MGA Gene

  • Protein details for MGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWI9-MGAP_HUMAN
    Recommended name:
    MAX gene-associated protein
    Protein Accession:
    Q8IWI9
    Secondary Accessions:
    • E7ENI0
    • F5H7K2
    • Q9H8R3
    • Q9H9N7
    • Q9UG69
    • Q9Y4E9

    Protein attributes for MGA Gene

    Size:
    3026 amino acids
    Molecular mass:
    331836 Da
    Quaternary structure:
    • Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.
    SequenceCaution:
    • Sequence=BAB14186.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGA Gene

Proteomics data for MGA Gene at MOPED

Post-translational modifications for MGA Gene

  • Ubiquitination at Lys 708, Lys 715, Lys 1310, Lys 1461, and Lys 2374
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MGA Gene

Domains & Families for MGA Gene

Gene Families for MGA Gene

Protein Domains for MGA Gene

Suggested Antigen Peptide Sequences for MGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWI9

UniProtKB/Swiss-Prot:

MGAP_HUMAN :
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
Domain:
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 T-box DNA-binding domain.
genes like me logo Genes that share domains with MGA: view

Function for MGA Gene

Molecular function for MGA Gene

UniProtKB/Swiss-Prot Function:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Gene Ontology (GO) - Molecular Function for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with MGA: view
genes like me logo Genes that share phenotypes with MGA: view

Animal Model Products

miRNA for MGA Gene

miRTarBase miRNAs that target MGA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGA Gene

Localization for MGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGA Gene COMPARTMENTS Subcellular localization image for MGA gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MGA: view

Pathways & Interactions for MGA Gene

SuperPathways for MGA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MGA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MGA Gene

Drugs & Compounds for MGA Gene

No Compound Related Data Available

Transcripts for MGA Gene

mRNA/cDNA for MGA Gene

(20) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MGA Gene

MGA, MAX dimerization protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGA Gene

No ASD Table

Relevant External Links for MGA Gene

GeneLoc Exon Structure for
MGA
ECgene alternative splicing isoforms for
MGA

Expression for MGA Gene

mRNA expression in normal human tissues for MGA Gene

Protein differential expression in normal tissues from HIPED for MGA Gene

This gene is overexpressed in Hair follicle (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGA Gene



SOURCE GeneReport for Unigene cluster for MGA Gene Hs.187569

genes like me logo Genes that share expression patterns with MGA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MGA Gene

Orthologs for MGA Gene

This gene was present in the common ancestor of animals.

Orthologs for MGA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGA 35
  • 90.05 (n)
  • 88.36 (a)
MGA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGA 35
  • 91.51 (n)
  • 90.31 (a)
MGA 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mga 35
  • 86.53 (n)
  • 82.71 (a)
Mga 16
Mga 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGA 35
  • 99.63 (n)
  • 99.51 (a)
MGA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mga 35
  • 86.61 (n)
  • 83.43 (a)
oppossum
(Monodelphis domestica)
Mammalia MGA 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGA 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGA 35
  • 64.34 (n)
  • 58.99 (a)
MGA 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGA 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mga 35
  • 55.87 (n)
  • 47.73 (a)
zebrafish
(Danio rerio)
Actinopterygii MGA (2 of 2) 36
  • 32 (a)
OneToMany
mgaa 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbx-11 36
  • 29 (a)
ManyToMany
tbx-30 36
  • 24 (a)
ManyToMany
tbx-34 36
  • 25 (a)
ManyToMany
tbx-35 36
  • 22 (a)
ManyToMany
tbx-37 36
  • 26 (a)
ManyToMany
tbx-38 36
  • 27 (a)
ManyToMany
tbx-39 36
  • 17 (a)
ManyToMany
tbx-40 36
  • 17 (a)
ManyToMany
tbx-42 36
  • 24 (a)
ManyToMany
tbx-43 36
  • 26 (a)
ManyToMany
tbx-8 36
  • 34 (a)
ManyToMany
tbx-9 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for MGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGA Gene

ENSEMBL:
Gene Tree for MGA (if available)
TreeFam:
Gene Tree for MGA (if available)

Paralogs for MGA Gene

Paralogs for MGA Gene

(8) SIMAP similar genes for MGA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MGA: view

Variants for MGA Gene

Sequence variations from dbSNP and Humsavar for MGA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803348 - 41,669,906(-) ATCAG(C/T)ATCCA intron-variant, reference, missense
rs2178004 - 41,699,117(+) TGAAG(A/T)CTTTG reference, missense
rs17677811 - 41,729,314(+) CTTCA(A/C/T)GTCAT reference, missense
rs17677991 - 41,740,185(+) TTGTC(C/G)CAGCA reference, missense
rs2616 -- 41,753,462(+) ATCCT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGA Gene

Variant ID Type Subtype PubMed ID
esv988006 CNV Deletion 20482838
esv3921 CNV Deletion 18987735
esv6726 CNV Loss 19470904
esv2749621 CNV Deletion 23290073
nsv94393 CNV Loss 16902084
esv991459 CNV Deletion 20482838
esv1466405 CNV Deletion 17803354
dgv740e1 CNV Complex 17122850
dgv2363n71 CNV Gain 21882294

Variation tolerance for MGA Gene

Residual Variation Intolerance Score: 1.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGA Gene

Human Gene Mutation Database (HGMD)
MGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGA Gene

Disorders for MGA Gene

Relevant External Links for MGA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGA

No disorders were found for MGA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGA Gene

Publications for MGA Gene

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4 67
  2. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. (PMID: 10601024) Hurlin P.J. … Eisenman R.N. (EMBO J. 1999) 3 23
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. (PMID: 25944111) Zhao Y. … Mosammaparast N. (EMBO J. 2015) 3

Products for MGA Gene

Sources for MGA Gene

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