MGA Gene
protein-coding GIFtS: 48
GCID: GC15P041952
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MGA, MAX dimerization protein(Previous name: MAX gene associated )
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Aliases
for MGA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MGA, MAX Dimerization Protein1 2 | | MAX Dimerization Protein 52 3 | | MAD51 2 3 | | FLJ126341 | | MXD51 2 | | MAX Gene-Associated Protein2 | | MAX Gene Associated1 2 | | MGAM5 | | KIAA05181 3 | | |
Export aliases for MGA gene to outside databasesPrevious GC identifers: GC15P037399 GC15P034928 GC15P039612 GC15P039677 GC15P039749 GC15P018801 |
Summaries
for MGA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MGAP_HUMAN, Q8IWI9Function: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-boxfamily target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequenceand seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependentcell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dualfunction of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (Bysimilarity)
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Genomic Views
for MGA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MGA gene promoter:
POU3F2 LCR-F1 HNF-1A Max N-Myc HNF-1 c-Myc Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MGA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15MGA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P041952: view genomic region
(about GC identifiers)
Start:
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41,913,422 bp from pter |
End:
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42,062,141 bp from pter |
Size:
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148,720 bases |
Orientation:
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plus strand |
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Proteins
for MGA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MGAP_HUMAN, Q8IWI9 (See
protein sequence)Recommended Name: MAX gene-associated protein Size: 3026 amino acids; 331822 Da
Subunit: Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of someMLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as thefacultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20,PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB14186.1; Type=Erroneous initiation;
Secondary accessions: Q9H8R3 Q9H9N7 Q9UG69 Q9Y4E9Alternative splicing: 2 isoforms: Q8IWI9-1 Q8IWI9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MGA: NX_Q8IWI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWI9
MGA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001074010.2 NP_001157745.1
ENSEMBL proteins: ENSP00000457151 ENSP00000455155 ENSP00000456141 ENSP00000457035 ENSP00000457250 ENSP00000457474 ENSP00000219905 ENSP00000374586 ENSP00000442467
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MGA for ontologies About GeneDecksing
MGA Antibody Products:
Assay Products for MGA: |
Protein
Domains /
Families
for MGA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MGA for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWI9ProtoNet protein and cluster: Q8IWI9 UniProtKB/Swiss-Prot: MGAP_HUMAN, Q8IWI9Domain: Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (Bysimilarity)Similarity: Contains 1 bHLH (basic helix-loop-helix) domainSimilarity: Contains 1 T-box DNA-binding domain |
Function
for MGA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MGAP_HUMAN, Q8IWI9Function: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-boxfamily target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequenceand seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependentcell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dualfunction of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): MGA (NM_145903) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MGA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGA |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
MGA for ontologies About GeneDecksing
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Pathways & Interactions
for MGA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MGA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for MGA (Q8IWI92, 3 ENSP000002199054) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
MGA for ontologies About GeneDecksing
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Drugs & Compounds
for MGA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MGA
Search CenterWatch for drugs/clinical trials and news about MGA / MGAP
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Transcripts
for MGA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for MGA gene (2 alternative transcripts): NM_001080541.2 NM_001164273.1 Unigene Cluster for MGA: MGA, MAX dimerization protein Hs.187569 [show with all ESTs]Unigene Representative Sequence: NM_00116427312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000568630 ENST00000563576(uc001zog.1) ENST00000566718 ENST00000566586
ENST00000570161(uc010uda.1) ENST00000561532 ENST00000564190 ENST00000566288(uc001zoi.3)
ENST00000568255 ENST00000219905(uc010ucy.2 uc010ucz.2) ENST00000389936
ENST00000545763
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): MGA (NM_145903) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MGA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGA |
Additional cDNA sequence: AB011090.1 AF176922.1 AK022696.1 AK023360.1 AK025751.1 AK055203.1 AK056470.1 AK301207.1 AL050181.1 BC007584.1 BC016982.1 BC038449.2 BC136659.1 BX648098.1 10 DOTS entries: DT.213601 DT.110129 DT.100725455 DT.92416379 DT.121080625 DT.40209557 DT.121080571 DT.100806491 DT.421255 DT.95308439 1 AceView cDNA sequence: BQ710932
GeneLoc Exon Structure
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Expression
for MGA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCAATAG
About this image
See MGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MGA
SOURCE GeneReport for Unigene cluster: Hs.187569
SABiosciences Custom PCR Arrays for MGA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MGA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGA |
Orthologs
for MGA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MGA gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for MGA (if available)
TreeFam Gene Tree for MGA (if available) |
Paralogs
for MGA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MGA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MGA (41913422 - 42062141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for MGA
1 CNV: 3078
6 Indels: 42549 40089 25518 11789 40088 61440 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGA |
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Disorders
/ Diseases
for MGA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MGA for disorders About GeneDecksing
OMIM gene information: 154360
OMIM disorders: --
4  diseases for MGA: About MalaCardsmicroglandular adenosis ulnar neuropathy neuropathy pharyngitis
Export disorders for MGA gene to outside databases
|
Publications
for MGA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MGA gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MGA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. (PubMed id 10601024)1, 9 Hurlin P.J....Eisenman R.N. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
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External Searches for MGA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MGA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MGA gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MGA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MGA | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MGA gene:
Search GeneIP for patents involving MGA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MGA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MGA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MGA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MGA | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MGA | | OriGene 3'-UTR Clone for MGA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MGA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MGA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MGA | | OriGene Custom Protein Services for MGA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MGA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MGA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MGA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MGA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MGA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MGA |
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| | | | Search Tocris compounds for MGA |
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 | | | MGA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MGA |
|  |  |  | | | | Search ThermoFisher Antibodies for MGA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MGA |
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