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Aliases for MGA Gene

Aliases for MGA Gene

  • MGA, MAX Dimerization Protein 2 3 5
  • MAX Dimerization Protein 5 3 4
  • MAD5 3 4
  • MAX Gene-Associated Protein 3
  • MAX Gene Associated 2
  • KIAA0518 4
  • MXD5 3

External Ids for MGA Gene

Previous GeneCards Identifiers for MGA Gene

  • GC15P037399
  • GC15P034928
  • GC15P039612
  • GC15P039677
  • GC15P039749
  • GC15P041952
  • GC15P018801

Summaries for MGA Gene

GeneCards Summary for MGA Gene

MGA (MGA, MAX Dimerization Protein) is a Protein Coding gene. Diseases associated with MGA include Aicardi-Goutieres Syndrome. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is TBR1.

UniProtKB/Swiss-Prot for MGA Gene

  • Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Additional gene information for MGA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGA Gene

Genomics for MGA Gene

Regulatory Elements for MGA Gene

Enhancers for MGA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040762 1.4 ENCODE dbSUPER 37.1 -856.6 -856576 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 MGA ZFYVE19 ENSG00000259211 CCDC32 DNAJC17 INO80 RAD51-AS1 FAM92A1P1 BAHD1 EIF2AK4
GH15H041659 1.5 FANTOM5 ENCODE 33.7 +39.8 39797 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 MGA JMJD7 INO80 RAD51-AS1 DNAJC17 MAPKBP1 LOC105370795 GANC ENSG00000260814 PLA2G4B
GH15H041492 1.7 FANTOM5 ENCODE dbSUPER 28.1 -126.4 -126405 5 FOXA2 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SP3 NDUFAF1 MGA RPAP1 RTF1 RAD51-AS1 INO80 ENSG00000260814 DNAJC17 LOC105370795 GANC
GH15H041915 1.4 Ensembl ENCODE dbSUPER 33.4 +297.8 297792 6 FOXA2 ATF1 ZFP64 RAD21 RARA YY1 FOS ATF7 ZC3H11A USF2 SPTBN5 MGA CDAN1 ENSG00000260814 LOC105370792 PLA2G4E-AS1 EHD4 MAPKBP1 STARD9 INO80
GH15H041282 1.1 ENCODE 40.3 -336.4 -336428 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS NDUFAF1 MGA INO80 BAHD1 GANC RPAP1 ENSG00000259211 DNAJC17 LOC105370795 ENSG00000259536
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MGA on UCSC Golden Path with GeneCards custom track

Promoters for MGA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075658 376 1600 MLX ARID4B DMAP1 YY1 ZNF143 DEK SP3 SP5 ZHX2 MXD4

Genomic Location for MGA Gene

Chromosome:
15
Start:
41,621,224 bp from pter
End:
41,773,081 bp from pter
Size:
151,858 bases
Orientation:
Plus strand

Genomic View for MGA Gene

Genes around MGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGA Gene

Proteins for MGA Gene

  • Protein details for MGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWI9-MGAP_HUMAN
    Recommended name:
    MAX gene-associated protein
    Protein Accession:
    Q8IWI9
    Secondary Accessions:
    • E7ENI0
    • F5H7K2
    • Q9H8R3
    • Q9H9N7
    • Q9UG69
    • Q9Y4E9

    Protein attributes for MGA Gene

    Size:
    3026 amino acids
    Molecular mass:
    331836 Da
    Quaternary structure:
    • Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.
    SequenceCaution:
    • Sequence=BAB14186.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGA Gene

Post-translational modifications for MGA Gene

  • Ubiquitination at posLast=708708, Lys715, posLast=13101310, Lys1461, and posLast=23742374
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MGA Gene

Domains & Families for MGA Gene

Gene Families for MGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for MGA Gene

Suggested Antigen Peptide Sequences for MGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWI9

UniProtKB/Swiss-Prot:

MGAP_HUMAN :
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
Domain:
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
genes like me logo Genes that share domains with MGA: view

Function for MGA Gene

Molecular function for MGA Gene

UniProtKB/Swiss-Prot Function:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Phenotypes From GWAS Catalog for MGA Gene

Gene Ontology (GO) - Molecular Function for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 20936779
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MGA: view
genes like me logo Genes that share phenotypes with MGA: view

Animal Model Products

CRISPR Products

miRNA for MGA Gene

miRTarBase miRNAs that target MGA

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGA Gene

Localization for MGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGA gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with MGA: view

Pathways & Interactions for MGA Gene

genes like me logo Genes that share pathways with MGA: view

Pathways by source for MGA Gene

1 BioSystems pathway for MGA Gene

Gene Ontology (GO) - Biological Process for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MGA: view

No data available for SIGNOR curated interactions for MGA Gene

Drugs & Compounds for MGA Gene

No Compound Related Data Available

Transcripts for MGA Gene

Unigene Clusters for MGA Gene

MGA, MAX dimerization protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGA Gene

No ASD Table

Relevant External Links for MGA Gene

GeneLoc Exon Structure for
MGA
ECgene alternative splicing isoforms for
MGA

Expression for MGA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGA Gene

Protein differential expression in normal tissues from HIPED for MGA Gene

This gene is overexpressed in Hair follicle (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGA Gene



NURSA nuclear receptor signaling pathways regulating expression of MGA Gene:

MGA

SOURCE GeneReport for Unigene cluster for MGA Gene:

Hs.187569

Evidence on tissue expression from TISSUES for MGA Gene

  • Intestine(4.6)
  • Nervous system(4.3)
  • Gall bladder(3.5)
  • Liver(2.9)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MGA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGA Gene

Orthologs for MGA Gene

This gene was present in the common ancestor of animals.

Orthologs for MGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGA 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia MGA 33 34
  • 91.51 (n)
cow
(Bos Taurus)
Mammalia MGA 33 34
  • 90.05 (n)
rat
(Rattus norvegicus)
Mammalia Mga 33
  • 86.61 (n)
mouse
(Mus musculus)
Mammalia Mga 33 16 34
  • 86.53 (n)
oppossum
(Monodelphis domestica)
Mammalia MGA 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGA 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGA 33 34
  • 64.34 (n)
lizard
(Anolis carolinensis)
Reptilia MGA 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mga 33
  • 55.87 (n)
zebrafish
(Danio rerio)
Actinopterygii MGA (2 of 2) 34
  • 32 (a)
OneToMany
mgaa 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbx-9 34
  • 36 (a)
ManyToMany
tbx-8 34
  • 34 (a)
ManyToMany
tbx-11 34
  • 29 (a)
ManyToMany
tbx-38 34
  • 27 (a)
ManyToMany
tbx-37 34
  • 26 (a)
ManyToMany
tbx-43 34
  • 26 (a)
ManyToMany
tbx-34 34
  • 25 (a)
ManyToMany
tbx-30 34
  • 24 (a)
ManyToMany
tbx-42 34
  • 24 (a)
ManyToMany
tbx-35 34
  • 22 (a)
ManyToMany
tbx-39 34
  • 17 (a)
ManyToMany
tbx-40 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for MGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGA Gene

ENSEMBL:
Gene Tree for MGA (if available)
TreeFam:
Gene Tree for MGA (if available)

Paralogs for MGA Gene

Paralogs for MGA Gene

(8) SIMAP similar genes for MGA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MGA: view

Variants for MGA Gene

Sequence variations from dbSNP and Humsavar for MGA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000001663 -- 41,667,920(+) TGCCT(C/T)AGCCT intron-variant
rs1000023361 -- 41,738,838(+) TTGTA(C/T)CAAAC intron-variant
rs1000025799 -- 41,738,014(+) TAGCA(A/G)ATGTG intron-variant
rs1000034922 -- 41,624,680(+) GGCCA(A/G)GCTGG intron-variant
rs1000062825 -- 41,705,547(+) TGTAG(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGA Gene

Variant ID Type Subtype PubMed ID
dgv1203n106 CNV deletion 24896259
dgv2581n100 CNV gain 25217958
dgv449e214 CNV gain 21293372
esv1466405 CNV deletion 17803354
esv2749621 CNV deletion 23290073
esv2760027 CNV loss 17122850
esv3233790 CNV deletion 24192839
esv3415439 CNV insertion 20981092
esv3552369 CNV deletion 23714750
esv3921 CNV loss 18987735
esv6726 CNV loss 19470904
esv988006 CNV deletion 20482838
esv991459 CNV deletion 20482838
nsv1038894 CNV gain 25217958
nsv1041861 CNV loss 25217958
nsv1044347 CNV loss 25217958
nsv1048655 CNV loss 25217958
nsv1049514 CNV gain 25217958
nsv1069857 CNV deletion 25765185
nsv1147042 CNV deletion 26484159
nsv94393 CNV deletion 16902084
nsv957959 CNV deletion 24416366
nsv976925 CNV duplication 23825009

Variation tolerance for MGA Gene

Residual Variation Intolerance Score: 1.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGA Gene

Human Gene Mutation Database (HGMD)
MGA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGA Gene

Disorders for MGA Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGA Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
aicardi-goutieres syndrome
  • cree encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search MGA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGA
genes like me logo Genes that share disorders with MGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGA Gene

Publications for MGA Gene

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y … Roeder RG (Cell 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. (PMID: 10601024) Hurlin PJ … Eisenman RN (The EMBO journal 1999) 3 22 60
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for MGA Gene

Sources for MGA Gene

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