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Aliases for MGA Gene

Aliases for MGA Gene

  • MGA, MAX Dimerization Protein 2 3
  • MAX Dimerization Protein 5 3 4
  • MAD5 3 4
  • MAX Gene-Associated Protein 3
  • MAX Gene Associated 2
  • KIAA0518 4
  • MXD5 3

External Ids for MGA Gene

Summaries for MGA Gene

GeneCards Summary for MGA Gene

MGA (MGA, MAX Dimerization Protein) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot for MGA Gene

  • Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGA Gene

Genomics for MGA Gene

Genomic Location for MGA Gene

Start:
41,621,224 bp from pter
End:
41,773,081 bp from pter
Size:
151,858 bases
Orientation:
Plus strand

Genomic View for MGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGA Gene

Regulatory Elements for MGA Gene

Proteins for MGA Gene

  • Protein details for MGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWI9-MGAP_HUMAN
    Recommended name:
    MAX gene-associated protein
    Protein Accession:
    Q8IWI9
    Secondary Accessions:
    • E7ENI0
    • F5H7K2
    • Q9H8R3
    • Q9H9N7
    • Q9UG69
    • Q9Y4E9

    Protein attributes for MGA Gene

    Size:
    3026 amino acids
    Molecular mass:
    331836 Da
    Quaternary structure:
    • Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.
    SequenceCaution:
    • Sequence=BAB14186.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGA Gene

Proteomics data for MGA Gene at MOPED

Post-translational modifications for MGA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys708, Lys715, Lys1310, Lys1461, and Lys2374

No data available for DME Specific Peptides for MGA Gene

Domains for MGA Gene

Gene Families for MGA Gene

HGNC:
  • MXD :MAX dimerization proteins
  • TBX :T-boxes

Protein Domains for MGA Gene

Suggested Antigen Peptide Sequences for MGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWI9

UniProtKB/Swiss-Prot:

MGAP_HUMAN
Domain:
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.:
    • Q8IWI9
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q8IWI9
  • Contains 1 T-box DNA-binding domain.:
    • Q8IWI9
genes like me logo Genes that share domains with MGA: view

Function for MGA Gene

Molecular function for MGA Gene

UniProtKB/Swiss-Prot Function: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Gene Ontology (GO) - Molecular Function for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MGA: view

miRNA for MGA Gene

miRTarBase miRNAs that target MGA

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MGA Gene

Localization for MGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGA Gene COMPARTMENTS Subcellular localization image for MGA gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with MGA: view

Pathways for MGA Gene

SuperPathways for MGA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MGA: view

No data available for Pathways by source for MGA Gene

Transcripts for MGA Gene

mRNA/cDNA for MGA Gene

(20) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MGA Gene

MGA, MAX dimerization protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGA Gene

No ASD Table

Relevant External Links for MGA Gene

GeneLoc Exon Structure for
MGA
ECgene alternative splicing isoforms for
MGA

Expression for MGA Gene

mRNA expression in normal human tissues for MGA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGA Gene

SOURCE GeneReport for Unigene cluster for MGA Gene Hs.187569

genes like me logo Genes that share expressions with MGA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MGA Gene

Orthologs for MGA Gene

This gene was present in the common ancestor of animals.

Orthologs for MGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGA 35
  • 99.63 (n)
  • 99.51 (a)
MGA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGA 35
  • 90.05 (n)
  • 88.36 (a)
MGA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGA 35
  • 91.51 (n)
  • 90.31 (a)
MGA 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mga 35
  • 86.53 (n)
  • 82.71 (a)
Mga 16
Mga 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGA 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGA 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mga 35
  • 86.61 (n)
  • 83.43 (a)
chicken
(Gallus gallus)
Aves MGA 35
  • 64.34 (n)
  • 58.99 (a)
MGA 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGA 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mga 35
  • 55.87 (n)
  • 47.73 (a)
zebrafish
(Danio rerio)
Actinopterygii MGA (2 of 2) 36
  • 32 (a)
OneToMany
mgaa 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbx-11 36
  • 29 (a)
ManyToMany
tbx-30 36
  • 24 (a)
ManyToMany
tbx-34 36
  • 25 (a)
ManyToMany
tbx-35 36
  • 22 (a)
ManyToMany
tbx-37 36
  • 26 (a)
ManyToMany
tbx-38 36
  • 27 (a)
ManyToMany
tbx-39 36
  • 17 (a)
ManyToMany
tbx-40 36
  • 17 (a)
ManyToMany
tbx-42 36
  • 24 (a)
ManyToMany
tbx-43 36
  • 26 (a)
ManyToMany
tbx-8 36
  • 34 (a)
ManyToMany
tbx-9 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for MGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGA Gene

ENSEMBL:
Gene Tree for MGA (if available)
TreeFam:
Gene Tree for MGA (if available)

Paralogs for MGA Gene

Paralogs for MGA Gene

Selected SIMAP similar genes for MGA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MGA: view

Variants for MGA Gene

Sequence variations from dbSNP and Humsavar for MGA Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2616 -- 41,753,462(+) ATCCT(A/G)TATAT intron-variant
rs1107858 -- 41,676,028(-) TGTCA(C/T)ACATG intron-variant
rs1112234 -- 41,701,084(+) TCATA(G/T)CAATC intron-variant
rs1128754 -- 41,767,782(+) TGGGT(A/C)CCATG utr-variant-3-prime
rs1197768 -- 41,763,612(+) gtggc(G/T)catgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGA Gene

Variant ID Type Subtype PubMed ID
esv988006 CNV Deletion 20482838
esv3921 CNV Deletion 18987735
esv6726 CNV Loss 19470904
esv2749621 CNV Deletion 23290073
nsv94393 CNV Loss 16902084
esv991459 CNV Deletion 20482838
esv1466405 CNV Deletion 17803354
dgv740e1 CNV Complex 17122850
dgv2363n71 CNV Gain 21882294

Relevant External Links for MGA Gene

HapMap Linkage Disequilibrium report
MGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGA Gene

Disorders for MGA Gene

No disorders were found for MGA Gene.

No data available for UniProtKB/Swiss-Prot for MGA Gene

Publications for MGA Gene

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4
  2. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. (PMID: 10601024) Hurlin P.J. … Eisenman R.N. (EMBO J. 1999) 3 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3

Products for MGA Gene

Sources for MGA Gene

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