Aliases for MGA Gene
External Ids for MGA Gene
Previous GeneCards Identifiers for MGA Gene
GeneCards Summary for MGA Gene
MGA (MGA, MAX Dimerization Protein) is a Protein Coding gene. Diseases associated with MGA include Aicardi-Goutieres Syndrome. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is TBR1.
UniProtKB/Swiss-Prot for MGA Gene
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5-AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).