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Aliases for MFSD9 Gene

Aliases for MFSD9 Gene

  • Major Facilitator Superfamily Domain Containing 9 2 3 5

External Ids for MFSD9 Gene

Previous GeneCards Identifiers for MFSD9 Gene

  • GC02M103332
  • GC02M097097

Summaries for MFSD9 Gene

GeneCards Summary for MFSD9 Gene

MFSD9 (Major Facilitator Superfamily Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLC22A18.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD9 Gene

Genomics for MFSD9 Gene

Regulatory Elements for MFSD9 Gene

Enhancers for MFSD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F102801 1 Ensembl ENCODE 18.5 -65.8 -65842 2.5 TAL1 RAD21 CHAMP1 YY1 NCOR1 GATA2 HNF4G TRIM24 RFX1 ZNF280D MFSD9 TMEM182 LINC01796
GH02F102770 0.6 ENCODE 25.9 -35.3 -35294 3.6 JUND CTBP1 GATA3 CEBPB DPF2 CUX1 YY1 MFSD9 TMEM182 LINC01796
GH02F102761 0.2 ENCODE 58.5 -25.2 -25247 1.7 MFSD9 TMEM182 LINC01796
GH02F102121 1.3 FANTOM5 Ensembl ENCODE 7.5 +614.8 614751 2.4 L3MBTL2 JUNB NR3C1 GABPA GATA3 JUND SCRT2 CUX1 FOS MAFK LOC105373516 MFSD9 IL1R1 PIR60869 GC02M102141
GH02F102126 1.2 FANTOM5 Ensembl ENCODE 7.4 +608.0 608028 4.8 ZNF316 GATA3 HLF CEBPB FOS PRDM1 IL1R1 LOC105373516 MFSD9 IL1RL2 MAP4K4 GC02M102141 PIR60869
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD9 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000677153 88 2001 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 SLC30A9 GLIS2 KLF13

Genomic Location for MFSD9 Gene

Chromosome:
2
Start:
102,714,630 bp from pter
End:
102,736,888 bp from pter
Size:
22,259 bases
Orientation:
Minus strand

Genomic View for MFSD9 Gene

Genes around MFSD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD9 Gene

Proteins for MFSD9 Gene

  • Protein details for MFSD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBP5-MFSD9_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 9
    Protein Accession:
    Q8NBP5
    Secondary Accessions:
    • Q4ZG89
    • Q53TU0
    • Q96GQ4
    • Q9BRI8

    Protein attributes for MFSD9 Gene

    Size:
    474 amino acids
    Molecular mass:
    50619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD9 Gene

Post-translational modifications for MFSD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD9 Gene

Domains & Families for MFSD9 Gene

Protein Domains for MFSD9 Gene

Suggested Antigen Peptide Sequences for MFSD9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBP5

UniProtKB/Swiss-Prot:

MFSD9_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD9: view

No data available for Gene Families for MFSD9 Gene

Function for MFSD9 Gene

Gene Ontology (GO) - Molecular Function for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD9: view
genes like me logo Genes that share phenotypes with MFSD9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD9

miRNA for MFSD9 Gene

miRTarBase miRNAs that target MFSD9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD9 Gene

Localization for MFSD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD9 gene
Compartment Confidence
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with MFSD9: view

Pathways & Interactions for MFSD9 Gene

SuperPathways for MFSD9 Gene

No Data Available

Interacting Proteins for MFSD9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258436%0d%0a9606.ENSP00000359518%0d%0a
Selected Interacting proteins: ENSP00000258436 Q8NBP5-MFSD9_HUMAN for MFSD9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with MFSD9: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD9 Gene

Transcripts for MFSD9 Gene

Unigene Clusters for MFSD9 Gene

Major facilitator superfamily domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for MFSD9 Gene

GeneLoc Exon Structure for
MFSD9
ECgene alternative splicing isoforms for
MFSD9

Expression for MFSD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD9 Gene

This gene is overexpressed in Retina (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD9 Gene



Protein tissue co-expression partners for MFSD9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD9 Gene:

MFSD9

SOURCE GeneReport for Unigene cluster for MFSD9 Gene:

Hs.720914
genes like me logo Genes that share expression patterns with MFSD9: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFSD9 Gene

Orthologs for MFSD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD9 34 35
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia MFSD9 34 35
  • 78.69 (n)
cow
(Bos Taurus)
Mammalia MFSD9 34 35
  • 76.67 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd9 34
  • 76.42 (n)
mouse
(Mus musculus)
Mammalia Mfsd9 34 16 35
  • 76.03 (n)
oppossum
(Monodelphis domestica)
Mammalia MFSD9 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD9 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD9 34 35
  • 65.28 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD9 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd9 34
  • 60.37 (n)
zebrafish
(Danio rerio)
Actinopterygii mfsd9 34 35
  • 60.94 (n)
worm
(Caenorhabditis elegans)
Secernentea C53B4.3 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4725 35
  • 29 (a)
OneToOne
Species where no ortholog for MFSD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD9 Gene

ENSEMBL:
Gene Tree for MFSD9 (if available)
TreeFam:
Gene Tree for MFSD9 (if available)

Paralogs for MFSD9 Gene

Paralogs for MFSD9 Gene

(2) SIMAP similar genes for MFSD9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MFSD9: view

Variants for MFSD9 Gene

Sequence variations from dbSNP and Humsavar for MFSD9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035966 A breast cancer sample
VAR_035967 A breast cancer sample
rs10169842 -- 102,716,213(+) GATTA(C/T)AAAGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10170889 -- 102,713,678(+) gtggc(A/G)cgtgc downstream-variant-500B
rs10174741 -- 102,715,177(+) TCCTT(A/G)CTGCG nc-transcript-variant, utr-variant-3-prime

Variation tolerance for MFSD9 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD9 Gene

Human Gene Mutation Database (HGMD)
MFSD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MFSD9 Gene

Disorders for MFSD9 Gene

Relevant External Links for MFSD9

Genetic Association Database (GAD)
MFSD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD9

No disorders were found for MFSD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD9 Gene

Publications for MFSD9 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3 64
  3. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PMID: 22952603) Hart A.B. … Palmer A.A. (PLoS ONE 2012) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64

Products for MFSD9 Gene

Sources for MFSD9 Gene

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