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Aliases for MFSD7 Gene

Aliases for MFSD7 Gene

  • Major Facilitator Superfamily Domain Containing 7 2 3 5
  • Myosin Light Polypeptide 5 Regulatory Protein 3 4
  • MYL5 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 7 3
  • LP2561 3

External Ids for MFSD7 Gene

Previous GeneCards Identifiers for MFSD7 Gene

  • GC04M000666

Summaries for MFSD7 Gene

GeneCards Summary for MFSD7 Gene

MFSD7 (Major Facilitator Superfamily Domain Containing 7) is a Protein Coding gene. An important paralog of this gene is DIRC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD7 Gene

Genomics for MFSD7 Gene

Regulatory Elements for MFSD7 Gene

Enhancers for MFSD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F000686 1.4 FANTOM5 ENCODE 21.1 +1.0 969 3.5 HDGF PKNOX1 CREB3L1 SIN3A ARID4B ZNF2 ZNF143 KLF13 SP3 SP5 MFSD7 LOC101928521 PCGF3 GAK MYL5 GC04M000682 GC04M000683
GH04F000683 1.3 Ensembl ENCODE 22.7 +5.6 5608 1.7 HDGF ARID4B ZNF48 ZNF2 GLIS2 ZNF143 KLF7 SP3 SP5 MXD4 MFSD7 LOC101928521 GC04M000682 GC04M000683
GH04F000673 1.1 ENCODE 20.9 +12.2 12167 8.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS MFSD7 CRIPAK ENSG00000272588 ZNF718 ZNF141 LOC100129917 LOC101928521 IDUA CTBP1-AS2 ENSG00000251535
GH04F000663 0.8 ENCODE 15.6 +25.5 25529 1.3 CTCF ESRRA USF1 MAX BCL11B ZBTB40 RARA CTBP1 EGR1 POLR2A LOC101928521 MFSD7 LOC102725200
GH04F000574 0.9 Ensembl 12.8 +113.2 113247 3.5 KLF17 GLI4 ZNF48 GLIS2 ZNF366 EGR2 SP3 REST ZEB2 ZNF341 MFSD7 LOC102725200 UVSSA LOC101928521 ENSG00000273238 LOC105374338
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD7 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001682779 468 1201 CTCF KLF1 SAP130 NRF1 ZEB2 ZIC2 ZEB1 ZGPAT POLR2A
ENSR00001856858 1968 201 ATF1 PKNOX1 CREB3L1 SIN3A ARID4B ZNF48 GLIS2 FOS KLF13 SP3

Genomic Location for MFSD7 Gene

Chromosome:
4
Start:
674,690 bp from pter
End:
689,468 bp from pter
Size:
14,779 bases
Orientation:
Minus strand

Genomic View for MFSD7 Gene

Genes around MFSD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD7 Gene

Proteins for MFSD7 Gene

  • Protein details for MFSD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXD7-MFSD7_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 7
    Protein Accession:
    Q6UXD7
    Secondary Accessions:
    • A8K7J5
    • Q6XYD4
    • Q8N6H1
    • Q9H6H6

    Protein attributes for MFSD7 Gene

    Size:
    560 amino acids
    Molecular mass:
    58427 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP34459.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD7 Gene

Post-translational modifications for MFSD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD7 Gene

Domains & Families for MFSD7 Gene

Protein Domains for MFSD7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD7 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXD7

UniProtKB/Swiss-Prot:

MFSD7_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD7: view

Function for MFSD7 Gene

Phenotypes for MFSD7 Gene

GenomeRNAi human phenotypes for MFSD7:
genes like me logo Genes that share phenotypes with MFSD7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MFSD7 Gene

Localization for MFSD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD7 gene
Compartment Confidence
plasma membrane 3
endosome 1

Gene Ontology (GO) - Cellular Components for MFSD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD7: view

Pathways & Interactions for MFSD7 Gene

SuperPathways for MFSD7 Gene

No Data Available

Interacting Proteins for MFSD7 Gene

Selected Interacting proteins: Q6UXD7-MFSD7_HUMAN for MFSD7 Gene via IID

Symbol External ID(s) Details
CREB3

Gene Ontology (GO) - Biological Process for MFSD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD7: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD7 Gene

Transcripts for MFSD7 Gene

Unigene Clusters for MFSD7 Gene

Major facilitator superfamily domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for MFSD7 Gene

GeneLoc Exon Structure for
MFSD7
ECgene alternative splicing isoforms for
MFSD7

Expression for MFSD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD7 Gene



NURSA nuclear receptor signaling pathways regulating expression of MFSD7 Gene:

MFSD7

SOURCE GeneReport for Unigene cluster for MFSD7 Gene:

Hs.567612
genes like me logo Genes that share expression patterns with MFSD7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MFSD7 Gene

Orthologs for MFSD7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MFSD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD7 34 35
  • 93.02 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd7 34
  • 80.4 (n)
cow
(Bos Taurus)
Mammalia MFSD7 34 35
  • 79.35 (n)
dog
(Canis familiaris)
Mammalia MFSD7 34 35
  • 77.43 (n)
mouse
(Mus musculus)
Mammalia Mfsd7a 34 16 35
  • 76.18 (n)
oppossum
(Monodelphis domestica)
Mammalia MFSD7 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD7 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD7 34 35
  • 63.39 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD7 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd7 34
  • 56.58 (n)
MGC75569 34
worm
(Caenorhabditis elegans)
Secernentea B0416.5 34 35
  • 47.42 (n)
C05G5.1 35
  • 30 (a)
OneToMany
C42C1.8 35
  • 24 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05990 34
  • 46.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
Species where no ortholog for MFSD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MFSD7 Gene

ENSEMBL:
Gene Tree for MFSD7 (if available)
TreeFam:
Gene Tree for MFSD7 (if available)

Paralogs for MFSD7 Gene

Paralogs for MFSD7 Gene

genes like me logo Genes that share paralogs with MFSD7: view

Variants for MFSD7 Gene

Sequence variations from dbSNP and Humsavar for MFSD7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10020292 -- 687,989(+) GACTC(A/G)TGGAT intron-variant, utr-variant-5-prime
rs10023220 -- 680,478(+) CCTGA(C/T)GGCCC intron-variant
rs10026699 -- 690,053(+) GAACA(A/G)TATTA upstream-variant-2KB
rs10030136 -- 683,203(+) ATGGA(C/T)ACTCA intron-variant, downstream-variant-500B
rs10716 -- 682,005(+) AGCCG(A/G)GTCAA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD7 Gene

Variant ID Type Subtype PubMed ID
nsv950325 CNV deletion 24416366
nsv829834 CNV loss 17160897
nsv822425 CNV loss 20364138
nsv593208 CNV loss 21841781
nsv593206 CNV loss 21841781
nsv508986 CNV insertion 20534489
nsv10413 CNV gain 18304495
esv2759217 CNV loss 17122850

Variation tolerance for MFSD7 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD7 Gene

Disorders for MFSD7 Gene

Relevant External Links for MFSD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD7

No disorders were found for MFSD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD7 Gene

Publications for MFSD7 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for MFSD7 Gene

Sources for MFSD7 Gene

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