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Aliases for MFSD7 Gene

Aliases for MFSD7 Gene

  • Major Facilitator Superfamily Domain Containing 7 2 3 5
  • Myosin Light Polypeptide 5 Regulatory Protein 3 4
  • MYL5 3 4
  • LP2561 3

External Ids for MFSD7 Gene

Previous GeneCards Identifiers for MFSD7 Gene

  • GC04M000666

Summaries for MFSD7 Gene

GeneCards Summary for MFSD7 Gene

MFSD7 (Major Facilitator Superfamily Domain Containing 7) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Regulation of actin cytoskeleton. An important paralog of this gene is FLVCR2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD7 Gene

Genomics for MFSD7 Gene

Regulatory Elements for MFSD7 Gene

Promoters for MFSD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFSD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD7 Gene

674,690 bp from pter
689,468 bp from pter
14,779 bases
Minus strand

Genomic View for MFSD7 Gene

Genes around MFSD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD7 Gene

Proteins for MFSD7 Gene

  • Protein details for MFSD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Major facilitator superfamily domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A8K7J5
    • Q6XYD4
    • Q8N6H1
    • Q9H6H6

    Protein attributes for MFSD7 Gene

    560 amino acids
    Molecular mass:
    58427 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP34459.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD7 Gene


neXtProt entry for MFSD7 Gene

Proteomics data for MFSD7 Gene at MOPED

Post-translational modifications for MFSD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD7 Gene

Domains & Families for MFSD7 Gene

Protein Domains for MFSD7 Gene


Suggested Antigen Peptide Sequences for MFSD7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD7: view

Function for MFSD7 Gene

Phenotypes for MFSD7 Gene

GenomeRNAi human phenotypes for MFSD7:
genes like me logo Genes that share phenotypes with MFSD7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MFSD7 Gene

Localization for MFSD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MFSD7 Gene COMPARTMENTS Subcellular localization image for MFSD7 gene
Compartment Confidence
plasma membrane 3
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for MFSD7 Gene

Pathways & Interactions for MFSD7 Gene

genes like me logo Genes that share pathways with MFSD7: view

Interacting Proteins for MFSD7 Gene

Gene Ontology (GO) - Biological Process for MFSD7 Gene


No data available for SIGNOR curated interactions for MFSD7 Gene

Drugs & Compounds for MFSD7 Gene

No Compound Related Data Available

Transcripts for MFSD7 Gene

Unigene Clusters for MFSD7 Gene

Major facilitator superfamily domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP4: -
SP5: - - - - -

Relevant External Links for MFSD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD7 Gene

mRNA expression in normal human tissues for MFSD7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD7 Gene

SOURCE GeneReport for Unigene cluster for MFSD7 Gene Hs.567612

genes like me logo Genes that share expression patterns with MFSD7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MFSD7 Gene

Orthologs for MFSD7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MFSD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MFSD7 35
  • 79.35 (n)
  • 73.97 (a)
MFSD7 36
  • 63 (a)
(Canis familiaris)
Mammalia MFSD7 35
  • 77.43 (n)
  • 70.31 (a)
MFSD7 36
  • 62 (a)
(Mus musculus)
Mammalia Mfsd7a 35
  • 76.18 (n)
  • 73.78 (a)
Mfsd7a 16
Mfsd7a 36
  • 68 (a)
(Pan troglodytes)
Mammalia MFSD7 35
  • 93.02 (n)
  • 91.59 (a)
MFSD7 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mfsd7 35
  • 80.4 (n)
  • 79.17 (a)
(Monodelphis domestica)
Mammalia MFSD7 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia MFSD7 36
  • 58 (a)
(Gallus gallus)
Aves MFSD7 35
  • 63.39 (n)
  • 59.37 (a)
MFSD7 36
  • 56 (a)
(Anolis carolinensis)
Reptilia MFSD7 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd7 35
  • 56.58 (n)
  • 54.24 (a)
MGC75569 35
(Caenorhabditis elegans)
Secernentea B0416.5 35
  • 47.42 (n)
  • 36.49 (a)
B0416.5 36
  • 32 (a)
C05G5.1 36
  • 30 (a)
C42C1.8 36
  • 24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05990 35
  • 46.49 (n)
  • 32.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
-- 36
  • 31 (a)
-- 36
  • 39 (a)
Species with no ortholog for MFSD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MFSD7 Gene

Gene Tree for MFSD7 (if available)
Gene Tree for MFSD7 (if available)

Paralogs for MFSD7 Gene

Paralogs for MFSD7 Gene Pseudogenes for MFSD7 Gene

genes like me logo Genes that share paralogs with MFSD7: view

Variants for MFSD7 Gene

Sequence variations from dbSNP and Humsavar for MFSD7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_030144 -
rs4518182 -- 683,958(+) GAGCA(A/T)AGCAA intron-variant
rs7690350 -- 687,054(+) AGGCC(A/G)GCCCC intron-variant
rs10026699 -- 690,053(+) GAACA(A/G)TATTA upstream-variant-2KB
rs9991613 -- 688,151(+) GGACA(C/T)GGTGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD7 Gene

Variant ID Type Subtype PubMed ID
nsv878245 CNV Loss 21882294
nsv508986 CNV Insertion 20534489
nsv822425 CNV Loss 20364138
nsv878246 CNV Loss 21882294
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5387n71 CNV Loss 21882294
nsv829834 CNV Loss 17160897
nsv10413 CNV Gain 18304495
dgv5388n71 CNV Loss 21882294

Variation tolerance for MFSD7 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD7 Gene

Disorders for MFSD7 Gene

Relevant External Links for MFSD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MFSD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD7 Gene

Publications for MFSD7 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for MFSD7 Gene

Sources for MFSD7 Gene

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