MFSD7 Gene
protein-coding GIFtS: 40
GCID: GC04M000675
|
|
major facilitator superfamily domain containing 7
| |
Aliases
for MFSD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Facilitator Superfamily Domain Containing 71 2 | | Myosin Light Polypeptide 5 Regulatory Protein2 3 | | MYL52 3 | | FLJ222691 | | LP25611 | | Major Facilitator Superfamily Domain-Containing Protein 72 |
Export aliases for MFSD7 gene to outside databasesPrevious GC identifer: GC04M000666 |
Summaries
for MFSD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
 summary
for MFSD7: Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.
|
Genomic Views
for MFSD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MFSD7 gene promoter:
STAT1 NF-1/L NF-1 AML1a YY1 HEN1 CREB deltaCREB ARP-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for MFSD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3MFSD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M000675: view genomic region
(about GC identifiers)
Start:
|
675,618 bp from pter |
End:
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683,230 bp from pter |
Size:
|
7,613 bases |
Orientation:
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minus strand |
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Proteins
for MFSD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MFSD7_HUMAN, Q6UXD7 (See
protein sequence)Recommended Name: Major facilitator superfamily domain-containing protein 7 Size: 560 amino acids; 58427 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAP34459.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A8K7J5 Q6XYD4 Q8N6H1 Q9H6H6Alternative splicing: 3 isoforms: Q6UXD7-1 Q6UXD7-2 Q6UXD7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MFSD7: NX_Q6UXD7
MFSD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115595.2
ENSEMBL proteins: ENSP00000307545 ENSP00000320234 ENSP00000384616 ENSP00000423204 ENSP00000425753 ENSP00000425038 ENSP00000424556
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MFSD7 for ontologies About GeneDecksing
MFSD7 Antibody Products:
Assay Products for MFSD7: |
Protein
Domains /
Families
for MFSD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MFSD7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXD7ProtoNet protein and cluster: Q6UXD7 UniProtKB/Swiss-Prot: MFSD7_HUMAN, Q6UXD7Similarity: Belongs to the major facilitator superfamily |
Function
for MFSD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MFSD7 (NM_032219) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD7 |
Animal Models:
Mouse knock-out Mfsd7atm1Lex for MFSD7
1 MGI phenotypic allele  for Mfsd7a (no phenotypes)
MFSD7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MFSD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD7
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055085 | transmembrane transport |
IEA | -- |
MFSD7 for ontologies About GeneDecksing
|
Drugs & Compounds
for MFSD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for MFSD7 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (R)-(+)-Blebbistatin | Selective inhibitor of myosin II. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760) | -- | | (S)-(-)-Blebbistatin | Selective inhibitor of myosin II. Active enantiomer of (±)-blebbistatin (Cat. No. 1760) | [856925-71-8] | | (±)-Blebbistatin | Selective inhibitor of myosin II | [674289-55-5] |
Search CenterWatch for drugs/clinical trials and news about MFSD7
|
Transcripts
for MFSD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MFSD7 gene: NM_032219.2 Unigene Cluster for MFSD7: Major facilitator superfamily domain containing 7 Hs.567612 [show with all ESTs]Unigene Representative Sequence: AK2920109 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000512400(uc003gaw.3) ENST00000347950(uc003gaz.3) ENST00000322224(uc003gax.3 uc003gay.3)
ENST00000404286 ENST00000515118 ENST00000503156 ENST00000512249 ENST00000507165
ENST00000513740
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MFSD7 (NM_032219) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD7 |
Additional cDNA sequence: AK025922.1 AK292010.1 AY203936.1 AY358401.1 BC030246.1 9 DOTS entries: DT.75154829 DT.95152088 DT.100741562 DT.121229615 DT.97858528 DT.75195954 DT.412074 DT.101981561 DT.99965324 24/50 AceView cDNA sequences (see all 50): CR626001 CD672588 CK725033 CD672589 NM_032219 CD671671 BX401055 AY203936 BC030246 CR609503 BQ067154 BX096336 AI306684 CR600243 C20852 BF589323 BQ005366 AK025922 BI829685 AW190606 AW051997 BM563743 BE677867 AI467848
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MFSD7 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | - | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MFSD7
|
Expression
for MFSD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MFSD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCAATGA
About this image
See MFSD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFSD7
SOURCE GeneReport for Unigene cluster: Hs.567612
SABiosciences Custom PCR Arrays for MFSD7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFSD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD7 |
Orthologs
for MFSD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MFSD7 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for MFSD7 (if available)
TreeFam Gene Tree for MFSD7 (if available) |
Paralogs
for MFSD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MFSD7 gene
- FLVCR12 FLVCR22 DIRC22
MFSD7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MFSD7
PGOHUM00000250689
|
Genomic Variants
for MFSD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MFSD7
2 CNVs: 3475 31150 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD7 |
|
Disorders
/ Diseases
for MFSD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MFSD7 for disorders About GeneDecksing
1  disease for MFSD7: About MalaCardsleukemia
Export disorders for MFSD7 gene to outside databases
|
Publications
for MFSD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MFSD7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MFSD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MFSD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MFSD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MFSD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MFSD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MFSD7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MFSD7 gene:
Search GeneIP for patents involving MFSD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MFSD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MFSD7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFSD7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD7 | | | OriGene Protein Over-expression Lysate for MFSD7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MFSD7 | | OriGene 3'-UTR Clone for MFSD7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MFSD7 | | OriGene Custom Protein Services for MFSD7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFSD7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFSD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD7 |
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 |  |  |  | |
| | | | Tocris compounds for MFSD7 |
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 |
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 | | | MFSD7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD7 |
|  |  |  | | | | Search ThermoFisher Antibodies for MFSD7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD7 |
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