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Aliases for MFSD6L Gene

Aliases for MFSD6L Gene

  • Major Facilitator Superfamily Domain Containing 6 Like 2 3
  • Major Facilitator Superfamily Domain Containing 6-Like 2 5

External Ids for MFSD6L Gene

Previous GeneCards Identifiers for MFSD6L Gene

  • GC17M008642
  • GC17M008700

Summaries for MFSD6L Gene

GeneCards Summary for MFSD6L Gene

MFSD6L (Major Facilitator Superfamily Domain Containing 6 Like) is a Protein Coding gene. An important paralog of this gene is MFSD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD6L Gene

Genomics for MFSD6L Gene

Regulatory Elements for MFSD6L Gene

Genomic Location for MFSD6L Gene

Chromosome:
17
Start:
8,797,110 bp from pter
End:
8,799,349 bp from pter
Size:
2,240 bases
Orientation:
Minus strand

Genomic View for MFSD6L Gene

Genes around MFSD6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD6L Gene

Proteins for MFSD6L Gene

  • Protein details for MFSD6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWD5-MFS6L_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 6-like
    Protein Accession:
    Q8IWD5
    Secondary Accessions:
    • Q6YL34
    • Q8NA76

    Protein attributes for MFSD6L Gene

    Size:
    586 amino acids
    Molecular mass:
    64005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM98769.1; Type=Frameshift; Positions=365; Evidence={ECO:0000305};

neXtProt entry for MFSD6L Gene

Proteomics data for MFSD6L Gene at MOPED

Post-translational modifications for MFSD6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD6L Gene

Domains & Families for MFSD6L Gene

Protein Domains for MFSD6L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD6L Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWD5

UniProtKB/Swiss-Prot:

MFS6L_HUMAN :
  • Belongs to the major facilitator superfamily. MFSD6 family.
Family:
  • Belongs to the major facilitator superfamily. MFSD6 family.
genes like me logo Genes that share domains with MFSD6L: view

No data available for Gene Families for MFSD6L Gene

Function for MFSD6L Gene

Phenotypes for MFSD6L Gene

genes like me logo Genes that share phenotypes with MFSD6L: view

Animal Model Products

CRISPR Products

miRNA for MFSD6L Gene

miRTarBase miRNAs that target MFSD6L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD6L Gene

Localization for MFSD6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD6L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD6L Gene COMPARTMENTS Subcellular localization image for MFSD6L gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for MFSD6L Gene

Pathways & Interactions for MFSD6L Gene

SuperPathways for MFSD6L Gene

No Data Available

Interacting Proteins for MFSD6L Gene

Gene Ontology (GO) - Biological Process for MFSD6L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD6L Gene

Drugs & Compounds for MFSD6L Gene

No Compound Related Data Available

Transcripts for MFSD6L Gene

mRNA/cDNA for MFSD6L Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MFSD6L Gene

Major facilitator superfamily domain containing 6-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD6L Gene

No ASD Table

Relevant External Links for MFSD6L Gene

GeneLoc Exon Structure for
MFSD6L
ECgene alternative splicing isoforms for
MFSD6L

Expression for MFSD6L Gene

mRNA expression in normal human tissues for MFSD6L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD6L Gene

This gene is overexpressed in Testis (x22.2), Pancreas (x5.6), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for MFSD6L Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD6L Gene



SOURCE GeneReport for Unigene cluster for MFSD6L Gene Hs.213603

genes like me logo Genes that share expression patterns with MFSD6L: view

Protein tissue co-expression partners for MFSD6L Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MFSD6L Gene

Orthologs for MFSD6L Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD6L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFSD6L 35
  • 79.41 (n)
  • 69.97 (a)
MFSD6L 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD6L 35
  • 78.67 (n)
  • 74.3 (a)
MFSD6L 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd6l 35
  • 77.34 (n)
  • 68.5 (a)
Mfsd6l 16
Mfsd6l 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFSD6L 35
  • 98.98 (n)
  • 97.95 (a)
MFSD6L 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd6l 35
  • 77.44 (n)
  • 66.5 (a)
oppossum
(Monodelphis domestica)
Mammalia MFSD6L 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD6L 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd6l 35
  • 53.22 (n)
  • 44.44 (a)
zebrafish
(Danio rerio)
Actinopterygii mfsd6l 35
  • 49.86 (n)
  • 41.34 (a)
mfsd6l 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sug 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for MFSD6L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD6L Gene

ENSEMBL:
Gene Tree for MFSD6L (if available)
TreeFam:
Gene Tree for MFSD6L (if available)

Paralogs for MFSD6L Gene

Paralogs for MFSD6L Gene

genes like me logo Genes that share paralogs with MFSD6L: view

Variants for MFSD6L Gene

Sequence variations from dbSNP and Humsavar for MFSD6L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2242373 - 8,797,664(+) CCATG(C/T)GGGGA reference, missense
rs197078 -- 8,799,485(-) GCTCA(A/G)AACGC upstream-variant-2KB
rs367945 -- 8,799,344(-) cGCCT(C/T)TCCCT utr-variant-5-prime
rs904168 -- 8,799,810(-) cttgg(A/T)cagtg upstream-variant-2KB
rs1826924 -- 8,800,296(-) AGGTG(A/G)CTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD6L Gene

Variant ID Type Subtype PubMed ID
nsv518675 CNV Gain 19592680
nsv907668 CNV Loss 21882294
nsv1969 CNV Loss 18451855

Variation tolerance for MFSD6L Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.71; 95.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD6L Gene

HapMap Linkage Disequilibrium report
MFSD6L
Human Gene Mutation Database (HGMD)
MFSD6L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD6L Gene

Disorders for MFSD6L Gene

Relevant External Links for MFSD6L

Genetic Association Database (GAD)
MFSD6L
Human Genome Epidemiology (HuGE) Navigator
MFSD6L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD6L

No disorders were found for MFSD6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD6L Gene

Publications for MFSD6L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MFSD6L Gene

Sources for MFSD6L Gene

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