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MFSD6L Gene

protein-coding   GIFtS: 40
GCID: GC17M008700

Major Facilitator Superfamily Domain Containing 6-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Facilitator Superfamily Domain Containing 6-Like1 2
Major Facilitator Superfamily Domain-Containing Protein 6-Like2

External Ids:    HGNC: 266561   Entrez Gene: 1623872   Ensembl: ENSG000001851567   UniProtKB: Q8IWD53   

Export aliases for MFSD6L gene to outside databases

Previous GC identifer: GC17M008642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MFSD6L Gene:
MFSD6L (major facilitator superfamily domain containing 6-like) is a protein-coding gene. An important paralog of this gene is MFSD6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFSD6L gene promoter:
         SRF   c-Fos   AP-1   AML1a   SRF (504 AA)   USF2   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MFSD6L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFSD6L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

MFSD6L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFSD6L gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008700:  view genomic region     (about GC identifiers)

Start:
8,700,428 bp from pter      End:
8,702,667 bp from pter
Size:
2,240 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MFS6L_HUMAN, Q8IWD5 (See protein sequence)
Recommended Name: Major facilitator superfamily domain-containing protein 6-like  
Size: 586 amino acids; 64005 Da
Sequence caution: Sequence=AAM98769.1; Type=Frameshift; Positions=365;
Secondary accessions: Q6YL34 Q8NA76

Explore the universe of human proteins at neXtProt for MFSD6L: NX_Q8IWD5

Explore proteomics data for MFSD6L at MOPED


See MFSD6L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689812.3  
ENSEMBL proteins: 
 ENSP00000330051  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q8IWD5

ProtoNet protein and cluster: Q8IWD5

UniProtKB/Swiss-Prot: MFS6L_HUMAN, Q8IWD5
Similarity: Belongs to the major facilitator superfamily. MFSD6 family


Find genes that share domains with MFSD6L           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFSD6L
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hsa-mir-335-5p (MIRT017180)

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5 qRT-PCR Assays for microRNAs that regulate MFSD6L:
hsa-miR-136 hsa-miR-129-3p hsa-miR-630 hsa-miR-129* hsa-miR-548n
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MFS6L_HUMAN, Q8IWD5: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytoskeleton1
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MFSD6L           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFSD6L
Interactions:

    Search GeneGlobe Interaction Network for MFSD6L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MFSD6L (MFS6L)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MFSD6L gene: 
NM_152599.3  

Unigene Cluster for MFSD6L:

Major facilitator superfamily domain containing 6-like
Hs.213603  [show with all ESTs]
Unigene Representative Sequence: NM_152599
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000329805(uc002glp.2)
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat MFSD6L

Additional mRNA sequence: 

AK093092.1 AY129026.1 BC040487.1 

1 DOTS entry:

DT.95323913 

17 AceView cDNA sequences:

AI203269 BX118490 AY129026 BM986935 NM_152599 BC040487 BI826022 AK093092 
AX747916 BE045921 CD637894 BI461454 CF886914 AI916973 CD637893 BV191082 
CB854063 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MFSD6L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTTTCTTTA
MFSD6L Expression
About this image

MFSD6L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MFSD6L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.213603
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD6L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MFSD6L gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mfsd6l1 , 5 major facilitator superfamily domain containing 6-like1, 5 77.34(n)1
68.5(a)1
  11 (41.81 cM)5
2157231  NM_146004.11  NP_666116.11 
 685561865 
lizard
(Anolis carolinensis)
Reptilia MFSD6L6
major facilitator superfamily domain containing 6-...
44(a)
1 ↔ 1
2(105188555-105190522)
tropical clawed frog
(Xenopus tropicalis)
Amphibia AL896100.22   -- 74.53(n)    AL896100.2 
zebrafish
(Danio rerio)
Actinopterygii mfsd6l1 major facilitator superfamily domain containing 6-like 49.86(n)
41.34(a)
  445192  NM_001003586.2  NP_001003586.1 
fruit fly
(Drosophila melanogaster)
Insecta Sug6
Sug
13(a)
many ↔ many
3L(11677084-11683255)


ENSEMBL Gene Tree for MFSD6L (if available)
TreeFam Gene Tree for MFSD6L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MFSD6L gene
MFSD62  

Find genes that share paralogs with MFSD6L           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MFSD6L (see all 225)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1117263221,2
C,Funtested18702218(+) TTTTCA/C/TGGTAG 2 Q R mis13CSA WA NA 4664
rs1112377271,2
C,F--8699964(+) GCAACG/CTCCAC 1 -- int11Minor allele frequency- C:0.00CSA 1
rs1500519301,2
--8700030(+) GTGCGC/TGCCAC 1 -- int10--------
rs1836983211,2
--8700171(+) CACCAC/TGCCCG 1 -- int10--------
rs98912811,2
C,F,H--8700178(+) CCCGGC/TCCTCC 1 -- int125Minor allele frequency- T:0.25NS EA NA WA CSA 2347
rs1454106681,2
--8700240(+) CCTTTA/GTGACC 1 -- int10--------
rs1132049171,2
C--8700264(+) TGATTC/TATCCA 1 -- int12Minor allele frequency- T:0.04CSA WA 120
rs1492311151,2
--8700306(+) GCAGGG/TCCCCA 1 -- int10--------
rs795157181,2
C,F--8700419(+) GTGACT/CATAGA 1 -- int13Minor allele frequency- C:0.08CSA WA 121
rs1425064571,2
C--8700464(+) CATTAC/TCTAAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for MFSD6L (8700428 - 8702667 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MFSD6L:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1969CNV Loss18451855
nsv907668CNV Loss21882294
nsv518675CNV Gain19592680

Human Gene Mutation Database (HGMD): MFSD6L
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MFSD6L
DNA2.0 Custom Variant and Variant Library Synthesis for MFSD6L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with MFSD6L           About GenesLikeMe

Genetic Association Database (GAD): MFSD6L
Human Genome Epidemiology (HuGE) Navigator: MFSD6L (1 document)

Export disorders for MFSD6L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MFSD6L gene integrated from 10 sources:
(articles sorted by number of sources associating them with MFSD6L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 162387 HGNC: 26656 AceView: FLJ35773 Ensembl:ENSG00000185156 euGenes: HUgn162387
ECgene: MFSD6L H-InvDB: MFSD6L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MFSD6L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MFSD6L gene:
Search GeneIP for patents involving MFSD6L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 CLIAs for MFSD6L



 Browse ESI BIO Cell Lines and PureStem Progenitors for MFSD6L
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD6L
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MFSD6L
 Browse SwitchGear Promoter luciferase reporter plasmids for MFSD6L
 Search ThermoFisher Antibodies for MFSD6L
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD6L
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFSD6L
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFSD6L
 Search LSBio for Antibodies for MFSD6L
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for MFSD6L
  Search eBioscience for proteins for MFSD6L
  Search eBioscience for elisas for MFSD6L
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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