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Aliases for MFSD6L Gene

Aliases for MFSD6L Gene

  • Major Facilitator Superfamily Domain Containing 6 Like 2 3 5
  • Major Facilitator Superfamily Domain Containing 6-Like 2

External Ids for MFSD6L Gene

Previous GeneCards Identifiers for MFSD6L Gene

  • GC17M008642
  • GC17M008700

Summaries for MFSD6L Gene

GeneCards Summary for MFSD6L Gene

MFSD6L (Major Facilitator Superfamily Domain Containing 6 Like) is a Protein Coding gene. An important paralog of this gene is MFSD6.

Additional gene information for MFSD6L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD6L Gene

Genomics for MFSD6L Gene

Regulatory Elements for MFSD6L Gene

Enhancers for MFSD6L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H008744 1.3 FANTOM5 ENCODE 10.3 +53.8 53754 1.9 HDGF ARID4B SIN3A DMAP1 GLIS2 ZNF143 SP3 MXD4 ZNF592 RFX3 CCDC42 SPDYE4 ODF4 MFSD6L
GH17H008791 0.7 ENCODE 16.9 +7.4 7351 1.1 CTCF ZNF639 ZNF146 ZNF280D JUN CEBPB ZMYM3 TEAD3 JUND ZSCAN5C MFSD6L CCDC42 SPDYE4 GC17P008796 LOC105371530
GH17H008785 0.9 Ensembl ENCODE 12.2 +13.4 13400 0.7 ZSCAN5A CTCF ZNF654 TRIM22 REST ZNF2 RAD21 ZBTB48 ZNF143 SMC3 MFSD6L CCDC42 SPDYE4 GC17P008796 LOC105371530
GH17H008364 1.1 FANTOM5 Ensembl ENCODE 8.9 +433.4 433373 2.4 STAT1 POLR2A JUN ZNF600 ATF2 ODF4 CCDC42 SPDYE4 ENSG00000265749 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17H008798 0.7 Ensembl ENCODE 9.1 +0.1 88 1.5 CTCF POLR2A EZH2 MFSD6L PIR43788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD6L on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD6L Gene

Genomic Locations for MFSD6L Gene
2,240 bases
Minus strand

Genomic View for MFSD6L Gene

Genes around MFSD6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD6L Gene

Proteins for MFSD6L Gene

  • Protein details for MFSD6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Major facilitator superfamily domain-containing protein 6-like
    Protein Accession:
    Secondary Accessions:
    • Q6YL34
    • Q8NA76

    Protein attributes for MFSD6L Gene

    586 amino acids
    Molecular mass:
    64005 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM98769.1; Type=Frameshift; Positions=365; Evidence={ECO:0000305};

neXtProt entry for MFSD6L Gene

Post-translational modifications for MFSD6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD6L Gene

Domains & Families for MFSD6L Gene

Gene Families for MFSD6L Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MFSD6L Gene


Suggested Antigen Peptide Sequences for MFSD6L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. MFSD6 family.
  • Belongs to the major facilitator superfamily. MFSD6 family.
genes like me logo Genes that share domains with MFSD6L: view

Function for MFSD6L Gene

Phenotypes for MFSD6L Gene

genes like me logo Genes that share phenotypes with MFSD6L: view

Animal Model Products

miRNA for MFSD6L Gene

miRTarBase miRNAs that target MFSD6L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD6L Gene

Localization for MFSD6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD6L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD6L gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MFSD6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD6L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD6L Gene

Pathways & Interactions for MFSD6L Gene

SuperPathways for MFSD6L Gene

No Data Available

Interacting Proteins for MFSD6L Gene

Gene Ontology (GO) - Biological Process for MFSD6L Gene


No data available for Pathways by source and SIGNOR curated interactions for MFSD6L Gene

Drugs & Compounds for MFSD6L Gene

No Compound Related Data Available

Transcripts for MFSD6L Gene

mRNA/cDNA for MFSD6L Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MFSD6L Gene

Major facilitator superfamily domain containing 6-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD6L Gene

No ASD Table

Relevant External Links for MFSD6L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD6L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD6L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD6L Gene

This gene is overexpressed in Testis (x22.2), Pancreas (x5.6), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for MFSD6L Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD6L Gene

Protein tissue co-expression partners for MFSD6L Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD6L Gene:


SOURCE GeneReport for Unigene cluster for MFSD6L Gene:

genes like me logo Genes that share expression patterns with MFSD6L: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD6L Gene

Orthologs for MFSD6L Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD6L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFSD6L 33 34
  • 98.98 (n)
(Bos Taurus)
Mammalia MFSD6L 33 34
  • 79.41 (n)
(Canis familiaris)
Mammalia MFSD6L 33 34
  • 78.67 (n)
(Rattus norvegicus)
Mammalia Mfsd6l 33
  • 77.44 (n)
(Mus musculus)
Mammalia Mfsd6l 33 16 34
  • 77.34 (n)
(Monodelphis domestica)
Mammalia MFSD6L 34
  • 53 (a)
(Anolis carolinensis)
Reptilia MFSD6L 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd6l 33
  • 53.22 (n)
(Danio rerio)
Actinopterygii mfsd6l 33 34
  • 49.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sug 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for MFSD6L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD6L Gene

Gene Tree for MFSD6L (if available)
Gene Tree for MFSD6L (if available)

Paralogs for MFSD6L Gene

Paralogs for MFSD6L Gene

genes like me logo Genes that share paralogs with MFSD6L: view

Variants for MFSD6L Gene

Sequence variations from dbSNP and Humsavar for MFSD6L Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000004339 -- 8,796,857(+) ACGCC(C/T)GGTCC downstream-variant-500B
rs1005077914 -- 8,799,907(+) TCCCC(A/G)GGGCC upstream-variant-2KB
rs1005128792 -- 8,799,660(+) CTGTA(C/T)TGGAA upstream-variant-2KB
rs1005267042 -- 8,798,724(+) TTGGG(C/T)CGAGG reference, missense
rs1007716163 -- 8,800,364(+) ATCTA(G/T)AGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD6L Gene

Variant ID Type Subtype PubMed ID
nsv1969 CNV deletion 18451855
nsv518675 CNV gain 19592680
nsv953828 CNV deletion 24416366

Variation tolerance for MFSD6L Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.71; 95.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD6L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD6L Gene

Disorders for MFSD6L Gene

Relevant External Links for MFSD6L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MFSD6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD6L Gene

Publications for MFSD6L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for MFSD6L Gene

Sources for MFSD6L Gene

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