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Aliases for MFSD6 Gene

Aliases for MFSD6 Gene

  • Major Facilitator Superfamily Domain Containing 6 2 3 5
  • Macrophage MHC Class I Receptor 2 Homolog 3 4
  • MMR2 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 6 3
  • Macrophage MHC Receptor 2 3
  • HMMR2 3

External Ids for MFSD6 Gene

Previous GeneCards Identifiers for MFSD6 Gene

  • GC02P190981
  • GC02P191273
  • GC02P183132

Summaries for MFSD6 Gene

GeneCards Summary for MFSD6 Gene

MFSD6 (Major Facilitator Superfamily Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is MFSD6L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD6 Gene

Genomics for MFSD6 Gene

Regulatory Elements for MFSD6 Gene

Enhancers for MFSD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MFSD6 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFSD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD6 Gene

Chromosome:
2
Start:
190,408,355 bp from pter
End:
190,509,205 bp from pter
Size:
100,851 bases
Orientation:
Plus strand

Genomic View for MFSD6 Gene

Genes around MFSD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD6 Gene

Proteins for MFSD6 Gene

  • Protein details for MFSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSS7-MFSD6_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 6
    Protein Accession:
    Q6ZSS7
    Secondary Accessions:
    • D3KSZ4
    • Q86TH2
    • Q9NXM3

    Protein attributes for MFSD6 Gene

    Size:
    791 amino acids
    Molecular mass:
    88088 Da
    Quaternary structure:
    • May interact with HLA-B62.
    SequenceCaution:
    • Sequence=AAY24173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX10868.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MFSD6 Gene

Post-translational modifications for MFSD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD6 Gene

Domains & Families for MFSD6 Gene

Protein Domains for MFSD6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZSS7

UniProtKB/Swiss-Prot:

MFSD6_HUMAN :
  • Belongs to the major facilitator superfamily. MFSD6 family.
Family:
  • Belongs to the major facilitator superfamily. MFSD6 family.
genes like me logo Genes that share domains with MFSD6: view

No data available for Gene Families for MFSD6 Gene

Function for MFSD6 Gene

Phenotypes for MFSD6 Gene

genes like me logo Genes that share phenotypes with MFSD6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD6 Gene

Localization for MFSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD6 Gene COMPARTMENTS Subcellular localization image for MFSD6 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MFSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD6: view

Pathways & Interactions for MFSD6 Gene

SuperPathways for MFSD6 Gene

No Data Available

Interacting Proteins for MFSD6 Gene

Gene Ontology (GO) - Biological Process for MFSD6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD6 Gene

Drugs & Compounds for MFSD6 Gene

No Compound Related Data Available

Transcripts for MFSD6 Gene

Unigene Clusters for MFSD6 Gene

Major facilitator superfamily domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD6 Gene

No ASD Table

Relevant External Links for MFSD6 Gene

GeneLoc Exon Structure for
MFSD6
ECgene alternative splicing isoforms for
MFSD6

Expression for MFSD6 Gene

mRNA expression in normal human tissues for MFSD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD6 Gene

This gene is overexpressed in Nasal epithelium (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MFSD6 Gene



NURSA nuclear receptor signaling pathways regulating expression of MFSD6 Gene:

MFSD6

SOURCE GeneReport for Unigene cluster for MFSD6 Gene:

Hs.418581

mRNA Expression by UniProt/SwissProt for MFSD6 Gene:

Q6ZSS7-MFSD6_HUMAN
Tissue specificity: Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all.
genes like me logo Genes that share expression patterns with MFSD6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MFSD6 Gene

Orthologs for MFSD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFSD6 34
  • 88.48 (n)
  • 88.95 (a)
MFSD6 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD6 34
  • 87.13 (n)
  • 88.66 (a)
MFSD6 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd6 34
  • 86.5 (n)
  • 87.97 (a)
Mfsd6 16
Mfsd6 35
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFSD6 34
  • 99.66 (n)
  • 99.37 (a)
MFSD6 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd6 34
  • 85.7 (n)
  • 88.23 (a)
oppossum
(Monodelphis domestica)
Mammalia MFSD6 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD6 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD6 34
  • 73.87 (n)
  • 80.64 (a)
MFSD6 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD6 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd6 34
  • 66.81 (n)
  • 70.72 (a)
zebrafish
(Danio rerio)
Actinopterygii mfsd6a 34
  • 61.39 (n)
  • 60.22 (a)
mfsd6a 35
  • 54 (a)
OneToMany
mfsd6b 35
  • 51 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10268 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003204 34
  • 52.01 (n)
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12858 34
  • 51.18 (n)
  • 41.77 (a)
CG12858 35
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R13A5.9 34
  • 45.08 (n)
  • 35.42 (a)
R13A5.9 35
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
Species where no ortholog for MFSD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD6 Gene

ENSEMBL:
Gene Tree for MFSD6 (if available)
TreeFam:
Gene Tree for MFSD6 (if available)

Paralogs for MFSD6 Gene

Paralogs for MFSD6 Gene

genes like me logo Genes that share paralogs with MFSD6: view

Variants for MFSD6 Gene

Sequence variations from dbSNP and Humsavar for MFSD6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs9646748 - 190,436,642(+) AAACA(A/G)GGCTC reference, missense
rs6707691 -- 190,421,676(+) TCAGC(A/C)TCCCA intron-variant
rs6707836 -- 190,421,758(+) atctc(A/G)ctatg intron-variant
rs6707846 -- 190,421,790(+) AATTG(A/C)TCCTC intron-variant
rs6708018 -- 190,421,932(+) AAACC(A/G)AGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD6 Gene

Variant ID Type Subtype PubMed ID
dgv1198e212 CNV loss 25503493
dgv1199e212 CNV loss 25503493
esv1062211 CNV insertion 17803354
esv2318138 CNV deletion 18987734
esv2721268 CNV deletion 23290073
esv33134 CNV gain 17666407
esv3593754 CNV loss 21293372
esv3593755 CNV loss 21293372
esv3593756 CNV loss 21293372
nsv1143967 CNV deletion 24896259

Variation tolerance for MFSD6 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD6 Gene

Disorders for MFSD6 Gene

Relevant External Links for MFSD6

Genetic Association Database (GAD)
MFSD6
Human Genome Epidemiology (HuGE) Navigator
MFSD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD6

No disorders were found for MFSD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD6 Gene

Publications for MFSD6 Gene

  1. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 46 65
  2. HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. (PMID: 20123006) Shimizu T. … Yoshida R. (Gene 2010) 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65

Products for MFSD6 Gene

Sources for MFSD6 Gene

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