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Aliases for MFSD6 Gene

Aliases for MFSD6 Gene

  • Major Facilitator Superfamily Domain Containing 6 2 3
  • MMR2 3 4 6
  • Macrophage MHC Class I Receptor 2 Homolog 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 6 3
  • Macrophage MHC Receptor 2 3
  • HMMR2 3

External Ids for MFSD6 Gene

Previous GeneCards Identifiers for MFSD6 Gene

  • GC02P190981
  • GC02P191273
  • GC02P183132

Summaries for MFSD6 Gene

GeneCards Summary for MFSD6 Gene

MFSD6 (Major Facilitator Superfamily Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is MFSD6L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD6 Gene

Genomics for MFSD6 Gene

Regulatory Elements for MFSD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MFSD6 Gene

Start:
190,408,355 bp from pter
End:
190,509,205 bp from pter
Size:
100,851 bases
Orientation:
Plus strand

Genomic View for MFSD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD6 Gene

Proteins for MFSD6 Gene

  • Protein details for MFSD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSS7-MFSD6_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 6
    Protein Accession:
    Q6ZSS7
    Secondary Accessions:
    • D3KSZ4
    • Q86TH2
    • Q9NXM3

    Protein attributes for MFSD6 Gene

    Size:
    791 amino acids
    Molecular mass:
    88088 Da
    Quaternary structure:
    • May interact with HLA-B62
    SequenceCaution:
    • Sequence=AAY24173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX10868.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MFSD6 Gene

Proteomics data for MFSD6 Gene at MOPED

Post-translational modifications for MFSD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD6 Gene

Domains for MFSD6 Gene

Protein Domains for MFSD6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZSS7

UniProtKB/Swiss-Prot:

MFSD6_HUMAN :
  • Q6ZSS7
Family:
  • Belongs to the major facilitator superfamily. MFSD6 family.
genes like me logo Genes that share domains with MFSD6: view

No data available for Gene Families for MFSD6 Gene

Function for MFSD6 Gene

Phenotypes for MFSD6 Gene

GenomeRNAi human phenotypes for MFSD6:
genes like me logo Genes that share phenotypes with MFSD6: view

Animal Model Products

CRISPR Products

miRNA for MFSD6 Gene

miRTarBase miRNAs that target MFSD6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFSD6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFSD6 Gene

Localization for MFSD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD6 Gene COMPARTMENTS Subcellular localization image for MFSD6 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MFSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD6: view

Pathways for MFSD6 Gene

SuperPathways for MFSD6 Gene

No Data Available

Interacting Proteins for MFSD6 Gene

Gene Ontology (GO) - Biological Process for MFSD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD6: view

No data available for Pathways by source for MFSD6 Gene

Transcripts for MFSD6 Gene

Unigene Clusters for MFSD6 Gene

Major facilitator superfamily domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFSD6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MFSD6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD6 Gene

No ASD Table

Relevant External Links for MFSD6 Gene

GeneLoc Exon Structure for
MFSD6
ECgene alternative splicing isoforms for
MFSD6

Expression for MFSD6 Gene

mRNA expression in normal human tissues for MFSD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MFSD6 Gene

SOURCE GeneReport for Unigene cluster for MFSD6 Gene Hs.418581

mRNA Expression by UniProt/SwissProt for MFSD6 Gene

Q6ZSS7-MFSD6_HUMAN
Tissue specificity: Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all.
genes like me logo Genes that share expressions with MFSD6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MFSD6 Gene

Orthologs for MFSD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD6 35
  • 99.66 (n)
  • 99.37 (a)
MFSD6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFSD6 35
  • 88.48 (n)
  • 88.95 (a)
MFSD6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD6 35
  • 87.13 (n)
  • 88.66 (a)
MFSD6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd6 35
  • 86.5 (n)
  • 87.97 (a)
Mfsd6 16
Mfsd6 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD6 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD6 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd6 35
  • 85.7 (n)
  • 88.23 (a)
chicken
(Gallus gallus)
Aves MFSD6 35
  • 73.87 (n)
  • 80.64 (a)
MFSD6 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD6 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd6 35
  • 66.81 (n)
  • 70.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10268 35
zebrafish
(Danio rerio)
Actinopterygii mfsd6a 35
  • 61.39 (n)
  • 60.22 (a)
mfsd6a 36
  • 54 (a)
OneToMany
mfsd6b 36
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003204 35
  • 52.01 (n)
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12858 35
  • 51.18 (n)
  • 41.77 (a)
CG12858 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R13A5.9 35
  • 45.08 (n)
  • 35.42 (a)
R13A5.9 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 22 (a)
OneToMany
Species with no ortholog for MFSD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD6 Gene

ENSEMBL:
Gene Tree for MFSD6 (if available)
TreeFam:
Gene Tree for MFSD6 (if available)

Paralogs for MFSD6 Gene

Paralogs for MFSD6 Gene

genes like me logo Genes that share paralogs with MFSD6: view

Variants for MFSD6 Gene

Sequence variations from dbSNP and Humsavar for MFSD6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7721 -- 190,501,853(-) ATCTG(A/C)TTTTA utr-variant-3-prime
rs894070 -- 190,408,424(-) GGGGC(C/G)CCGGG utr-variant-5-prime
rs894071 -- 190,408,220(-) GGCCC(C/G)GGCCT upstream-variant-2KB
rs894072 -- 190,407,424(-) ATGTA(C/T)GGGGC upstream-variant-2KB
rs1081098 -- 190,480,384(-) AACTA(-/CTAA)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD6 Gene

Variant ID Type Subtype PubMed ID
esv2318138 CNV Deletion 18987734
esv1062211 CNV Insertion 17803354
esv33134 CNV Gain 17666407
esv2721268 CNV Deletion 23290073

Relevant External Links for MFSD6 Gene

HapMap Linkage Disequilibrium report
MFSD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD6 Gene

Disorders for MFSD6 Gene

(1) University of Copenhagen DISEASES for MFSD6 Gene

Relevant External Links for MFSD6

Genetic Association Database (GAD)
MFSD6
Human Genome Epidemiology (HuGE) Navigator
MFSD6
genes like me logo Genes that share disorders with MFSD6: view

No data available for UniProtKB/Swiss-Prot for MFSD6 Gene

Publications for MFSD6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  3. HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. (PMID: 20123006) Shimizu T. … Yoshida R. (Gene 2010) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Gene-environment interaction in the etiology of mathematical ability using SNP sets. (PMID: 20978832) Docherty S.J. … Plomin R. (Behav. Genet. 2011) 3

Products for MFSD6 Gene

Sources for MFSD6 Gene

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