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Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • HsMOT2 3 4
  • Molybdate-Anion Transporter 3

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include molybdate ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

Regulatory Elements for MFSD5 Gene

Enhancers for MFSD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F053294 1.2 ENCODE 11.5 +46.4 46429 6.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ESPL1 AAAS IGFBP6 SP1 ENSG00000258344 ENSG00000257500 LOC105378250 MAP3K12 PFDN5 ATP5G2
GH12F053060 1.3 Ensembl ENCODE 9.9 -184.3 -184323 13.5 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF48 ZNF2 SLC30A9 AAAS LOC100652999 IGFBP6 SOAT2 ZNF740 ITGB7 RNU6-333P ESPL1 PFDN5 C12orf10
GH12F053320 1.2 ENCODE 10.5 +70.1 70137 2.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 AAAS ESPL1 PFDN5 MIR3198-2 IGFBP6 MAP3K12 SP1 ENSG00000258344 C12orf10 ENSG00000260470
GH12F053190 0.8 ENCODE 10.8 -61.0 -60970 0.2 CTCF ZNF76 ARID4B EBF1 ZIC2 RAD21 TEAD3 POLR2A PATZ1 SCRT2 ESPL1 SOAT2 MFSD5 RNU6-333P C12orf10 CSAD ITGB7
GH12F053287 0.7 ENCODE 11.6 +36.6 36631 0.2 CTCF PKNOX1 ZNF654 WRNIP1 SIN3A TRIM22 REST RAD21 POLR2A MBD1 ESPL1 MFSD5 ITGB7 CSAD ZNF740 IGFBP6 SOAT2 PFDN5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD5 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088578 949 1601 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 DEK SP3

Genomic Location for MFSD5 Gene

Chromosome:
12
Start:
53,251,251 bp from pter
End:
53,254,406 bp from pter
Size:
3,156 bases
Orientation:
Plus strand

Genomic View for MFSD5 Gene

Genes around MFSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N075-MFSD5_HUMAN
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Q6N075
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    Size:
    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD5 Gene

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains & Families for MFSD5 Gene

Protein Domains for MFSD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N075

UniProtKB/Swiss-Prot:

MFSD5_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

No data available for Gene Families for MFSD5 Gene

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269 PubMed:21464289};
UniProtKB/Swiss-Prot Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Gene Ontology (GO) - Molecular Function for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015098 molybdate ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD5: view
genes like me logo Genes that share phenotypes with MFSD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD5

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

Pathways & Interactions for MFSD5 Gene

SuperPathways for MFSD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015689 molybdate ion transport IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD5 Gene

Transcripts for MFSD5 Gene

Unigene Clusters for MFSD5 Gene

Major facilitator superfamily domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
MFSD5
ECgene alternative splicing isoforms for
MFSD5

Expression for MFSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD5 Gene

This gene is overexpressed in Breast (26.3), Placenta (16.4), Blymphocyte (16.0), and Islet of Langerhans (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MFSD5 Gene



Protein tissue co-expression partners for MFSD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD5 Gene:

MFSD5

SOURCE GeneReport for Unigene cluster for MFSD5 Gene:

Hs.654660

mRNA Expression by UniProt/SwissProt for MFSD5 Gene:

Q6N075-MFSD5_HUMAN
Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.
genes like me logo Genes that share expression patterns with MFSD5: view

No data available for mRNA differential expression in normal tissues for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD5 34 35
  • 99.34 (n)
oppossum
(Monodelphis domestica)
Mammalia MFSD5 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD5 34 35
  • 91.33 (n)
cow
(Bos Taurus)
Mammalia MFSD5 34 35
  • 91.04 (n)
mouse
(Mus musculus)
Mammalia Mfsd5 34 16 35
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd5 34
  • 87.56 (n)
chicken
(Gallus gallus)
Aves MFSD5 34
  • 69.37 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD5 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd5 34
  • 64.74 (n)
Str.15101 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 34
zebrafish
(Danio rerio)
Actinopterygii mfsd5 34 35
  • 61.47 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.4 35
  • 35 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.1382 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for MFSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

ENSEMBL:
Gene Tree for MFSD5 (if available)
TreeFam:
Gene Tree for MFSD5 (if available)

Paralogs for MFSD5 Gene

No data available for Paralogs for MFSD5 Gene

Variants for MFSD5 Gene

Sequence variations from dbSNP and Humsavar for MFSD5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10876422 -- 53,253,589(+) TGCTG(C/T)TGGGC reference, synonymous-codon
rs111462157 -- 53,251,084(+) AACTC(A/C)TGACC upstream-variant-2KB
rs11170492 -- 53,250,901(+) cccag(A/G)ctgga upstream-variant-2KB
rs113078978 -- 53,251,702(+) TCCCT(C/T)AGGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs114347088 -- 53,250,215(+) AAGCG(C/T)GCACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv832417 CNV gain 17160897
nsv558996 CNV loss 21841781
nsv558994 CNV loss 21841781
nsv517066 CNV loss 19592680
nsv472441 CNV novel sequence insertion 20440878

Variation tolerance for MFSD5 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD5 Gene

Disorders for MFSD5 Gene

Relevant External Links for MFSD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD5

No disorders were found for MFSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD5 Gene

Publications for MFSD5 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MFSD5 Gene

Sources for MFSD5 Gene

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