Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • HsMOT2 3 4

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include molybdate ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

Regulatory Elements for MFSD5 Gene

Enhancers for MFSD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MFSD5 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFSD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD5 Gene

Chromosome:
12
Start:
53,251,251 bp from pter
End:
53,254,406 bp from pter
Size:
3,156 bases
Orientation:
Plus strand

Genomic View for MFSD5 Gene

Genes around MFSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N075-MFSD5_HUMAN
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Q6N075
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    Size:
    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD5 Gene

Proteomics data for MFSD5 Gene at MOPED

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains & Families for MFSD5 Gene

Protein Domains for MFSD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N075

UniProtKB/Swiss-Prot:

MFSD5_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

No data available for Gene Families for MFSD5 Gene

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269 PubMed:21464289};
UniProtKB/Swiss-Prot Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Phenotypes for MFSD5 Gene

genes like me logo Genes that share phenotypes with MFSD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD5

CRISPR Products

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD5 Gene COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

Pathways & Interactions for MFSD5 Gene

SuperPathways for MFSD5 Gene

No Data Available

Interacting Proteins for MFSD5 Gene

Gene Ontology (GO) - Biological Process for MFSD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD5 Gene

Drugs & Compounds for MFSD5 Gene

No Compound Related Data Available

Transcripts for MFSD5 Gene

Unigene Clusters for MFSD5 Gene

Major facilitator superfamily domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
MFSD5
ECgene alternative splicing isoforms for
MFSD5

Expression for MFSD5 Gene

mRNA expression in normal human tissues for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD5 Gene

This gene is overexpressed in Breast (26.3), Placenta (16.4), Blymphocyte (16.0), and Islet of Langerhans (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFSD5 Gene



SOURCE GeneReport for Unigene cluster for MFSD5 Gene Hs.654660

mRNA Expression by UniProt/SwissProt for MFSD5 Gene

Q6N075-MFSD5_HUMAN
Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.
genes like me logo Genes that share expression patterns with MFSD5: view

Protein tissue co-expression partners for MFSD5 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFSD5 35
  • 91.04 (n)
  • 96.67 (a)
MFSD5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD5 35
  • 91.33 (n)
  • 96.67 (a)
MFSD5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd5 35
  • 88.15 (n)
  • 96.22 (a)
Mfsd5 16
Mfsd5 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFSD5 35
  • 99.34 (n)
  • 98.92 (a)
MFSD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd5 35
  • 87.56 (n)
  • 96 (a)
oppossum
(Monodelphis domestica)
Mammalia MFSD5 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD5 35
  • 69.37 (n)
  • 71.23 (a)
lizard
(Anolis carolinensis)
Reptilia MFSD5 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd5 35
  • 64.74 (n)
  • 66.59 (a)
Str.15101 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 35
zebrafish
(Danio rerio)
Actinopterygii mfsd5 35
  • 61.47 (n)
  • 62.3 (a)
mfsd5 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.4 36
  • 35 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.1382 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for MFSD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

ENSEMBL:
Gene Tree for MFSD5 (if available)
TreeFam:
Gene Tree for MFSD5 (if available)

Paralogs for MFSD5 Gene

No data available for Paralogs for MFSD5 Gene

Variants for MFSD5 Gene

Sequence variations from dbSNP and Humsavar for MFSD5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10876422 -- 53,253,589(+) TGCTG(C/T)TGGGC reference, synonymous-codon
rs7309502 -- 53,249,266(+) caccc(A/C)cattg upstream-variant-2KB
rs17124993 -- 53,252,785(+) AGGAT(A/G)GATAT intron-variant
rs7398691 -- 53,252,101(+) CGTGA(C/T)GAAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs79750193 -- 53,251,484(+) GTAGG(G/T)AATTA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897

Variation tolerance for MFSD5 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MFSD5 Gene

Disorders for MFSD5 Gene

Relevant External Links for MFSD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD5

No disorders were found for MFSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD5 Gene

Publications for MFSD5 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for MFSD5 Gene

Sources for MFSD5 Gene

Content