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Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • HsMOT2 3 4
  • Molybdate-Anion Transporter 3

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

Regulatory Elements for MFSD5 Gene

Genomic Location for MFSD5 Gene

Start:
53,251,251 bp from pter
End:
53,254,406 bp from pter
Size:
3,156 bases
Orientation:
Plus strand

Genomic View for MFSD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N075-MFSD5_HUMAN
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Q6N075
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    Size:
    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD5 Gene

Proteomics data for MFSD5 Gene at MOPED

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains for MFSD5 Gene

Protein Domains for MFSD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6N075

UniProtKB/Swiss-Prot:

MFSD5_HUMAN :
  • Q6N075
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

No data available for Gene Families for MFSD5 Gene

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269 PubMed:21464289};
UniProtKB/Swiss-Prot Function: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Gene Ontology (GO) - Molecular Function for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015098 molybdate ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD5: view

Animal Model Products

CRISPR Products

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD5 Gene COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

Pathways for MFSD5 Gene

SuperPathways for MFSD5 Gene

No Data Available

Interacting Proteins for MFSD5 Gene

Gene Ontology (GO) - Biological Process for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0015689 molybdate ion transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Pathways by source for MFSD5 Gene

Transcripts for MFSD5 Gene

Unigene Clusters for MFSD5 Gene

Major facilitator superfamily domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFSD5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
MFSD5
ECgene alternative splicing isoforms for
MFSD5

Expression for MFSD5 Gene

mRNA expression in normal human tissues for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFSD5 Gene

SOURCE GeneReport for Unigene cluster for MFSD5 Gene Hs.654660

mRNA Expression by UniProt/SwissProt for MFSD5 Gene

Q6N075-MFSD5_HUMAN
Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.
genes like me logo Genes that share expressions with MFSD5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD5 35
  • 99.34 (n)
  • 98.92 (a)
MFSD5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFSD5 35
  • 91.04 (n)
  • 96.67 (a)
MFSD5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD5 35
  • 91.33 (n)
  • 96.67 (a)
MFSD5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd5 35
  • 88.15 (n)
  • 96.22 (a)
Mfsd5 16
Mfsd5 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD5 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd5 35
  • 87.56 (n)
  • 96 (a)
chicken
(Gallus gallus)
Aves MFSD5 35
  • 69.37 (n)
  • 71.23 (a)
lizard
(Anolis carolinensis)
Reptilia MFSD5 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd5 35
  • 64.74 (n)
  • 66.59 (a)
Str.15101 35
zebrafish
(Danio rerio)
Actinopterygii mfsd5 35
  • 61.47 (n)
  • 62.3 (a)
mfsd5 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.4 36
  • 35 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.1382 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for MFSD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

ENSEMBL:
Gene Tree for MFSD5 (if available)
TreeFam:
Gene Tree for MFSD5 (if available)

Paralogs for MFSD5 Gene

No data available for Paralogs for MFSD5 Gene

Variants for MFSD5 Gene

Sequence variations from dbSNP and Humsavar for MFSD5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1801346 -- 53,254,228(+) TTGAA(A/T)TCCAG utr-variant-3-prime
rs6580938 -- 53,252,585(+) ATGGG(G/T)TGAGT intron-variant
rs7309502 -- 53,249,266(+) caccc(A/C)cattg upstream-variant-2KB
rs7398691 -- 53,252,101(+) CGTGA(C/T)GAAGC intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs7954360 -- 53,251,414(+) gagat(A/G)atacg upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897

Relevant External Links for MFSD5 Gene

HapMap Linkage Disequilibrium report
MFSD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD5 Gene

Disorders for MFSD5 Gene

No disorders were found for MFSD5 Gene.

No data available for UniProtKB/Swiss-Prot for MFSD5 Gene

Publications for MFSD5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3

Products for MFSD5 Gene

Sources for MFSD5 Gene

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