MFSD5 Gene
protein-coding GIFtS: 39
GCID: GC12P053645
|
|
major facilitator superfamily domain containing 5
| |
Aliases
for MFSD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Facilitator Superfamily Domain Containing 51 2 | | MGC113081 | | Major Facilitator Superfamily Domain-Containing Protein 52 |
Export aliases for MFSD5 gene to outside databasesPrevious GC identifers: GC12P051932 GC12P050689 |
Summaries
for MFSD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MFSD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MFSD5 gene promoter:
PPAR-gamma1 E2F p300 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MFSD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13MFSD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P053645: view genomic region
(about GC identifiers)
Start:
|
53,645,035 bp from pter |
End:
|
53,648,190 bp from pter |
Size:
|
3,156 bases |
Orientation:
|
plus strand |
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Proteins
for MFSD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MFSD5_HUMAN, Q6N075 (See
protein sequence)Recommended Name: Major facilitator superfamily domain-containing protein 5 Size: 450 amino acids; 49765 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6NW04 Q8N7W8 Q8NCK0 Q96IA5Explore the universe of human proteins at neXtProt for MFSD5: NX_Q6N075
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6N075
MFSD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001164261.1 NP_116278.3
ENSEMBL proteins: ENSP00000449354 ENSP00000332624 ENSP00000442688
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MFSD5 for ontologies About GeneDecksing
MFSD5 Antibody Products:
Assay Products for MFSD5: |
Protein
Domains /
Families
for MFSD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MFSD5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6N075ProtoNet protein and cluster: Q6N075 UniProtKB/Swiss-Prot: MFSD5_HUMAN, Q6N075Similarity: Belongs to the major facilitator superfamily |
Function
for MFSD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MFSD5 (NM_032889) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD5 |
Animal Models:
Mouse knock-out Mfsd5tm1Lex for MFSD5
1 MGI phenotypic allele  for Mfsd5 (no phenotypes)
MFSD5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MFSD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for MFSD5 (Q6N0753 ENSP000003326244) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
MFSD5 for ontologies About GeneDecksing
|
Drugs & Compounds
for MFSD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MFSD5
Search CenterWatch for drugs/clinical trials and news about MFSD5
|
Transcripts
for MFSD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MFSD5 gene (2 alternative transcripts): NM_001170790.1 NM_032889.4 Unigene Cluster for MFSD5: Major facilitator superfamily domain containing 5 Hs.654660 [show with all ESTs]Unigene Representative Sequence: NM_0011707905 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000546655 ENST00000551660 ENST00000329548(uc001sci.2) ENST00000552097
ENST00000534842(uc001sch.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MFSD5 (NM_032889) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD5 |
Additional cDNA sequence: AK074684.1 AK097576.1 AK225998.1 AY358604.1 BC007703.2 BC067795.1 BX640649.1 6 DOTS entries: DT.443705 DT.97797060 DT.100766967 DT.95208877 DT.100811026 DT.97817240 24/162 AceView cDNA sequences (see all 162): BM015349 BF437217 BM781993 BM764084 BM763616 BU509556 BE877799 BF574940 AA306638 AL555944 AL534846 BU622768 BF725651 AK097576 AY358604 BQ014518 AJ289878 BI916905 BM820296 BX640649 AI583572 BQ072939 AL529419 BI916174
GeneLoc Exon Structure
|
Expression
for MFSD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MFSD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGGGTGA
About this image
See MFSD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFSD5
SOURCE GeneReport for Unigene cluster: Hs.654660
SABiosciences Custom PCR Arrays for MFSD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFSD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD5 |
Orthologs
for MFSD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MFSD5 gene from 8/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mfsd51 , 5 |
major facilitator superfamily domain containing 51, 5 |
88.15(n)1
96.22(a)1 |
|
15 (57.44 cM)5
1060731 NM_134100.41 NP_598861.11
1022794565 |
chicken
(Gallus gallus) |
Aves |
MFSD51 |
major facilitator superfamily domain containing 5 |
69.37(n)
71.23(a) |
|
777286 XM_003643455.1 XP_003643503.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MFSD56 |
-- |
77(a) |
1 ↔ 1 |
2(69787475-69788833) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.190802 |
Xenopus laevis transcribed sequences |
83.26(n) |
|
BI675619.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mfsd51 |
major facilitator superfamily domain containing 5 |
61.47(n)
62.3(a) |
|
436986 NM_001002713.1 NP_001002713.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y54G2A.46 |
-- |
32(a) |
1 ↔ 1 |
IV(2931407-2936824) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G230936 |
major facilitator protein |
18(a) |
1 ↔ 1 |
2(9832123-9834739) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
18(a) |
1 ↔ 1 |
8(739821-744515) |
ENSEMBL Gene Tree for MFSD5 (if available)
TreeFam Gene Tree for MFSD5 (if available) |
Paralogs
for MFSD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MFSD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MFSD5 (53645035 - 53648190 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MFSD5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD5 |
|
Disorders
/ Diseases
for MFSD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MFSD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MFSD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MFSD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for MFSD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MFSD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MFSD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MFSD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MFSD5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MFSD5 gene:
Search GeneIP for patents involving MFSD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MFSD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MFSD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFSD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD5 | | | OriGene Protein Over-expression Lysate for MFSD5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MFSD5 | | OriGene 3'-UTR Clone for MFSD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MFSD5 | | OriGene Custom Protein Services for MFSD5 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFSD5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFSD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD5 |
| |
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| | | | Search Tocris compounds for MFSD5 |
| |  |  |  |  | | | | |
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 |
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 | | | MFSD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD5 |
|  |  |  | | | | Search ThermoFisher Antibodies for MFSD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD5 |
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