Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • HsMOT2 3 4
  • Molybdate-Anion Transporter 3

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include molybdate ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

Regulatory Elements for MFSD5 Gene

Enhancers for MFSD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053294 1.4 ENCODE dbSUPER 11.5 +46.4 46429 6.5 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ESPL1 AAAS MAP3K12 ATP5G2 ZNF740 MFSD5 ITGB7 SOAT2 AMHR2 IGFBP6
GH12G053060 1.6 Ensembl ENCODE dbSUPER 9.9 -184.3 -184323 13.5 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A YBX1 DMAP1 ZNF2 PFDN5 AAAS LOC283335 LOC100652999 IGFBP6 SOAT2 ZNF740 ITGB7 RNU6-333P ESPL1
GH12G053320 1.2 ENCODE 10.5 +70.1 70137 2.3 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ESPL1 AAAS MAP3K12 C12orf10 PFDN5 SP7 CBX5 RARG AMHR2 ITGB7
GH12G053289 0.8 dbSUPER 11.5 +38.9 38948 2.3 PKNOX1 ZBTB21 ZFP64 ZNF101 ZNF697 NFE2 ZNF433 ZNF654 ZNF680 ZBTB11 ESPL1 AAAS MAP3K12 ITGB7 MFSD5 CBX5 RNU6-333P SOAT2 IGFBP6 AMHR2
GH12G053073 0.9 ENCODE dbSUPER 9.9 -176.8 -176760 1.2 PAF1 POLR2A ZSCAN4 PRDM10 CEBPG ZNF644 SUPT5H RBFOX2 IGFBP6 SOAT2 RNU6-333P MFSD5 EIF4B SPRYD3 MIR6757
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD5 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052167 949 1201 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK SP3 SP5

Genomic Location for MFSD5 Gene

53,251,251 bp from pter
53,254,406 bp from pter
3,156 bases
Plus strand

Genomic View for MFSD5 Gene

Genes around MFSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene


neXtProt entry for MFSD5 Gene

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at posLast=367367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains & Families for MFSD5 Gene

Protein Domains for MFSD5 Gene


Suggested Antigen Peptide Sequences for MFSD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

No data available for Gene Families for MFSD5 Gene

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269 PubMed:21464289};
UniProtKB/Swiss-Prot Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Gene Ontology (GO) - Molecular Function for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015098 molybdate ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD5: view
genes like me logo Genes that share phenotypes with MFSD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD5

CRISPR Products

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

Pathways & Interactions for MFSD5 Gene

SuperPathways for MFSD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015689 molybdate ion transport IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD5 Gene

Drugs & Compounds for MFSD5 Gene

No Compound Related Data Available

Transcripts for MFSD5 Gene

Unigene Clusters for MFSD5 Gene

Major facilitator superfamily domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD5 Gene

This gene is overexpressed in Breast (26.3), Placenta (16.4), Blymphocyte (16.0), and Islet of Langerhans (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MFSD5 Gene

Protein tissue co-expression partners for MFSD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD5 Gene:


SOURCE GeneReport for Unigene cluster for MFSD5 Gene:


mRNA Expression by UniProt/SwissProt for MFSD5 Gene:

Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.

Evidence on tissue expression from TISSUES for MFSD5 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MFSD5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFSD5 34 35
  • 99.34 (n)
(Monodelphis domestica)
Mammalia MFSD5 35
  • 92 (a)
(Canis familiaris)
Mammalia MFSD5 34 35
  • 91.33 (n)
(Bos Taurus)
Mammalia MFSD5 34 35
  • 91.04 (n)
(Mus musculus)
Mammalia Mfsd5 34 16 35
  • 88.15 (n)
(Rattus norvegicus)
Mammalia Mfsd5 34
  • 87.56 (n)
(Gallus gallus)
Aves MFSD5 34
  • 69.37 (n)
(Anolis carolinensis)
Reptilia MFSD5 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd5 34
  • 64.74 (n)
Str.15101 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 34
(Danio rerio)
Actinopterygii mfsd5 34 35
  • 61.47 (n)
(Caenorhabditis elegans)
Secernentea Y54G2A.4 35
  • 35 (a)
(Triticum aestivum)
Liliopsida Ta.1382 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for MFSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

Gene Tree for MFSD5 (if available)
Gene Tree for MFSD5 (if available)

Paralogs for MFSD5 Gene

No data available for Paralogs for MFSD5 Gene

Variants for MFSD5 Gene

Sequence variations from dbSNP and Humsavar for MFSD5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001732463 -- 53,254,490(+) TTTTT(-/G)TTTTG downstream-variant-500B
rs1002069568 -- 53,252,701(+) CTGAG(A/C)TCTTG intron-variant
rs1002744927 -- 53,251,415(+) AGATG(A/C)TACGG upstream-variant-2KB, utr-variant-5-prime
rs1003100687 -- 53,251,828(+) TGGCT(C/G)TACCG upstream-variant-2KB, reference, synonymous-codon
rs1003697912 -- 53,250,440(+) TCGCC(A/T)TATTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv472441 CNV novel sequence insertion 20440878
nsv517066 CNV loss 19592680
nsv558994 CNV loss 21841781
nsv558996 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for MFSD5 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD5 Gene

Disorders for MFSD5 Gene

Relevant External Links for MFSD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MFSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD5 Gene

Publications for MFSD5 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MFSD5 Gene

Sources for MFSD5 Gene

Loading form....