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Aliases for MFSD4B Gene

Aliases for MFSD4B Gene

  • Major Facilitator Superfamily Domain Containing 4B 2 3 5
  • KIAA1919 2 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 4B 3 4
  • NaGLT1 3 4
  • Sodium-Dependent Glucose Transporter 1 3

External Ids for MFSD4B Gene

Previous HGNC Symbols for MFSD4B Gene

  • KIAA1919

Summaries for MFSD4B Gene

GeneCards Summary for MFSD4B Gene

MFSD4B (Major Facilitator Superfamily Domain Containing 4B) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. An important paralog of this gene is MFSD4A.

UniProtKB/Swiss-Prot for MFSD4B Gene

  • May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD4B Gene

Genomics for MFSD4B Gene

Regulatory Elements for MFSD4B Gene

Enhancers for MFSD4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F111563 1.6 FANTOM5 Ensembl ENCODE 40 +307.1 307106 6.3 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 FOS KLF7 MFSD4B ENSG00000220506 ENSG00000255389 TRAF3IP2 REV3L BRD7P4 FCF1P5 ENSG00000231046 FEM1AP3 TRAF3IP2-AS1
GH06F111258 1.1 ENCODE 47.1 +0.8 760 2.9 HDGF ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 MFSD4B FCF1P5 ENSG00000220506 BRD7P4 ENSG00000230177 LOC105377943
GH06F110553 1.5 FANTOM5 ENCODE 28.5 -704.7 -704671 2.5 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MFSD4B FCF1P5 RN7SL617P ENSG00000231046 ENSG00000220506 WASF1 RPF2 BRD7P4 TRAF3IP2-AS1 CDK19
GH06F111587 1.3 Ensembl ENCODE 25.2 +332.4 332388 7.6 SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 JUNB ZHX2 ZNF592 PPARGC1A ENSG00000255389 MFSD4B FCF1P5 ENSG00000220506 TRAF3IP2 REV3L TRAF3IP2-AS1 BRD7P4 GC06P111586 GC06P111602
GH06F110873 1.5 FANTOM5 ENCODE 20.6 -382.7 -382724 6.6 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FCF1P5 MFSD4B RPF2 CDK19 ENSG00000231046 RN7SL617P ENSG00000220506 GTF3C6 RNU6-957P WASF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD4B on UCSC Golden Path with GeneCards custom track

Promoters for MFSD4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001224464 621 2601 HDGF ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9

Genomic Location for MFSD4B Gene

Chromosome:
6
Start:
111,259,279 bp from pter
End:
111,271,167 bp from pter
Size:
11,889 bases
Orientation:
Plus strand

Genomic View for MFSD4B Gene

Genes around MFSD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD4B Gene

Proteins for MFSD4B Gene

  • Protein details for MFSD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TF39-MFS4B_HUMAN
    Recommended name:
    Sodium-dependent glucose transporter 1
    Protein Accession:
    Q5TF39
    Secondary Accessions:
    • A8K9M0
    • Q8IYB6
    • Q96PW9
    • Q9P0D6

    Protein attributes for MFSD4B Gene

    Size:
    518 amino acids
    Molecular mass:
    56218 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD4B Gene

Post-translational modifications for MFSD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD4B Gene

Domains & Families for MFSD4B Gene

Protein Domains for MFSD4B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5TF39

UniProtKB/Swiss-Prot:

MFS4B_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD4B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MFSD4B Gene

Function for MFSD4B Gene

Molecular function for MFSD4B Gene

UniProtKB/Swiss-Prot Function:
May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.

Gene Ontology (GO) - Molecular Function for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with MFSD4B: view
genes like me logo Genes that share phenotypes with MFSD4B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD4B Gene

Localization for MFSD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD4B Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD4B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with MFSD4B: view

Pathways & Interactions for MFSD4B Gene

genes like me logo Genes that share pathways with MFSD4B: view

Interacting Proteins for MFSD4B Gene

Selected Interacting proteins: Q5TF39-MFS4B_HUMAN for MFSD4B Gene via IID

Gene Ontology (GO) - Biological Process for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD4B: view

No data available for SIGNOR curated interactions for MFSD4B Gene

Transcripts for MFSD4B Gene

mRNA/cDNA for MFSD4B Gene

Unigene Clusters for MFSD4B Gene

KIAA1919:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD4B Gene

No ASD Table

Relevant External Links for MFSD4B Gene

GeneLoc Exon Structure for
MFSD4B
ECgene alternative splicing isoforms for
MFSD4B

Expression for MFSD4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MFSD4B Gene:

MFSD4B

SOURCE GeneReport for Unigene cluster for MFSD4B Gene:

Hs.400572
genes like me logo Genes that share expression patterns with MFSD4B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MFSD4B Gene

Orthologs for MFSD4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1919 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia KIAA1919 34 35
  • 87.49 (n)
dog
(Canis familiaris)
Mammalia KIAA1919 34 35
  • 85.69 (n)
mouse
(Mus musculus)
Mammalia 2010001E11Rik 35
  • 78 (a)
OneToMany
G630090E17Rik 35
  • 78 (a)
OneToMany
AI317395 34 35
  • 77.65 (n)
AA474331 35
  • 72 (a)
OneToMany
BC021785 35
  • 66 (a)
OneToMany
Mfsd4b1 16
rat
(Rattus norvegicus)
Mammalia RGD1559971 34
  • 77.69 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1919 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1919 34 35
  • 62.59 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1919 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1919 34
  • 62.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10832 34
zebrafish
(Danio rerio)
Actinopterygii zgc:162161 34 35
  • 56.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
Species where no ortholog for MFSD4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD4B Gene

ENSEMBL:
Gene Tree for MFSD4B (if available)
TreeFam:
Gene Tree for MFSD4B (if available)

Paralogs for MFSD4B Gene

Paralogs for MFSD4B Gene

Pseudogenes.org Pseudogenes for MFSD4B Gene

genes like me logo Genes that share paralogs with MFSD4B: view

Variants for MFSD4B Gene

Sequence variations from dbSNP and Humsavar for MFSD4B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456872 -- 111,265,464(+) GCTAC(C/T)AACAG intron-variant
rs10872066 -- 111,272,408(+) aaatt(C/G)cacat intron-variant
rs111470366 -- 111,261,876(+) CGTGA(C/G)CTACT intron-variant
rs111515930 -- 111,259,400(+) TGCCC(C/T)GGTTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs11153277 -- 111,259,358(+) TTTTG(A/C)CACGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD4B Gene

Variant ID Type Subtype PubMed ID
nsv604517 CNV gain 21841781
nsv1028349 CNV gain 25217958
nsv1020627 CNV gain 25217958
esv3610378 CNV loss 21293372
esv3610377 CNV loss 21293372

Variation tolerance for MFSD4B Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD4B Gene

Disorders for MFSD4B Gene

Relevant External Links for MFSD4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD4B

No disorders were found for MFSD4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD4B Gene

Publications for MFSD4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for MFSD4B Gene

Sources for MFSD4B Gene

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