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Aliases for MFSD4A Gene

Aliases for MFSD4A Gene

  • Major Facilitator Superfamily Domain Containing 4A 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 4 3 4
  • Major Facilitator Superfamily Domain Containing 4 2 3
  • MFSD4 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 4A 3
  • UNQ3064 3

External Ids for MFSD4A Gene

Previous HGNC Symbols for MFSD4A Gene

  • MFSD4

Summaries for MFSD4A Gene

GeneCards Summary for MFSD4A Gene

MFSD4A (Major Facilitator Superfamily Domain Containing 4A) is a Protein Coding gene. An important paralog of this gene is MFSD4B.

Additional gene information for MFSD4A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD4A Gene

Genomics for MFSD4A Gene

GeneHancer (GH) Regulatory Elements for MFSD4A Gene

Promoters and enhancers for MFSD4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205567 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 555.3 -0.5 -487 2.7 CTCF SUZ12 KLF17 ZIC2 ZNF335 ZFHX2 GLIS2 ATF7 ZNF600 EGR2 MFSD4A RNU2-19P
GH01I205629 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.9 +62.8 62780 4.6 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ELK4 GC01P205631 MFSD4A RAB29 RNU6-418P CDK18 NUCKS1 PM20D1 LOC100420878
GH01I205543 Enhancer 1.2 Ensembl ENCODE dbSUPER 25.4 -25.0 -24990 1.6 PKNOX1 NFIB BRCA1 ZNF335 GLIS2 ZNF366 EGR1 FOS RCOR1 CREM MFSD4A RNU2-19P CDK18 RNU6-418P LOC100420878 ELK4 GC01M205361
GH01I205667 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +101.5 101464 4.8 HDGF CLOCK FOXA2 ARID4B SIN3A IRF4 ETS1 ZNF143 ATF7 RUNX3 SLC45A3 RAB29 RNU6-418P NUCKS1 ELK4 LOC100420878 MFSD4A CDK18 PM20D1 LOC105371701
GH01I205293 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -269.6 -269604 12.4 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS KLF13 DEK SP5 TMCC2 NUAK2 DSTYK CDK18 LOC101929459 MFSD4A CNTN2 TMEM81 KLHDC8A ELK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD4A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD4A Gene

Genomic Locations for MFSD4A Gene
chr1:205,568,885-205,602,918
(GRCh38/hg38)
Size:
34,034 bases
Orientation:
Plus strand
chr1:205,538,013-205,572,046
(GRCh37/hg19)

Genomic View for MFSD4A Gene

Genes around MFSD4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD4A Gene

Proteins for MFSD4A Gene

  • Protein details for MFSD4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N468-MFD4A_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 4A
    Protein Accession:
    Q8N468
    Secondary Accessions:
    • B7Z8X3
    • Q6UY25
    • Q8NAY0
    • Q8TCP4

    Protein attributes for MFSD4A Gene

    Size:
    514 amino acids
    Molecular mass:
    56265 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88474.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD4A Gene

Post-translational modifications for MFSD4A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MFSD4A Gene

Domains & Families for MFSD4A Gene

Gene Families for MFSD4A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MFSD4A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N468

UniProtKB/Swiss-Prot:

MFD4A_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD4A: view

Function for MFSD4A Gene

Phenotypes From GWAS Catalog for MFSD4A Gene

Gene Ontology (GO) - Molecular Function for MFSD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD4A: view
genes like me logo Genes that share phenotypes with MFSD4A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD4A Gene

Localization for MFSD4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD4A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD4A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MFSD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD4A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD4A Gene

Pathways & Interactions for MFSD4A Gene

SuperPathways for MFSD4A Gene

No Data Available

Interacting Proteins for MFSD4A Gene

Selected Interacting proteins: Q8N468-MFD4A_HUMAN for MFSD4A Gene via IID

Gene Ontology (GO) - Biological Process for MFSD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IEA --
GO:1904659 glucose transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD4A: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD4A Gene

Drugs & Compounds for MFSD4A Gene

No Compound Related Data Available

Transcripts for MFSD4A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD4A Gene

No ASD Table

Relevant External Links for MFSD4A Gene

GeneLoc Exon Structure for
MFSD4A
ECgene alternative splicing isoforms for
MFSD4A

Expression for MFSD4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MFSD4A Gene:

MFSD4A

Evidence on tissue expression from TISSUES for MFSD4A Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with MFSD4A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD4A Gene

Orthologs for MFSD4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD4 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia MFSD4 33 34
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia MFSD4 33 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Mfsd4 33 34
  • 87.45 (n)
Mfsd4a 16
rat
(Rattus norvegicus)
Mammalia Mfsd4 33
  • 86.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD4 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD4 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD4 33 34
  • 76.33 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD4 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd4 33
  • 62.98 (n)
zebrafish
(Danio rerio)
Actinopterygii mfsd4a 33 34
  • 62.82 (n)
mfsd4b 34
  • 49 (a)
OneToMany
zgc66461 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToOne
Species where no ortholog for MFSD4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD4A Gene

ENSEMBL:
Gene Tree for MFSD4A (if available)
TreeFam:
Gene Tree for MFSD4A (if available)

Paralogs for MFSD4A Gene

Paralogs for MFSD4A Gene

genes like me logo Genes that share paralogs with MFSD4A: view

Variants for MFSD4A Gene

Sequence variations from dbSNP and Humsavar for MFSD4A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004555 -- 205,582,395(+) AT/ intron_variant
rs1000034645 -- 205,572,856(+) G/A intron_variant
rs1000250374 -- 205,591,261(+) T/C intron_variant
rs1000280364 -- 205,603,150(+) T/C downstream_transcript_variant
rs1000281579 -- 205,590,942(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD4A Gene

Variant ID Type Subtype PubMed ID
nsv549044 CNV loss 21841781

Variation tolerance for MFSD4A Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.60; 89.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD4A Gene

Disorders for MFSD4A Gene

No disorders were found for MFSD4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD4A Gene

Publications for MFSD4A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice. (PMID: 29049335) Perland E … Fredriksson R (PloS one 2017) 3 58

Products for MFSD4A Gene

Sources for MFSD4A Gene

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