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Aliases for MFSD4 Gene

Aliases for MFSD4 Gene

  • Major Facilitator Superfamily Domain Containing 4 2 3
  • Major Facilitator Superfamily Domain-Containing Protein 4 3
  • UNQ3064 3

External Ids for MFSD4 Gene

Summaries for MFSD4 Gene

GeneCards Summary for MFSD4 Gene

MFSD4 (Major Facilitator Superfamily Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is KIAA1919.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD4 Gene

Genomics for MFSD4 Gene

Genomic Location for MFSD4 Gene

Start:
205,568,885 bp from pter
End:
205,602,918 bp from pter
Size:
34,034 bases
Orientation:
Plus strand

Genomic View for MFSD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD4 Gene

Regulatory Elements for MFSD4 Gene

Proteins for MFSD4 Gene

  • Protein details for MFSD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N468-MFSD4_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 4
    Protein Accession:
    Q8N468
    Secondary Accessions:
    • B7Z8X3
    • Q6UY25
    • Q8NAY0
    • Q8TCP4

    Protein attributes for MFSD4 Gene

    Size:
    514 amino acids
    Molecular mass:
    56265 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88474.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD4 Gene

Proteomics data for MFSD4 Gene at MOPED

Post-translational modifications for MFSD4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn177

Other Protein References for MFSD4 Gene

No data available for DME Specific Peptides for MFSD4 Gene

Domains for MFSD4 Gene

Protein Domains for MFSD4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MFSD4_HUMAN
Family:
  • Belongs to the major facilitator superfamily.:
    • Q8N468
genes like me logo Genes that share domains with MFSD4: view

No data available for Gene Families for MFSD4 Gene

Function for MFSD4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MFSD4 Gene

Localization for MFSD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD4 Gene COMPARTMENTS Subcellular localization image for MFSD4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MFSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD4: view

Pathways for MFSD4 Gene

SuperPathways for MFSD4 Gene

No Data Available

Interacting Proteins for MFSD4 Gene

Gene Ontology (GO) - Biological Process for MFSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD4: view

No data available for Pathways by source for MFSD4 Gene

Transcripts for MFSD4 Gene

Unigene Clusters for MFSD4 Gene

Major facilitator superfamily domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2:
SP3:
SP4: - -
SP5:
SP6: -

Relevant External Links for MFSD4 Gene

GeneLoc Exon Structure for
MFSD4
ECgene alternative splicing isoforms for
MFSD4

Expression for MFSD4 Gene

mRNA expression in normal human tissues for MFSD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD4 Gene

This gene is overexpressed in Stomach (10.0), Brain - Cortex (5.1), Brain - Frontal Cortex (BA9) (5.0), and Brain - Anterior cingulate cortex (BA24) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MFSD4 Gene

SOURCE GeneReport for Unigene cluster for MFSD4 Gene Hs.567714

genes like me logo Genes that share expressions with MFSD4: view

Orthologs for MFSD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD4 36
  • 99.47 (n)
  • 99.32 (a)
MFSD4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFSD4 36
  • 88.89 (n)
  • 89.03 (a)
MFSD4 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD4 36
  • 90.79 (n)
  • 91.25 (a)
MFSD4 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd4 36
  • 87.45 (n)
  • 87.45 (a)
Mfsd4 16
Mfsd4 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD4 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD4 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd4 36
  • 86.11 (n)
  • 87.4 (a)
chicken
(Gallus gallus)
Aves MFSD4 36
  • 76.33 (n)
  • 73.77 (a)
MFSD4 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD4 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd4 36
  • 62.98 (n)
  • 64.72 (a)
zebrafish
(Danio rerio)
Actinopterygii mfsd4a 36
  • 62.82 (n)
  • 57.14 (a)
mfsd4a 37
  • 48 (a)
OneToMany
mfsd4b 37
  • 49 (a)
OneToMany
zgc66461 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
OneToOne
Species with no ortholog for MFSD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD4 Gene

ENSEMBL:
Gene Tree for MFSD4 (if available)
TreeFam:
Gene Tree for MFSD4 (if available)

Paralogs for MFSD4 Gene

Paralogs for MFSD4 Gene

genes like me logo Genes that share paralogs with MFSD4: view

Variants for MFSD4 Gene

Sequence variations from dbSNP and Humsavar for MFSD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1361773 -- 205,582,977(-) GCCCA(C/T)GGGAG intron-variant
rs1361774 -- 205,582,704(-) GCTGA(C/G)CCCTA intron-variant
rs1891506 -- 205,574,734(-) ttgca(C/T)gcctg intron-variant
rs2153901 -- 205,581,649(-) CCCCC(A/G)GCCCA intron-variant
rs3065071 -- 205,579,327(+) AGCTC(-/TG)AGACT intron-variant

Relevant External Links for MFSD4 Gene

HapMap Linkage Disequilibrium report
MFSD4

No data available for Structural Variations from Database of Genomic Variants (DGV) for MFSD4 Gene

Disorders for MFSD4 Gene

No disorders were found for MFSD4 Gene.

No data available for UniProtKB/Swiss-Prot for MFSD4 Gene

Publications for MFSD4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for MFSD4 Gene

Sources for MFSD4 Gene

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