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Aliases for MFSD3 Gene

Aliases for MFSD3 Gene

  • Major Facilitator Superfamily Domain Containing 3 2 3 5

External Ids for MFSD3 Gene

Previous GeneCards Identifiers for MFSD3 Gene

  • GC08P145706
  • GC08P140847
  • GC08P145735

Summaries for MFSD3 Gene

GeneCards Summary for MFSD3 Gene

MFSD3 (Major Facilitator Superfamily Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include solute:proton symporter activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD3 Gene

Genomics for MFSD3 Gene

Regulatory Elements for MFSD3 Gene

Enhancers for MFSD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144506 1.4 ENCODE dbSUPER 6.2 +1.7 1703 4.0 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF251 LRRC14 ZNF250 VPS28 PPP1R16A ZNF623 LOC105375803 ENSG00000254533 ZNF517 TMED10P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD3 Gene

Chromosome:
8
Start:
144,507,267 bp from pter
End:
144,511,228 bp from pter
Size:
3,962 bases
Orientation:
Plus strand

Genomic View for MFSD3 Gene

Genes around MFSD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD3 Gene

Proteins for MFSD3 Gene

  • Protein details for MFSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES6-MFSD3_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 3
    Protein Accession:
    Q96ES6

    Protein attributes for MFSD3 Gene

    Size:
    412 amino acids
    Molecular mass:
    42696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD3 Gene

Post-translational modifications for MFSD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD3 Gene

Domains & Families for MFSD3 Gene

Protein Domains for MFSD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96ES6

UniProtKB/Swiss-Prot:

MFSD3_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD3: view

No data available for Gene Families for MFSD3 Gene

Function for MFSD3 Gene

Gene Ontology (GO) - Molecular Function for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015295 solute:proton symporter activity IBA --
genes like me logo Genes that share ontologies with MFSD3: view
genes like me logo Genes that share phenotypes with MFSD3: view

Animal Model Products

CRISPR Products

miRNA for MFSD3 Gene

miRTarBase miRNAs that target MFSD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD3 Gene

Localization for MFSD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD3 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD3: view

Pathways & Interactions for MFSD3 Gene

SuperPathways for MFSD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA,IEA --
GO:0015992 proton transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD3: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD3 Gene

Transcripts for MFSD3 Gene

Unigene Clusters for MFSD3 Gene

Major facilitator superfamily domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for MFSD3 Gene

GeneLoc Exon Structure for
MFSD3
ECgene alternative splicing isoforms for
MFSD3

Expression for MFSD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD3 Gene

Protein differential expression in normal tissues from HIPED for MFSD3 Gene

This gene is overexpressed in Islet of Langerhans (31.0), Testis (25.3), and Placenta (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MFSD3 Gene



Protein tissue co-expression partners for MFSD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD3 Gene:

MFSD3

SOURCE GeneReport for Unigene cluster for MFSD3 Gene:

Hs.7678
genes like me logo Genes that share expression patterns with MFSD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD3 Gene

Orthologs for MFSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD3 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia MFSD3 34 35
  • 79.92 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd3 34
  • 77.05 (n)
mouse
(Mus musculus)
Mammalia Mfsd3 34 16 35
  • 76.72 (n)
cow
(Bos Taurus)
Mammalia MFSD3 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD3 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD3 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD3 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100332553 34
  • 56.51 (n)
MFSD3 35
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4723 34
Species where no ortholog for MFSD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD3 Gene

ENSEMBL:
Gene Tree for MFSD3 (if available)
TreeFam:
Gene Tree for MFSD3 (if available)

Paralogs for MFSD3 Gene

No data available for Paralogs for MFSD3 Gene

Variants for MFSD3 Gene

Sequence variations from dbSNP and Humsavar for MFSD3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs386833854 Likely pathogenic 144,511,458(-) GGCCA(-/CG)GAAGA nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant
rs199885535 Likely benign 144,511,485(+) TGGAA(A/G)CTCAG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs201384843 Likely benign 144,511,449(+) TGCAG(A/G)AGCTC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs202083938 Likely benign 144,511,688(+) ATGCC(A/G)TGGAA nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs772747279 Likely benign 144,511,476(+) ACCAG(A/G/T)GCATG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for MFSD3 Gene

Variant ID Type Subtype PubMed ID
dgv1207n67 CNV gain 20364138
dgv12434n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12442n54 CNV loss 21841781
dgv12443n54 CNV loss 21841781
dgv907n27 CNV loss 19166990
esv29999 CNV loss 17803354
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612940 CNV loss 21841781
nsv612951 CNV loss 21841781
nsv612962 CNV loss 21841781
nsv612964 CNV loss 21841781
nsv612965 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for MFSD3 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD3 Gene

Disorders for MFSD3 Gene

Relevant External Links for MFSD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD3

No disorders were found for MFSD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD3 Gene

Publications for MFSD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MFSD3 Gene

Sources for MFSD3 Gene

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