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Aliases for MFSD3 Gene

Aliases for MFSD3 Gene

  • Major Facilitator Superfamily Domain Containing 3 2 3

External Ids for MFSD3 Gene

Previous GeneCards Identifiers for MFSD3 Gene

  • GC08P145706
  • GC08P140847
  • GC08P145735

Summaries for MFSD3 Gene

GeneCards Summary for MFSD3 Gene

MFSD3 (Major Facilitator Superfamily Domain Containing 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD3 Gene

Genomics for MFSD3 Gene

Regulatory Elements for MFSD3 Gene

Genomic Location for MFSD3 Gene

Start:
144,509,074 bp from pter
End:
144,511,213 bp from pter
Size:
2,140 bases
Orientation:
Plus strand

Genomic View for MFSD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD3 Gene

Proteins for MFSD3 Gene

  • Protein details for MFSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES6-MFSD3_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 3
    Protein Accession:
    Q96ES6
    Secondary Accessions:

    Protein attributes for MFSD3 Gene

    Size:
    412 amino acids
    Molecular mass:
    42696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD3 Gene

Proteomics data for MFSD3 Gene at MOPED

Post-translational modifications for MFSD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD3 Gene

Domains for MFSD3 Gene

Protein Domains for MFSD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96ES6

UniProtKB/Swiss-Prot:

MFSD3_HUMAN :
  • Q96ES6
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD3: view

No data available for Gene Families for MFSD3 Gene

Function for MFSD3 Gene

Gene Ontology (GO) - Molecular Function for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015295 solute:proton symporter activity IBA --
genes like me logo Genes that share ontologies with MFSD3: view

Phenotypes for MFSD3 Gene

genes like me logo Genes that share phenotypes with MFSD3: view

miRNA for MFSD3 Gene

miRTarBase miRNAs that target MFSD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFSD3 Gene

Localization for MFSD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD3 Gene COMPARTMENTS Subcellular localization image for MFSD3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MFSD3: view

Pathways for MFSD3 Gene

SuperPathways for MFSD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
GO:0015992 proton transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD3: view

No data available for Pathways by source for MFSD3 Gene

Transcripts for MFSD3 Gene

mRNA/cDNA for MFSD3 Gene

Unigene Clusters for MFSD3 Gene

Major facilitator superfamily domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for MFSD3 Gene

GeneLoc Exon Structure for
MFSD3
ECgene alternative splicing isoforms for
MFSD3

Expression for MFSD3 Gene

mRNA expression in normal human tissues for MFSD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFSD3 Gene

SOURCE GeneReport for Unigene cluster for MFSD3 Gene Hs.7678

genes like me logo Genes that share expressions with MFSD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFSD3 Gene

Orthologs for MFSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD3 35
  • 99.11 (n)
  • 99.51 (a)
MFSD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFSD3 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD3 35
  • 79.92 (n)
  • 79.27 (a)
MFSD3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd3 35
  • 76.72 (n)
  • 78.1 (a)
Mfsd3 16
Mfsd3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD3 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD3 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd3 35
  • 77.05 (n)
  • 78.1 (a)
lizard
(Anolis carolinensis)
Reptilia MFSD3 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4723 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332553 35
  • 56.51 (n)
  • 49.62 (a)
MFSD3 36
  • 47 (a)
OneToOne
Species with no ortholog for MFSD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD3 Gene

ENSEMBL:
Gene Tree for MFSD3 (if available)
TreeFam:
Gene Tree for MFSD3 (if available)

Paralogs for MFSD3 Gene

No data available for Paralogs for MFSD3 Gene

Variants for MFSD3 Gene

Sequence variations from dbSNP and Humsavar for MFSD3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2306387 - 144,510,641(-) GCCCC(C/T)GAGGC missense, reference
rs7837302 -- 144,510,694(+) GGGGC(C/T)AGCAT reference, synonymous-codon
rs11436836 -- 144,508,411(+) GGTCC(-/G)GCACC upstream-variant-2KB
rs11542085 -- 144,509,113(+) CCGCT(C/T)CGCCC upstream-variant-2KB
rs11986164 -- 144,507,861(+) CACTG(A/C)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD3 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
nsv891911 CNV Loss 21882294
nsv891912 CNV Loss 21882294
dgv7981n71 CNV Loss 21882294
dgv7982n71 CNV Loss 21882294
dgv7983n71 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294

Relevant External Links for MFSD3 Gene

HapMap Linkage Disequilibrium report
MFSD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD3 Gene

Disorders for MFSD3 Gene

No disorders were found for MFSD3 Gene.

No data available for UniProtKB/Swiss-Prot for MFSD3 Gene

Publications for MFSD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MFSD3 Gene

Sources for MFSD3 Gene

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