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Aliases for MFSD2B Gene

Aliases for MFSD2B Gene

  • Major Facilitator Superfamily Domain Containing 2B 2 3

External Ids for MFSD2B Gene

Previous GeneCards Identifiers for MFSD2B Gene

  • GC02P024087
  • GC02P024232

Summaries for MFSD2B Gene

GeneCards Summary for MFSD2B Gene

MFSD2B (Major Facilitator Superfamily Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is MFSD2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD2B Gene

Genomics for MFSD2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MFSD2B Gene

24,010,081 bp from pter
24,063,321 bp from pter
53,241 bases
Plus strand

Genomic View for MFSD2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD2B Gene

No data available for Regulatory Elements for MFSD2B Gene

Proteins for MFSD2B Gene

  • Protein details for MFSD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Major facilitator superfamily domain-containing protein 2B
    Protein Accession:
    Secondary Accessions:
    • B5MC32

    Protein attributes for MFSD2B Gene

    497 amino acids
    Molecular mass:
    52964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD2B Gene

Proteomics data for MFSD2B Gene at MOPED

Post-translational modifications for MFSD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD2B Gene

Domains for MFSD2B Gene

Protein Domains for MFSD2B Gene


Suggested Antigen Peptide Sequences for MFSD2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD2B: view

No data available for Gene Families for MFSD2B Gene

Function for MFSD2B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MFSD2B Gene

Localization for MFSD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD2B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MFSD2B Gene COMPARTMENTS Subcellular localization image for MFSD2B gene
Compartment Confidence
plasma membrane 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MFSD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD2B: view

Pathways for MFSD2B Gene

SuperPathways for MFSD2B Gene

No Data Available

Interacting Proteins for MFSD2B Gene

Gene Ontology (GO) - Biological Process for MFSD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with MFSD2B: view

No data available for Pathways by source for MFSD2B Gene

Transcripts for MFSD2B Gene

mRNA/cDNA for MFSD2B Gene

Unigene Clusters for MFSD2B Gene

Major facilitator superfamily domain containing 2B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFSD2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD2B Gene

No ASD Table

Relevant External Links for MFSD2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD2B Gene

mRNA expression in normal human tissues for MFSD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD2B Gene

This gene is overexpressed in Whole Blood (24.4).

Protein differential expression in normal tissues for MFSD2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (67.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MFSD2B Gene

SOURCE GeneReport for Unigene cluster for MFSD2B Gene Hs.407482

genes like me logo Genes that share expressions with MFSD2B: view

Expression partners for MFSD2B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MFSD2B Gene

Orthologs for MFSD2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MFSD2B 35
  • 82.61 (n)
  • 81.72 (a)
  • 77 (a)
(Canis familiaris)
Mammalia MFSD2B 35
  • 85.95 (n)
  • 86.55 (a)
  • 85 (a)
(Mus musculus)
Mammalia Mfsd2b 35
  • 83.54 (n)
  • 84.1 (a)
Mfsd2b 16
Mfsd2b 36
  • 80 (a)
(Pan troglodytes)
Mammalia MFSD2B 35
  • 97.13 (n)
  • 96.02 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Mfsd2b 35
  • 83.61 (n)
  • 84.52 (a)
(Monodelphis domestica)
Mammalia MFSD2B 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia MFSD2B 36
  • 55 (a)
(Gallus gallus)
Aves MFSD2B 35
  • 60.47 (n)
  • 55.11 (a)
  • 50 (a)
(Anolis carolinensis)
Reptilia MFSD2B 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd2b 35
  • 60.42 (n)
  • 55.6 (a)
(Danio rerio)
Actinopterygii si:dkeyp-115a10.3 35
  • 58.3 (n)
  • 54.59 (a)
mfsd2b 36
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1120 35
Species with no ortholog for MFSD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD2B Gene

Gene Tree for MFSD2B (if available)
Gene Tree for MFSD2B (if available)

Paralogs for MFSD2B Gene

Paralogs for MFSD2B Gene

(1) SIMAP similar genes for MFSD2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MFSD2B: view

Variants for MFSD2B Gene

Sequence variations from dbSNP and Humsavar for MFSD2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs925228 -- 24,023,809(-) TGCCC(C/T)GAGCT intron-variant
rs925229 -- 24,011,570(-) TGACA(C/T)GGCTT intron-variant
rs1876721 -- 24,009,854(-) CGGCG(A/G)CCCTG upstream-variant-2KB
rs2102451 -- 24,022,297(-) TCCCC(C/T)ACAAA intron-variant
rs2136264 -- 24,020,257(-) agagc(A/G)tccag intron-variant

Relevant External Links for MFSD2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MFSD2B Gene

Disorders for MFSD2B Gene

Relevant External Links for MFSD2B

Genetic Association Database (GAD)

No disorders were found for MFSD2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MFSD2B Gene

Publications for MFSD2B Gene

  1. Mfsd2a encodes a novel major facilitator superfamily domain- containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. (PMID: 18694395) Angers M. … Jetten A.M. (Biochem. J. 2008) 2 3 4
  2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 48
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MFSD2B Gene

Sources for MFSD2B Gene

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