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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFSD2B Gene

protein-coding   GIFtS: 38
GCID: GC02P024232

Major Facilitator Superfamily Domain Containing 2B

  Search for MFSD2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Facilitator Superfamily Domain Containing 2B1 2
Major Facilitator Superfamily Domain-Containing Protein 2B2

External Ids:    HGNC: 372071   Entrez Gene: 3889312   Ensembl: ENSG000002056397   UniProtKB: A6NFX13   

Export aliases for MFSD2B gene to outside databases

Previous GC identifers: GC02P024087 GC02P023971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MFSD2B Gene: 
MFSD2B (major facilitator superfamily domain containing 2B) is a protein-coding gene. An important paralog of this gene is MFSD2A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MFSD2B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MFSD2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

MFSD2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFSD2B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P024232:  view genomic region     (about GC identifiers)

Start:
24,232,951 bp from pter      End:
24,286,191 bp from pter
Size:
53,241 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFS2B_HUMAN, A6NFX1 (See protein sequence)
Recommended Name: Major facilitator superfamily domain-containing protein 2B  
Size: 497 amino acids; 52964 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B5MC32

Explore the universe of human proteins at neXtProt for MFSD2B: NX_A6NFX1

Explore proteomics data for MFSD2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NFX1

  • MFSD2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MFSD2B Protein Expression
    REFSEQ proteins: NP_001073942.1  
    ENSEMBL proteins: 
     ENSP00000385527   ENSP00000390490   ENSP00000342501  

    Human Recombinant Protein Products for MFSD2B: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    MFSD2B for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MFSD2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry A6NFX1

    ProtoNet protein and cluster: A6NFX1

    UniProtKB/Swiss-Prot: MFS2B_HUMAN, A6NFX1
    Similarity: Belongs to the major facilitator superfamily


    MFSD2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MFSD2B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD2B

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    MFSD2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFSD2B (MFS2B)

    Search CenterWatch for drugs/clinical trials and news about MFSD2B / MFS2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MFSD2B gene: 
    NM_001080473.1  

    Unigene Cluster for MFSD2B:

    Major facilitator superfamily domain containing 2B
    Hs.407482  [show with all ESTs]
    Unigene Representative Sequence: BX647146
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406420(uc002reo.2) ENST00000495018(uc010exz.2) ENST00000469562
    ENST00000453731 ENST00000338315
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MFSD2B
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                         Customized lentivirus expression plasmids for stable overexpression of MFSD2B 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MFSD2B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD2B

    Additional mRNA sequence: 

    BC033385.1 BX647146.1 

    14 DOTS entries:

    DT.99969818  DT.87079470  DT.100712711  DT.91833221  DT.100844933  DT.100701929  DT.100701974  DT.100775071 
    DT.40116522  DT.453256  DT.95156524  DT.97823072  DT.100701923  DT.95156551 

    24/106 AceView cDNA sequences (see all 106):

    AA778361 BC050998 BQ448196 BX644798 CR614690 AA403064 AI078220 AF322070 
    NM_054033 BM716287 AW440529 BC033385 BQ719265 AI002601 BM802489 CR626535 
    AA831473 BQ001343 BC002614 L37086 CR616275 AI352461 AI350209 BM709528 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFSD2B expression in normal human tissues (normalized intensities)      MFSD2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTATCCCA
    MFSD2B Expression
    About this image


    MFSD2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

     -- (Nervous System)
             trigeminal ganglia   

    See MFSD2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFSD2B

    SOURCE GeneReport for Unigene cluster: Hs.407482
        SABiosciences Custom PCR Arrays for MFSD2B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MFSD2B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd2b1 , 5 major facilitator superfamily domain containing 2B1, 5 83.37(n)1
    83.16(a)1
      12 (2.11 cM)5
    4326281  NM_001033488.21  NP_001028660.21 
     48624405 
    chicken
    (Gallus gallus)
    Aves MFSD2B1 major facilitator superfamily domain containing 2B 62.12(n)
    57.05(a)
      428656  XM_426214.3  XP_426214.3 
    lizard
    (Anolis carolinensis)
    Reptilia MFSD2B6
    MFSD2B6
    Uncharacterized protein
    47(a)
    34(a)
    1 ↔ 1
    possible ortholog
    1(140330476-140382581)
    GL343346.1(908466-938307)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-115a10.31 si:dkeyp-115a10.3 59.03(n)
    56.01(a)
      566968  XM_690251.3  XP_695343.3 


    ENSEMBL Gene Tree for MFSD2B (if available)
    TreeFam Gene Tree for MFSD2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFSD2B gene
    MFSD2A2  
    1 SIMAP similar gene for MFSD2B using alignment to 3 protein entries:     MFS2B_HUMAN (see all proteins):
    MFSD2A

    MFSD2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 SNPs in MFSD2B are shown (see all 384)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116962861,2
    C--24230971(+) ATTTCC/TGTAGG 1 -- us2k10--------
    rs116771101,2
    H--24230993(+) taagaA/Gtggaa 1 -- us2k10--------
    rs1448689221,2
    --24231002(+) AATTGC/TGGGTC 1 -- us2k10--------
    rs1917731211,2
    --24231067(+) GTCACC/TAGTTT 1 -- us2k10--------
    rs727816711,2
    C,F--24231123(+) TCCCCA/GATACT 1 -- us2k13Minor allele frequency- G:0.09WA NA EA 358
    rs751122201,2
    C--24231241(+) TATCCA/CAATTC 1 -- us2k10--------
    rs1490323621,2
    --24231280(+) TTAATC/TGTTGA 1 -- us2k10--------
    rs1848911061,2
    --24231312(+) ACAAAC/TCCCTT 1 -- us2k10--------
    rs1430505451,2
    C--24231556(+) CAGTGA/GCACGA 1 -- us2k10--------
    rs1133831301,2
    C,F--24231560(+) GGCACG/AATCTT 1 -- us2k12Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for MFSD2B (24232951 - 24286191 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MFSD2B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MFSD2B
    DNA2.0 Custom Variant and Variant Library Synthesis for MFSD2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MFSD2B for disorders           About MalaCards

    MFSD2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): MFSD2B

    Export disorders for MFSD2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFSD2B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MFSD2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. (PubMed id 18694395)1, 2, 3 Angers M....Jetten A.M. (2008)
    2. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388931 HGNC: 37207 AceView: FKBP1B Ensembl:ENSG00000205639 euGenes: HUgn388931
    ECgene: MFSD2B H-InvDB: MFSD2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFSD2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MFSD2B gene:
    Search GeneIP for patents involving MFSD2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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