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Aliases for MFSD2B Gene

Aliases for MFSD2B Gene

  • Major Facilitator Superfamily Domain Containing 2B 2 3 5

External Ids for MFSD2B Gene

Previous GeneCards Identifiers for MFSD2B Gene

  • GC02P024087
  • GC02P024232

Summaries for MFSD2B Gene

GeneCards Summary for MFSD2B Gene

MFSD2B (Major Facilitator Superfamily Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is MFSD2A.

Additional gene information for MFSD2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD2B Gene

Genomics for MFSD2B Gene

Regulatory Elements for MFSD2B Gene

Enhancers for MFSD2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H024009 1.6 FANTOM5 ENCODE dbSUPER 11.5 +1.4 1374 4 HDGF PKNOX1 ATF1 ARNT ZFP64 YY1 TCF12 ZNF766 GATA2 ELK1 MFSD2B UBXN2A WDCP ENSG00000271936 CENPO ATAD2B RNU6-370P
GH02H023924 1.1 ENCODE 11.3 -83.5 -83517 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FAM228B UBXN2A MFSD2B SF3B6 FKBP1B PFN4 ATAD2B RPS13P4
GH02H024048 0.9 ENCODE 11.8 +39.7 39721 1 ELF3 ARID4B KLF17 ZNF2 ZNF121 GLIS2 ZNF366 ZNF391 RUNX3 THAP11 FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 FKBP1B PIR43014 GC02M024079
GH02H023938 1 ENCODE 10.6 -69.5 -69459 3 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF766 UBXN2A MFSD2B PFN4 ATAD2B GC02P023938 SDHCP3
GH02H023944 0.7 ENCODE 10.6 -65.4 -65376 0 SOX13 GATAD2A HMG20B SP5 ZNF644 RAD21 YY1 TCF12 ZFHX2 EGR1 MFSD2B GC02P023944 RN7SL610P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD2B on UCSC Golden Path with GeneCards custom track

Promoters for MFSD2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114004 19 601 HDGF TBP RB1 FUS NFRKB ZFP64 YY1 ZNF766 EGR1 CEBPB

Genomic Location for MFSD2B Gene

Chromosome:
2
Start:
24,010,081 bp from pter
End:
24,063,321 bp from pter
Size:
53,241 bases
Orientation:
Plus strand

Genomic View for MFSD2B Gene

Genes around MFSD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD2B Gene

Proteins for MFSD2B Gene

  • Protein details for MFSD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFX1-MFS2B_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 2B
    Protein Accession:
    A6NFX1
    Secondary Accessions:
    • B5MC32

    Protein attributes for MFSD2B Gene

    Size:
    497 amino acids
    Molecular mass:
    52964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD2B Gene

Post-translational modifications for MFSD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD2B Gene

Domains & Families for MFSD2B Gene

Gene Families for MFSD2B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD2B Gene

Graphical View of Domain Structure for InterPro Entry

A6NFX1

UniProtKB/Swiss-Prot:

MFS2B_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD2B: view

Function for MFSD2B Gene

Phenotypes From GWAS Catalog for MFSD2B Gene

Phenotypes for MFSD2B Gene

genes like me logo Genes that share phenotypes with MFSD2B: view

Animal Models for MFSD2B Gene

MGI Knock Outs for MFSD2B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MFSD2B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MFSD2B Gene

Localization for MFSD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD2B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD2B gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MFSD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD2B Gene

Pathways & Interactions for MFSD2B Gene

SuperPathways for MFSD2B Gene

No Data Available

Interacting Proteins for MFSD2B Gene

Gene Ontology (GO) - Biological Process for MFSD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with MFSD2B: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD2B Gene

Drugs & Compounds for MFSD2B Gene

No Compound Related Data Available

Transcripts for MFSD2B Gene

Unigene Clusters for MFSD2B Gene

Major facilitator superfamily domain containing 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MFSD2B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD2B Gene

No ASD Table

Relevant External Links for MFSD2B Gene

GeneLoc Exon Structure for
MFSD2B
ECgene alternative splicing isoforms for
MFSD2B

Expression for MFSD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD2B Gene

This gene is overexpressed in Whole Blood (x24.4).

Protein differential expression in normal tissues from HIPED for MFSD2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD2B Gene



Protein tissue co-expression partners for MFSD2B Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD2B Gene:

MFSD2B

SOURCE GeneReport for Unigene cluster for MFSD2B Gene:

Hs.407482
genes like me logo Genes that share expression patterns with MFSD2B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD2B Gene

Orthologs for MFSD2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD2B 33 34
  • 97.13 (n)
dog
(Canis familiaris)
Mammalia MFSD2B 33 34
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd2b 33
  • 83.61 (n)
mouse
(Mus musculus)
Mammalia Mfsd2b 33 16 34
  • 83.54 (n)
cow
(Bos Taurus)
Mammalia MFSD2B 33 34
  • 82.61 (n)
oppossum
(Monodelphis domestica)
Mammalia MFSD2B 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD2B 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD2B 33 34
  • 60.47 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD2B 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd2b 33
  • 60.42 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-115a10.3 33
  • 58.3 (n)
mfsd2b 34
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1120 33
Species where no ortholog for MFSD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD2B Gene

ENSEMBL:
Gene Tree for MFSD2B (if available)
TreeFam:
Gene Tree for MFSD2B (if available)

Paralogs for MFSD2B Gene

Paralogs for MFSD2B Gene

(1) SIMAP similar genes for MFSD2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MFSD2B: view

Variants for MFSD2B Gene

Sequence variations from dbSNP and Humsavar for MFSD2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000012917 -- 24,025,943(+) GGTTT(A/C)GATCT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000066663 -- 24,020,894(+) ATTTT(A/T)ATTTT intron-variant, downstream-variant-500B
rs1000234531 -- 24,018,215(+) TGACC(A/G)AATCC intron-variant
rs1000287005 -- 24,018,000(+) CCCCA(A/G)CCCGC intron-variant
rs1000442489 -- 24,024,011(+) GGGTG(C/G/T)GGTGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MFSD2B Gene

Variant ID Type Subtype PubMed ID
nsv961020 CNV duplication 23825009
nsv997445 CNV gain 25217958

Variation tolerance for MFSD2B Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD2B Gene

Disorders for MFSD2B Gene

Relevant External Links for MFSD2B

Genetic Association Database (GAD)
MFSD2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD2B

No disorders were found for MFSD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD2B Gene

Publications for MFSD2B Gene

  1. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. (PMID: 18694395) Angers M … Jetten AM (The Biochemical journal 2008) 2 3 4 60
  2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe JK … Friedman JM (PLoS genetics 2009) 3 45 60
  3. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer. (PMID: 27301951) Bao L … Wang X (Cell biology and toxicology 2016) 3 60
  4. Understanding transport by the major facilitator superfamily (MFS): structures pave the way. (PMID: 26758938) Quistgaard EM … Nordlund P (Nature reviews. Molecular cell biology 2016) 3 60
  5. Structural Biology of the Major Facilitator Superfamily Transporters. (PMID: 26098515) Yan N (Annual review of biophysics 2015) 3 60

Products for MFSD2B Gene

Sources for MFSD2B Gene

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