MFSD2A Gene
protein-coding GIFtS : 47
GCID: GC01 P040421
major facilitator superfamily domain containing 2A (Previous name: major facilitator superfamily domain containing 2 ) (Previous symbol: MFSD2 )
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Aliasesfor MFSD2A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Major Facilitator Superfamily Domain Containing 2A 1 2 MFSD21 2 3 Major Facilitator Superfamily Domain Containing 21 2 FLJ144901 Major Facilitator Superfamily Domain-Containing Protein 2A2
Export aliases for MFSD2A gene to outside databases Previous GC identifers: GC01P040194 GC01P038539
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Summariesfor MFSD2A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MFS2A_HUMAN, Q8NA29 Function : Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membranetunicamycin transporter Gene Wiki entry for MFSD2A (MFSD2)
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Genomic Viewsfor MFSD2A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MFSD2A Other transcription factors Search SABiosciences Chromatin IP Primers for MFSD2A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MFSD2A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2 MFSD2A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P040421: view genomic region
(about GC identifiers )
Start:
40,420,784 bp from pter
End:
40,435,638 bp from pter
Size:
14,855 bases
Orientation:
plus strand
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Proteinsfor MFSD2A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MFS2A_HUMAN, Q8NA29 (See
protein sequence )Recommended Name: Major facilitator superfamily domain-containing protein 2A Size : 543 amino acids; 60170 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane (Bysimilarity); Multi-pass membrane protein (Potential). Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane
Secondary accessions : A8K675 Q6UWU5 Q96F59 Q9BRC8Alternative splicing : 3 isoforms : Q8NA29-1 Q8NA29-2 Q8NA29-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MFSD2A: NX_Q8NA29 Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NA29 MFSD2A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001129965.1 NP_116182.2 ENSEMBL proteins: ENSP00000361898 ENSP00000407606 ENSP00000361895 ENSP00000391261 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005789 endoplasmic reticulum membrane
IEA -- GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
MFSD2A for ontologies About GeneDecksing MFSD2A Antibody Products: Assay Products for MFSD2A:
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Protein
Domains / Familiesfor MFSD2A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MFSD2A for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q8NA29 ProtoNet protein and cluster: Q8NA29
UniProtKB/Swiss-Prot: MFS2A_HUMAN, Q8NA29 Similarity : Belongs to the major facilitator superfamily
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Functionfor MFSD2A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MFS2A_HUMAN, Q8NA29 Function : Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membranetunicamycin transporter
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MFSD2A (NM_032793 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD2A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MFSD2A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD2A
Animal Models: Mouse knock-out Mfsd2a tm1Lex for MFSD2A 1 MGI phenotypic allele for Mfsd2a (no phenotypes)
MFSD2A for phenotypes About GeneDecksing
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Pathways & Interactionsfor MFSD2A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD2A STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MFSD2A (ENSP00000361895 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA --
MFSD2A for ontologies About GeneDecksing
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Drugs & Compoundsfor MFSD2A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MFSD2A Search CenterWatch for drugs/clinical trials and news about MFSD2A / MFS2A
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Transcriptsfor MFSD2A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MFSD2A gene (2 alternative transcripts): NM_001136493.1 NM_032793.3 Unigene Cluster for MFSD2A:
Major facilitator superfamily domain containing 2A Hs.655177 [show with all ESTs ] Unigene Representative Sequence: AF370364 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000372811 (uc010ojb.1 uc001ceu.3 uc010ojc.2 uc009vvy.3 )ENST00000434861 ENST00000372809 (uc001cev.3 ) ENST00000483824 ENST00000469745 ENST00000480630 ENST00000491515 ENST00000459917 ENST00000481612 ENST00000420632 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MFSD2A (NM_032793 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD2A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MFSD2A
Additional cDNA sequence: AB073383.1 AF289609.1 AF370364.1 AF370393.1 AK074186.1 AK075183.1 AK093223.1 AK291540.1 AK297991.1 AL834184.1 AY358636.1 BC006353.2 BC011587.1 BC069694.1 BC069771.1 BC092414.1
23 DOTS entries : DT.100025632 DT.455069
DT.100025634 DT.97823445 DT.121393426 DT.91871632 DT.121393337 DT.95265519 DT.121393425 DT.97816338 DT.101986336 DT.91965396 DT.121393349 DT.121393352 DT.91746908 DT.95193735 DT.121393328 DT.121393401 DT.121393415 DT.114349 DT.121393421 DT.95109872 DT.95193737 24/232 AceView cDNA sequences (see all 232 ):
AL543601 BM827369 AK075183 BG315105 BM764676 AK027396 AL834184 BC069771 AK093223 BX464860 AL548198 CB155410 CR608085 BI916322 CR598887 BC011587 BM554312 BQ642553 AA338469 BF516522 AL541052 NM_032793 BP369548 AW059861 GeneLoc Exon Structure
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Expression for MFSD2A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MFSD2A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGAAGGCCA
About this image MFSD2A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MFSD2A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MFSD2A SOURCE GeneReport for Unigene cluster: Hs.655177 SABiosciences Custom PCR Arrays for MFSD2A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MFSD2ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MFSD2A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MFSD2A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MFSD2A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD2A
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Orthologsfor MFSD2A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MFSD2A gene from 5/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for MFSD2A (if available)TreeFam Gene Tree for MFSD2A (if available)
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Paralogsfor MFSD2A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MFSD2A gene MFSD2B 2 1 SIMAP similar gene for MFSD2A using alignment to 3 protein entries: MFS2A_HUMAN (see all proteins ):MFSD2B
MFSD2A for paralogs About GeneDecksing
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Genomic Variantsfor MFSD2A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MFSD2A (40420784 - 40435638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for MFSD2A 1 CNV : 3289 Human Gene Mutation Database (HGMD) : MFSD2A SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MFSD2A
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Disorders
/ Diseasesfor MFSD2A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MFSD2A for disorders About GeneDecksing
OMIM gene information: 614397
OMIM disorders : --3 diseases for MFSD2A : About MalaCards hepatoblastoma choriocarcinoma lung cancer Human Genome Epidemiology (HuGE) Navigator: MFSD2A (0 documents) Export disorders for MFSD2A gene to outside databases
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Publicationsfor MFSD2A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MFSD2A gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with MFSD2A) Utopia : connect your pdf to the dynamic world of online information
Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. (PubMed id 18694395) 1 , 2 , 3 Angers M....Jetten A.M. (2008) A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. (PubMed id 21677192) 1 , 2 Reiling J.H.... Sabatini D.M. (2011) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 , 2 Otsuki T....Isogai T. (2005) Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005) 1 , 2 Yamada S....Nakagawara A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874) 1 , 2 Wan D....Gu J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A. (PubMed id 21736709) 1 Colombo F....Dragani T.A. (2011)
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External Searches for MFSD2A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MFSD2A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MFSD2A gene
(According to HUGE )
About This Section --
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Specialized Databases showing MFSD2A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MFSD2A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MFSD2A gene: Search GeneIP for patents involving MFSD2A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MFSD2A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MFSD2A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MFSD2A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MFSD2A OriGene Protein Over-expression Lysate for MFSD2A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MFSD2A OriGene 3'-UTR Clone for MFSD2A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MFSD2A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MFSD2A OriGene Custom Protein Services for MFSD2A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFSD2A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MFSD2A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MFSD2A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MFSD2A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MFSD2A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MFSD2A
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MFSD2A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD2A
Search ThermoFisher Antibodies for MFSD2A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MFSD2A
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Aliases for MFSD2A
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Disorders / Diseases for MFSD2A
Domains / Families for MFSD2A
Drugs / Compounds for MFSD2A
Expression for MFSD2A
Function for MFSD2A
Genomic Views for MFSD2A
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Pathways / Interactions for MFSD2A
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