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Aliases for MFSD14C Gene

Aliases for MFSD14C Gene

  • Major Facilitator Superfamily Domain Containing 14C 2 3 5
  • Hippocampus Abundant Transcript-Like 2 2 3
  • HIATL2 3 4
  • Major Facilitator Superfamily Domain-Containing 14C 4
  • Hippocampus Abundant Gene Transcript-Like 2 3

External Ids for MFSD14C Gene

Previous HGNC Symbols for MFSD14C Gene

  • HIATL2

Summaries for MFSD14C Gene

GeneCards Summary for MFSD14C Gene

MFSD14C (Major Facilitator Superfamily Domain Containing 14C) is a Pseudogene. An important paralog of this gene is MFSD14B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14C Gene

Genomics for MFSD14C Gene

Regulatory Elements for MFSD14C Gene

Enhancers for MFSD14C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F097510 1.1 Ensembl ENCODE 13.5 -497.6 -497571 2.1 HDGF PKNOX1 FOS YY2 JUNB REST TSHZ1 TBX21 ZNF264 ZNF658 LOC105376168 NCBP1 MFSD14C NUTM2G LOC441454 TMOD1
GH09F097236 0.5 ENCODE 12.2 -224.7 -224690 2.9 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF263 SP3 REST ANKRD18CP CCDC180 XPA LOC441454 ZNF322P1 MFSD14C NCBP1 LOC100421693 LOC105376165 LOC100499484
GH09F097918 1.1 FANTOM5 ENCODE 12.1 -907.5 -907530 5.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 NCBP1 ZNF322P1 TRMO LOC105376165 XPA LOC286359 TCEA1P1 LOC100288125 ANP32B LOC101928408
GH09F096653 0.2 ENCODE 12.1 +359.0 359016 3.0 ATF1 SIN3A GTF3C2 GLIS2 SP3 JUNB SMARCA4 ZNF585B GLIS1 NBN NCBP1 ZNF322P1 ZNF510 LOC441454 CDC14B LINC00476 MFSD14C CCDC180 ZNF782 EIF4BP3
GH09F097631 0.6 ENCODE 12.1 -619.7 -619706 4.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 LOC441454 ENSG00000224848 ZNF510 MFSD14C NCBP1 AAED1 TDRD7 LOC105376171 TMOD1 GC09P097607
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MFSD14C on UCSC Golden Path with GeneCards custom track

Promoters for MFSD14C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001309380 608 2600 HDAC1 CBX3 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZBTB40 CHAMP1 GLIS2

Genomic Location for MFSD14C Gene

Chromosome:
9
Start:
96,897,917 bp from pter
End:
97,013,708 bp from pter
Size:
115,792 bases
Orientation:
Minus strand

Genomic View for MFSD14C Gene

Genes around MFSD14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14C Gene

Proteins for MFSD14C Gene

  • Protein details for MFSD14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZR4-MF14C_HUMAN
    Recommended name:
    Hippocampus abundant transcript-like protein 2
    Protein Accession:
    Q5VZR4
    Secondary Accessions:
    • Q9BSG7

    Protein attributes for MFSD14C Gene

    Size:
    134 amino acids
    Molecular mass:
    14477 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC005058; Type=Miscellaneous discrepancy; Note=The sequence differs at the 3 end.; Evidence={ECO:0000305};

neXtProt entry for MFSD14C Gene

Post-translational modifications for MFSD14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD14C Gene

No data available for DME Specific Peptides for MFSD14C Gene

Domains & Families for MFSD14C Gene

Protein Domains for MFSD14C Gene

Suggested Antigen Peptide Sequences for MFSD14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZR4

UniProtKB/Swiss-Prot:

MF14C_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14C: view

No data available for Gene Families for MFSD14C Gene

Function for MFSD14C Gene

Gene Ontology (GO) - Molecular Function for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14C: view

Phenotypes for MFSD14C Gene

GenomeRNAi human phenotypes for MFSD14C:
genes like me logo Genes that share phenotypes with MFSD14C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MFSD14C Gene

Localization for MFSD14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14C Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with MFSD14C: view

No data available for Subcellular locations from COMPARTMENTS for MFSD14C Gene

Pathways & Interactions for MFSD14C Gene

SuperPathways for MFSD14C Gene

No Data Available

Interacting Proteins for MFSD14C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364371%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000364371 for MFSD14C Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14C: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14C Gene

Transcripts for MFSD14C Gene

Unigene Clusters for MFSD14C Gene

Hippocampus abundant transcript-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14C Gene

No ASD Table

Relevant External Links for MFSD14C Gene

GeneLoc Exon Structure for
MFSD14C
ECgene alternative splicing isoforms for
MFSD14C

Expression for MFSD14C Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14C Gene:

MFSD14C

SOURCE GeneReport for Unigene cluster for MFSD14C Gene:

Hs.610084
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MFSD14C Gene

Orthologs for MFSD14C Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIATL2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 24 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HIATL1 35
  • 23 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hiatl1 35
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 19 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU856539.1 35
  • 17 (a)
ManyToMany
si:ch211-87m7.2 35
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5078 35
  • 14 (a)
ManyToMany
CG11537 35
  • 10 (a)
ManyToMany
CG17637 35
  • 9 (a)
ManyToMany
CG18281 35
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 35
  • 15 (a)
OneToMany
Species where no ortholog for MFSD14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MFSD14C Gene

ENSEMBL:
Gene Tree for MFSD14C (if available)
TreeFam:
Gene Tree for MFSD14C (if available)

Paralogs for MFSD14C Gene

Paralogs for MFSD14C Gene

genes like me logo Genes that share paralogs with MFSD14C: view

Variants for MFSD14C Gene

Sequence variations from dbSNP and Humsavar for MFSD14C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10118447 -- 96,992,689(+) TAAAT(A/C)CCCTT intron-variant
rs10118891 -- 97,005,952(+) tctgg(A/G)caaca intron-variant
rs10119753 -- 96,949,238(+) CCCTA(A/T)ACCAG intron-variant
rs10120422 -- 96,954,721(+) TTTTA(A/C/T)GCAAT intron-variant
rs10124176 -- 97,004,473(+) agacc(C/T)agaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14C Gene

Variant ID Type Subtype PubMed ID
esv2738813 CNV deletion 23290073
esv3621176 CNV loss 21293372
esv3621177 CNV loss 21293372
nsv1075257 CNV deletion 25765185
nsv1147999 OTHER inversion 26484159
nsv520001 CNV loss 19592680
nsv6625 CNV insertion 18451855
nsv831661 CNV loss 17160897
nsv831662 CNV gain 17160897
nsv972789 CNV duplication 23825009
nsv972790 CNV duplication 23825009

Variation tolerance for MFSD14C Gene

Gene Damage Index Score: 3.64; 56.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14C Gene

Disorders for MFSD14C Gene

Relevant External Links for MFSD14C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14C

No disorders were found for MFSD14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14C Gene

Publications for MFSD14C Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MFSD14C Gene

Sources for MFSD14C Gene

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