Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MFSD14A Gene

Aliases for MFSD14A Gene

  • Major Facilitator Superfamily Domain Containing 14A 2 3 5
  • Putative Tetracycline Transporter-Like Protein 3 4
  • HIAT1 3 4
  • Major Facilitator Superfamily Domain-Containing 14A 4
  • Hippocampus Abundant Transcript 1 Protein 3
  • Hippocampus Abundant Gene Transcript 1 3
  • Tetracycline Transporter-Like Protein 3
  • Hippocampus Abundant Transcript 1 2

External Ids for MFSD14A Gene

Previous HGNC Symbols for MFSD14A Gene

  • HIAT1

Summaries for MFSD14A Gene

GeneCards Summary for MFSD14A Gene

MFSD14A (Major Facilitator Superfamily Domain Containing 14A) is a Protein Coding gene. Diseases associated with MFSD14A include Fanconi Renotubular Syndrome 1. An important paralog of this gene is MFSD14B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14A Gene

Genomics for MFSD14A Gene

Regulatory Elements for MFSD14A Gene

Enhancers for MFSD14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F100348 0.8 FANTOM5 ENCODE 43 +314.2 314156 7.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 MFSD14A SLC30A7 BRI3P1 CDC14A HNRNPA1P68 ENSG00000235795 SASS6 TRMT13 LOC646970 ENSG00000226952
GH01F100036 1 ENCODE 17 +0.6 649 4.1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 KLF13 SP3 MFSD14A LRRC39 SLC30A7 SASS6 BRI3P1 RTCA AGL ENSG00000241073
GH01F100362 0.8 FANTOM5 ENCODE 16.3 +325.0 324985 0.6 HDGF TBP HDAC1 PKNOX1 CBX3 ATF1 TBL1XR1 CREB3L1 NFRKB DEAF1 MFSD14A CDC14A SLC30A7 HNRNPA1P68 BRI3P1 MIR553 SASS6 BCAS2P2
GH01F100893 0.2 ENCODE 16.2 +857.6 857609 4.3 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 MFSD14A SLC30A7 BRI3P1 EXTL2 GC01M100877
GH01F100535 1.1 FANTOM5 Ensembl 13.2 +497.8 497818 1.3 PKNOX1 ARNT TAL1 BACH1 FEZF1 RELA ZNF664 FOSL1 ZNF316 ZFHX2 SLC30A7 BRI3P1 MFSD14A ENSG00000235795 HNRNPA1P68 TRMT13 CDC14A GPR88 ENSG00000228086
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MFSD14A on UCSC Golden Path with GeneCards custom track

Promoters for MFSD14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000541744 322 4001 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 KLF13 SP3

Genomic Location for MFSD14A Gene

Chromosome:
1
Start:
100,038,078 bp from pter
End:
100,083,377 bp from pter
Size:
45,300 bases
Orientation:
Plus strand

Genomic View for MFSD14A Gene

Genes around MFSD14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14A Gene

Proteins for MFSD14A Gene

  • Protein details for MFSD14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MC6-MF14A_HUMAN
    Recommended name:
    Hippocampus abundant transcript 1 protein
    Protein Accession:
    Q96MC6
    Secondary Accessions:
    • Q6P2N7
    • Q8N8K2
    • Q8NBV3
    • Q96NY0
    • Q9NT25

    Protein attributes for MFSD14A Gene

    Size:
    490 amino acids
    Molecular mass:
    53027 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MFSD14A Gene

Post-translational modifications for MFSD14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD14A Gene

No data available for DME Specific Peptides for MFSD14A Gene

Domains & Families for MFSD14A Gene

Protein Domains for MFSD14A Gene

Suggested Antigen Peptide Sequences for MFSD14A Gene

Graphical View of Domain Structure for InterPro Entry

Q96MC6

UniProtKB/Swiss-Prot:

MF14A_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14A: view

No data available for Gene Families for MFSD14A Gene

Function for MFSD14A Gene

Gene Ontology (GO) - Molecular Function for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14A: view
genes like me logo Genes that share phenotypes with MFSD14A: view

Animal Models for MFSD14A Gene

MGI Knock Outs for MFSD14A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD14A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MFSD14A Gene

Localization for MFSD14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with MFSD14A: view

No data available for Subcellular locations from COMPARTMENTS for MFSD14A Gene

Pathways & Interactions for MFSD14A Gene

SuperPathways for MFSD14A Gene

No Data Available

Interacting Proteins for MFSD14A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359171%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359171 Q96MC6-MF14A_HUMAN for MFSD14A Gene via STRING IID

Gene Ontology (GO) - Biological Process for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14A: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14A Gene

Transcripts for MFSD14A Gene

Unigene Clusters for MFSD14A Gene

Hippocampus abundant transcript 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14A Gene

No ASD Table

Relevant External Links for MFSD14A Gene

GeneLoc Exon Structure for
MFSD14A
ECgene alternative splicing isoforms for
MFSD14A

Expression for MFSD14A Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14A Gene:

MFSD14A

SOURCE GeneReport for Unigene cluster for MFSD14A Gene:

Hs.124156
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MFSD14A Gene

Orthologs for MFSD14A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIAT1 34 35
  • 99.93 (n)
oppossum
(Monodelphis domestica)
Mammalia HIAT1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIAT1 34 35
  • 94.69 (n)
dog
(Canis familiaris)
Mammalia HIAT1 34 35
  • 93.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HIAT1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hiat1 34
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Hiat1 34 35
  • 92.24 (n)
Mfsd14a 16
chicken
(Gallus gallus)
Aves HIAT1 35
  • 84 (a)
OneToOne
LOC428335 34
  • 71.86 (n)
lizard
(Anolis carolinensis)
Reptilia HIAT1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hiat1 34
  • 78.71 (n)
Str.8911 34
African clawed frog
(Xenopus laevis)
Amphibia hiat1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii hiat1b 35
  • 86 (a)
OneToOne
hiat1a 34
  • 72.04 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.869 34
fruit fly
(Drosophila melanogaster)
Insecta CG5078 35
  • 48 (a)
ManyToMany
CG11537 35
  • 39 (a)
ManyToMany
CG17637 35
  • 32 (a)
ManyToMany
CG18281 35
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 35
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 35
  • 56 (a)
OneToMany
Species where no ortholog for MFSD14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD14A Gene

ENSEMBL:
Gene Tree for MFSD14A (if available)
TreeFam:
Gene Tree for MFSD14A (if available)

Paralogs for MFSD14A Gene

Paralogs for MFSD14A Gene

genes like me logo Genes that share paralogs with MFSD14A: view

Variants for MFSD14A Gene

Sequence variations from dbSNP and Humsavar for MFSD14A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1109770 -- 100,038,008(+) TAGAG(C/T)GGGCT upstream-variant-2KB
rs111335635 -- 100,060,762(+) TTTTT(C/T)CCACT intron-variant
rs111342991 -- 100,040,686(+) TGAAC(G/T)CCTGA intron-variant
rs111444551 -- 100,045,384(+) ATCTC(A/G)GAGCT intron-variant
rs111496473 -- 100,063,132(+) ACCCA(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14A Gene

Variant ID Type Subtype PubMed ID
nsv546888 CNV loss 21841781
nsv830804 CNV gain 17160897

Variation tolerance for MFSD14A Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14A Gene

Disorders for MFSD14A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MFSD14A Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi renotubular syndrome 1
  • fanconi-bickel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MFSD14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14A
genes like me logo Genes that share disorders with MFSD14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MFSD14A Gene

Publications for MFSD14A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. (PMID: 9299464) Matsuo N. … Okubo K. (Biochem. Biophys. Res. Commun. 1997) 2 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for MFSD14A Gene

Sources for MFSD14A Gene

Content
Loading form....