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Aliases for MFSD14A Gene

Aliases for MFSD14A Gene

  • Major Facilitator Superfamily Domain Containing 14A 2 3 5
  • Putative Tetracycline Transporter-Like Protein 3 4
  • HIAT1 3 4
  • Major Facilitator Superfamily Domain-Containing 14A 4
  • Hippocampus Abundant Transcript 1 Protein 3
  • Hippocampus Abundant Gene Transcript 1 3
  • Tetracycline Transporter-Like Protein 3
  • Hippocampus Abundant Transcript 1 2

External Ids for MFSD14A Gene

Previous HGNC Symbols for MFSD14A Gene

  • HIAT1

Summaries for MFSD14A Gene

GeneCards Summary for MFSD14A Gene

MFSD14A (Major Facilitator Superfamily Domain Containing 14A) is a Protein Coding gene. An important paralog of this gene is ENSG00000283761.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14A Gene

Genomics for MFSD14A Gene

Regulatory Elements for MFSD14A Gene

Enhancers for MFSD14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G100348 1.7 FANTOM5 ENCODE dbSUPER 30.8 +314.2 314156 7.1 CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC CDC14A MFSD14A SLC30A7 BRI3P1 ENSG00000235795 HNRNPA1P68 SASS6 TRMT13 RTCA VCAM1
GH01G100036 1.4 ENCODE dbSUPER 24.9 +0.6 649 4.1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 MFSD14A LRRC39 SLC30A7 SASS6 BRI3P1 RTCA AGL ENSG00000241073
GH01G100893 1.4 ENCODE dbSUPER 16.2 +857.6 857609 4.3 PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MFSD14A SLC30A7 BRI3P1 EXTL2 GC01M100877
GH01G100707 1 ENCODE dbSUPER 19.5 +671.0 671008 2.3 ZFP64 ZNF140 SIN3A ZNF266 ZNF101 ZNF697 ZNF354C ZNF680 ZBTB11 BHLHE40 SASS6 TRMT13 MFSD14A HNRNPA1P68 EXTL2 SLC30A7 BRI3P1 GPR88 VCAM1 PIR61471
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD14A on UCSC Golden Path with GeneCards custom track

Promoters for MFSD14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010608 422 3401 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for MFSD14A Gene

100,038,078 bp from pter
100,083,377 bp from pter
45,300 bases
Plus strand

Genomic View for MFSD14A Gene

Genes around MFSD14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14A Gene

Proteins for MFSD14A Gene

  • Protein details for MFSD14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hippocampus abundant transcript 1 protein
    Protein Accession:
    Secondary Accessions:
    • Q6P2N7
    • Q8N8K2
    • Q8NBV3
    • Q96NY0
    • Q9NT25

    Protein attributes for MFSD14A Gene

    490 amino acids
    Molecular mass:
    53027 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MFSD14A Gene

Post-translational modifications for MFSD14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD14A Gene

No data available for DME Specific Peptides for MFSD14A Gene

Domains & Families for MFSD14A Gene

Protein Domains for MFSD14A Gene

Suggested Antigen Peptide Sequences for MFSD14A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14A: view

No data available for Gene Families for MFSD14A Gene

Function for MFSD14A Gene

Gene Ontology (GO) - Molecular Function for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14A: view
genes like me logo Genes that share phenotypes with MFSD14A: view

Animal Models for MFSD14A Gene

MGI Knock Outs for MFSD14A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD14A

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MFSD14A Gene

Localization for MFSD14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD14A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD14A: view

Pathways & Interactions for MFSD14A Gene

SuperPathways for MFSD14A Gene

No Data Available

Interacting Proteins for MFSD14A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96MC6-MF14A_HUMAN ENSP00000359171 for MFSD14A Gene via IID STRING

Gene Ontology (GO) - Biological Process for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14A: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14A Gene

Drugs & Compounds for MFSD14A Gene

No Compound Related Data Available

Transcripts for MFSD14A Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14A Gene

No ASD Table

Relevant External Links for MFSD14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD14A Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14A Gene:


Evidence on tissue expression from TISSUES for MFSD14A Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Stomach(4.3)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD14A Gene

Orthologs for MFSD14A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIAT1 34 35
  • 99.93 (n)
(Monodelphis domestica)
Mammalia HIAT1 35
  • 96 (a)
(Bos Taurus)
Mammalia HIAT1 34 35
  • 94.69 (n)
(Canis familiaris)
Mammalia HIAT1 34 35
  • 93.8 (n)
(Ornithorhynchus anatinus)
Mammalia HIAT1 35
  • 93 (a)
(Rattus norvegicus)
Mammalia Hiat1 34
  • 92.45 (n)
(Mus musculus)
Mammalia Hiat1 34 35
  • 92.24 (n)
Mfsd14a 16
(Gallus gallus)
Aves HIAT1 35
  • 84 (a)
LOC428335 34
  • 71.86 (n)
(Anolis carolinensis)
Reptilia HIAT1 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hiat1 34
  • 78.71 (n)
Str.8911 34
African clawed frog
(Xenopus laevis)
Amphibia hiat1-A-prov 34
(Danio rerio)
Actinopterygii hiat1b 35
  • 86 (a)
hiat1a 34
  • 72.04 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.869 34
fruit fly
(Drosophila melanogaster)
Insecta CG5078 35
  • 48 (a)
CG11537 35
  • 39 (a)
CG17637 35
  • 32 (a)
CG18281 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea T25D3.4 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 35
  • 56 (a)
Species where no ortholog for MFSD14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD14A Gene

Gene Tree for MFSD14A (if available)
Gene Tree for MFSD14A (if available)

Paralogs for MFSD14A Gene

Paralogs for MFSD14A Gene

genes like me logo Genes that share paralogs with MFSD14A: view

Variants for MFSD14A Gene

Sequence variations from dbSNP and Humsavar for MFSD14A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000055421 -- 100,049,185(+) GCAGC(A/C/G)GTATA intron-variant
rs1000089439 -- 100,059,707(+) CTATC(C/T)TGGGA intron-variant
rs1000166467 -- 100,076,570(+) AGAGA(C/T)AAAAG intron-variant
rs1000167955 -- 100,072,779(+) TTACT(G/T)CCTGG intron-variant
rs1000220454 -- 100,069,606(+) GAAAC(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14A Gene

Variant ID Type Subtype PubMed ID
nsv546888 CNV loss 21841781
nsv830804 CNV gain 17160897

Variation tolerance for MFSD14A Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14A Gene

Disorders for MFSD14A Gene

Relevant External Links for MFSD14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MFSD14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14A Gene

Publications for MFSD14A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. (PMID: 9299464) Matsuo N. … Okubo K. (Biochem. Biophys. Res. Commun. 1997) 2 3 64
  4. An organellar nI+-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H. … Arnesen T. (Cell Rep 2015) 4 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for MFSD14A Gene

Sources for MFSD14A Gene

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