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Aliases for MFSD14A Gene

Aliases for MFSD14A Gene

  • Major Facilitator Superfamily Domain Containing 14A 2 3 5
  • Major Facilitator Superfamily Domain-Containing 14A 3 4
  • Putative Tetracycline Transporter-Like Protein 3 4
  • HIAT1 3 4
  • Hippocampus Abundant Gene Transcript 1 3
  • Tetracycline Transporter-Like Protein 3
  • Hippocampus Abundant Transcript 1 2

External Ids for MFSD14A Gene

Previous HGNC Symbols for MFSD14A Gene

  • HIAT1

Summaries for MFSD14A Gene

GeneCards Summary for MFSD14A Gene

MFSD14A (Major Facilitator Superfamily Domain Containing 14A) is a Protein Coding gene. An important paralog of this gene is MFSD14B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14A Gene

Genomics for MFSD14A Gene

Regulatory Elements for MFSD14A Gene

Enhancers for MFSD14A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MFSD14A on UCSC Golden Path with GeneCards custom track

Promoters for MFSD14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFSD14A on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD14A Gene

Chromosome:
1
Start:
100,038,078 bp from pter
End:
100,083,377 bp from pter
Size:
45,300 bases
Orientation:
Plus strand

Genomic View for MFSD14A Gene

Genes around MFSD14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14A Gene

Proteins for MFSD14A Gene

  • Protein details for MFSD14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MC6-MF14A_HUMAN
    Recommended name:
    Hippocampus abundant transcript 1 protein
    Protein Accession:
    Q96MC6
    Secondary Accessions:
    • Q6P2N7
    • Q8N8K2
    • Q8NBV3
    • Q96NY0
    • Q9NT25

    Protein attributes for MFSD14A Gene

    Size:
    490 amino acids
    Molecular mass:
    53027 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MFSD14A Gene

Proteomics data for MFSD14A Gene at MOPED

Post-translational modifications for MFSD14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD14A Gene

Domains & Families for MFSD14A Gene

Protein Domains for MFSD14A Gene

Suggested Antigen Peptide Sequences for MFSD14A Gene

Graphical View of Domain Structure for InterPro Entry

Q96MC6

UniProtKB/Swiss-Prot:

MF14A_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14A: view

No data available for Gene Families for MFSD14A Gene

Function for MFSD14A Gene

genes like me logo Genes that share phenotypes with MFSD14A: view

Animal Models for MFSD14A Gene

MGI Knock Outs for MFSD14A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD14A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MFSD14A Gene

Localization for MFSD14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14A Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MFSD14A Gene

Pathways & Interactions for MFSD14A Gene

SuperPathways for MFSD14A Gene

No Data Available

Interacting Proteins for MFSD14A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359171%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359171 for MFSD14A Gene via STRING

Gene Ontology (GO) - Biological Process for MFSD14A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD14A Gene

Drugs & Compounds for MFSD14A Gene

No Compound Related Data Available

Transcripts for MFSD14A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14A Gene

No ASD Table

Relevant External Links for MFSD14A Gene

GeneLoc Exon Structure for
MFSD14A
ECgene alternative splicing isoforms for
MFSD14A

Expression for MFSD14A Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MFSD14A Gene

Orthologs for MFSD14A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIAT1 35
  • 94.69 (n)
  • 99.59 (a)
HIAT1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIAT1 35
  • 93.8 (n)
  • 99.57 (a)
HIAT1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hiat1 35
  • 92.24 (n)
  • 99.8 (a)
Mfsd14a 16
Hiat1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIAT1 35
  • 99.93 (n)
  • 100 (a)
HIAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hiat1 35
  • 92.45 (n)
  • 99.39 (a)
oppossum
(Monodelphis domestica)
Mammalia HIAT1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIAT1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC428335 35
  • 71.86 (n)
  • 81.56 (a)
HIAT1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIAT1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hiat1 35
  • 78.71 (n)
  • 93.43 (a)
Str.8911 35
African clawed frog
(Xenopus laevis)
Amphibia hiat1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii hiat1a 35
  • 72.04 (n)
  • 82.86 (a)
hiat1b 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.869 35
fruit fly
(Drosophila melanogaster)
Insecta CG11537 36
  • 39 (a)
ManyToMany
CG17637 36
  • 32 (a)
ManyToMany
CG18281 36
  • 30 (a)
ManyToMany
CG5078 36
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 36
  • 56 (a)
OneToMany
Species with no ortholog for MFSD14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD14A Gene

ENSEMBL:
Gene Tree for MFSD14A (if available)
TreeFam:
Gene Tree for MFSD14A (if available)

Paralogs for MFSD14A Gene

Paralogs for MFSD14A Gene

genes like me logo Genes that share paralogs with MFSD14A: view

Variants for MFSD14A Gene

Sequence variations from dbSNP and Humsavar for MFSD14A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5876 -- 100,082,438(+) TTTCT(C/T)GCCAC utr-variant-3-prime
rs483217 -- 100,064,612(-) aattt(A/C)tatga intron-variant
rs485619 -- 100,051,354(-) GAGGG(C/T)AGTGG intron-variant
rs487805 -- 100,064,125(-) acaca(C/T)acata intron-variant
rs531407 -- 100,052,338(-) AAAGA(C/T)AGCCT intron-variant

Variation tolerance for MFSD14A Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MFSD14A Gene

Disorders for MFSD14A Gene

Relevant External Links for MFSD14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD14A

No disorders were found for MFSD14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14A Gene

Publications for MFSD14A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. (PMID: 9299464) Matsuo N. … Okubo K. (Biochem. Biophys. Res. Commun. 1997) 2 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for MFSD14A Gene

Sources for MFSD14A Gene

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