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Aliases for MFSD13A Gene

Aliases for MFSD13A Gene

  • Major Facilitator Superfamily Domain Containing 13A 2 3 5
  • Transmembrane Protein 180 2 3
  • C10orf77 3 4
  • TMEM180 3 4
  • Major Facilitator Superfamily Domain-Containing 13A 4
  • BA18I14.8 3

External Ids for MFSD13A Gene

Previous HGNC Symbols for MFSD13A Gene

  • C10orf77
  • TMEM180

Summaries for MFSD13A Gene

GeneCards Summary for MFSD13A Gene

MFSD13A (Major Facilitator Superfamily Domain Containing 13A) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD13A Gene

Genomics for MFSD13A Gene

Regulatory Elements for MFSD13A Gene

Enhancers for MFSD13A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G102595 1.9 FANTOM5 Ensembl ENCODE dbSUPER 41.2 +139.3 139290 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10G102578 1.6 Ensembl ENCODE dbSUPER 39.3 +118.7 118671 2.3 HDGF PKNOX1 ARNT SIN3A FEZF1 YY1 ZNF766 ZNF143 FOS ZNF263 MFSD13A ACTR1A SUFU C10orf95 NFKB2 AS3MT RPL23AP58 GC10P102592
GH10G102509 1.2 Ensembl ENCODE 44.7 +48.2 48224 0.8 HDGF PKNOX1 AGO1 SIN3A ZNF2 ZNF143 FOS SP3 CEBPZ REST MFSD13A PDCD11 PPRC1 RNU6-43P C10orf95 GC10P102507 GC10M102448
GH10G102625 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.8 +169.3 169340 10.6 ATF1 ZFP64 ARID4B YY1 GLIS2 GATA2 FOS NFYC REST MIER3 MFSD13A SFXN2 ACTR1A CUEDC2 GBF1 TRIM8 RNU6-43P
GH10G102501 1.1 ENCODE 45.6 +42.0 42008 4.6 HDGF PKNOX1 FOXA2 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MFSD13A PDCD11 PPRC1 RNU6-43P C10orf95 MGEA5 PSD FBXL15 RPARP-AS1 GC10P102507
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFSD13A on UCSC Golden Path with GeneCards custom track

Promoters for MFSD13A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032742 119 601 ATF1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ETS1 GLIS2 ZNF143 ZNF207

Genomic Location for MFSD13A Gene

Chromosome:
10
Start:
102,461,381 bp from pter
End:
102,480,118 bp from pter
Size:
18,738 bases
Orientation:
Plus strand

Genomic View for MFSD13A Gene

Genes around MFSD13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD13A Gene

Proteins for MFSD13A Gene

  • Protein details for MFSD13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX5-MF13A_HUMAN
    Recommended name:
    Transmembrane protein 180
    Protein Accession:
    Q14CX5
    Secondary Accessions:
    • Q6NWM8
    • Q6NWM9
    • Q6PEZ7
    • Q9H679

    Protein attributes for MFSD13A Gene

    Size:
    517 amino acids
    Molecular mass:
    57381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67530.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67531.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12524.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MFSD13A Gene

Post-translational modifications for MFSD13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD13A Gene

Domains & Families for MFSD13A Gene

Protein Domains for MFSD13A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD13A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MFSD13A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MFSD13A Gene

Function for MFSD13A Gene

genes like me logo Genes that share phenotypes with MFSD13A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD13A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD13A Gene

Localization for MFSD13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD13A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD13A gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for MFSD13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD13A: view

Pathways & Interactions for MFSD13A Gene

SuperPathways for MFSD13A Gene

No Data Available

Interacting Proteins for MFSD13A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000238936%0d%0a9606.ENSP00000225964%0d%0a9606.ENSP00000078429%0d%0a
Selected Interacting proteins: Q14CX5-MF13A_HUMAN ENSP00000238936 for MFSD13A Gene via IID STRING

Gene Ontology (GO) - Biological Process for MFSD13A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD13A Gene

Drugs & Compounds for MFSD13A Gene

No Compound Related Data Available

Transcripts for MFSD13A Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD13A Gene

No ASD Table

Relevant External Links for MFSD13A Gene

GeneLoc Exon Structure for
MFSD13A
ECgene alternative splicing isoforms for
MFSD13A

Expression for MFSD13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MFSD13A Gene:

MFSD13A
genes like me logo Genes that share expression patterns with MFSD13A: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD13A Gene

Orthologs for MFSD13A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD13A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM180 34 35
  • 96.7 (n)
dog
(Canis familiaris)
Mammalia TMEM180 34 35
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia TMEM180 34 35
  • 89.88 (n)
mouse
(Mus musculus)
Mammalia Tmem180 34 35
  • 86.59 (n)
Mfsd13a 16
oppossum
(Monodelphis domestica)
Mammalia TMEM180 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM180 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM180 34 35
  • 70.44 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM180 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem180 34
  • 65.87 (n)
Str.2014 34
zebrafish
(Danio rerio)
Actinopterygii tmem180 34 35
  • 69.24 (n)
worm
(Caenorhabditis elegans)
Secernentea C27H5.4 34 35
  • 39.46 (n)
F10E7.3 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for MFSD13A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD13A Gene

ENSEMBL:
Gene Tree for MFSD13A (if available)
TreeFam:
Gene Tree for MFSD13A (if available)

Paralogs for MFSD13A Gene

No data available for Paralogs for MFSD13A Gene

Variants for MFSD13A Gene

Sequence variations from dbSNP and Humsavar for MFSD13A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000011576 -- 102,479,760(+) AGGGC(A/G)CTGGC utr-variant-3-prime
rs1000135735 -- 102,469,901(+) GGGCC(A/T)TCTTT intron-variant
rs1000167205 -- 102,470,128(+) GCTAC(C/G)CAGGA intron-variant
rs1000248149 -- 102,462,561(+) CAGAA(A/G)TCAGG intron-variant
rs1000362988 -- 102,479,418(+) CAGGG(A/G)CCTTT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD13A Gene

Variant ID Type Subtype PubMed ID
nsv1129499 CNV tandem duplication 24896259

Variation tolerance for MFSD13A Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD13A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD13A Gene

Disorders for MFSD13A Gene

Relevant External Links for MFSD13A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD13A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD13A

No disorders were found for MFSD13A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD13A Gene

Publications for MFSD13A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MFSD13A Gene

Sources for MFSD13A Gene

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