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Aliases for MFSD12 Gene

Aliases for MFSD12 Gene

  • Major Facilitator Superfamily Domain Containing 12 2 3 5
  • C19orf28 3 4
  • Chromosome 19 Open Reading Frame 28 2
  • PP3501 3

External Ids for MFSD12 Gene

Previous HGNC Symbols for MFSD12 Gene

  • C19orf28

Summaries for MFSD12 Gene

GeneCards Summary for MFSD12 Gene

MFSD12 (Major Facilitator Superfamily Domain Containing 12) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD12 Gene

Genomics for MFSD12 Gene

Regulatory Elements for MFSD12 Gene

Enhancers for MFSD12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MFSD12 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFSD12 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD12 Gene

Chromosome:
19
Start:
3,538,261 bp from pter
End:
3,574,290 bp from pter
Size:
36,030 bases
Orientation:
Minus strand

Genomic View for MFSD12 Gene

Genes around MFSD12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD12 Gene

Proteins for MFSD12 Gene

  • Protein details for MFSD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUT3-MFS12_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 12
    Protein Accession:
    Q6NUT3
    Secondary Accessions:
    • A8MXP7
    • D6W615
    • E9PAJ8
    • Q8N459

    Protein attributes for MFSD12 Gene

    Size:
    480 amino acids
    Molecular mass:
    52075 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MFSD12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD12 Gene

Proteomics data for MFSD12 Gene at MOPED

Post-translational modifications for MFSD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD12 Gene

Domains & Families for MFSD12 Gene

Protein Domains for MFSD12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD12 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUT3

UniProtKB/Swiss-Prot:

MFS12_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD12: view

No data available for Gene Families for MFSD12 Gene

Function for MFSD12 Gene

Phenotypes for MFSD12 Gene

genes like me logo Genes that share phenotypes with MFSD12: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD12 Gene

Localization for MFSD12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD12 Gene COMPARTMENTS Subcellular localization image for MFSD12 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for MFSD12 Gene

Pathways & Interactions for MFSD12 Gene

SuperPathways for MFSD12 Gene

No Data Available

Interacting Proteins for MFSD12 Gene

Gene Ontology (GO) - Biological Process for MFSD12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD12 Gene

Drugs & Compounds for MFSD12 Gene

No Compound Related Data Available

Transcripts for MFSD12 Gene

Unigene Clusters for MFSD12 Gene

Major facilitator superfamily domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:
SP2: -
SP3:

Relevant External Links for MFSD12 Gene

GeneLoc Exon Structure for
MFSD12
ECgene alternative splicing isoforms for
MFSD12

Expression for MFSD12 Gene

mRNA expression in normal human tissues for MFSD12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MFSD12 Gene



SOURCE GeneReport for Unigene cluster for MFSD12 Gene Hs.656901

genes like me logo Genes that share expression patterns with MFSD12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MFSD12 Gene

Orthologs for MFSD12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD12 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MFSD12 35
  • 86.02 (n)
  • 85.55 (a)
MFSD12 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd12 35
  • 83.33 (n)
  • 87.01 (a)
Mfsd12 16
Mfsd12 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFSD12 35
  • 99.07 (n)
  • 98.37 (a)
MFSD12 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd12 35
  • 82.61 (n)
  • 85.71 (a)
cow
(Bos Taurus)
Mammalia MFSD12 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD12 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD12 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF28 35
  • 74.8 (n)
  • 72.73 (a)
MFSD12 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd12 35
  • 64.56 (n)
  • 68.69 (a)
Str.19055 35
zebrafish
(Danio rerio)
Actinopterygii mfsd12a 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011492 35
  • 52.74 (n)
  • 38.46 (a)
worm
(Caenorhabditis elegans)
Secernentea F16H11.1 35
  • 45.36 (n)
  • 42.45 (a)
F16H11.1 36
  • 37 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os03g0168000 35
  • 47.62 (n)
  • 35.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for MFSD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD12 Gene

ENSEMBL:
Gene Tree for MFSD12 (if available)
TreeFam:
Gene Tree for MFSD12 (if available)

Paralogs for MFSD12 Gene

genes like me logo Genes that share paralogs with MFSD12: view

No data available for Paralogs for MFSD12 Gene

Variants for MFSD12 Gene

Sequence variations from dbSNP and Humsavar for MFSD12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2240751 - 3,548,233(+) GCCGT(A/G)GACGG reference, missense
rs10414812 - 3,547,957(+) GCCGG(A/C/T)GCCTC reference, missense
rs7252640 - 3,544,727(+) ATCAC(A/G)GTCCC intron-variant, reference, missense
rs34562175 - 3,548,170(-) AAGAC(A/G)TCAGC reference, missense
rs34878396 - 3,546,266(-) TCATC(A/G)GTCCC intron-variant, reference, missense

Variation tolerance for MFSD12 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD12 Gene

HapMap Linkage Disequilibrium report
MFSD12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MFSD12 Gene

Disorders for MFSD12 Gene

Relevant External Links for MFSD12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD12

No disorders were found for MFSD12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD12 Gene

Publications for MFSD12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH-SY5Y cell proliferation. (PMID: 22441875) Wang Y. … Wu J. (J. Cell. Biochem. 2012) 3

Products for MFSD12 Gene

Sources for MFSD12 Gene

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