MFSD12 Gene
protein-coding GIFtS: 39
GCID: GC19M003539
|
|
major facilitator superfamily domain containing 12(Previous name: chromosome 19 open reading frame 28 )
(Previous symbol: C19orf28)
| |
Aliases
for MFSD12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Facilitator Superfamily Domain Containing 121 2 | | C19orf281 2 3 | | PP35011 2 | | MGC207001 | | Chromosome 19 Open Reading Frame 281 | | Major Facilitator Superfamily Domain-Containing Protein 122 |
Export aliases for MFSD12 gene to outside databases |
Summaries
for MFSD12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MFSD12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MFSD12
Other transcription factors
Search SABiosciences Chromatin IP Primers for MFSD12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MFSD12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M003539: view genomic region
(about GC identifiers)
Start:
|
3,538,259 bp from pter |
End:
|
3,574,288 bp from pter |
Size:
|
36,030 bases |
Orientation:
|
minus strand |
|
Proteins
for MFSD12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MFS12_HUMAN, Q6NUT3 (See
protein sequence)Recommended Name: Major facilitator superfamily domain-containing protein 12 Size: 480 amino acids; 52075 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D6W615 Q8N459Alternative splicing: 2 isoforms: Q6NUT3-1 Q6NUT3-2 Explore the universe of human proteins at neXtProt for MFSD12: NX_Q6NUT3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NUT3
MFSD12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001036145.1 NP_068377.2 NP_778148.2
ENSEMBL proteins: ENSP00000374046 ENSP00000381566 ENSP00000467207 ENSP00000347583 ENSP00000467635 ENSP00000465302 ENSP00000465782 ENSP00000466906 ENSP00000468287
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MFSD12 for ontologies About GeneDecksing
MFSD12 Antibody Products:
Assay Products for MFSD12: |
Protein
Domains /
Families
for MFSD12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MFSD12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NUT3ProtoNet protein and cluster: Q6NUT3 UniProtKB/Swiss-Prot: MFS12_HUMAN, Q6NUT3Similarity: Belongs to the major facilitator superfamily |
Function
for MFSD12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for MFSD12 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD12 |
1 GenomeRNAi human phenotype for MFSD12:
|
Pathways & Interactions
for MFSD12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD12
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
MFSD12 for ontologies About GeneDecksing
|
Drugs & Compounds
for MFSD12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MFSD12
Search CenterWatch for drugs/clinical trials and news about MFSD12 / MFS12
|
Transcripts
for MFSD12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MFSD12 gene (3 alternative transcripts): NM_001042680.1 NM_021731.2 NM_174983.3 Unigene Cluster for MFSD12: Major facilitator superfamily domain containing 12 Hs.656901 [show with all ESTs]Unigene Representative Sequence: NM_02173113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389395(uc002lxx.3) ENST00000585788 ENST00000398558(uc002lxw.3)
ENST00000589157 ENST00000588918 ENST00000355415(uc002lxy.3 uc002lxz.3)
ENST00000589063 ENST00000589995 ENST00000585814 ENST00000592652 ENST00000591878
ENST00000588626 ENST00000586402
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MFSD12 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD12 |
Additional cDNA sequence: AF218008.1 BC068439.1 BC094804.1 EU375738.1 19 DOTS entries: DT.100786677 DT.95367053 DT.100030392 DT.100030391 DT.87015162 DT.452780 DT.121490023 DT.447888 DT.100786676 DT.40230860 DT.121490112 DT.100708918 DT.100786674 DT.40133168 DT.87015161 DT.102833743 DT.455695 DT.95075154 DT.95175265 24/289 AceView cDNA sequences (see all 289): AW451885 CA433487 BG680236 BU076394 AW237082 AI694388 NM_174983 BX282182 CR601769 BG762037 AI244284 CB529077 BI966202 BQ188093 AA417588 BU846448 BM142205 AW025220 CR623233 BQ010690 CR607935 AI394639 BX283858 BX372207
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MFSD12 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MFSD12
|
Expression
for MFSD12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MFSD12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCATCCAGA
About this image
See MFSD12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFSD12
SOURCE GeneReport for Unigene cluster: Hs.656901
SABiosciences Custom PCR Arrays for MFSD12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD12
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MFSD12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD12 |
Orthologs
for MFSD12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MFSD12 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for MFSD12 (if available)
TreeFam Gene Tree for MFSD12 (if available) |
Paralogs
for MFSD12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MFSD12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MFSD12 (3538259 - 3574288 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MFSD12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD12 |
|
Disorders
/ Diseases
for MFSD12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MFSD12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MFSD12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MFSD12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH-SY5Y cell proliferation. (PubMed id 22441875)1 Wang Y....Wu J. (2012)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for MFSD12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MFSD12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MFSD12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MFSD12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MFSD12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MFSD12 gene:
Search GeneIP for patents involving MFSD12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MFSD12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MFSD12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFSD12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD12 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MFSD12 | | OriGene 3'-UTR Clone for MFSD12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MFSD12 | | OriGene Custom Protein Services for MFSD12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFSD12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFSD12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MFSD12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MFSD12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD12 |
|  |  |  | | | | Search ThermoFisher Antibodies for MFSD12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD12 |
|
|
|
|
