MFSD11 Gene
protein-coding GIFtS: 39
GCID: GC17P074733
|
|
major facilitator superfamily domain containing 11
| |
Aliases
for MFSD11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Facilitator Superfamily Domain Containing 111 2 | | FLJ202261 | | Major Facilitator Superfamily Domain-Containing Protein 112 3 | | FLJ221961 | | Protein ET2 3 | | UNC93-Like Protein MFSD112 | | ET2 3 | | |
Export aliases for MFSD11 gene to outside databasesPrevious GC identifers: GC17P072245 GC17P070161 |
Summaries
for MFSD11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MFSD11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MFSD11 gene promoter:
Max1 Max AML1a MyoD c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MFSD11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1MFSD11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P074733: view genomic region
(about GC identifiers)
Start:
|
74,731,947 bp from pter |
End:
|
74,777,531 bp from pter |
Size:
|
45,585 bases |
Orientation:
|
plus strand |
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Proteins
for MFSD11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MFS11_HUMAN, O43934 (See
protein sequence)Recommended Name: UNC93-like protein MFSD11 Size: 449 amino acids; 49202 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: Despite its name, it is related to the unc-93 family and not to the major facilitator superfamily
Secondary accessions: O43442 Q9NXI5Alternative splicing: 2 isoforms: O43934-1 O43934-2 Explore the universe of human proteins at neXtProt for MFSD11: NX_O43934
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43934
MFSD11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001229461.1 NP_001229462.1 NP_001229463.1 NP_001229464.1 NP_001229465.1 NP_001229466.1 NP_077287.1
ENSEMBL proteins: ENSP00000466613 ENSP00000464932 ENSP00000467375 ENSP00000467879 ENSP00000466223 ENSP00000468758 ENSP00000466782 ENSP00000337240 ENSP00000468309 ENSP00000466412 ENSP00000468223 ENSP00000468616 ENSP00000466584 ENSP00000468562 ENSP00000348225
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MFSD11 for ontologies About GeneDecksing
MFSD11 Antibody Products:
Assay Products for MFSD11: |
Protein
Domains /
Families
for MFSD11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MFSD11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43934ProtoNet protein and cluster: O43934 UniProtKB/Swiss-Prot: MFS11_HUMAN, O43934Similarity: Belongs to the unc-93 family |
Function
for MFSD11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MFSD11 (NM_024311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MFSD11 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MFSD11:
|
Pathways & Interactions
for MFSD11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD11
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MFSD11 for ontologies About GeneDecksing
|
Drugs & Compounds
for MFSD11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MFSD11
Search CenterWatch for drugs/clinical trials and news about MFSD11 / MFS11
|
Transcripts
for MFSD11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MFSD11 gene (7 alternative transcripts): NM_001242532.1 NM_001242533.1 NM_001242534.1 NM_001242535.1 NM_001242536.1 NM_001242537.1 NM_024311.3 Unigene Clusters for MFSD11: Major facilitator superfamily domain containing 11 Hs.73965 [show with all ESTs], Hs.732019 [show with all ESTs]Unigene Representative Sequences: NM_001242532, AF01518918/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000586622 ENST00000588460 ENST00000591864 ENST00000590393 ENST00000586689
ENST00000587661 ENST00000593181 ENST00000336509(uc002jta.2 uc002jtd.4 uc002jtb.3 uc002jtc.3 uc002jte.3)
ENST00000590514 ENST00000588031 ENST00000588670 ENST00000588768 ENST00000585584
ENST00000585958 ENST00000585692 ENST00000585865 ENST00000588647 ENST00000590070
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MFSD11 (NM_024311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MFSD11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD11 |
Additional cDNA sequence: AF015187.1 AF015188.1 AF015189.1 24/25 DOTS entries (see all 25): DT.92463619 DT.92463576 DT.92463582 DT.97766762 DT.100674710 DT.100674715 DT.120924960 DT.100674714 DT.120924924 DT.100674718 DT.100674705 DT.95126016 DT.100039138 DT.100674711 DT.95125986 DT.120924952 DT.101961750 DT.87077676 DT.92049803 DT.100719737 DT.102837053 DT.121641516 DT.121641519 DT.75123739 24/236 AceView cDNA sequences (see all 236): BP363853 AI554859 BQ777640 AA811536 AA694389 BQ015185 AK025849 BX104922 AW375322 AA811537 BG035314 W73876 BM693639 AL571123 AW366202 CA748679 CB132021 BG678046 AI188913 AI056823 CB128646 BX399407 H28654 T07875
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MFSD11 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e | ^ | 17 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MFSD11
|
Expression
for MFSD11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MFSD11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATAGAATG
About this image
See MFSD11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFSD11
SOURCE GeneReport for Unigene clusters: Hs.73965 Hs.732019
SABiosciences Custom PCR Arrays for MFSD11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFSD11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD11 |
Orthologs
for MFSD11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MFSD11 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for MFSD11 (if available)
TreeFam Gene Tree for MFSD11 (if available) |
Paralogs
for MFSD11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MFSD11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MFSD11 (74731947 - 74777531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MFSD11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD11 |
|
Disorders
/ Diseases
for MFSD11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MFSD11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MFSD11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MFSD11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. (PubMed id 9358160)1, 2, 3 Sureau A.... Perbal B. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MFSD11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MFSD11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MFSD11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MFSD11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MFSD11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MFSD11 gene:
Search GeneIP for patents involving MFSD11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MFSD11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MFSD11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFSD11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFSD11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MFSD11 | | OriGene 3'-UTR Clone for MFSD11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFSD11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MFSD11 | | OriGene Custom Protein Services for MFSD11 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFSD11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFSD11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFSD11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFSD11 |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | MFSD11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD11 |
|  |  |  | | | | Search ThermoFisher Antibodies for MFSD11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD11 |
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