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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFSD11 Gene

protein-coding   GIFtS: 40
GCID: GC17P074733

Major Facilitator Superfamily Domain Containing 11

  Search for MFSD11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Facilitator Superfamily Domain Containing 111 2
Major Facilitator Superfamily Domain-Containing Protein 112 3
Protein ET2 3
ET2 3
UNC93-Like Protein MFSD112

External Ids:    HGNC: 254581   Entrez Gene: 791572   Ensembl: ENSG000000929317   UniProtKB: O439343   

Export aliases for MFSD11 gene to outside databases

Previous GC identifers: GC17P072245 GC17P070161


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MFSD11 Gene: 
MFSD11 (major facilitator superfamily domain containing 11) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFSD11 gene promoter:
         Max1   Max   AML1a   MyoD   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFSD11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MFSD11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

MFSD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFSD11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P074733:  view genomic region     (about GC identifiers)

Start:
74,731,947 bp from pter      End:
74,777,531 bp from pter
Size:
45,585 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFS11_HUMAN, O43934 (See protein sequence)
Recommended Name: UNC93-like protein MFSD11  
Size: 449 amino acids; 49202 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: Despite its name, it is related to the unc-93 family and not to the major facilitator superfamily
Secondary accessions: O43442 Q9NXI5
Alternative splicing: 2 isoforms:  O43934-1   O43934-2   

Explore the universe of human proteins at neXtProt for MFSD11: NX_O43934

Explore proteomics data for MFSD11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43934

  • MFSD11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MFSD11 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001229461.1  NP_001229462.1  NP_001229463.1  NP_001229464.1  NP_001229465.1  NP_001229466.1  NP_077287.1  

    ENSEMBL proteins: 
     ENSP00000466613   ENSP00000464932   ENSP00000467375   ENSP00000467879   ENSP00000466223  
     ENSP00000468758   ENSP00000466782   ENSP00000337240   ENSP00000468309   ENSP00000466412  
     ENSP00000468223   ENSP00000468616   ENSP00000466584   ENSP00000468562   ENSP00000348225  

    Human Recombinant Protein Products for MFSD11: 
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    Cloud-Clone Corp. Proteins for MFSD11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    MFSD11 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for MFSD11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR010291 Ion_channel_UNC-93
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O43934

    ProtoNet protein and cluster: O43934

    UniProtKB/Swiss-Prot: MFS11_HUMAN, O43934
    Similarity: Belongs to the unc-93 family


    MFSD11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MFSD11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MFSD11:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MFSD11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MFSD11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFSD11 
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MFSD11 (see all 12):
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    SwitchGear 3'UTR luciferase reporter plasmidMFSD11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD11

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0055085transmembrane transport ----

    MFSD11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFSD11 (MFS11)

    Search CenterWatch for drugs/clinical trials and news about MFSD11 / MFS11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MFSD11 gene (7 alternative transcripts): 
    NM_001242532.1  NM_001242533.1  NM_001242534.1  NM_001242535.1  NM_001242536.1  NM_001242537.1  NM_024311.3  

    Unigene Clusters for MFSD11:

    Major facilitator superfamily domain containing 11
    Hs.73965  [show with all ESTs], Hs.732019  [show with all ESTs]
    Unigene Representative Sequences: NM_001242532, AF015189
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000586622 ENST00000588460 ENST00000591864 ENST00000590393 ENST00000586689
    ENST00000587661 ENST00000593181 ENST00000336509(uc002jta.2 uc002jtd.4 uc002jtb.3 uc002jtc.3 uc002jte.3)
    ENST00000590514 ENST00000588031 ENST00000588670 ENST00000588768 ENST00000585584
    ENST00000585958 ENST00000585692 ENST00000585865 ENST00000588647 ENST00000590070

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFSD11
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MFSD11 (see all 12):
    hsa-miR-623 hsa-miR-30c hsa-miR-3607-3p hsa-miR-30d hsa-miR-1253 hsa-miR-570 hsa-miR-211 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMFSD11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MFSD11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFSD11
    Clone
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    OriGene clones in human, mouse for MFSD11 (see all 5)
    OriGene ORF clones in mouse, rat for MFSD11
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    GenScript: all cDNA clones in your preferred vector: MFSD11 (NM_024311)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD11
    Sirion Biotech Customized lentivirus for stable overexpression of MFSD11 
                         Customized lentivirus expression plasmids for stable overexpression of MFSD11 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFSD11

    Additional mRNA sequence: 

    AF015187.1 AF015188.1 AF015189.1 

    24/25 DOTS entries (see all 25):

    DT.92463619  DT.92463576  DT.92463582  DT.97766762  DT.100674710  DT.100674715  DT.120924960  DT.100674714 
    DT.120924924  DT.100674718  DT.100674705  DT.95126016  DT.100039138  DT.100674711  DT.95125986  DT.120924952 
    DT.101961750  DT.87077676  DT.92049803  DT.100719737  DT.102837053  DT.121641516  DT.121641519  DT.75123739 

    24/236 AceView cDNA sequences (see all 236):

    BQ718878 AA811536 BG571717 CA427643 AA746163 AA186774 AI077360 CB305444 
    T07875 AW375322 CB132021 AI188913 AL571123 CB128646 W73876 BX399407 
    BG035314 H28654 AA811537 BM693639 BX104922 BQ015185 AA694389 BQ777640 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MFSD11 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17
    SP1:              -     -     -     -                                                                                                                     
    SP2:                    -     -     -                                                                                                                     
    SP3:                          -     -                                                                                                                     
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for MFSD11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFSD11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATAGAATG
    MFSD11 Expression
    About this image


    See MFSD11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFSD11

    SOURCE GeneReport for Unigene clusters: Hs.73965 Hs.732019
        SABiosciences Custom PCR Arrays for MFSD11
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MFSD11 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd111 , 5 major facilitator superfamily domain containing 111, 5 87.53(n)1
    93.1(a)1
      11 (81.49 cM)5
    699001  NM_178620.31  NP_848735.11 
     1168524405 
    chicken
    (Gallus gallus)
    Aves MFSD111 major facilitator superfamily domain containing 11 76.61(n)
    81.29(a)
      417352  XM_415615.3  XP_415615.2 
    lizard
    (Anolis carolinensis)
    Reptilia MFSD116
    Uncharacterized protein
    81(a)
    1 ↔ 1
    2(111609409-111627053)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685442 hypothetical protein MGC68544 74.59(n)    AF549901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7992651 UNC93-like protein MFSD11-like 59.42(n)
    57.24(a)
      799265  XM_001339605.3  XP_001339641.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG185491 CG18549 52.45(n)
    45.3(a)
      41538  NM_141946.2  NP_650203.3 
    worm
    (Caenorhabditis elegans)
    Secernentea M153.21 Protein M153.2 47.56(n)
    36.72(a)
      187483  NM_077632.2  NP_510033.2 


    ENSEMBL Gene Tree for MFSD11 (if available)
    TreeFam Gene Tree for MFSD11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/794 SNPs in MFSD11 are shown (see all 794)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907524851,2
    --74735539(+) GTCCCA/CATTTT 7 -- int10--------
    rs80817111,2
    C,F,A,H--74735676(+) gacaaA/Gtgaaa 7 -- int114Minor allele frequency- G:0.11NS EA NA WA 1938
    rs1829822931,2
    --74735743(+) ACATTA/GAGCTG 7 -- int10--------
    rs1880611461,2
    --74735827(+) ACTCAC/TACTTG 7 -- int10--------
    rs620867851,2
    C,F--74735966(+) AAATGC/TGGCCG 7 -- int11Minor allele frequency- T:0.50NA 2
    rs112895031,2
    C--74736256(+) AAAAA-/AAAAAA 7 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs1910309011,2
    --74736440(+) AGTAAC/GTGAGT 7 -- int10--------
    rs1828777071,2
    --74736513(+) CTCTGC/TGCTTG 7 -- int10--------
    rs1874726621,2
    --74736555(+) CCAGAG/TTTGTA 7 -- int10--------
    rs106352631,2
    C--74736685(+) ctttt-/TTctttc 7 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for MFSD11 (74731947 - 74777531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MFSD11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833550CNV Loss17160897
    nsv908833CNV Loss21882294
    nsv828110CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MFSD11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MFSD11 for disorders           About MalaCards

    MFSD11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MFSD11

    Export disorders for MFSD11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFSD11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MFSD11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. (PubMed id 9358160)1, 2, 3 Sureau A.... Perbal B. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79157 HGNC: 25458 AceView: ET Ensembl:ENSG00000092931 euGenes: HUgn79157
    ECgene: MFSD11 H-InvDB: MFSD11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFSD11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MFSD11 gene:
    Search GeneIP for patents involving MFSD11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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