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Aliases for MFSD11 Gene

Aliases for MFSD11 Gene

  • Major Facilitator Superfamily Domain Containing 11 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 11 3 4
  • Protein ET 3 4
  • ET 3 4
  • UNC93-Like Protein MFSD11 3

External Ids for MFSD11 Gene

Previous GeneCards Identifiers for MFSD11 Gene

  • GC17P072245
  • GC17P074733
  • GC17P070161

Summaries for MFSD11 Gene

GeneCards Summary for MFSD11 Gene

MFSD11 (Major Facilitator Superfamily Domain Containing 11) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD11 Gene

Genomics for MFSD11 Gene

Regulatory Elements for MFSD11 Gene


Enhancers around MFSD11 on UCSC Golden Path with GeneCards custom track

Promoters for MFSD11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353815 1335 5201 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for MFSD11 Gene

Chromosome:
17
Start:
76,735,865 bp from pter
End:
76,804,356 bp from pter
Size:
68,492 bases
Orientation:
Plus strand

Genomic View for MFSD11 Gene

Genes around MFSD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD11 Gene

Proteins for MFSD11 Gene

  • Protein details for MFSD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43934-MFS11_HUMAN
    Recommended name:
    UNC93-like protein MFSD11
    Protein Accession:
    O43934
    Secondary Accessions:
    • O43442
    • Q9NXI5

    Protein attributes for MFSD11 Gene

    Size:
    449 amino acids
    Molecular mass:
    49202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MFSD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD11 Gene

Post-translational modifications for MFSD11 Gene

  • Glycosylation at Asn 40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFSD11 Gene

Domains & Families for MFSD11 Gene

Protein Domains for MFSD11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43934

UniProtKB/Swiss-Prot:

MFS11_HUMAN :
  • Belongs to the unc-93 family.
Family:
  • Belongs to the unc-93 family.
genes like me logo Genes that share domains with MFSD11: view

No data available for Gene Families for MFSD11 Gene

Function for MFSD11 Gene

Gene Ontology (GO) - Molecular Function for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MFSD11: view
genes like me logo Genes that share phenotypes with MFSD11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD11 Gene

Localization for MFSD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD11 Gene COMPARTMENTS Subcellular localization image for MFSD11 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD11: view

Pathways & Interactions for MFSD11 Gene

SuperPathways for MFSD11 Gene

No Data Available

Interacting Proteins for MFSD11 Gene

Selected Interacting proteins: O43934-MFS11_HUMAN for MFSD11 Gene via IID

Symbol External ID(s) Details
CREB3

Gene Ontology (GO) - Biological Process for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MFSD11: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD11 Gene

Transcripts for MFSD11 Gene

Unigene Clusters for MFSD11 Gene

Major facilitator superfamily domain containing 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - -
SP8: - - - -

Relevant External Links for MFSD11 Gene

GeneLoc Exon Structure for
MFSD11
ECgene alternative splicing isoforms for
MFSD11

Expression for MFSD11 Gene

mRNA expression in normal human tissues for MFSD11 Gene

Protein differential expression in normal tissues from HIPED for MFSD11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD11 Gene



Protein tissue co-expression partners for MFSD11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MFSD11 Gene:

MFSD11

SOURCE GeneReport for Unigene cluster for MFSD11 Gene:

Hs.73965
genes like me logo Genes that share expression patterns with MFSD11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFSD11 Gene

Orthologs for MFSD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD11 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia MFSD11 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD11 34 35
  • 90.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD11 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD11 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd11 34 16 35
  • 87.53 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd11 34
  • 86.93 (n)
chicken
(Gallus gallus)
Aves MFSD11 34 35
  • 76.91 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD11 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd11 34
  • 69.14 (n)
Str.14929 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68544 34
zebrafish
(Danio rerio)
Actinopterygii mfsd11 35
  • 66 (a)
OneToOne
LOC799265 34
  • 59.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18549 34 35
  • 52.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000311 34
  • 51.7 (n)
worm
(Caenorhabditis elegans)
Secernentea C27C12.4 34 35
  • 44.91 (n)
M153.2 35
  • 32 (a)
OneToMany
C08D8.1 35
  • 30 (a)
OneToMany
F36G9.3 35
  • 29 (a)
OneToMany
F31D5.2 35
  • 28 (a)
OneToMany
Y52E8A.6 35
  • 27 (a)
OneToMany
F31D5.1 35
  • 24 (a)
OneToMany
Y39D8A.1 35
  • 23 (a)
OneToMany
Y52E8A.4 35
  • 23 (a)
OneToMany
B0554.5 35
  • 22 (a)
OneToMany
B0554.7 35
  • 21 (a)
OneToMany
Y39B6A.29 35
  • 20 (a)
OneToMany
Y11D7A.3 35
  • 19 (a)
OneToMany
Y39B6A.27 35
  • 19 (a)
OneToMany
ZK6.8 35
  • 19 (a)
OneToMany
Y37A1A.2 35
  • 18 (a)
OneToMany
ZK6.6 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10944 34
Species where no ortholog for MFSD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD11 Gene

ENSEMBL:
Gene Tree for MFSD11 (if available)
TreeFam:
Gene Tree for MFSD11 (if available)

Paralogs for MFSD11 Gene

No data available for Paralogs for MFSD11 Gene

Variants for MFSD11 Gene

Sequence variations from dbSNP and Humsavar for MFSD11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10438704 -- 76,775,832(+) atttg(A/G)aacac intron-variant
rs10451221 -- 76,755,038(+) catgg(C/T)gaaac intron-variant
rs10468452 -- 76,797,788(+) aggcc(A/G)tccat intron-variant, upstream-variant-2KB
rs10468453 -- 76,799,363(+) acaca(C/T)ctcag intron-variant, nc-transcript-variant
rs10635263 -- 76,740,607(+) TTTTC(-/TT)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD11 Gene

Variant ID Type Subtype PubMed ID
nsv1110921 OTHER inversion 24896259
nsv828110 CNV gain 20364138
nsv833550 CNV loss 17160897

Variation tolerance for MFSD11 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFSD11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD11 Gene

Disorders for MFSD11 Gene

Relevant External Links for MFSD11

Genetic Association Database (GAD)
MFSD11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD11

No disorders were found for MFSD11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD11 Gene

Publications for MFSD11 Gene

  1. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. (PMID: 9358160) Sureau A. … Perbal B. (Nucleic Acids Res. 1997) 2 3 4 64
  2. Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X. … Wong T.Y. (PLoS ONE 2013) 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for MFSD11 Gene

Sources for MFSD11 Gene

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