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Aliases for MFSD10 Gene

Aliases for MFSD10 Gene

  • Major Facilitator Superfamily Domain Containing 10 2 3 5
  • Tetracycline Transporter-Like Protein 3 4
  • TETRAN 3 4
  • Tetracycline Transporter Like Protein 2
  • TETTRAN 3

External Ids for MFSD10 Gene

Summaries for MFSD10 Gene

Entrez Gene Summary for MFSD10 Gene

  • This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for MFSD10 Gene

MFSD10 (Major Facilitator Superfamily Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and tetracycline transporter activity.

UniProtKB/Swiss-Prot for MFSD10 Gene

  • Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD10 Gene

Genomics for MFSD10 Gene

Regulatory Elements for MFSD10 Gene

Enhancers for MFSD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MFSD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFSD10 Gene

Chromosome:
4
Start:
2,930,560 bp from pter
End:
2,934,868 bp from pter
Size:
4,309 bases
Orientation:
Minus strand

Genomic View for MFSD10 Gene

Genes around MFSD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD10 Gene

Proteins for MFSD10 Gene

  • Protein details for MFSD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14728-MFS10_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 10
    Protein Accession:
    Q14728
    Secondary Accessions:
    • Q07706

    Protein attributes for MFSD10 Gene

    Size:
    455 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD10 Gene

Proteomics data for MFSD10 Gene at MOPED

Post-translational modifications for MFSD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD10 Gene

Domains & Families for MFSD10 Gene

Protein Domains for MFSD10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14728

UniProtKB/Swiss-Prot:

MFS10_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD10: view

No data available for Gene Families for MFSD10 Gene

Function for MFSD10 Gene

Molecular function for MFSD10 Gene

UniProtKB/Swiss-Prot Function:
Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.
genes like me logo Genes that share phenotypes with MFSD10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD10

CRISPR Products

miRNA for MFSD10 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD10 Gene

Localization for MFSD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD10 Gene COMPARTMENTS Subcellular localization image for MFSD10 gene
Compartment Confidence
plasma membrane 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for MFSD10 Gene

Pathways & Interactions for MFSD10 Gene

SuperPathways for MFSD10 Gene

No Data Available

Interacting Proteins for MFSD10 Gene

Gene Ontology (GO) - Biological Process for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0015904 tetracycline transport TAS 8353488
genes like me logo Genes that share ontologies with MFSD10: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD10 Gene

Drugs & Compounds for MFSD10 Gene

No Compound Related Data Available

Transcripts for MFSD10 Gene

Unigene Clusters for MFSD10 Gene

Major facilitator superfamily domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - -
SP11:
SP12:
SP13: -
SP14: - - - - -
SP15:
SP16:
SP17: -
SP18:

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MFSD10 Gene

GeneLoc Exon Structure for
MFSD10
ECgene alternative splicing isoforms for
MFSD10

Expression for MFSD10 Gene

mRNA expression in normal human tissues for MFSD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD10 Gene

This gene is overexpressed in Nasal epithelium (35.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MFSD10 Gene



SOURCE GeneReport for Unigene cluster for MFSD10 Gene Hs.632581

genes like me logo Genes that share expression patterns with MFSD10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MFSD10 Gene

Orthologs for MFSD10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MFSD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFSD10 35
  • 83.96 (n)
  • 83.3 (a)
MFSD10 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD10 35
  • 84.41 (n)
  • 85.61 (a)
MFSD10 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd10 35
  • 80.54 (n)
  • 80.54 (a)
Mfsd10 16
Mfsd10 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFSD10 35
  • 99.41 (n)
  • 99.56 (a)
MFSD10 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd10 35
  • 81.95 (n)
  • 81.66 (a)
oppossum
(Monodelphis domestica)
Mammalia MFSD10 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD10 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD10 35
  • 65.38 (n)
  • 68.36 (a)
MFSD10 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD10 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd10 35
  • 65.52 (n)
  • 66.58 (a)
Str.17192 35
zebrafish
(Danio rerio)
Actinopterygii mfsd10 35
  • 59.73 (n)
  • 61.26 (a)
mfsd10 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2297 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001391 35
  • 55.18 (n)
  • 48.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta rtet 35
  • 52.38 (n)
  • 44.47 (a)
rtet 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10D7.2 35
  • 48.93 (n)
  • 41.9 (a)
F10D7.2 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09098 35
  • 47.22 (n)
  • 34.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6758 36
  • 44 (a)
OneToOne
Species with no ortholog for MFSD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD10 Gene

ENSEMBL:
Gene Tree for MFSD10 (if available)
TreeFam:
Gene Tree for MFSD10 (if available)

Paralogs for MFSD10 Gene

(1) SIMAP similar genes for MFSD10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MFSD10: view

No data available for Paralogs for MFSD10 Gene

Variants for MFSD10 Gene

Sequence variations from dbSNP and Humsavar for MFSD10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1263348 -- 2,931,544(+) GGAGG(A/G)AGCCC intron-variant
rs1263349 -- 2,932,581(+) CAAAG(A/G)CCCAG intron-variant
rs1034400 -- 2,930,862(-) TACCC(A/G/T)GCACA nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, utr-variant-3-prime
rs2301374 -- 2,933,524(-) GTCCT(A/G/T)TGTTT intron-variant
rs3034869 -- 2,930,682(+) TAAGT(-/AAGT)CTGGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MFSD10 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv461163 CNV Gain 19166990

Variation tolerance for MFSD10 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MFSD10 Gene

Disorders for MFSD10 Gene

Relevant External Links for MFSD10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFSD10

No disorders were found for MFSD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD10 Gene

Publications for MFSD10 Gene

  1. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. (PMID: 17362938) Mima S. … Mizushima T. (FEBS Lett. 2007) 2 3 4 23 67
  2. Expression and function of TETRAN, a new type of membrane transporter. (PMID: 18638446) Ushijima H. … Mizushima T. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. (PMID: 8353488) Duyao M.P. … Gusella J.F. (Hum. Mol. Genet. 1993) 2 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for MFSD10 Gene

Sources for MFSD10 Gene

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