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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFSD10 Gene

protein-coding   GIFtS: 48
GCID: GC04M002903

Major Facilitator Superfamily Domain Containing 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Facilitator Superfamily Domain Containing 101 2     TETTRAN2
TETRAN2 3 5     Major Facilitator Superfamily Domain-Containing Protein 102
Tetracycline Transporter-Like Protein2 3     TPO15
Tetracycline Transporter Like Protein1     

External Ids:    HGNC: 168941   Entrez Gene: 102272   Ensembl: ENSG000001097367   OMIM: 6109775   UniProtKB: Q147283   

Export aliases for MFSD10 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFSD10 Gene:
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein
likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin
and diclofenac. Alternatively spliced transcript variants have been described. (provided by RefSeq, Mar 2009)

GeneCards Summary for MFSD10 Gene: 
MFSD10 (major facilitator superfamily domain containing 10) is a protein-coding gene. Diseases associated with MFSD10 include actinomycosis, and wolman disease. GO annotations related to this gene include tetracycline transporter activity.

UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728
Function: Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs
indomethacin and diclofenac. May act as an efflux pump




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFSD10 gene promoter:
         Nkx3-1   Nkx3-1 v4   RelA   Nkx3-1 v1   Nkx2-5   NF-kappaB   Nkx3-1 v2   Nkx3-1 v3   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFSD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MFSD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFSD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MFSD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFSD10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002903:  view genomic region     (about GC identifiers)

Start:
2,932,288 bp from pter      End:
2,936,586 bp from pter
Size:
4,299 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728 (See protein sequence)
Recommended Name: Major facilitator superfamily domain-containing protein 10  
Size: 455 amino acids; 48339 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q07706

Explore the universe of human proteins at neXtProt for MFSD10: NX_Q14728

Explore proteomics data for MFSD10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14728

  • MFSD10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MFSD10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001111.3  NP_001139541.1  

    ENSEMBL proteins: 
     ENSP00000426907   ENSP00000347619   ENSP00000332646   ENSP00000423509   ENSP00000425757  
     ENSP00000427637   ENSP00000423402  

    Human Recombinant Protein Products for MFSD10: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    MFSD10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q14728

    ProtoNet protein and cluster: Q14728

    UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728
    Similarity: Belongs to the major facilitator superfamily


    MFSD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFS10_HUMAN, Q14728
    Function: Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs
    indomethacin and diclofenac. May act as an efflux pump

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008493tetracycline transporter activity TAS8353488
    GO:0022857transmembrane transporter activity ----
         
    MFSD10 for ontologies           About GeneDecksing


    Animal Models:
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    miRTarBase miRNAs that target MFSD10:
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    SwitchGear 3'UTR luciferase reporter plasmidMFSD10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFSD10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MFSD10 (Q147283 ENSP000003326464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNB1Q149743I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8353488
    GO:0006915apoptotic process IEA--
    GO:0015904tetracycline transport TAS8353488
    GO:0055085transmembrane transport IEA--

    MFSD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFSD10 (MFS10)

    Search CenterWatch for drugs/clinical trials and news about MFSD10 / MFS10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MFSD10 gene (2 alternative transcripts): 
    NM_001120.4  NM_001146069.1  

    Unigene Cluster for MFSD10:

    Major facilitator superfamily domain containing 10
    Hs.632581  [show with all ESTs]
    Unigene Representative Sequence: NM_001120
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514800(uc021xks.1) ENST00000514031 ENST00000355443(uc003gfz.3)
    ENST00000329687(uc003gfw.3) ENST00000503596 ENST00000508221 ENST00000507272
    ENST00000507555 ENST00000508276 ENST00000512781 ENST00000509676
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC001502.2 BC014979.1 BC023537.2 L11669.1 

    24/25 DOTS entries (see all 25):

    DT.95168976  DT.75129619  DT.100845768  DT.100845781  DT.97766425  DT.100845765  DT.95168972  DT.95340387 
    DT.121237132  DT.100845761  DT.95168970  DT.100845769  DT.100668777  DT.121237136  DT.92439853  DT.95088100 
    DT.100712457  DT.100728821  DT.100836679  DT.121237097  DT.121237101  DT.121237117  DT.95168969  DT.95227077 

    24/346 AceView cDNA sequences (see all 346):

    BM907012 CA488150 CA310745 CR615910 BM842823 CR622686 BG751901 BM982158 
    BI915203 BQ937108 CR609779 CR617179 BM552134 BE743576 CR617484 CR610651 
    BC001502 CA426698 BM918354 CR624960 CR595403 T27678 CR601259 CR599208 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MFSD10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
    SP1:                                                                          -     -     -                                                                     
    SP2:                                                                          -     -     -                                                                     
    SP3:                                                              -           -     -     -     -     -                                                         
    SP4:                    -                                                     -     -     -     -     -                                                         
    SP5:                                                                          -     -     -                             -                                       

    ExUns: 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                            -               
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MFSD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFSD10 expression in normal human tissues (normalized intensities)      MFSD10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTACACTGC
    MFSD10 Expression
    About this image


    MFSD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Neuron (Nervous System)
             nerve   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             c-kit+ gr1+ mac1- myeloblasts   

    See MFSD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFSD10

    SOURCE GeneReport for Unigene cluster: Hs.632581
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MFSD10 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd101 , 5 major facilitator superfamily domain containing 101, 5 80.59(n)1
    80.22(a)1
      5 (17.90 cM)5
    682941  NM_026660.21  NP_080936.11 
     346336425 
    chicken
    (Gallus gallus)
    Aves MFSD101 major facilitator superfamily domain containing 10 65.32(n)
    68.57(a)
      422881  XM_420825.3  XP_420825.2 
    lizard
    (Anolis carolinensis)
    Reptilia MFSD106
    Uncharacterized protein
    60(a)
    1 ↔ 1
    5(80224332-80255468)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171922 Transcribed sequence with moderate similarity to protein more 77.36(n)    AL873659.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1120421 zgc:112042 59.09(n)
    60.42(a)
      550360  NM_001017667.1  NP_001017667.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rtet1 tetracycline resistance 52.74(n)
    44.93(a)
      42500  NM_079705.2  NP_524429.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.21 Protein F10D7.2 48.18(n)
    40.76(a)
      181765  NM_078413.2  NP_510814.1 


    ENSEMBL Gene Tree for MFSD10 (if available)
    TreeFam Gene Tree for MFSD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFSD10 gene
    1 SIMAP similar gene for MFSD10 using alignment to 6 protein entries:     MFS10_HUMAN (see all proteins):
    MFSD9

    MFSD10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 SNPs in MFSD10 are shown (see all 177)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012224791,2
    --2932337(+) GTGCA-/TAGTT 
            
    TAGTT
    2 -- ut310--------
    rs1437950221,2
    C--2932387(+) CAGCTC/TGGAGT 2 -- ut310--------
    rs717808991,2
    C--2932402(+) GAAGG-/AGTA  
            
    AGTAA
    2 -- ut310--------
    rs30348691,2
    C--2932405(+) TAAGT-/AAGT  
            
    CTGGA
    2 -- ut310--------
    rs1915403761,2
    --2932409(+) TAAGTA/CAGTCT 2 -- ut310--------
    rs1829343311,2
    --2932440(+) CTGCTC/TAGGGG 2 -- ut310--------
    rs2008931861,2
    C,F--2932546(+) CACAGC/TCTGGG 2 -- ut311Minor allele frequency- T:0.00EU 513
    rs10344001,2
    C,F,H--2932589(-) TACCCG/AGCACA 4 /P syn1 ese319Minor allele frequency- A:0.01EA NA MN NS WA EU 7805
    rs1463770121,2
    C--2932684(+) CACTGC/TGGAGA 2 -- int10--------
    rs2002041981,2
    --2932685(+) ACTGCA/GGAGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MFSD10 (2932288 - 2936586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MFSD10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726835CNV Deletion23290073
    nsv461163CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610977    OMIM disorders: --

    5 diseases for MFSD10:    About MalaCards
    actinomycosis    wolman disease    pulpitis    wolf-hirschhorn syndrome
    sinusitis

    2 diseases from the University of Copenhagen DISEASES database for MFSD10:
    Wolman disease     Maxillary sinusitis

    MFSD10 for disorders           About GeneDecksing


    Export disorders for MFSD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFSD10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MFSD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. (PubMed id 17362938)1, 2, 3, 9 Mima S....Mizushima T. (2007)
    2. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. (PubMed id 8353488)1, 2, 3 Duyao M.P.... Gusella J.F. (1993)
    3. Expression and function of TETRAN, a new type of membrane transporter. (PubMed id 18638446)1, 9 Ushijima H....Mizushima T. (2008)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10227 HGNC: 16894 AceView: TETRAN Ensembl:ENSG00000109736 euGenes: HUgn10227
    ECgene: MFSD10 H-InvDB: MFSD10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFSD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MFSD10 gene:
    Search GeneIP for patents involving MFSD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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