Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MFSD10 Gene

protein-coding   GIFtS: 49
GCID: GC04M002903

Major Facilitator Superfamily Domain Containing 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Major Facilitator Superfamily Domain Containing 101 2     TETTRAN2
TETRAN2 3 5     Major Facilitator Superfamily Domain-Containing Protein 102
Tetracycline Transporter-Like Protein2 3     TPO15
Tetracycline Transporter Like Protein1     

External Ids:    HGNC: 168941   Entrez Gene: 102272   Ensembl: ENSG000001097367   OMIM: 6109775   UniProtKB: Q147283   

Export aliases for MFSD10 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MFSD10 Gene:
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein
likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin
and diclofenac. Alternatively spliced transcript variants have been described. (provided by RefSeq, Mar 2009)

GeneCards Summary for MFSD10 Gene:
MFSD10 (major facilitator superfamily domain containing 10) is a protein-coding gene. Diseases associated with MFSD10 include actinomycosis, and wolman disease. GO annotations related to this gene include tetracycline transporter activity.

UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728
Function: Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs
indomethacin and diclofenac. May act as an efflux pump




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFSD10 gene promoter:
         Nkx3-1   Nkx3-1 v4   RelA   Nkx3-1 v1   Nkx2-5   NF-kappaB   Nkx3-1 v2   Nkx3-1 v3   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFSD10 promoter sequence
   Search Chromatin IP Primers for MFSD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFSD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

MFSD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFSD10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002903:  view genomic region     (about GC identifiers)

Start:
2,932,288 bp from pter      End:
2,936,586 bp from pter
Size:
4,299 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728 (See protein sequence)
Recommended Name: Major facilitator superfamily domain-containing protein 10  
Size: 455 amino acids; 48339 Da
Secondary accessions: Q07706

Explore the universe of human proteins at neXtProt for MFSD10: NX_Q14728

Explore proteomics data for MFSD10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MFSD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001111.3  NP_001139541.1  

    ENSEMBL proteins: 
     ENSP00000426907   ENSP00000347619   ENSP00000332646   ENSP00000423509   ENSP00000425757  
     ENSP00000427637   ENSP00000423402  

    MFSD10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MFSD10
    GenScript Custom Purified and Recombinant Proteins Services for MFSD10
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MFSD10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MFSD10
    Novus Biologicals MFSD10 Antibody
    Abcam antibodies for MFSD10
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for MFSD10
    LSBio Antibodies in human, mouse, rat for MFSD10

    MFSD10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MFSD10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MFSD10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q14728

    ProtoNet protein and cluster: Q14728

    UniProtKB/Swiss-Prot: MFS10_HUMAN, Q14728
    Similarity: Belongs to the major facilitator superfamily


    MFSD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFS10_HUMAN, Q14728
    Function: Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs
    indomethacin and diclofenac. May act as an efflux pump

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008493tetracycline transporter activity TAS8353488
    GO:0022857transmembrane transporter activity ----
         
    MFSD10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFSD10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFSD10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFSD10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFSD10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MFSD10:
    hsa-mir-1 (MIRT023778), hsa-mir-192-5p (MIRT004147), hsa-mir-7-5p (MIRT025768), hsa-mir-124-3p (MIRT022603)

    Block miRNA regulation of human, mouse, rat MFSD10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MFSD10
    SwitchGear 3'UTR luciferase reporter plasmidMFSD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MFSD10
    Predesigned siRNA for gene silencing in human, mouse, rat MFSD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MFSD10

    Clone
    Products:
         
    OriGene clones in human, mouse for MFSD10 (see all 12)
    OriGene ORF clones in mouse, rat for MFSD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MFSD10 (NM_001120)
    Sino Biological Human cDNA Clone for MFSD10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFSD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MFSD10
    Browse ESI BIO Cell Lines and PureStem Progenitors for MFSD10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MFS10_HUMAN, Q14728: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    MFSD10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFSD10
    Interactions:

        Search GeneGlobe Interaction Network for MFSD10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MFSD10 (Q147283 ENSP000003326464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNB1Q149743I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8353488
    GO:0006915apoptotic process IEA--
    GO:0015904tetracycline transport TAS8353488
    GO:0055085transmembrane transport IEA--

    MFSD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFSD10 (MFS10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MFSD10 gene (2 alternative transcripts): 
    NM_001120.4  NM_001146069.1  

    Unigene Cluster for MFSD10:

    Major facilitator superfamily domain containing 10
    Hs.632581  [show with all ESTs]
    Unigene Representative Sequence: NM_001120
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514800(uc021xks.1) ENST00000514031 ENST00000355443(uc003gfz.3)
    ENST00000329687(uc003gfw.3) ENST00000503596 ENST00000508221 ENST00000507272
    ENST00000507555 ENST00000508276 ENST00000512781 ENST00000509676
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MFSD10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MFSD10
    SwitchGear 3'UTR luciferase reporter plasmidMFSD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MFSD10
    Predesigned siRNA for gene silencing in human, mouse, rat MFSD10
    Clone
    Products:
         
    OriGene clones in human, mouse for MFSD10 (see all 12)
    OriGene ORF clones in mouse, rat for MFSD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MFSD10 (NM_001120)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFSD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MFSD10
    OriGene qSTAR qPCR primer pairs in human, mouse for MFSD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFSD10
      QuantiTect SYBR Green Assays in human, mouse, rat MFSD10
      QuantiFast Probe-based Assays in human, mouse, rat MFSD10

    Additional mRNA sequence: 

    BC001502.2 BC014979.1 BC023537.2 L11669.1 

    Selected DOTS entries (see all 25):

    DT.95168976  DT.75129619  DT.100845768  DT.100845781  DT.97766425  DT.100845765  DT.95168972  DT.95340387 
    DT.121237132  DT.100845761  DT.95168970  DT.100845769  DT.100668777  DT.121237136  DT.92439853  DT.95088100 
    DT.100712457  DT.100728821  DT.100836679  DT.121237097  DT.121237101  DT.121237117  DT.95168969  DT.95227077 

    Selected AceView cDNA sequences (see all 346):

    CA310745 CR615910 BG056548 AI590543 BM907012 AI348333 CR622686 BC023537 
    CR601259 CR599208 AW440346 BU845278 BM699657 CR624236 CR592738 CR626767 
    AI089559 CD672686 BI764749 BU624491 BI761794 BF197241 BU931617 BM727630 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MFSD10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
    SP1:                                                                          -     -     -                                                                     
    SP2:                                                                          -     -     -                                                                     
    SP3:                                                              -           -     -     -     -     -                                                         
    SP4:                    -                                                     -     -     -     -     -                                                         
    SP5:                                                                          -     -     -                             -                                       

    ExUns: 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                            -               
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MFSD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MFSD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTACACTGC
    MFSD10 Expression
    About this image


    MFSD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MFSD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFSD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632581
        Custom PCR Arrays for MFSD10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MFSD10
    OriGene qSTAR qPCR primer pairs in human, mouse for MFSD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFSD10
    QuantiTect SYBR Green Assays in human, mouse, rat MFSD10
    QuantiFast Probe-based Assays in human, mouse, rat MFSD10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MFSD10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd101 , 5 major facilitator superfamily domain containing 101, 5 80.54(n)1
    80.54(a)1
      5 (17.90 cM)5
    682941  NM_026660.21  NP_080936.11 
     346336425 
    chicken
    (Gallus gallus)
    Aves MFSD101 major facilitator superfamily domain containing 10 65.38(n)
    68.36(a)
      422881  XM_420825.4  XP_420825.2 
    lizard
    (Anolis carolinensis)
    Reptilia MFSD106
    major facilitator superfamily domain containing 10...
    62(a)
    1 ↔ 1
    5(80224332-80255468)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171922 Transcribed sequence with moderate similarity to protein more 77.36(n)    AL873659.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mfsd101 major facilitator superfamily domain containing 10 59.73(n)
    61.26(a)
      550360  NM_001017667.1  NP_001017667.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rtet1 tetracycline resistance 52.38(n)
    44.47(a)
      42500  NM_079705.3  NP_524429.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.21 F10D7.2 48.93(n)
    41.9(a)
      181765  NM_078413.3  NP_510814.1 


    ENSEMBL Gene Tree for MFSD10 (if available)
    TreeFam Gene Tree for MFSD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MFSD10 gene
    1 SIMAP similar gene for MFSD10 using alignment to 6 protein entries:     MFS10_HUMAN (see all proteins):
    MFSD9

    MFSD10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MFSD10 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012224791,2
    --2932337(+) GTGCA-/TAGTT 
            
    TAGTT
    2 -- ut310--------
    rs1437950221,2
    C--2932387(+) CAGCTC/TGGAGT 2 -- ut310--------
    rs717808991,2
    C--2932402(+) GAAGG-/AGTA  
            
    AGTAA
    2 -- ut310--------
    rs30348691,2
    C--2932405(+) TAAGT-/AAGT  
            
    CTGGA
    2 -- ut310--------
    rs1915403761,2
    --2932409(+) TAAGTA/CAGTCT 2 -- ut310--------
    rs1829343311,2
    --2932440(+) CTGCTC/TAGGGG 2 -- ut310--------
    rs2008931861,2
    C,F--2932546(+) CACAGC/TCTGGG 2 -- ut311Minor allele frequency- T:0.00EU 513
    rs10344001,2
    C,F,H--2932589(-) TACCCG/AGCACA 4 /P syn1 ese319Minor allele frequency- A:0.01EA NA MN NS WA EU 7805
    rs1463770121,2
    C--2932684(+) CACTGC/TGGAGA 2 -- int10--------
    rs2002041981,2
    --2932685(+) ACTGCA/GGAGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MFSD10 (2932288 - 2936586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MFSD10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726835CNV Deletion23290073
    nsv461163CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MFSD10
    DNA2.0 Custom Variant and Variant Library Synthesis for MFSD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610977    OMIM disorders: --

    6 diseases for MFSD10:    
    About MalaCards
    actinomycosis    wolman disease    pulpitis    wolf-hirschhorn syndrome
    sinusitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for MFSD10:
    Wolman disease     Maxillary sinusitis

    MFSD10 for disorders           About GeneDecksing


    Export disorders for MFSD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MFSD10 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MFSD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. (PubMed id 17362938)1, 2, 3, 9 Mima S.... Mizushima T. (FEBS Lett. 2007)
    2. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. (PubMed id 8353488)1, 2, 3 Duyao M.P.... Gusella J.F. (Hum. Mol. Genet. 1993)
    3. Expression and function of TETRAN, a new type of membrane transporter. (PubMed id 18638446)1, 9 Ushijima H....Mizushima T. (Biochem. Biophys. Res. Commun. 2008)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10227 HGNC: 16894 AceView: TETRAN Ensembl:ENSG00000109736 euGenes: HUgn10227
    ECgene: MFSD10 H-InvDB: MFSD10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MFSD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MFSD10 gene:
    Search GeneIP for patents involving MFSD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MFSD10  
     OriGene qPCR primer pairs and template standards for MFSD10   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MFSD10  
     OriGene qSTAR qPCR primer pairs in human, mouse for MFSD10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MFSD10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MFSD10   OriGene Custom Protein Services for MFSD10  

     
     
     Block miRNA regulation of human, mouse, rat MFSD10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MFSD10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFSD10 Predesigned siRNA for gene silencing in human, mouse, rat MFSD10
     QuantiFast Probe-based Assays in human, mouse, rat MFSD10 QuantiTect SYBR Green Assays in human, mouse, rat MFSD10
     Custom PCR Arrays for MFSD10 Search Chromatin IP Primers for MFSD10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFSD10  Search GeneGlobe Interaction Network for MFSD10
     Regulatory tfbs in MFSD10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MFSD10 GenScript cDNA clones with any tag delivered in your preferred vector for MFSD10
     GenScript Custom Assay Services for MFSD10 GenScript Custom overexpressing Cell Line Services for MFSD10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MFSD10 (MFS10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MFSD10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MFSD10 antibodies
     Antibodies for MFSD10
     See all of Abcam's Antibodies, Kits and Proteins for MFSD10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MFSD10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFSD10
     SwitchGear 3'UTR luciferase reporter plasmids for MFSD10
     SwitchGear Promoter luciferase reporter plasmids for MFSD10
     Search ThermoFisher Antibodies for MFSD10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFSD10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFSD10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFSD10
     LSBio Antibodies in human, mouse, rat for MFSD10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MFSD10 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4