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Aliases for MFSD10 Gene

Aliases for MFSD10 Gene

  • Major Facilitator Superfamily Domain Containing 10 2 3 5
  • Tetracycline Transporter-Like Protein 3 4
  • TETRAN 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 10 3
  • Tetracycline Transporter Like Protein 2
  • TETTRAN 3

External Ids for MFSD10 Gene

Summaries for MFSD10 Gene

Entrez Gene Summary for MFSD10 Gene

  • This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for MFSD10 Gene

MFSD10 (Major Facilitator Superfamily Domain Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and tetracycline transmembrane transporter activity.

UniProtKB/Swiss-Prot for MFSD10 Gene

  • Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

Additional gene information for MFSD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD10 Gene

Genomics for MFSD10 Gene

GeneHancer (GH) Regulatory Elements for MFSD10 Gene

Promoters and enhancers for MFSD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I002930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 666 8.2 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 NOP14-AS1 MFSD10 GRK4 HTT-AS HTT PIR46708 GC04P002904 NOP14
GH04I002329 Enhancer 1.1 Ensembl ENCODE 21.3 +604.6 604589 1.3 HDGF ARNT ZNF133 FEZF1 ZNF2 GLIS2 ZNF416 FOS SP3 YY2 NELFA RNF4 CRIPAK HAUS3 FAM193A NOP14 ENSG00000270195 MFSD10 ENSG00000254094 ZFYVE28
GH04I002007 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +925.7 925662 3.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 NELFA NOP14-AS1 MAEA SCARNA22 C4orf48 SH3BP2 NSD2 MXD4 ENSG00000251148 ZFYVE28
GH04I002866 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.7 +67.2 67163 3.4 ATF1 FOXA2 ARNT ARID4B YY1 TCF12 ZNF766 GATA2 E2F8 RXRA ADD1 GRK4 TNIP2 MFSD10 NOP14-AS1 NOP14 GC04P002845 GC04P002844 GC04P002843 PIR46708
GH04I003480 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -549.1 -549096 7.7 HDGF CLOCK ARID4B NEUROD1 SIN3A ZBTB7B GLIS2 ELK1 ZNF143 REST LRPAP1 MFSD10 ZBTB49 ENSG00000261643 LINC00955 FAM193A NOP14 DOK7 HTT-AS MSANTD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MFSD10 gene promoter:

Genomic Locations for MFSD10 Gene

Genomic Locations for MFSD10 Gene
chr4:2,930,560-2,934,868
(GRCh38/hg38)
Size:
4,309 bases
Orientation:
Minus strand
chr4:2,932,288-2,936,586
(GRCh37/hg19)

Genomic View for MFSD10 Gene

Genes around MFSD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD10 Gene

Proteins for MFSD10 Gene

  • Protein details for MFSD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14728-MFS10_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 10
    Protein Accession:
    Q14728
    Secondary Accessions:
    • Q07706

    Protein attributes for MFSD10 Gene

    Size:
    455 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD10 Gene

Post-translational modifications for MFSD10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MFSD10 Gene

Domains & Families for MFSD10 Gene

Gene Families for MFSD10 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14728

UniProtKB/Swiss-Prot:

MFS10_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD10: view

Function for MFSD10 Gene

Molecular function for MFSD10 Gene

UniProtKB/Swiss-Prot Function:
Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

Phenotypes From GWAS Catalog for MFSD10 Gene

Gene Ontology (GO) - Molecular Function for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008493 tetracycline transmembrane transporter activity TAS 8353488
GO:0008514 organic anion transmembrane transporter activity IDA 18638446
genes like me logo Genes that share ontologies with MFSD10: view
genes like me logo Genes that share phenotypes with MFSD10: view

Animal Model Products

CRISPR Products

miRNA for MFSD10 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD10 Gene

Localization for MFSD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD10 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IDA 18638446
GO:0031526 brush border membrane IBA,IEA --
genes like me logo Genes that share ontologies with MFSD10: view

Pathways & Interactions for MFSD10 Gene

SuperPathways for MFSD10 Gene

No Data Available

Interacting Proteins for MFSD10 Gene

Selected Interacting proteins: Q14728-MFS10_HUMAN for MFSD10 Gene via IID

Gene Ontology (GO) - Biological Process for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8353488
GO:0006915 apoptotic process IEA --
GO:0015904 tetracycline transport IEA --
GO:0043252 sodium-independent organic anion transport IDA 18638446
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD10: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD10 Gene

Drugs & Compounds for MFSD10 Gene

No Compound Related Data Available

Transcripts for MFSD10 Gene

Unigene Clusters for MFSD10 Gene

Major facilitator superfamily domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - -
SP11:
SP12:
SP13: -
SP14: - - - - -
SP15:
SP16:
SP17: -
SP18:

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MFSD10 Gene

GeneLoc Exon Structure for
MFSD10
ECgene alternative splicing isoforms for
MFSD10

Expression for MFSD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD10 Gene

This gene is overexpressed in Nasal epithelium (35.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MFSD10 Gene



NURSA nuclear receptor signaling pathways regulating expression of MFSD10 Gene:

MFSD10

SOURCE GeneReport for Unigene cluster for MFSD10 Gene:

Hs.632581

Evidence on tissue expression from TISSUES for MFSD10 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with MFSD10: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD10 Gene

Orthologs for MFSD10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MFSD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD10 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia MFSD10 33 34
  • 84.41 (n)
cow
(Bos Taurus)
Mammalia MFSD10 33 34
  • 83.96 (n)
rat
(Rattus norvegicus)
Mammalia Mfsd10 33
  • 81.95 (n)
mouse
(Mus musculus)
Mammalia Mfsd10 33 16 34
  • 80.54 (n)
oppossum
(Monodelphis domestica)
Mammalia MFSD10 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD10 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFSD10 33 34
  • 65.38 (n)
lizard
(Anolis carolinensis)
Reptilia MFSD10 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd10 33
  • 65.52 (n)
Str.17192 33
zebrafish
(Danio rerio)
Actinopterygii mfsd10 33 34
  • 59.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2297 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001391 33
  • 55.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta rtet 33 34
  • 52.38 (n)
worm
(Caenorhabditis elegans)
Secernentea F10D7.2 33 34
  • 48.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09098 33
  • 47.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6758 34
  • 44 (a)
OneToOne
Species where no ortholog for MFSD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD10 Gene

ENSEMBL:
Gene Tree for MFSD10 (if available)
TreeFam:
Gene Tree for MFSD10 (if available)

Paralogs for MFSD10 Gene

(1) SIMAP similar genes for MFSD10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MFSD10: view

No data available for Paralogs for MFSD10 Gene

Variants for MFSD10 Gene

Sequence variations from dbSNP and Humsavar for MFSD10 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000010069 -- 2,934,039(-) G/A 5_prime_UTR_variant, intron_variant
rs1000166912 -- 2,930,575(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000277392 -- 2,934,782(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000503473 -- 2,931,464(-) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000522141 -- 2,933,517(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD10 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV deletion 23290073
nsv1074672 CNV deletion 25765185
nsv461163 CNV gain 19166990
nsv593437 CNV gain 21841781

Variation tolerance for MFSD10 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD10 Gene

Disorders for MFSD10 Gene

Additional Disease Information for MFSD10

No disorders were found for MFSD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD10 Gene

Publications for MFSD10 Gene

  1. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. (PMID: 17362938) Mima S … Mizushima T (FEBS letters 2007) 2 3 4 22 58
  2. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. (PMID: 8353488) Duyao MP … Housman DE (Human molecular genetics 1993) 2 3 4 58
  3. Expression and function of TETRAN, a new type of membrane transporter. (PMID: 18638446) Ushijima H … Mizushima T (Biochemical and biophysical research communications 2008) 3 22 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58

Products for MFSD10 Gene

Sources for MFSD10 Gene

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