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Aliases for MFSD10 Gene

Aliases for MFSD10 Gene

  • Major Facilitator Superfamily Domain Containing 10 2 3
  • TETRAN 3 4 6
  • Tetracycline Transporter-Like Protein 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 10 3
  • Tetracycline Transporter Like Protein 2
  • TETTRAN 3
  • TPO1 6

External Ids for MFSD10 Gene

Summaries for MFSD10 Gene

Entrez Gene Summary for MFSD10 Gene

  • This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

GeneCards Summary for MFSD10 Gene

MFSD10 (Major Facilitator Superfamily Domain Containing 10) is a Protein Coding gene. Diseases associated with MFSD10 include wolman disease. GO annotations related to this gene include tetracycline transporter activity.

UniProtKB/Swiss-Prot for MFSD10 Gene

  • Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD10 Gene

Genomics for MFSD10 Gene

Genomic Location for MFSD10 Gene

Start:
2,930,561 bp from pter
End:
2,934,859 bp from pter
Size:
4,299 bases
Orientation:
Minus strand

Genomic View for MFSD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD10 Gene

Regulatory Elements for MFSD10 Gene

Proteins for MFSD10 Gene

  • Protein details for MFSD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14728-MFS10_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 10
    Protein Accession:
    Q14728
    Secondary Accessions:
    • Q07706

    Protein attributes for MFSD10 Gene

    Size:
    455 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD10 Gene

Proteomics data for MFSD10 Gene at MOPED

Post-translational modifications for MFSD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD10 Gene

Domains for MFSD10 Gene

Protein Domains for MFSD10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14728

UniProtKB/Swiss-Prot:

MFS10_HUMAN
Family:
  • Belongs to the major facilitator superfamily.:
    • Q14728
genes like me logo Genes that share domains with MFSD10: view

No data available for Gene Families for MFSD10 Gene

Function for MFSD10 Gene

Molecular function for MFSD10 Gene

UniProtKB/Swiss-Prot Function: Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

Gene Ontology (GO) - Molecular Function for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008493 tetracycline transporter activity TAS 8353488
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with MFSD10: view

miRNA for MFSD10 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFSD10 Gene

Localization for MFSD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFSD10 Gene COMPARTMENTS Subcellular localization image for MFSD10 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD10: view

Pathways for MFSD10 Gene

SuperPathways for MFSD10 Gene

No Data Available

Interacting Proteins for MFSD10 Gene

Gene Ontology (GO) - Biological Process for MFSD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8353488
GO:0006915 apoptotic process IEA --
GO:0015904 tetracycline transport TAS 8353488
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD10: view

No data available for Pathways by source for MFSD10 Gene

Transcripts for MFSD10 Gene

Unigene Clusters for MFSD10 Gene

Major facilitator superfamily domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - -
SP11:
SP12:
SP13: -
SP14: - - - - -
SP15:
SP16:
SP17: -
SP18:

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MFSD10 Gene

GeneLoc Exon Structure for
MFSD10
ECgene alternative splicing isoforms for
MFSD10

Expression for MFSD10 Gene

mRNA expression in normal human tissues for MFSD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFSD10 Gene

SOURCE GeneReport for Unigene cluster for MFSD10 Gene Hs.632581

genes like me logo Genes that share expressions with MFSD10: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFSD10 Gene

Orthologs for MFSD10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MFSD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFSD10 35
  • 99.41 (n)
  • 99.56 (a)
MFSD10 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFSD10 35
  • 83.96 (n)
  • 83.3 (a)
MFSD10 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFSD10 35
  • 84.41 (n)
  • 85.61 (a)
MFSD10 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfsd10 35
  • 80.54 (n)
  • 80.54 (a)
Mfsd10 16
Mfsd10 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFSD10 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFSD10 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfsd10 35
  • 81.95 (n)
  • 81.66 (a)
chicken
(Gallus gallus)
Aves MFSD10 35
  • 65.38 (n)
  • 68.36 (a)
MFSD10 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFSD10 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd10 35
  • 65.52 (n)
  • 66.58 (a)
Str.17192 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2297 35
zebrafish
(Danio rerio)
Actinopterygii mfsd10 35
  • 59.73 (n)
  • 61.26 (a)
mfsd10 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001391 35
  • 55.18 (n)
  • 48.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta rtet 35
  • 52.38 (n)
  • 44.47 (a)
rtet 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10D7.2 35
  • 48.93 (n)
  • 41.9 (a)
F10D7.2 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09098 35
  • 47.22 (n)
  • 34.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6758 36
  • 44 (a)
OneToOne
Species with no ortholog for MFSD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD10 Gene

ENSEMBL:
Gene Tree for MFSD10 (if available)
TreeFam:
Gene Tree for MFSD10 (if available)

Paralogs for MFSD10 Gene

Selected SIMAP similar genes for MFSD10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MFSD10: view

No data available for Paralogs for MFSD10 Gene

Variants for MFSD10 Gene

Sequence variations from dbSNP and Humsavar for MFSD10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1034400 -- 2,930,862(-) TACCC(A/G)GCACA synonymous-codon, reference, utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1263348 -- 2,931,544(+) GGAGG(A/G)AGCCC intron-variant
rs1263349 -- 2,932,581(+) CAAAG(A/G)CCCAG intron-variant
rs1419045 -- 2,935,758(-) TTAGG(A/C)AGAGG upstream-variant-2KB
rs2185885 -- 2,936,692(-) AAGCC(C/T)TTGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFSD10 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv461163 CNV Gain 19166990

Relevant External Links for MFSD10 Gene

HapMap Linkage Disequilibrium report
MFSD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD10 Gene

Disorders for MFSD10 Gene

(1) MalaCards Diseases for MFSD10 Gene

Search for MFSD10 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MFSD10 Gene

genes like me logo Genes that share disorders with MFSD10: view

No data available for UniProtKB/Swiss-Prot for MFSD10 Gene

Publications for MFSD10 Gene

  1. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. (PMID: 17362938) Mima S. … Mizushima T. (FEBS Lett. 2007) 2 3 4 23
  2. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. (PMID: 8353488) Duyao M.P. … Gusella J.F. (Hum. Mol. Genet. 1993) 2 3 4
  3. Expression and function of TETRAN, a new type of membrane transporter. (PMID: 18638446) Ushijima H. … Mizushima T. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for MFSD10 Gene

  • antibodies-online peptides for MFSD10
  • antibodies-online antibodies for MFSD10
  • antibodies-online kits for MFSD10

Sources for MFSD10 Gene

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