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Aliases for MFSD1 Gene

Aliases for MFSD1 Gene

  • Major Facilitator Superfamily Domain Containing 1 2 3
  • Smooth Muscle Cell-Associated Protein 4 3 4
  • SMAP4 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 1 3
  • SMAP-4 4

External Ids for MFSD1 Gene

Previous GeneCards Identifiers for MFSD1 Gene

  • GC03P160003
  • GC03P158449
  • GC03P155915

Summaries for MFSD1 Gene

GeneCards Summary for MFSD1 Gene

MFSD1 (Major Facilitator Superfamily Domain Containing 1) is a Protein Coding gene. Diseases associated with MFSD1 include intraductal papilloma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD1 Gene

Genomics for MFSD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MFSD1 Gene

158,732,198 bp from pter
158,829,719 bp from pter
97,522 bases
Plus strand

Genomic View for MFSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD1 Gene

Proteins for MFSD1 Gene

  • Protein details for MFSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Major facilitator superfamily domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DGJ8
    • B4DMR8
    • B4DU49
    • B4DWU1
    • C9JS94
    • J3KQL7
    • Q05C07
    • Q5XKJ1
    • Q8IVS1
    • Q8IXG4
    • Q9H7X1

    Protein attributes for MFSD1 Gene

    465 amino acids
    Molecular mass:
    51209 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30542.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAN76517.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB20269.1; Type=Frameshift; Positions=289, 296, 305; Evidence={ECO:0000305}; Sequence=BAG57809.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG59980.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD1 Gene

neXtProt entry for MFSD1 Gene

Proteomics data for MFSD1 Gene at MOPED

Post-translational modifications for MFSD1 Gene

  • Ubiquitination at Lys249, Lys255, and Lys460
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFSD1 Gene

Domains for MFSD1 Gene

Protein Domains for MFSD1 Gene


Suggested Antigen Peptide Sequences for MFSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H3U5
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD1: view

No data available for Gene Families for MFSD1 Gene

Function for MFSD1 Gene

Phenotypes for MFSD1 Gene

genes like me logo Genes that share phenotypes with MFSD1: view

Animal Model Products

CRISPR Products

miRNA for MFSD1 Gene

miRTarBase miRNAs that target MFSD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MFSD1 Gene

Localization for MFSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MFSD1 Gene COMPARTMENTS Subcellular localization image for MFSD1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MFSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD1: view

Pathways for MFSD1 Gene

SuperPathways for MFSD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD1: view

No data available for Pathways by source for MFSD1 Gene

Transcripts for MFSD1 Gene

Unigene Clusters for MFSD1 Gene

Major facilitator superfamily domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFSD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -

Relevant External Links for MFSD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD1 Gene

mRNA expression in normal human tissues for MFSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MFSD1 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFSD1 Gene

SOURCE GeneReport for Unigene cluster for MFSD1 Gene Hs.58663

genes like me logo Genes that share expressions with MFSD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MFSD1 Gene

Orthologs for MFSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFSD1 35
  • 99.35 (n)
  • 99.81 (a)
MFSD1 36
  • 100 (a)
(Bos Taurus)
Mammalia MFSD1 35
  • 90.25 (n)
  • 92.69 (a)
MFSD1 36
  • 92 (a)
(Canis familiaris)
Mammalia MFSD1 35
  • 91.83 (n)
  • 92.26 (a)
MFSD1 36
  • 92 (a)
(Mus musculus)
Mammalia Mfsd1 35
  • 85.49 (n)
  • 88.58 (a)
Mfsd1 16
Mfsd1 36
  • 89 (a)
(Monodelphis domestica)
Mammalia MFSD1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MFSD1 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Mfsd1 35
  • 85.7 (n)
  • 87.72 (a)
(Gallus gallus)
Aves MFSD1 35
  • 74.96 (n)
  • 80.7 (a)
MFSD1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia MFSD1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd1 35
  • 71.26 (n)
  • 76.44 (a)
(Danio rerio)
Actinopterygii CABZ01033130.1 36
  • 61 (a)
mfsd1 35
  • 67.4 (n)
  • 73.79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009523 35
  • 56.26 (n)
  • 56.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12194 35
  • 55.58 (n)
  • 54.87 (a)
CG12194 36
  • 47 (a)
CG8602 36
  • 48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7889 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8860 36
  • 64 (a)
Species with no ortholog for MFSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD1 Gene

Gene Tree for MFSD1 (if available)
Gene Tree for MFSD1 (if available)

Paralogs for MFSD1 Gene Pseudogenes for MFSD1 Gene

genes like me logo Genes that share paralogs with MFSD1: view

No data available for Paralogs for MFSD1 Gene

Variants for MFSD1 Gene

Sequence variations from dbSNP and Humsavar for MFSD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1381462 -- 158,801,174(+) AATCC(C/T)TGCAT upstream-variant-2KB
rs1381463 -- 158,805,171(+) ATTTT(C/T)CTGGG intron-variant
rs1381464 -- 158,806,802(+) CCTCC(A/G)GAATC intron-variant
rs1548092 -- 158,821,505(+) AAGCT(A/G)ATTAA intron-variant
rs1548093 -- 158,821,697(+) GAAGT(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD1 Gene

Variant ID Type Subtype PubMed ID
nsv877692 CNV Loss 21882294
nsv877693 CNV Gain 21882294

Relevant External Links for MFSD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD1 Gene

Disorders for MFSD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MFSD1 Gene including...

Search for MFSD1 Gene in MalaCards »
genes like me logo Genes that share disorders with MFSD1: view

No data available for UniProtKB/Swiss-Prot for MFSD1 Gene

Publications for MFSD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PMID: 21752829) Palmieri M. … Ballabio A. (Hum. Mol. Genet. 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for MFSD1 Gene

Sources for MFSD1 Gene

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