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MFRP Gene

protein-coding GIFtS: 46
GCID: GC11M119218

Membrane Frizzled-Related Protein

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Membrane Frizzled-Related Protein¹ ²
Membrane-Type Frizzled-Related Protein¹ ² ³
MCOP5² ⁵
NNO2² ⁵
Complement C1q Tumor Necrosis Factor-Related Protein 5 Precursor Variant 1¹
RD6²

External Ids:	HGNC: 18121¹	Entrez Gene: 83552²	Ensembl: ENSG00000235718⁷	OMIM: 606227⁵	UniProtKB: Q9BY79³

Export aliases for MFRP gene to outside databases

Previous GC identifers: GC11M121209 GC11M120722 GC11M119244 GC11M118749 GC11M118714 GC11M115150

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MFRP Gene:

This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in

eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia,

retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript

which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). (provided by RefSeq, Jun 2013)

GeneCards Summary for MFRP Gene:

MFRP (membrane frizzled-related protein) is a protein-coding gene. Diseases associated with MFRP include nanophthalmos 2, and isolated microphthalmia 5. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Wiki entry for MFRP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for MFRP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFRP promoter sequence

Search Chromatin IP Primers for MFRP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

MFRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFRP gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M119218: view genomic region (about GC identifiers)

Start:	119,209,652 bp from pter	End:	119,217,383 bp from pter
Size:	7,732 bases	Orientation:	minus strand

1 alternative location:

Chr11- 119,209,652-119,217,368

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79 (See protein sequence)

Recommended Name: Membrane frizzled-related protein

Size: 579 amino acids; 62212 Da

Developmental stage: Expressed in fetal brain

Miscellaneous: This protein is produced by a bicistronic gene which also produces the C1QTNF5 protein from a

non-overlapping reading frame

Secondary accessions: B0YJ36 B0YJ37 Q335M3 Q96DQ9

Alternative splicing: 2 isoforms: Q9BY79-1 Q9BY79-2

Explore the universe of human proteins at neXtProt for MFRP: NX_Q9BY79

Explore proteomics data for MFRP at MOPED

Post-translational modifications:

Glycosylation² at Asn227, Asn415

See MFRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_113621.1

ENSEMBL proteins:

ENSP00000391664 ENSP00000353291 ENSP00000450509

MFRP Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR023415 LDLR_class-A_CS

IPR020067 Frizzled_dom

IPR000859 CUB_dom

IPR002172 LDrepeatLR_classA_rpt

Graphical View of Domain Structure for InterPro Entry Q9BY79

ProtoNet protein and cluster: Q9BY79

2 Blocks protein domains:

IPB000859 CUB domain

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Similarity: Contains 2 CUB domains

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 2 LDL-receptor class A domains

MFRP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	--	--

MFRP for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mfrp):

nervous system

pigmentation

vision/eye

MFRP for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFRP

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFRP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFRP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFRP

miRNA Products:		Block miRNA regulation of human, mouse, rat MFRP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MFRP (see all 10):
		hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185

		SwitchGear 3'UTR luciferase reporter plasmid: MFRP 3' UTR sequence

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MFRP_HUMAN, Q9BY79: Membrane; Single-pass type II membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	4
plasma membrane	3
cytosol	1
endoplasmic reticulum	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	TAS	11263980

MFRP for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MFRP
Interactions:

Search GeneGlobe Interaction Network for MFRP

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for MFRP (Q9BY79³ ENSP00000391664⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
SLC2A4	P14672³	I2D: score=1
C1QTNF5	ENSP00000402389⁴	STRING: ENSP00000402389

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009790	embryo development	NAS	11263980

MFRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MFRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MFRP gene:

NM_031433.3

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449574(uc010rzg.1) ENST00000360167 ENST00000529147 ENST00000526059

ENST00000555262(uc001pwj.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat MFRP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MFRP (see all 10):
		hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185

		SwitchGear 3'UTR luciferase reporter plasmid: MFRP 3' UTR sequence

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		QuantiFast Probe-based Assays in human, mouse, rat MFRP

Selected AceView cDNA sequences (see all 96):

BM966954 AI783751 AI619600 BM722889 BM893691 BM021381 BM924569 AB055505

BM893587 CA397875 CK904254 BM052913 AI805087 AL110261 AF086482 BM544255

BM684116 BM966810 BM929480 CA390714 NM_015645 BU742804 CF994392 BM673416

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MFRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MFRP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MFRP Protein Expression

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Tissue specificity: Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent

in hippocampus and corpus callosum. Expressed in keratinocytes

Custom PCR Arrays for MFRP

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		QuantiFast Probe-based Assays in human, mouse, rat MFRP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MFRP gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mfrp^{1 , 5}	membrane-type frizzled-related protein^{1, 5}	77.85(n)¹ 69.72(a)¹		9 (24.60 cM)⁵ 259172¹ NM_147126.3¹ NP_667337.1¹ 44101738⁵
chicken (Gallus gallus)	Aves	MFRP¹	membrane frizzled-related protein	62.15(n) 52.78(a)		100859299 XM_003642601.2 XP_003642649.2
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	53(a)	1 → many	GL343797.1(1526-16473)
zebrafish (Danio rerio)	Actinopterygii	LOC101885305¹	membrane frizzled-related protein-like	56.37(n) 48.44(a)		101885305 XM_005173345.1 XP_005173402.1
fruit fly (Drosophila melanogaster)	Insecta	CG42255⁶ CG32702⁶	--	3(a) 3(a)	many ↔ many many ↔ many	3L(11795051-11807855) X(9452698-9465341)
worm (Caenorhabditis elegans)	Secernentea	ZC116.3⁶	Protein ZC116.3 (ZC116.3) mRNA, complete cds	3(a)	1 → many	V(12611329-12628738) WBGene00013855

ENSEMBL Gene Tree for MFRP (if available)
TreeFam Gene Tree for MFRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MFRP gene

TLL2² CUBN² CDCP2² PCOLCE² BMP1² PCOLCE2² NETO2² NETO1²

TLL1²

1 SIMAP similar gene for MFRP using alignment to 2 protein entries: MFRP_HUMAN (see all proteins):

CUBN

MFRP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
VAR_025694⁴	Nanophthalmos 2 (NNO2)⁴	--	see VAR_025694	2	I T	mis⁴		0	--	--	--	--
VAR_025695⁴	--	--	see VAR_025695	2	G S	mis⁴		0	--	--	--	--
rs3814762^1,2,4	--	--	see VAR_025693	2		mis⁴		0	--	--	--	--
rs4639950^1,2,4	--	--	see VAR_025692	2		mis⁴		0	--	--	--	--
VAR_025696⁴	--	--	see VAR_025696	2	Q H	mis⁴		0	--	--	--	--
rs139436396^1,2,4	--	--	see VAR_025691	2		mis⁴		0	--	--	--	--

HapMap Linkage Disequilibrium report for MFRP (119209652 - 119217383 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MFRP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv898417	CNV	Loss	21882294
nsv898418	CNV	Loss	21882294
nsv826103	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): MFRP

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MFRP

DNA2.0 Custom Variant and Variant Library Synthesis for MFRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606227
OMIM disorders: 611040 609549
UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Nanophthalmos 2 (NNO2) [MIM:609549]: Rare autosomal recessive disorder of eye development characterized

by extreme hyperopia and small functional eyes. Note=The disease is caused by mutations affecting the gene

represented in this entry

Microphthalmia, isolated, 5 (MCOP5) [MIM:611040]: A disorder characterized by posterior microphthalmia,

retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging

from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like

opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.

Note=The disease is caused by mutations affecting the gene represented in this entry

Selected diseases for MFRP (see all 21):
About MalaCards

nanophthalmos 2 isolated microphthalmia 5 optic disk drusen primary angle-closure glaucoma

isolated microphthalmia late-onset retinal degeneration pigmentary retinopathy hyperopia

microphthalmia cone dystrophy retinal degeneration age related macular degeneration

retinitis pigmentosa myopia retinitis fanconi's anemia

choroiditis glaucoma cataract multiple myeloma

4 diseases from the University of Copenhagen DISEASES database for MFRP:

Optic disk drusen Microphthalmia Hyperopia Retinal degeneration

MFRP for disorders About GeneDecksing

3 Novoseek inferred disease relationships for MFRP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinal degeneration	70.6	7	17122143 (2), 12140190 (1), 16352475 (1), 17167404 (1)
retinitis pigmentosa	68.3	1	17167404 (1)
tumors	0	2	11263980 (1), 17122143 (1)

Genetic Association Database (GAD): MFRP
Human Genome Epidemiology (HuGE) Navigator: MFRP (3 documents)

Export disorders for MFRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MFRP gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with MFRP)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type frizzled-related protein. (PubMed id 11263980)^{1, 2, 3, 9} Katoh M. (Biochem. Biophys. Res. Commun. 2001)
Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. (PubMed id 18334955)^{1, 4, 9} Metlapally R....Young T.L. (Mol. Vis. 2008)
Evaluation of MFRP as a candidate gene for high hyperopia. (PubMed id 19169412)^{1, 4, 9} Wang P....Zhang Q. (Mol. Vis. 2009)
A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation. (PubMed id 17167404)^{1, 2, 9} Ayala-Ramirez R.... Zenteno J.C. (Mol. Vis. 2006)
Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes. (PubMed id 18648522)^{1, 4, 9} Aung T....Vithana E.N. (Mol. Vis. 2008)
Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. (PubMed id 16352475)^{1, 2, 9} Pauer G.J.T.... Hagstrom S.A. (Ophthalmic Genet. 2005)
Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. (PubMed id 16442268)^{1, 2} Yang L.... Hashimoto K. (J. Dermatol. Sci. 2006)
Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein. (PubMed id 15976030)^{1, 2} Sundin O.H.... Weinberg E.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
Sequencing arrays for screening multiple genes associated with early- onset human retinal degenerations on a high-throughput platform. (PubMed id 16123440)^{1, 2} Mandal M.N.A.... Ayyagari R. (Invest. Ophthalmol. Vis. Sci. 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83552	HGNC: 18121	AceView: C1QTNF5andMFRP	Ensembl:ENSG00000235718	euGenes: HUgn83552
ECgene: MFRP	H-InvDB: MFRP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MFRP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MFRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MFRP gene:
Search GeneIP for patents involving MFRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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MFRP Gene

Membrane Frizzled-Related Protein

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MFRP Gene

Membrane Frizzled-Related Protein

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