Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

MFRP Gene

protein-coding GIFtS: 46
GCID: GC11M119218

Membrane Frizzled-Related Protein

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Membrane Frizzled-Related Protein¹ ²
Membrane-Type Frizzled-Related Protein¹ ² ³
MCOP5² ⁵
NNO2² ⁵
Complement C1q Tumor Necrosis Factor-Related Protein 5 Precursor Variant 1¹
RD6²

External Ids:	HGNC: 18121¹	Entrez Gene: 83552²	Ensembl: ENSG00000235718⁷	OMIM: 606227⁵	UniProtKB: Q9BY79³

Export aliases for MFRP gene to outside databases

Previous GC identifers: GC11M121209 GC11M120722 GC11M119244 GC11M118749 GC11M118714 GC11M115150

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MFRP Gene:

This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in

eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia,

retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript

which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). (provided by RefSeq, Jun 2013)

GeneCards Summary for MFRP Gene:

MFRP (membrane frizzled-related protein) is a protein-coding gene. Diseases associated with MFRP include nanophthalmos 2, and isolated microphthalmia 5. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Wiki entry for MFRP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

Regulatory elements:

Search for regulatory transcription factor binding sites for MFRP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFRP promoter sequence

Search Chromatin IP Primers for MFRP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

MFRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFRP gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M119218: view genomic region (about GC identifiers)

Start:	119,209,652 bp from pter	End:	119,217,383 bp from pter
Size:	7,732 bases	Orientation:	minus strand

1 alternative location:

Chr11- 119,209,652-119,217,368

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79 (See protein sequence)

Recommended Name: Membrane frizzled-related protein

Size: 579 amino acids; 62212 Da

Developmental stage: Expressed in fetal brain

Miscellaneous: This protein is produced by a bicistronic gene which also produces the C1QTNF5 protein from a

non-overlapping reading frame

Secondary accessions: B0YJ36 B0YJ37 Q335M3 Q96DQ9

Alternative splicing: 2 isoforms: Q9BY79-1 Q9BY79-2

Explore the universe of human proteins at neXtProt for MFRP: NX_Q9BY79

Explore proteomics data for MFRP at MOPED

Post-translational modifications:

Glycosylation² at Asn227, Asn415

See MFRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_113621.1

ENSEMBL proteins:

ENSP00000391664 ENSP00000353291 ENSP00000450509

MFRP Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MFRP
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for MFRP OriGene Protein Over-expression Lysate for MFRP OriGene Custom MassSpec OriGene Custom Protein Services for MFRP
	GenScript Custom Purified and Recombinant Proteins Services for MFRP
	Novus Biologicals MFRP Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MFRP

MFRP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for MFRP
	Browse OriGene Antibodies OriGene Custom Antibody Services for MFRP
	Novus Biologicals MFRP Antibodies
	Abcam antibodies for MFRP
	Cloud-Clone Corp. Antibodies for MFRP
	Search ThermoFisher Antibodies for MFRP
	LSBio Antibodies in human, mouse, rat for MFRP

MFRP Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MFRP
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MFRP
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MFRP Cloud-Clone Corp. CLIAs for MFRP

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

4 InterPro protein domains:

IPR023415 LDLR_class-A_CS

IPR020067 Frizzled_dom

IPR000859 CUB_dom

IPR002172 LDrepeatLR_classA_rpt

Graphical View of Domain Structure for InterPro Entry Q9BY79

ProtoNet protein and cluster: Q9BY79

2 Blocks protein domains:

IPB000859 CUB domain

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Similarity: Contains 2 CUB domains

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 2 LDL-receptor class A domains

MFRP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	--	--

MFRP for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mfrp):

nervous system

pigmentation

vision/eye

MFRP for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFRP

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFRP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFRP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFRP

miRNA Products:		Block miRNA regulation of human, mouse, rat MFRP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MFRP (see all 10):
		hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185

		SwitchGear 3'UTR luciferase reporter plasmid: MFRP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MFRP
		Predesigned siRNA for gene silencing in human, mouse, rat MFRP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MFRP

Clone Products:		OriGene clones in human, mouse for MFRP (see all 6) OriGene ORF clones in mouse, rat for MFRP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MFRP (NM_031433)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MFRP
		Browse ESI BIO Cell Lines and PureStem Progenitors for MFRP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

MFRP_HUMAN, Q9BY79: Membrane; Single-pass type II membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	4
plasma membrane	3
cytosol	1
endoplasmic reticulum	1
nucleus	1
peroxisome	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	TAS	11263980

MFRP for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MFRP
Interactions:

Search GeneGlobe Interaction Network for MFRP

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for MFRP (Q9BY79³ ENSP00000391664⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
SLC2A4	P14672³	I2D: score=1
C1QTNF5	ENSP00000402389⁴	STRING: ENSP00000402389

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009790	embryo development	NAS	11263980

MFRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MFRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for MFRP gene:

NM_031433.3

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449574(uc010rzg.1) ENST00000360167 ENST00000529147 ENST00000526059

ENST00000555262(uc001pwj.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat MFRP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MFRP (see all 10):
		hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185

		SwitchGear 3'UTR luciferase reporter plasmid: MFRP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MFRP
		Predesigned siRNA for gene silencing in human, mouse, rat MFRP

Clone Products:		OriGene clones in human, mouse for MFRP (see all 6) OriGene ORF clones in mouse, rat for MFRP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MFRP (NM_031433)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MFRP
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat MFRP
		QuantiTect SYBR Green Assays in human, mouse, rat MFRP
		QuantiFast Probe-based Assays in human, mouse, rat MFRP

Selected AceView cDNA sequences (see all 96):

BM966954 AI783751 AI619600 BM722889 BM893691 BM021381 BM924569 AB055505

BM893587 CA397875 CK904254 BM052913 AI805087 AL110261 AF086482 BM544255

BM684116 BM966810 BM929480 CA390714 NM_015645 BU742804 CF994392 BM673416

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

MFRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MFRP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MFRP Protein Expression

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Tissue specificity: Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent

in hippocampus and corpus callosum. Expressed in keratinocytes

Custom PCR Arrays for MFRP

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MFRP
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat MFRP
		QuantiTect SYBR Green Assays in human, mouse, rat MFRP
		QuantiFast Probe-based Assays in human, mouse, rat MFRP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for MFRP gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mfrp^{1 , 5}	membrane-type frizzled-related protein^{1, 5}	77.85(n)¹ 69.72(a)¹		9 (24.60 cM)⁵ 259172¹ NM_147126.3¹ NP_667337.1¹ 44101738⁵
chicken (Gallus gallus)	Aves	MFRP¹	membrane frizzled-related protein	62.15(n) 52.78(a)		100859299 XM_003642601.2 XP_003642649.2
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	53(a)	1 → many	GL343797.1(1526-16473)
zebrafish (Danio rerio)	Actinopterygii	LOC101885305¹	membrane frizzled-related protein-like	56.37(n) 48.44(a)		101885305 XM_005173345.1 XP_005173402.1
fruit fly (Drosophila melanogaster)	Insecta	CG42255⁶ CG32702⁶	--	3(a) 3(a)	many ↔ many many ↔ many	3L(11795051-11807855) X(9452698-9465341)
worm (Caenorhabditis elegans)	Secernentea	ZC116.3⁶	Protein ZC116.3 (ZC116.3) mRNA, complete cds	3(a)	1 → many	V(12611329-12628738) WBGene00013855

ENSEMBL Gene Tree for MFRP (if available)
TreeFam Gene Tree for MFRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for MFRP gene

TLL2² CUBN² CDCP2² PCOLCE² BMP1² PCOLCE2² NETO2² NETO1²

TLL1²

1 SIMAP similar gene for MFRP using alignment to 2 protein entries: MFRP_HUMAN (see all proteins):

CUBN

MFRP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
VAR_025694⁴	Nanophthalmos 2 (NNO2)⁴	--	see VAR_025694	2	I T	mis⁴		0	--	--	--	--
VAR_025695⁴	--	--	see VAR_025695	2	G S	mis⁴		0	--	--	--	--
rs3814762^1,2,4	--	--	see VAR_025693	2		mis⁴		0	--	--	--	--
rs4639950^1,2,4	--	--	see VAR_025692	2		mis⁴		0	--	--	--	--
VAR_025696⁴	--	--	see VAR_025696	2	Q H	mis⁴		0	--	--	--	--
rs139436396^1,2,4	--	--	see VAR_025691	2		mis⁴		0	--	--	--	--

HapMap Linkage Disequilibrium report for MFRP (119209652 - 119217383 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MFRP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv898417	CNV	Loss	21882294
nsv898418	CNV	Loss	21882294
nsv826103	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): MFRP

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MFRP

DNA2.0 Custom Variant and Variant Library Synthesis for MFRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 606227
OMIM disorders: 611040 609549
UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Nanophthalmos 2 (NNO2) [MIM:609549]: Rare autosomal recessive disorder of eye development characterized

by extreme hyperopia and small functional eyes. Note=The disease is caused by mutations affecting the gene

represented in this entry

Microphthalmia, isolated, 5 (MCOP5) [MIM:611040]: A disorder characterized by posterior microphthalmia,

retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging

from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like

opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.

Note=The disease is caused by mutations affecting the gene represented in this entry

Selected diseases for MFRP (see all 21): About MalaCards

nanophthalmos 2 isolated microphthalmia 5 optic disk drusen primary angle-closure glaucoma

isolated microphthalmia late-onset retinal degeneration pigmentary retinopathy hyperopia

microphthalmia cone dystrophy retinal degeneration age related macular degeneration

retinitis pigmentosa myopia retinitis fanconi's anemia

choroiditis glaucoma cataract multiple myeloma

4 diseases from the University of Copenhagen DISEASES database for MFRP:

Optic disk drusen Microphthalmia Hyperopia Retinal degeneration

MFRP for disorders About GeneDecksing

3 Novoseek inferred disease relationships for MFRP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinal degeneration	70.6	7	17122143 (2), 12140190 (1), 16352475 (1), 17167404 (1)
retinitis pigmentosa	68.3	1	17167404 (1)
tumors	0	2	11263980 (1), 17122143 (1)

Genetic Association Database (GAD): MFRP
Human Genome Epidemiology (HuGE) Navigator: MFRP (3 documents)

Export disorders for MFRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for MFRP gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with MFRP)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type frizzled-related protein. (PubMed id 11263980)^{1, 2, 3, 9} Katoh M. (Biochem. Biophys. Res. Commun. 2001)
Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. (PubMed id 18334955)^{1, 4, 9} Metlapally R....Young T.L. (Mol. Vis. 2008)
Evaluation of MFRP as a candidate gene for high hyperopia. (PubMed id 19169412)^{1, 4, 9} Wang P....Zhang Q. (Mol. Vis. 2009)
A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation. (PubMed id 17167404)^{1, 2, 9} Ayala-Ramirez R.... Zenteno J.C. (Mol. Vis. 2006)
Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes. (PubMed id 18648522)^{1, 4, 9} Aung T....Vithana E.N. (Mol. Vis. 2008)
Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. (PubMed id 16352475)^{1, 2, 9} Pauer G.J.T.... Hagstrom S.A. (Ophthalmic Genet. 2005)
Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. (PubMed id 16442268)^{1, 2} Yang L.... Hashimoto K. (J. Dermatol. Sci. 2006)
Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein. (PubMed id 15976030)^{1, 2} Sundin O.H.... Weinberg E.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
Sequencing arrays for screening multiple genes associated with early- onset human retinal degenerations on a high-throughput platform. (PubMed id 16123440)^{1, 2} Mandal M.N.A.... Ayyagari R. (Invest. Ophthalmol. Vis. Sci. 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 83552	HGNC: 18121	AceView: C1QTNF5andMFRP	Ensembl:ENSG00000235718	euGenes: HUgn83552
ECgene: MFRP	H-InvDB: MFRP

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for MFRP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MFRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for MFRP gene:
Search GeneIP for patents involving MFRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Antibodies for MFRP (MFRP)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Recombinant/Natural Proteins for MFRP (MFRP)		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for MFRP
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for MFRP
	OriGene Custom Mass Spec		OriGene clones in human, mouse for MFRP
	OriGene qSTAR qPCR primer pairs in human, mouse for MFRP		OriGene Purified Protein for MFRP
	OriGene ORF clones in mouse, rat for MFRP		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MFRP		OriGene Custom Protein Services for MFRP

	Block miRNA regulation of human, mouse, rat MFRP using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing MFRP
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFRP		Predesigned siRNA for gene silencing in human, mouse, rat MFRP
	QuantiFast Probe-based Assays in human, mouse, rat MFRP		QuantiTect SYBR Green Assays in human, mouse, rat MFRP
	Custom PCR Arrays for MFRP		Search Chromatin IP Primers for MFRP
	Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat MFRP		Search GeneGlobe Interaction Network for MFRP
	Search Regulatory tfbs for MFRP

	GenScript Custom Purified and Recombinant Proteins Services for MFRP		GenScript cDNA clones with any tag delivered in your preferred vector for MFRP
	GenScript Custom Assay Services for MFRP		GenScript Custom overexpressing Cell Line Services for MFRP
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for MFRP

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MFRP antibodies
	MFRP proteins

	Antibodies for MFRP
	See all of Abcam's Antibodies, Kits and Proteins for MFRP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for MFRP
	Antibodies for MFRP
	ELISAs for MFRP
	CLIAs for MFRP

Browse ESI BIO Cell Lines and PureStem Progenitors for MFRP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

	SwitchGear 3'UTR luciferase reporter plasmids for MFRP
	SwitchGear Promoter luciferase reporter plasmids for MFRP

Search ThermoFisher Antibodies for MFRP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFRP
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFRP

LSBio Antibodies in human, mouse, rat for MFRP

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MFRP gene at Home site.

Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

MFRP Gene

Membrane Frizzled-Related Protein

Aliases
for MFRP gene

Summaries
for MFRP gene

Genomic Views
for MFRP gene

Proteins
for MFRP gene

MFRP Human Recombinant Protein Products:

MFRP Antibody Products:

MFRP Assay Products:

Domains /
Families
for MFRP gene

Function
for MFRP gene

Localization
for MFRP gene

Pathways & Interactions
for MFRP gene

Drugs & Compounds
for MFRP gene

Transcripts
for MFRP gene

Expression
for MFRP gene

Orthologs
for MFRP gene

Paralogs
for MFRP gene

Genomic Variants
for MFRP gene

Disorders / Diseases
for MFRP gene

Publications
for MFRP gene

External Searches for MFRP gene

Genome Databases showing MFRP gene

Other Databases showing MFRP gene

Specialized Databases showing MFRP gene

Intellectual Property
for MFRP gene

Products
for MFRP gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

MFRP Gene

Membrane Frizzled-Related Protein

Aliasesfor MFRP gene

Summariesfor MFRP gene

Genomic Viewsfor MFRP gene

Proteinsfor MFRP gene

MFRP Human Recombinant Protein Products:

MFRP Antibody Products:

MFRP Assay Products:

Domains /Familiesfor MFRP gene

Functionfor MFRP gene

Localizationfor MFRP gene

Pathways & Interactionsfor MFRP gene

Drugs & Compoundsfor MFRP gene

Transcriptsfor MFRP gene

Expression for MFRP gene

Orthologsfor MFRP gene

Paralogsfor MFRP gene

Genomic Variantsfor MFRP gene

Disorders / Diseasesfor MFRP gene

Publicationsfor MFRP gene

External Searches for MFRP gene

Genome Databases showing MFRP gene

Other Databases showing MFRP gene

Specialized Databases showing MFRP gene

Intellectual Propertyfor MFRP gene

Productsfor MFRP gene

View Random Gene

Aliases
for MFRP gene

Summaries
for MFRP gene

Genomic Views
for MFRP gene

Proteins
for MFRP gene

Domains /
Families
for MFRP gene

Function
for MFRP gene

Localization
for MFRP gene

Pathways & Interactions
for MFRP gene

Drugs & Compounds
for MFRP gene

Transcripts
for MFRP gene

Expression
for MFRP gene

Orthologs
for MFRP gene

Paralogs
for MFRP gene

Genomic Variants
for MFRP gene

Disorders / Diseases
for MFRP gene

Publications
for MFRP gene

Intellectual Property
for MFRP gene

Products
for MFRP gene