Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFRP Gene

protein-coding   GIFtS: 46
GCID: GC11M119244

Membrane Frizzled-Related Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane Frizzled-Related Protein1 2
Membrane-Type Frizzled-Related Protein1 2 3
MCOP52 5
Complement C1q Tumor Necrosis Factor-Related Protein 5 Precursor Variant 11
NNO22
RD62

External Ids:    HGNC: 181211   Entrez Gene: 835522   Ensembl: ENSG000002357187   OMIM: 6062275   UniProtKB: Q9BY793   

Export aliases for MFRP gene to outside databases

Previous GC identifers: GC11M121209 GC11M120722 GC11M118749 GC11M118714 GC11M115150


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFRP Gene:
This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in
eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia,
retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript
which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). (provided by RefSeq, Jun 2013)

GeneCards Summary for MFRP Gene: 
MFRP (membrane frizzled-related protein) is a protein-coding gene. Diseases associated with MFRP include microphthalmia, and optic disk drusen. GO annotations related to this gene include molecular_function. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79
Function: May play a role in eye development

Gene Wiki entry for MFRP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MFRP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFRP promoter sequence
   Search SABiosciences Chromatin IP Primers for MFRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

MFRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFRP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119244:  view genomic region     (about GC identifiers)

Start:
119,209,652 bp from pter      End:
119,217,383 bp from pter
Size:
7,732 bases      Orientation:
minus strand

1 alternative location:
Chr11- 119,209,652-119,217,368     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79 (See protein sequence)
Recommended Name: Membrane frizzled-related protein  
Size: 579 amino acids; 62212 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Developmental stage: Expressed in fetal brain
Miscellaneous: This protein is produced by a bicistronic gene which also produces the C1QTNF5 protein from a
non-overlapping reading frame
Secondary accessions: B0YJ36 B0YJ37 Q335M3 Q96DQ9
Alternative splicing: 2 isoforms:  Q9BY79-1   Q9BY79-2   

Explore the universe of human proteins at neXtProt for MFRP: NX_Q9BY79

Explore proteomics data for MFRP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BY79

  • MFRP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MFRP Protein Expression
    REFSEQ proteins: NP_113621.1  
    ENSEMBL proteins: 
     ENSP00000391664   ENSP00000353291   ENSP00000450509  

    Human Recombinant Protein Products for MFRP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MFRP
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MFRP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MFRP
    GenScript Custom Purified and Recombinant Proteins Services for MFRP
    Novus Biologicals MFRP Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MFRP 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane TAS11263980

    MFRP for ontologies           About GeneDecksing



    MFRP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MFRP
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MFRP
    GenScript Custom Superior Antibodies Services for MFRP
    Novus Biologicals MFRP Antibodies
    Abcam antibodies for MFRP
    Cloud-Clone Corp. Antibodies for MFRP 
    Search ThermoFisher Antibodies for MFRP
    LSBio Antibodies in human, mouse, rat for MFRP 

    Assay Products for MFRP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MFRP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MFRP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MFRP 
    Cloud-Clone Corp. CLIAs for MFRP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR023415 LDLR_class-A_CS
     IPR020067 Frizzled_dom
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR027122 MFRP

    Graphical View of Domain Structure for InterPro Entry Q9BY79

    ProtoNet protein and cluster: Q9BY79

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 2 LDL-receptor class A domains


    MFRP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFRP_HUMAN, Q9BY79
    Function: May play a role in eye development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    MFRP for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mfrp):
     nervous system  pigmentation  vision/eye 

    MFRP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MFRP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MFRP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFRP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFRP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFRP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MFRP (see all 10):
    hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidMFRP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MFRP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFRP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MFRP
    Sirion Biotech Customized adenovirus for overexpression of MFRP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MFRP (see all 7)
    OriGene ORF clones in mouse, rat for MFRP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MFRP (NM_031433)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP
    Sirion Biotech Customized lentivirus for stable overexpression of MFRP 
                         Customized lentivirus expression plasmids for stable overexpression of MFRP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MFRP
    Search LifeMap BioReagents cell lines for MFRP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFRP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MFRP (Q9BY793 ENSP000003916644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SLC2A4P146723I2D: score=1 
    C1QTNF5ENSP000004023894STRING: ENSP00000402389
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009790embryo development NAS11263980

    MFRP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFRP

    Search CenterWatch for drugs/clinical trials and news about MFRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MFRP gene: 
    NM_031433.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449574(uc010rzg.1) ENST00000360167 ENST00000529147 ENST00000526059
    ENST00000555262(uc001pwj.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFRP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MFRP (see all 10):
    hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidMFRP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MFRP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFRP
    Clone
    Products:
         
    OriGene clones in human, mouse for MFRP (see all 7)
    OriGene ORF clones in mouse, rat for MFRP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MFRP (NM_031433)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP
    Sirion Biotech Customized lentivirus for stable overexpression of MFRP 
                         Customized lentivirus expression plasmids for stable overexpression of MFRP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MFRP
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MFRP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFRP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFRP

    24/96 AceView cDNA sequences (see all 96):

    BM021381 BM893691 BM966810 BM021127 BM924569 BM673416 AI924106 AL110261 
    BM684116 AI805087 BM966954 CF994392 AI783751 BU742804 BM052913 BF724241 
    CK904254 AI619600 BE138819 AW190639 NM_031433 CA390714 BM722889 AB055505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MFRP Expression
    About this image


    See MFRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFRP

    UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79
    Tissue specificity: Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent
    in hippocampus and corpus callosum. Expressed in keratinocytes

        SABiosciences Custom PCR Arrays for MFRP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MFRP
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MFRP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFRP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFRP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MFRP gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfrp1 , 5 membrane-type frizzled-related protein1, 5 78.2(n)1
    70.24(a)1
      9 (24.60 cM)5
    2591721  NM_147126.31  NP_667337.11 
     441017385 
    chicken
    (Gallus gallus)
    Aves LOC1008592991 membrane frizzled-related protein-like 63.63(n)
    54.27(a)
      100859299  XM_003642601.1  XP_003642649.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    53(a)
    1 → many
    GL343797.1(1526-16473)
    zebrafish
    (Danio rerio)
    Actinopterygii MFRP6
    membrane frizzled-related protein
    49(a)
    1 → many
    15(148682-156045)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG327026
    CG422556
    --
    2(a)
    2(a)
    possible ortholog
    possible ortholog
    X(9452698-9465341)
    3L(11795051-11807855)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC116.36
    Probable cubilin
    2(a)
    possible ortholog
    V(12611329-12628738)


    ENSEMBL Gene Tree for MFRP (if available)
    TreeFam Gene Tree for MFRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFRP gene
    TLL22  CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  NETO22  NETO12  
    TLL12  
    1 SIMAP similar gene for MFRP using alignment to 2 protein entries:     MFRP_HUMAN (see all proteins):
    CUBN

    MFRP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in MFRP are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0256944
    Nanophthalmos 2 (NNO2)4--see VAR_0256942 I T mis40--------
    VAR_0256954
    ----see VAR_0256952 G S mis40--------
    VAR_0256934
    ----see VAR_0256932 V M mis40--------
    VAR_0256924
    ----see VAR_0256922 I V mis40--------
    VAR_0256964
    ----see VAR_0256962 Q H mis40--------
    VAR_0256914
    ----see VAR_0256912 R G mis40--------

    HapMap Linkage Disequilibrium report for MFRP (119209652 - 119217383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MFRP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898417CNV Loss21882294
    nsv898418CNV Loss21882294
    nsv826103CNV Gain20364138


    Human Gene Mutation Database (HGMD): MFRP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MFRP
    DNA2.0 Custom Variant and Variant Library Synthesis for MFRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606227   
    OMIM disorders: 611040  
    UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79
  • Nanophthalmos 2 (NNO2) [MIM:609549]: Rare autosomal recessive disorder of eye development characterized
    by extreme hyperopia and small functional eyes. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Microphthalmia, isolated, 5 (MCOP5) [MIM:611040]: A disorder characterized by posterior microphthalmia,
    retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging
    from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like
    opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 19 diseases for MFRP:    About MalaCards
    microphthalmia    optic disk drusen    primary angle-closure glaucoma    late-onset retinal degeneration
    isolated microphthalmia    isolated microphthalmia 5    hyperopia    pigmentary retinopathy
    retinal degeneration    age related macular degeneration    macular degeneration    retinitis pigmentosa
    glaucoma    myopia    retinitis    fanconi's anemia
    choroiditis    cataract    anemia

    4 diseases from the University of Copenhagen DISEASES database for MFRP:
    Optic disk drusen     Microphthalmia     Hyperopia     Retinal degeneration

    MFRP for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MFRP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 70.6 7 17122143 (2), 12140190 (1), 16352475 (1), 17167404 (1)
    retinitis pigmentosa 68.3 1 17167404 (1)
    tumors 0 2 11263980 (1), 17122143 (1)

    Genetic Association Database (GAD): MFRP
    Human Genome Epidemiology (HuGE) Navigator: MFRP (3 documents)

    Export disorders for MFRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFRP gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with MFRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type frizzled-related protein. (PubMed id 11263980)1, 2, 3, 9 Katoh M. (2001)
    2. Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. (PubMed id 18334955)1, 4, 9 Metlapally R....Young T.L. (2008)
    3. Evaluation of MFRP as a candidate gene for high hyperopia. (PubMed id 19169412)1, 4, 9 Wang P....Zhang Q. (2009)
    4. A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation. (PubMed id 17167404)1, 2, 9 Ayala-Ramirez R.... Zenteno J.C. (2006)
    5. Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes. (PubMed id 18648522)1, 4, 9 Aung T....Vithana E.N. (2008)
    6. Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. (PubMed id 16352475)1, 2, 9 Pauer G.J.T.... Hagstrom S.A. (2005)
    7. Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. (PubMed id 16442268)1, 2 Yang L.... Hashimoto K. (2006)
    8. Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein. (PubMed id 15976030)1, 2 Sundin O.H.... Weinberg E.M. (2005)
    9. Sequencing arrays for screening multiple genes associated with early- onset human retinal degenerations on a high-throughput platform. (PubMed id 16123440)1, 2 Mandal M.N.A.... Ayyagari R. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83552 HGNC: 18121 AceView: C1QTNF5andMFRP Ensembl:ENSG00000235718 euGenes: HUgn83552
    ECgene: MFRP H-InvDB: MFRP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFRP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MFRP gene:
    Search GeneIP for patents involving MFRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MFRP (MFRP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for MFRP (MFRP)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MFRP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MFRP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MFRP  
     OriGene qSTAR qPCR primer pairs in human, mouse for MFRP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MFRP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MFRP   OriGene Custom Protein Services for MFRP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFRP
     QIAGEN SeqTarget long-range PCR primers for resequencing MFRP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFRP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFRP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFRP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFRP
     GenScript Custom Purified and Recombinant Proteins Services for MFRP GenScript cDNA clones with any tag delivered in your preferred vector for MFRP
     GenScript Custom Assay Services for MFRP GenScript Custom Superior Antibodies Services for MFRP
     GenScript Custom overexpressing Cell Line Services for MFRP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for MFRP
     Search Chromatin IP Primers for MFRP
     Search RT2 qPCR Primer Assays in human, mouse, rat MFRP
     Search GNC Networks for MFRP
     SABiosciences Custom PCR Arrays for MFRP
     Search Tocris compounds for MFRP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MFRP antibodies
     MFRP proteins
     Antibodies for MFRP
     See all of Abcam's Antibodies, Kits and Proteins for MFRP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MFRP
     Antibodies for MFRP
     ELISAs for MFRP
     CLIAs for MFRP
     Search LifeMap BioReagents cell lines for MFRP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFRP
     SwitchGear 3'UTR luciferase reporter plasmids for MFRP
     SwitchGear Promoter luciferase reporter plasmids for MFRP
     Search ThermoFisher Antibodies for MFRP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFRP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MFRP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MFRP
    Customized:
     lentivirus for stable overexpression of MFRP
     lentivirus expression plasmids for stable overexpression of MFRP
     adenovirus for overexpression of MFRP
     LSBio Antibodies in human, mouse, rat for MFRP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MFRP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4