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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MFRP Gene

protein-coding GIFtS: 46
GCID: GC11M119244

Membrane Frizzled-Related Protein

19 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Membrane Frizzled-Related Protein¹ ²
Membrane-Type Frizzled-Related Protein¹ ² ³
MCOP5² ⁵
Complement C1q Tumor Necrosis Factor-Related Protein 5 Precursor Variant 1¹
NNO2²
RD6²

External Ids:	HGNC: 18121¹	Entrez Gene: 83552²	Ensembl: ENSG00000235718⁷	OMIM: 606227⁵	UniProtKB: Q9BY79³

Export aliases for MFRP gene to outside databases

Previous GC identifers: GC11M121209 GC11M120722 GC11M118749 GC11M118714 GC11M115150

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFRP Gene:

This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye

development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis

pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes

C1q and tumor necrosis factor related protein 5 (C1QTNF5). (provided by RefSeq, Jun 2013)

GeneCards Summary for MFRP Gene:

MFRP (membrane frizzled-related protein) is a protein-coding gene. Diseases associated with MFRP include microphthalmia, and optic disk drusen. GO annotations related to this gene include molecular_function. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Wiki entry for MFRP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MFRP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFRP promoter sequence

Search SABiosciences Chromatin IP Primers for MFRP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

MFRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFRP gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M119244: view genomic region (about GC identifiers)

Start:	119,209,652 bp from pter	End:	119,217,383 bp from pter
Size:	7,732 bases	Orientation:	minus strand

1 alternative location:

Chr11- 119,209,652-119,217,368

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79 (See protein sequence)

Recommended Name: Membrane frizzled-related protein

Size: 579 amino acids; 62212 Da

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Developmental stage: Expressed in fetal brain

Miscellaneous: This protein is produced by a bicistronic gene which also produces the C1QTNF5 protein from a

non-overlapping reading frame

Secondary accessions: B0YJ36 B0YJ37 Q335M3 Q96DQ9

Alternative splicing: 2 isoforms: Q9BY79-1 Q9BY79-2

Explore the universe of human proteins at neXtProt for MFRP: NX_Q9BY79

Explore proteomics data for MFRP at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BY79

MFRP Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_113621.1

ENSEMBL proteins:

ENSP00000391664 ENSP00000353291 ENSP00000450509

Human Recombinant Protein Products for MFRP:

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	Cloud-Clone Corp. Proteins for MFRP

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	TAS	11263980

MFRP for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro protein domains:

IPR023415 LDLR_class-A_CS

IPR020067 Frizzled_dom

IPR000859 CUB_dom

IPR002172 LDrepeatLR_classA_rpt

IPR027122 MFRP

Graphical View of Domain Structure for InterPro Entry Q9BY79

ProtoNet protein and cluster: Q9BY79

2 Blocks protein domains:

IPB000859 CUB domain

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Similarity: Contains 2 CUB domains

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 2 LDL-receptor class A domains

MFRP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MFRP_HUMAN, Q9BY79

Function: May play a role in eye development

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	--	--

MFRP for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mfrp):

nervous system

pigmentation

vision/eye

MFRP for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MFRP

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for MFRP (Q9BY79³ ENSP00000391664⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
SLC2A4	P14672³	I2D: score=1
C1QTNF5	ENSP00000402389⁴	STRING: ENSP00000402389

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009790	embryo development	NAS	11263980

MFRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MFRP

Search CenterWatch for drugs/clinical trials and news about MFRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MFRP gene:

NM_031433.3

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000449574(uc010rzg.1) ENST00000360167 ENST00000529147 ENST00000526059

ENST00000555262(uc001pwj.2)

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		hsa-miR-3194-5p hsa-miR-4251 hsa-miR-4306 hsa-miR-4290 hsa-miR-3921 hsa-miR-3125 hsa-miR-3916 hsa-miR-185

		SwitchGear 3'UTR luciferase reporter plasmid: MFRP 3' UTR sequence

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24/96 AceView cDNA sequences (see all 96):

BM021381 BM893691 BM966810 BM021127 BM924569 BM673416 AI924106 AL110261

BM684116 AI805087 BM966954 CF994392 AI783751 BU742804 BM052913 BF724241

CK904254 AI619600 BE138819 AW190639 NM_031433 CA390714 BM722889 AB055505

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MFRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See MFRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFRP

UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Tissue specificity: Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent in

hippocampus and corpus callosum. Expressed in keratinocytes

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MFRP gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mfrp^{1 , 5}	membrane-type frizzled-related protein^{1, 5}	78.2(n)¹ 70.24(a)¹		9 (24.60 cM)⁵ 259172¹ NM_147126.3¹ NP_667337.1¹ 44101738⁵
chicken (Gallus gallus)	Aves	LOC100859299¹	membrane frizzled-related protein-like	63.63(n) 54.27(a)		100859299 XM_003642601.1 XP_003642649.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	53(a)	1 → many	GL343797.1(1526-16473)
zebrafish (Danio rerio)	Actinopterygii	MFRP⁶	membrane frizzled-related protein	49(a)	1 → many	15(148682-156045)
fruit fly (Drosophila melanogaster)	Insecta	CG32702⁶ CG42255⁶	--	2(a) 2(a)	possible ortholog possible ortholog	X(9452698-9465341) 3L(11795051-11807855)
worm (Caenorhabditis elegans)	Secernentea	ZC116.3⁶	Probable cubilin	2(a)	possible ortholog	V(12611329-12628738)

ENSEMBL Gene Tree for MFRP (if available)
TreeFam Gene Tree for MFRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MFRP gene

TLL2² CUBN² CDCP2² PCOLCE² BMP1² PCOLCE2² NETO2² NETO1²

TLL1²

1 SIMAP similar gene for MFRP using alignment to 2 protein entries: MFRP_HUMAN (see all proteins):

CUBN

MFRP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
VAR_025694⁴	Nanophthalmos 2 (NNO2)⁴	--	see VAR_025694	2	I T	mis⁴		0	--	--	--	--
VAR_025695⁴	--	--	see VAR_025695	2	G S	mis⁴		0	--	--	--	--
VAR_025693⁴	--	--	see VAR_025693	2	V M	mis⁴		0	--	--	--	--
VAR_025692⁴	--	--	see VAR_025692	2	I V	mis⁴		0	--	--	--	--
VAR_025696⁴	--	--	see VAR_025696	2	Q H	mis⁴		0	--	--	--	--
VAR_025691⁴	--	--	see VAR_025691	2	R G	mis⁴		0	--	--	--	--

HapMap Linkage Disequilibrium report for MFRP (119209652 - 119217383 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for MFRP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv898417	CNV	Loss	21882294
nsv898418	CNV	Loss	21882294
nsv826103	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): MFRP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFRP

DNA2.0 Custom Variant and Variant Library Synthesis for MFRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MFRP for disorders           About GeneDecksing

OMIM gene information: 606227
OMIM disorders: 611040
UniProtKB/Swiss-Prot: MFRP_HUMAN, Q9BY79

Nanophthalmos 2 (NNO2) [MIM:609549]: Rare autosomal recessive disorder of eye development characterized by

extreme hyperopia and small functional eyes. Note=The disease is caused by mutations affecting the gene represented in

this entry

Microphthalmia, isolated, 5 (MCOP5) [MIM:611040]: A disorder characterized by posterior microphthalmia,

retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging from

small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the

cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Note=The disease is

caused by mutations affecting the gene represented in this entry

19 diseases for MFRP: About MalaCards

microphthalmia optic disk drusen primary angle-closure glaucoma late-onset retinal degeneration

isolated microphthalmia isolated microphthalmia 5 hyperopia pigmentary retinopathy

retinal degeneration age related macular degeneration macular degeneration retinitis pigmentosa

glaucoma myopia retinitis fanconi's anemia

choroiditis cataract anemia

4 diseases from the University of Copenhagen DISEASES database for MFRP:

Optic disk drusen Microphthalmia Hyperopia Retinal degeneration

3 Novoseek inferred disease relationships for MFRP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinal degeneration	70.6	7	17122143 (2), 12140190 (1), 16352475 (1), 17167404 (1)
retinitis pigmentosa	68.3	1	17167404 (1)
tumors	0	2	11263980 (1), 17122143 (1)

Genetic Association Database (GAD): MFRP
Human Genome Epidemiology (HuGE) Navigator: MFRP (3 documents)

Export disorders for MFRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MFRP gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MFRP)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type frizzled-related protein. (PubMed id 11263980)^{1, 2, 3, 9} Katoh M. (2001)
Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. (PubMed id 18334955)^{1, 4, 9} Metlapally R....Young T.L. (2008)
Evaluation of MFRP as a candidate gene for high hyperopia. (PubMed id 19169412)^{1, 4, 9} Wang P....Zhang Q. (2009)
A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation. (PubMed id 17167404)^{1, 2, 9} Ayala-Ramirez R.... Zenteno J.C. (2006)
Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes. (PubMed id 18648522)^{1, 4, 9} Aung T....Vithana E.N. (2008)
Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations. (PubMed id 16352475)^{1, 2, 9} Pauer G.J.T.... Hagstrom S.A. (2005)
Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. (PubMed id 16442268)^{1, 2} Yang L.... Hashimoto K. (2006)
Extreme hyperopia is the result of null mutations in MFRP, which encodes a frizzled-related protein. (PubMed id 15976030)^{1, 2} Sundin O.H.... Weinberg E.M. (2005)
Sequencing arrays for screening multiple genes associated with early- onset human retinal degenerations on a high-throughput platform. (PubMed id 16123440)^{1, 2} Mandal M.N.A.... Ayyagari R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83552	HGNC: 18121	AceView: C1QTNF5andMFRP	Ensembl:ENSG00000235718	euGenes: HUgn83552
ECgene: MFRP	H-InvDB: MFRP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MFRP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MFRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MFRP gene:
Search GeneIP for patents involving MFRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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MFRP Gene

Membrane Frizzled-Related Protein

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MFRP Gene

Membrane Frizzled-Related Protein

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