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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFNG Gene

protein-coding   GIFtS: 64
GCID: GC22M037865

MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

(Previous names: manic fringe (Drosophila) homolog, manic fringe homolog...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase1 2
O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase2 3
EC 2.4.1.2223 8
Manic Fringe (Drosophila) Homolog1
Manic Fringe Homolog (Drosophila)1
Beta-1,3-N-Acetylglucosaminyltransferase Manic Fringe2

External Ids:    HGNC: 70381   Entrez Gene: 42422   Ensembl: ENSG000001000607   OMIM: 6025775   UniProtKB: O005873   
ORGUL members:         
NONCODE14:n408343      

Export aliases for MFNG gene to outside databases

Previous GC identifers: GC22M034479 GC22M036108 GC22M036189 GC22M020831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFNG Gene:
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all
encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries
during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe
proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of
O-linked fucose residues on Notch, which alters Notch signaling. (provided by RefSeq, Oct 2009)

GeneCards Summary for MFNG Gene: 
MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with MFNG include alagille syndrome, and basal cell carcinoma, and among its related super-pathways are Notch signaling pathway and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants. GO annotations related to this gene include O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity and metal ion binding. An important paralog of this gene is LFNG.

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587
Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling.
Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity

Gene Wiki entry for MFNG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFNG gene promoter:
         MAZR   AML1a   AP-2gamma   LCR-F1   HEN1   AREB6   c-Rel   S8   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFNG promoter sequence
   Search SABiosciences Chromatin IP Primers for MFNG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFNG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFNG gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037865:  view genomic region     (about GC identifiers)

Start:
37,865,101 bp from pter      End:
37,882,478 bp from pter
Size:
17,378 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587 (See protein sequence)
Recommended Name: Beta-1,3-N-acetylglucosaminyltransferase manic fringe  
Size: 321 amino acids; 36202 Da
Cofactor: Manganese (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B4DLT6 O43730 Q504S9
Alternative splicing: 2 isoforms:  O00587-1   O00587-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFNG: NX_O00587

Explore proteomics data for MFNG at MOPED 

4/9 DME Specific Peptides for MFNG (O00587) (see all 9)
 DDDNYVN  RLPDDCT  QVTLSYG  FIAVKTT 

MFNG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MFNG Protein Expression
REFSEQ proteins (2 alternative transcripts): 
NP_001159815.1  NP_002396.2  

ENSEMBL proteins: 
 ENSP00000349490   ENSP00000407094   ENSP00000414222   ENSP00000394081   ENSP00000414342  
 ENSP00000389274   ENSP00000407110   ENSP00000413855  
Reactome Protein details: O00587
Human Recombinant Protein Products for MFNG: 
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Novus Biologicals MFNG Proteins
Novus Biologicals MFNG Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for MFNG 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS9187150
GO:0016020membrane ----
GO:0030173integral to Golgi membrane IEA--

MFNG for ontologies           About GeneDecksing



MFNG Antibody Products: 
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Abcam antibodies for MFNG
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LSBio Antibodies in human, mouse, rat for MFNG 

Assay Products for MFNG: 
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Cloud-Clone Corp. CLIAs for MFNG


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
B3GT: Beta 3-glycosyltransferases

2 InterPro protein domains:
 IPR017374 Fringe
 IPR003378 Fringe-like

Graphical View of Domain Structure for InterPro Entry O00587

ProtoNet protein and cluster: O00587

1 Blocks protein domain: IPB003378 Fringe-like

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587
Similarity: Belongs to the glycosyltransferase 31 family


MFNG for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MFNG_HUMAN, O00587
Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling.
Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity
Catalytic activity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated
protein acceptor

     Genatlas biochemistry entry for MFNG:
manic fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor
genes or their specific ligands,essential mediator of somite segmentaion and patterning

     Enzyme Number (IUBMB): EC 2.4.1.2221 2

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0016757transferase activity, transferring glycosyl groups ----
GO:0033829O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA--
GO:0046872metal ion binding IEA--
     
MFNG for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for MFNG:
 Increased Salmonella enterica   Increased circadian period len 

     10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mfng):
 embryogenesis  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
 limbs/digits/tail  mortality/aging  no phenotypic analysis  normal  skeleton 

MFNG for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for MFNG: Mfngtm1Cjg Mfngtm1Seco Mfngtm1.1Heed

   inGenious Targeting Laboratory - Custom generated mouse model solutions for MFNG 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MFNG

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFNG 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFNG 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFNG
8 QIAGEN miScript miRNA Assays for microRNAs that regulate MFNG:
hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmidMFNG 3' UTR sequence
Inhib. RNA
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Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFNG
Sirion Biotech Customized lentivirus for stable overexpression of MFNG 
                     Customized lentivirus expression plasmids for stable overexpression of MFNG 

Cell Line
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Search LifeMap BioReagents cell lines for MFNG
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFNG


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MFNG About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Notch signaling pathway
Notch signaling pathway0.84
Delta-Notch Signaling Pathway0.33
Notch Signaling Pathway0.84
2Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
Signaling by NOTCH0.74
Notch Signaling0.31
3Pre-NOTCH Processing in Golgi
Pre-NOTCH Expression and Processing0.55
Pre-NOTCH Processing in Golgi0.55
4Signaling by GPCR
Signal Transduction0.55
5Development NOTCH1-mediated pathway for NF-KB activity modulation
Development Notch Signaling Pathway0.54

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for MFNG
    Development Notch Signaling Pathway

1 R&D Systems Pathway for MFNG
    Notch Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MFNG
    Notch Signaling

1 GeneGo (Thomson Reuters) Pathway for MFNG
    Development Notch Signaling Pathway

2 BioSystems Pathways for MFNG
    Notch Signaling Pathway
Delta-Notch Signaling Pathway

4        Reactome Pathways for MFNG
    Pre-NOTCH Expression and Processing
Signaling by NOTCH
Pre-NOTCH Processing in Golgi
Signal Transduction


2         Kegg Pathways  (Kegg details for MFNG):
    Other types of O-glycan biosynthesis
Notch signaling pathway


MFNG for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MFNG

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/9 Interacting proteins for MFNG (O005873 ENSP000003494904) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
NOTCH2Q047213, ENSP000002566464I2D: score=4 STRING: ENSP00000256646
JAG1P785043, ENSP000002549584I2D: score=2 STRING: ENSP00000254958
JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
DLL1O005483, ENSP000003557184I2D: score=2 STRING: ENSP00000355718
NOTCH1P465313, ENSP000002775414I2D: score=1 STRING: ENSP00000277541
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007389pattern specification process IEA--
GO:0032092positive regulation of protein binding IEA--
GO:0045747positive regulation of Notch signaling pathway IEA--

MFNG for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MFNG

Search CenterWatch for drugs/clinical trials and news about MFNG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MFNG gene (2 alternative transcripts): 
NM_001166343.1  NM_002405.3  

Unigene Cluster for MFNG:

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Hs.517603  [show with all ESTs]
Unigene Representative Sequence: NM_002405
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000356998(uc003ass.2 uc011ani.2) ENST00000489515 ENST00000454291
ENST00000438891 ENST00000436341 ENST00000430411 ENST00000442496 ENST00000466943
ENST00000424765 ENST00000416983(uc011anj.2)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFNG
8 QIAGEN miScript miRNA Assays for microRNAs that regulate MFNG:
hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmidMFNG 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for MFNG
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFNG
Clone
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OriGene clones in human, mouse for MFNG (see all 12)
OriGene ORF clones in mouse, rat for MFNG
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MFNG (NM_002405)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFNG
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFNG
Sirion Biotech Customized lentivirus for stable overexpression of MFNG 
                     Customized lentivirus expression plasmids for stable overexpression of MFNG 
Primer
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OriGene qPCR primer pairs and template standards for MFNG
OriGene qSTAR qPCR primer pairs in human, mouse for MFNG
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFNG
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFNG
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFNG

Additional mRNA sequence: 

AK292123.1 AK297149.1 AK297833.1 AK316555.1 BC094814.1 CR456518.1 NR_029413.1 U94352.1 

10 DOTS entries:

DT.455946  DT.97821268  DT.40131711  DT.40111304  DT.92426736  DT.95118583  DT.95118581  DT.97778954 
DT.97843956  DT.100797695 

24/246 AceView cDNA sequences (see all 246):

H55274 BQ053547 BQ053444 AA447378 BQ052074 BF590841 BI832589 AI363008 
BF975091 AA834543 AI762505 AI219859 CR604551 AI374778 AA418830 AW592848 
AA484997 BQ030410 AI802936 W32714 BM921577 BI524246 BF593767 BF439301 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MFNG (see all 10)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1:                                -     -     -           -                                                                                             
SP2:                                            -           -                                                                                             
SP3:                                                                                                                                -                     
SP4:                                      -     -           -                                                                                             
SP5:                                -     -     -     -     -                                                                                             


ECgene alternative splicing isoforms for MFNG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MFNG expression in normal human tissues (normalized intensities)      MFNG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGAAAGGC
MFNG Expression
About this image


MFNG expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Brain (Nervous System)    fully expand to see all 8 entries
         Thalamus
         Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
         brain/midbrain   
 
 Nose (Sensory Organs)    fully expand to see all 4 entries
         sensory organ/nose/nasal cavity   
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Neural Crest (Sensory Organs)
         sensory organ/nose/vomeronasal organ   
 
 Neuron (Nervous System)
         Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...

See MFNG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFNG

SOURCE GeneReport for Unigene cluster: Hs.517603
    SABiosciences Expression via Pathway-Focused PCR Arrays including MFNG: 
          Glycosylation in human mouse rat
          Notch Signaling Pathway in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for MFNG
OriGene qSTAR qPCR primer pairs in human, mouse for MFNG
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFNG
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFNG
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFNG
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFNG

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MFNG gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mfng1 , 5 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less1, 5 83.65(n)1
83.12(a)1
  15 (37.69 cM)5
173051  NM_008595.21  NP_032621.11 
 787558825 
chicken
(Gallus gallus)
Aves MFNG1 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less 68.15(n)
66.24(a)
  418042  XM_416278.2  XP_416278.2 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
72(a)
58(a)
many → 1
many → 1
5(23435343-23437876)
5(23454225-23468687)
zebrafish
(Danio rerio)
Actinopterygii mfng1 manic fringe homolog 62.05(n)
62.92(a)
  493633  NM_001007788.1  NP_001007789.1 
fruit fly
(Drosophila melanogaster)
Insecta fng3 dorsal/ventral pattern formation,
imaginal disc UDP-glycosyltransferase less
44(a)   3 78A1   --


ENSEMBL Gene Tree for MFNG (if available)
TreeFam Gene Tree for MFNG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MFNG gene
LFNG2  RFNG2  
2 SIMAP similar genes for MFNG using alignment to 8 protein entries:     MFNG_HUMAN (see all proteins):
LFNG    RFNG

MFNG for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/453 SNPs in MFNG are shown (see all 453)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1510757261,2
C--37864684(+) TCAGGA/GGGCTG 3 -- ds50010--------
rs1409793541,2
C--37864793(+) TCTGTA/CTCAAA 3 -- ds50010--------
rs57566881,2
C,F,H--37864834(+) GACATC/GTTTAT 3 -- ds500114Minor allele frequency- G:0.01NS EA NA WA CSA 790
rs1145248991,2
F--37864875(+) ACACAC/TACATA 3 -- ds50011Minor allele frequency- T:0.07WA 118
rs794225001,2
F--37864893(+) GTACCG/ACCTCA 3 -- ds50011Minor allele frequency- A:0.02WA 118
rs1502023711,2
--37865034(+) TGTGAC/TAGACA 3 -- ds50010--------
rs96226261,2
H--37865036(+) TGATAG/AACAGA 3 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
rs37885271,2
C,F,H--37865057(+) ACCCCA/GTCAGG 3 -- ds500125Minor allele frequency- N:0.00NA EA NS WA 2978
rs556988911,2
C,F--37865234(-) GCTATA/TAATGT 3 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.10WA 120
rs1387958131,2
C--37865353(+) AGGCTA/GGGAAA 3 -- ut31 nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for MFNG (37865101 - 37882478 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MFNG:    About this table     
Variant IDTypeSubtypePubMed ID
nsv829203CNV Loss20364138
nsv915028CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602577    OMIM disorders: --

5 diseases for MFNG:    About MalaCards
alagille syndrome    basal cell carcinoma    psoriasis    hepatitis b
hepatitis


MFNG for disorders           About GeneDecksing

Genetic Association Database (GAD): MFNG
Human Genome Epidemiology (HuGE) Navigator: MFNG (2 documents)

Export disorders for MFNG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MFNG gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MFNG)
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world of online information

  1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PubMed id 9187150)1, 2, 3 Johnston S.H....Vogt T.F. (1997)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  4. Fringe is a glycosyltransferase that modifies Notch. (PubMed id 10935626)1, 2 Moloney D.J.... Vogt T.F. (2000)
  5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
  6. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. (PubMed id 9878264)1, 3 Egan S....Scherer S.W. (1998)
  7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
  8. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (PubMed id 18617639)4 Litonjua A.A....Weiss S.T. (2008)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. (PubMed id 15280477)1 Veeraraghavalu K....Krishna S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4242 HGNC: 7038 AceView: MFNG Ensembl:ENSG00000100060 euGenes: HUgn4242
ECgene: MFNG Kegg: 4242 H-InvDB: MFNG

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MFNG Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MFNG Genetics and Cytogenetics in Oncology and Haematology
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_552

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MFNG gene:
Search GeneIP for patents involving MFNG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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