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Aliases for MFNG Gene

Aliases for MFNG Gene

  • MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 2 3
  • EC 2.4.1.222 4 63
  • O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase 4
  • Manic Fringe (Drosophila) Homolog 2
  • Manic Fringe Homolog (Drosophila) 2

External Ids for MFNG Gene

Previous GeneCards Identifiers for MFNG Gene

  • GC22M034479
  • GC22M036108
  • GC22M036189
  • GC22M037865
  • GC22M020831

Summaries for MFNG Gene

Entrez Gene Summary for MFNG Gene

  • This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]

GeneCards Summary for MFNG Gene

MFNG (MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1 PEST Domain Mutants in Cancer. GO annotations related to this gene include O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.

UniProtKB/Swiss-Prot for MFNG Gene

  • Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.

Gene Wiki entry for MFNG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFNG Gene

Genomics for MFNG Gene

Regulatory Elements for MFNG Gene

Genomic Location for MFNG Gene

Start:
37,469,063 bp from pter
End:
37,486,440 bp from pter
Size:
17,378 bases
Orientation:
Minus strand

Genomic View for MFNG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFNG Gene

Proteins for MFNG Gene

  • Protein details for MFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00587-MFNG_HUMAN
    Recommended name:
    Beta-1,3-N-acetylglucosaminyltransferase manic fringe
    Protein Accession:
    O00587
    Secondary Accessions:
    • B4DLT6
    • O43730
    • Q504S9

    Protein attributes for MFNG Gene

    Size:
    321 amino acids
    Molecular mass:
    36202 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MFNG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFNG Gene

Proteomics data for MFNG Gene at MOPED

Selected DME Specific Peptides for MFNG Gene

Post-translational modifications for MFNG Gene

  • Glycosylation at Asn109 and Asn185
  • Modification sites at PhosphoSitePlus

Other Protein References for MFNG Gene

Domains for MFNG Gene

Gene Families for MFNG Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for MFNG Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00587

UniProtKB/Swiss-Prot:

MFNG_HUMAN :
  • O00587
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with MFNG: view

Function for MFNG Gene

Molecular function for MFNG Gene

GENATLAS Biochemistry: manic fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor genes or their specific ligands,essential mediator of somite segmentaion and patterning
UniProtKB/Swiss-Prot CatalyticActivity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.
UniProtKB/Swiss-Prot Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.

Enzyme Numbers (IUBMB) for MFNG Gene

Gene Ontology (GO) - Molecular Function for MFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MFNG: view
genes like me logo Genes that share phenotypes with MFNG: view

Animal Models for MFNG Gene

MGI Knock Outs for MFNG:

miRNA for MFNG Gene

miRTarBase miRNAs that target MFNG

No data available for Transcription Factor Targeting and HOMER Transcription for MFNG Gene

Localization for MFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFNG Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFNG Gene COMPARTMENTS Subcellular localization image for MFNG gene
Compartment Confidence
golgi apparatus 5
extracellular 4

Gene Ontology (GO) - Cellular Components for MFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9187150
GO:0016020 membrane --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with MFNG: view

Pathways for MFNG Gene

genes like me logo Genes that share pathways with MFNG: view

Pathways by source for MFNG Gene

1 GeneGo (Thomson Reuters) pathway for MFNG Gene
1 R&D Systems pathway for MFNG Gene

Gene Ontology (GO) - Biological Process for MFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007389 pattern specification process IEA --
GO:0008152 metabolic process IEA --
GO:0032092 positive regulation of protein binding IEA --
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with MFNG: view

Transcripts for MFNG Gene

Unigene Clusters for MFNG Gene

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFNG Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - -
SP9: -
SP10: -

Relevant External Links for MFNG Gene

GeneLoc Exon Structure for
MFNG
ECgene alternative splicing isoforms for
MFNG

Expression for MFNG Gene

mRNA expression in normal human tissues for MFNG Gene

mRNA differential expression in normal tissues according to GTEx for MFNG Gene

This gene is overexpressed in Whole Blood (9.9) and Spleen (5.8).

SOURCE GeneReport for Unigene cluster for MFNG Gene Hs.517603

genes like me logo Genes that share expressions with MFNG: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for MFNG Gene

Orthologs for MFNG Gene

This gene was present in the common ancestor of animals.

Orthologs for MFNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFNG 35
  • 98.96 (n)
  • 98.44 (a)
MFNG 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFNG 35
  • 87.08 (n)
  • 87.81 (a)
MFNG 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFNG 35
  • 86.8 (n)
  • 88.74 (a)
MFNG 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfng 35
  • 83.65 (n)
  • 83.12 (a)
Mfng 16
Mfng 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFNG 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFNG 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfng 35
  • 82.81 (n)
  • 83.44 (a)
chicken
(Gallus gallus)
Aves MFNG 35
  • 71.02 (n)
  • 71.27 (a)
MFNG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mfng 35
  • 62.05 (n)
  • 62.92 (a)
mfng 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fng 36
  • 32 (a)
OneToMany
fng 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for MFNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFNG Gene

ENSEMBL:
Gene Tree for MFNG (if available)
TreeFam:
Gene Tree for MFNG (if available)

Paralogs for MFNG Gene

Paralogs for MFNG Gene

Selected SIMAP similar genes for MFNG Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MFNG: view

Variants for MFNG Gene

Sequence variations from dbSNP and Humsavar for MFNG Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2071839 -- 37,486,521(-) CTGGC(A/G)GAGCC upstream-variant-2KB
rs2071840 -- 37,485,804(-) CCTGC(C/T)TAATC intron-variant
rs2071841 -- 37,474,733(-) GCCCA(C/T)GGCTC intron-variant
rs2105911 -- 37,486,415(-) GGCGG(G/T)CCCGG upstream-variant-2KB, utr-variant-5-prime, nc-transcript-variant
rs2284052 -- 37,483,434(+) CCACC(A/C)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFNG Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294

Relevant External Links for MFNG Gene

HapMap Linkage Disequilibrium report
MFNG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFNG Gene

Disorders for MFNG Gene

Relevant External Links for MFNG

Genetic Association Database (GAD)
MFNG
Human Genome Epidemiology (HuGE) Navigator
MFNG
genes like me logo Genes that share disorders with MFNG: view

No data available for UniProtKB/Swiss-Prot for MFNG Gene

Publications for MFNG Gene

  1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PMID: 9187150) Johnston S.H. … Vogt T.F. (Development 1997) 2 3 4
  2. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. (PMID: 9878264) Egan S. … Scherer S.W. (Genomics 1998) 2 3
  3. Fringe is a glycosyltransferase that modifies Notch. (PMID: 10935626) Moloney D.J. … Vogt T.F. (Nature 2000) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MFNG Gene

Sources for MFNG Gene

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