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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MFNG Gene

protein-coding GIFtS: 62
GCID: GC22M037865

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

(Previous names: manic fringe (Drosophila) homolog, manic fringe homolog...)

Explore 6 diseases affiliated with
MFNG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase¹ ²
O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase² ³
EC 2.4.1.222³ ⁸
Manic Fringe (Drosophila) Homolog¹
Manic Fringe Homolog (Drosophila)¹
Beta-1,3-N-Acetylglucosaminyltransferase Manic Fringe²

External Ids:	HGNC: 7038¹	Entrez Gene: 4242²	Ensembl: ENSG00000100060⁷	OMIM: 602577⁵	UniProtKB: O00587³

ORGUL members:
	NONCODE:n408343

Export aliases for MFNG gene to outside databases

Previous GC identifers: GC22M034479 GC22M036108 GC22M036189 GC22M020831

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFNG:

This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode

evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during

embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have

a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose

residues on Notch, which alters Notch signaling. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587

Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses

fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity

Gene Wiki entry for MFNG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MFNG gene promoter:
MAZR AML1a AP-2gamma LCR-F1 HEN1 AREB6 c-Rel S8 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MFNG promoter sequence

Search SABiosciences Chromatin IP Primers for MFNG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFNG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

MFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFNG gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M037865: view genomic region (about GC identifiers)

Start:	37,865,101 bp from pter	End:	37,882,478 bp from pter
Size:	17,378 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587 (See protein sequence)

Recommended Name: Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Size: 321 amino acids; 36202 Da

Cofactor: Manganese (By similarity)

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Secondary accessions: B4DLT6 O43730 Q504S9

Alternative splicing: 2 isoforms: O00587-1 O00587-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFNG: NX_O00587

4/9 DME Specific Peptides for MFNG (O00587) (see all 9)

DDDNYVN

RLPDDCT

QVTLSYG

FIAVKTT

MFNG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001159815.1 NP_002396.2

ENSEMBL proteins:

ENSP00000349490 ENSP00000407094 ENSP00000414222 ENSP00000394081 ENSP00000396605

ENSP00000414342 ENSP00000389274 ENSP00000407110 ENSP00000413855

Reactome Protein details: O00587
Human Recombinant Protein Products:

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	Novus Biologicals MFNG Proteins Novus Biologicals MFNG Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MFNG

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	9187150
GO:0016020	membrane	--	--
GO:0030173	integral to Golgi membrane	IEA	--

MFNG for ontologies About GeneDecksing

MFNG Antibody Products:

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	Uscn Antibodies for MFNG
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Assay Products for MFNG:

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	Uscn ELISAs and CLIAs for MFNG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MFNG for domains About GeneDecksing

2 InterPro domains/families:

IPR017374 Fringe

IPR003378 Fringe-like

Graphical View of Domain Structure for InterPro Entry O00587

ProtoNet protein and cluster: O00587

1 Blocks protein family: IPB003378 Fringe-like

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587

Similarity: Belongs to the glycosyltransferase 31 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587

Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses

fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity

Catalytic activity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein

acceptor

Genatlas biochemistry entry for MFNG:

manic fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor

genes or their specific ligands,essential mediator of somite segmentaion and patterning

Enzyme Number (IUBMB): EC 2.4.1.222¹ ²

miRNA Products:		OriGene 3'-UTR Clone: MFNG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFNG
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate MFNG:
		hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFNG (see all 7) OriGene shRNA RFP: MFNG OriGene siRNA: MFNG
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for MFNG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MFNG
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFNG

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016757	transferase activity, transferring glycosyl groups	--	--
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

MFNG for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MFNG:

Increased Salmonella enterica

Increased circadian period len

Animal Models:
Mouse knock-outs for MFNG: Mfng^tm1Cjg Mfng^tm1Seco Mfng^tm1.1Heed
10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mfng):

embryogenesis	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
limbs/digits/tail	mortality/aging	no phenotypic analysis	normal	skeleton

MFNG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Notch Signaling Pathway

	Notch Signaling Pathway	1.00			Delta-Notch Signaling Pathway	0.27
	Notch signaling pathway	0.82

Development_Notch Signaling Pathway

Development_Notch Signaling Pathway

1.00

Development Notch Signaling Pathway

0.97

Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi

1.00

Pre-NOTCH Expression and Processing

0.55

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

Signaling by NOTCH

0.77

Notch Signaling

0.23

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MFNG

Development Notch Signaling Pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MFNG

Notch Signaling

1 GeneGo (Thomson Reuters) Pathway for MFNG

Development Notch Signaling Pathway

2 BioSystems Pathways for MFNG

	Notch Signaling Pathway
	Delta-Notch Signaling Pathway

4 Reactome Pathways for MFNG

	Pre-NOTCH Expression and Processing
	Signaling by NOTCH
	Pre-NOTCH Processing in Golgi
	Signal Transduction

2 Kegg Pathways (Kegg details for MFNG):

	Other types of O-glycan biosynthesis
	Notch signaling pathway

MFNG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MFNG

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/9 Interacting proteins for MFNG (O00587³ ENSP00000349490⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOTCH2	Q04721³, ENSP00000256646⁴	I2D: score=4 STRING: ENSP00000256646
JAG1	P78504³, ENSP00000254958⁴	I2D: score=2 STRING: ENSP00000254958
JAG2	Q9Y219³, ENSP00000328169⁴	I2D: score=1 STRING: ENSP00000328169
DLL1	O00548³, ENSP00000355718⁴	I2D: score=2 STRING: ENSP00000355718
NOTCH1	P46531³, ENSP00000277541⁴	I2D: score=1 STRING: ENSP00000277541

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007389	pattern specification process	IEA	--
GO:0032092	positive regulation of protein binding	IEA	--
GO:0045747	positive regulation of Notch signaling pathway	IEA	--

MFNG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MFNG
Search CenterWatch for drugs/clinical trials and news about MFNG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MFNG gene (2 alternative transcripts):

NM_001166343.1 NM_002405.3

Unigene Cluster for MFNG:

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Hs.517603 [show with all ESTs]

Unigene Representative Sequence: NM_002405

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356998(uc003ass.2 uc011ani.2) ENST00000489515 ENST00000454291

ENST00000438891 ENST00000436341 ENST00000450946 ENST00000430411 ENST00000442496

ENST00000466943 ENST00000424765 ENST00000416983(uc011anj.2)

miRNA Products:		OriGene 3'-UTR Clone: MFNG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFNG
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate MFNG:
		hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MFNG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFNG (see all 7) OriGene shRNA RFP: MFNG OriGene siRNA: MFNG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFNG

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		GenScript: all cDNA clones in your preferred vector (see all 2): MFNG (NM_002405)
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Additional cDNA sequence:

AK292123.1 AK297149.1 AK297833.1 AK316555.1 BC094814.1 CR456518.1 NR_029413.1 U94352.1

10 DOTS entries:

DT.455946 DT.97821268 DT.40131711 DT.40111304 DT.92426736 DT.95118583 DT.95118581 DT.97778954

DT.97843956 DT.100797695

24/246 AceView cDNA sequences (see all 246):

AI436390 AI160093 AI028193 AW574851 BM723051 BX099161 BI832589 AI459350

AA442522 BI524246 AI468985 AI539347 BF590841 AI699670 BE644660 BF975091

AW575229 AA451706 BF593767 AU143259 NM_002405 BX349861 CD368104 BQ057862

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MFNG (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	·	10c
SP1:											-		-		-				-
SP2:															-				-
SP3:																																											-
SP4:													-		-				-
SP5:											-		-		-		-		-

ECgene alternative splicing isoforms for MFNG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MFNG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAAGGC

About this image

MFNG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Brain

Brain

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MFNG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFNG

SOURCE GeneReport for Unigene cluster: Hs.517603

SABiosciences Expression via Pathway-Focused PCR Arrays including MFNG:

Glycosylation in human mouse rat

Notch Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFNG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFNG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MFNG gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mfng^{1 , 5}	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less^{1, 5}	83.65(n)¹ 83.12(a)¹		15 (37.69 cM)⁵ 17305¹ NM_008595.2¹ NP_032621.1¹ 78755882⁵
chicken (Gallus gallus)	Aves	MFNG¹	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less	68.15(n) 66.24(a)		418042 XM_416278.2 XP_416278.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	72(a) 59(a)	many → 1 many → 1	5(23435343-23437876) 5(23454225-23468687)
zebrafish (Danio rerio)	Actinopterygii	mfng¹	manic fringe homolog	62.05(n) 62.92(a)		493633 NM_001007788.1 NP_001007789.1
fruit fly (Drosophila melanogaster)	Insecta	fng³	dorsal/ventral pattern formation, imaginal disc UDP-glycosyltransferase less	44(a)		3 78A1 --

ENSEMBL Gene Tree for MFNG (if available)
TreeFam Gene Tree for MFNG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MFNG gene

LFNG² RFNG²

2 SIMAP similar genes for MFNG using alignment to 8 protein entries: MFNG_HUMAN (see all proteins):

LFNG RFNG

MFNG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151075726^1,2		--	37864684(+)	`TCAGGA/GGGCTG`	3	--	ds500¹		0	--	--	--	--
rs140979354^1,2		--	37864793(+)	`TCTGTA/CTCAAA`	3	--	ds500¹		0	--	--	--	--
rs5756688^1,2	C,F,H,	--	37864834(+)	`GACATC/GTTTAT`	3	--	ds500¹		14		NS EA NA WA CSA	790
rs114524899^1,2	F,	--	37864875(+)	`ACACAC/TACATA`	3	--	ds500¹		1		WA	118
rs79422500^1,2	F,	--	37864893(+)	`GTACCG/ACCTCA`	3	--	ds500¹		1		WA	118
rs150202371^1,2		--	37865034(+)	`TGTGAC/TAGACA`	3	--	ds500¹		0	--	--	--	--
rs9622626^1,2	H	--	37865036(+)	`TGATAG/AACAGA`	3	--	ds500¹		5		NS EA NA	422
rs3788527^1,2	C,F,H,	--	37865057(+)	`ACCCCA/GTCAGG`	3	--	ds500¹		25		NA EA NS WA	2978
rs55698891^1,2	C,	--	37865234(-)	`GCTATA/TAATGT`	3	--	ut3¹ nc-transcript-variant		2		WA	120
rs138795813^1,2		--	37865353(+)	`AGGCTA/GGGAAA`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for MFNG (37865101 - 37882478 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MFNG: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MFNG for disorders           About GeneDecksing

OMIM gene information: 602577    OMIM disorders: --

6 diseases for MFNG:    About MalaCards

alagille syndrome basal cell carcinoma hepatitis b psoriasis

hepatitis carcinoma

Human Genome Epidemiology (HuGE) Navigator: MFNG (2 documents)

Export disorders for MFNG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MFNG gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MFNG)

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A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PubMed id 9187150)^{1, 2, 3} Johnston S.H....Vogt T.F. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Fringe is a glycosyltransferase that modifies Notch. (PubMed id 10935626)^{1, 2} Moloney D.J.... Vogt T.F. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. (PubMed id 9878264)^{1, 3} Egan S....Scherer S.W. (1998)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. (PubMed id 15280477)¹ Veeraraghavalu K....Krishna S. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4242	HGNC: 7038	AceView: MFNG	Ensembl:ENSG00000100060	euGenes: HUgn4242
ECgene: MFNG	Kegg: 4242	H-InvDB: MFNG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MFNG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MFNG	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_552

Intellectual Property for MFNG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MFNG gene:
Search GeneIP for patents involving MFNG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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