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MFNG Gene

protein-coding   GIFtS: 64
GCID: GC22M037865

MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

(Previous names: manic fringe (Drosophila) homolog, manic fringe homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase1 2
O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase2 3
EC 2.4.1.2223 8
Manic Fringe (Drosophila) Homolog1
Manic Fringe Homolog (Drosophila)1
Beta-1,3-N-Acetylglucosaminyltransferase Manic Fringe2

External Ids:    HGNC: 70381   Entrez Gene: 42422   Ensembl: ENSG000001000607   OMIM: 6025775   UniProtKB: O005873   

Export aliases for MFNG gene to outside databases

Previous GC identifers: GC22M034479 GC22M036108 GC22M036189 GC22M020831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MFNG Gene:
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all
encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries
during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe
proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of
O-linked fucose residues on Notch, which alters Notch signaling. (provided by RefSeq, Oct 2009)

GeneCards Summary for MFNG Gene:
MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) is a protein-coding gene. GO annotations related to this gene include O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is LFNG.

UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587
Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling.
Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity

Gene Wiki entry for MFNG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFNG gene promoter:
         MAZR   AML1a   AP-2gamma   LCR-F1   HEN1   AREB6   c-Rel   S8   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFNG promoter sequence
   Search Chromatin IP Primers for MFNG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFNG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

MFNG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFNG gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037865:  view genomic region     (about GC identifiers)

Start:
37,865,101 bp from pter      End:
37,882,478 bp from pter
Size:
17,378 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587 (See protein sequence)
Recommended Name: Beta-1,3-N-acetylglucosaminyltransferase manic fringe  
Size: 321 amino acids; 36202 Da
Cofactor: Manganese (By similarity)
Secondary accessions: B4DLT6 O43730 Q504S9
Alternative splicing: 2 isoforms:  O00587-1   O00587-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFNG: NX_O00587

Explore proteomics data for MFNG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn109, Asn185
  • Selected DME Specific Peptides for MFNG (O00587) (see all 9)
     DDDNYVN  RLPDDCT  QVTLSYG  FIAVKTT 


    See MFNG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159815.1  NP_002396.2  

    ENSEMBL proteins: 
     ENSP00000349490   ENSP00000407094   ENSP00000414222   ENSP00000394081   ENSP00000414342  
     ENSP00000389274   ENSP00000407110   ENSP00000413855  
    Reactome Protein details: O00587

    MFNG Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MFNG

     
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    antibodies-online proteins for MFNG (8 products) 

     
    antibodies-online peptides for MFNG

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    antibodies-online antibodies for MFNG (41 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    2 InterPro protein domains:
     IPR017374 Fringe
     IPR003378 Fringe-like

    Graphical View of Domain Structure for InterPro Entry O00587

    ProtoNet protein and cluster: O00587

    1 Blocks protein domain: IPB003378 Fringe-like

    UniProtKB/Swiss-Prot: MFNG_HUMAN, O00587
    Similarity: Belongs to the glycosyltransferase 31 family


    Find genes that share domains with MFNG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFNG_HUMAN, O00587
    Function: Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling.
    Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity
    Catalytic activity: Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated
    protein acceptor

         Genatlas biochemistry entry for MFNG:
    manic fringe,putative regulator of developmental processes through regulation of the sensitivity of NOTCH receptor
    genes or their specific ligands,essential mediator of somite segmentaion and patterning

         Enzyme Number (IUBMB): EC 2.4.1.2221 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0033829O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MFNG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MFNG:
     Increased Salmonella enterica   Increased circadian period len 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mfng):
     embryogenesis  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  no phenotypic analysis  normal  skeleton 

    Find genes that share phenotypes with MFNG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MFNG: Mfngtm1Cjg Mfngtm1Seco Mfngtm1.1Heed

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFNG
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFNG
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    miRNA
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    hsa-mir-335-5p (MIRT018410)

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    8 qRT-PCR Assays for microRNAs that regulate MFNG:
    hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMFNG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MFNG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MFNG_HUMAN, O00587: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS9187150
    GO:0016020membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with MFNG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MFNG About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    Notch Signaling0.30
    2Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Pre-NOTCH Processing in Golgi0.00
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64
    4Signaling by GPCR
    Signal Transduction0.58
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50


    Find genes that share SuperPaths with MFNG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MFNG
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MFNG
        Notch Signaling

    1 GeneGo (Thomson Reuters) Pathway for MFNG
        Development Notch Signaling Pathway

    2 BioSystems Pathways for MFNG
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway

    1 Reactome Pathway for MFNG
        Pre-NOTCH Processing in Golgi


    2 Kegg Pathways  (Kegg details for MFNG):
        Other types of O-glycan biosynthesis
    Notch signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MFNG: 
              Glycosylation in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MFNG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for MFNG (O005873 ENSP000003494904) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOTCH2Q047213, ENSP000002566464I2D: score=4 STRING: ENSP00000256646
    JAG1P785043, ENSP000002549584I2D: score=2 STRING: ENSP00000254958
    NOTCH1P465313, ENSP000002775414I2D: score=1 STRING: ENSP00000277541
    DLL1O005483, ENSP000003557184I2D: score=2 STRING: ENSP00000355718
    LHX2P504583, ENSP000003627174I2D: score=1 STRING: ENSP00000362717
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process IEA--
    GO:0032092positive regulation of protein binding IEA--
    GO:0045747positive regulation of Notch signaling pathway IEA--

    Find genes that share ontologies with MFNG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFNG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MFNG gene (2 alternative transcripts): 
    NM_001166343.1  NM_002405.3  

    Unigene Cluster for MFNG:

    MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    Hs.517603  [show with all ESTs]
    Unigene Representative Sequence: NM_002405
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356998(uc003ass.2 uc011ani.2) ENST00000489515 ENST00000454291
    ENST00000438891 ENST00000436341 ENST00000430411 ENST00000442496 ENST00000466943
    ENST00000424765 ENST00000416983(uc011anj.2)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate MFNG:
    hsa-miR-647 hsa-miR-205 hsa-miR-548p hsa-miR-324-3p hsa-miR-219-5p hsa-miR-3691-5p hsa-miR-2355-5p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMFNG 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MFNG
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    Additional mRNA sequence: 

    AK292123.1 AK297149.1 AK297833.1 AK316555.1 BC094814.1 CR456518.1 NR_029413.1 U94352.1 

    10 DOTS entries:

    DT.455946  DT.97821268  DT.40131711  DT.40111304  DT.92426736  DT.95118583  DT.95118581  DT.97778954 
    DT.97843956  DT.100797695 

    Selected AceView cDNA sequences (see all 246):

    BM708354 NM_002405 BE644660 W32714 BQ057862 CD368104 BX349861 AA428876 
    AI419319 AI439547 W25384 AI436390 AI439552 AU131692 AW592848 BF975091 
    AI261691 AA418830 BM921648 AW574851 BX099161 BI524246 AI699670 BM564281 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MFNG (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                                -     -     -           -                                                                                             
    SP2:                                            -           -                                                                                             
    SP3:                                                                                                                                -                     
    SP4:                                      -     -           -                                                                                             
    SP5:                                -     -     -     -     -                                                                                             


    ECgene alternative splicing isoforms for MFNG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MFNG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAAGGC
    MFNG Expression
    About this image


    MFNG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Tonsil (Hematopoietic System)
    MFNG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFNG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517603
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MFNG: 
              Glycosylation in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat MFNG
    QuantiFast Probe-based Assays in human, mouse, rat MFNG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFNG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MFNG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfng1 , 5 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less1, 5 83.65(n)1
    83.12(a)1
      15 (37.69 cM)5
    173051  NM_008595.21  NP_032621.11 
     787558825 
    chicken
    (Gallus gallus)
    Aves MFNG1 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase less 71.02(n)
    71.27(a)
      418042  XM_416278.3  XP_416278.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    60(a)
    many → 1
    many → 1
    5(23435343-23437876)
    5(23454225-23468687)
    zebrafish
    (Danio rerio)
    Actinopterygii mfng1 manic fringe homolog 62.05(n)
    62.92(a)
      493633  NM_001007788.1  NP_001007789.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fng3 dorsal/ventral pattern formation,
    imaginal disc UDP-glycosyltransferase less
    44(a)   3 78A1   --


    ENSEMBL Gene Tree for MFNG (if available)
    TreeFam Gene Tree for MFNG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MFNG gene
    LFNG2  RFNG2  
    2 SIMAP similar genes for MFNG using alignment to 8 protein entries:     MFNG_HUMAN (see all proteins):
    LFNG    RFNG

    Find genes that share paralogs with MFNG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MFNG (see all 453)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510757261,2
    C--37864684(+) TCAGGA/GGGCTG 3 -- ds50010--------
    rs1409793541,2
    C--37864793(+) TCTGTA/CTCAAA 3 -- ds50010--------
    rs57566881,2
    C,F,H--37864834(+) GACATC/GTTTAT 3 -- ds500114Minor allele frequency- G:0.01NS EA NA WA CSA 790
    rs1145248991,2
    F--37864875(+) ACACAC/TACATA 3 -- ds50011Minor allele frequency- T:0.07WA 118
    rs794225001,2
    F--37864893(+) GTACCG/ACCTCA 3 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1502023711,2
    --37865034(+) TGTGAC/TAGACA 3 -- ds50010--------
    rs96226261,2
    H--37865036(+) TGATAG/AACAGA 3 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs37885271,2
    C,F,H--37865057(+) ACCCCA/GTCAGG 3 -- ds500125Minor allele frequency- N:0.00NA EA NS WA 2978
    rs556988911,2
    C,F--37865234(-) GCTATA/TAATGT 3 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.10WA 120
    rs1387958131,2
    C--37865353(+) AGGCTA/GGGAAA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for MFNG (37865101 - 37882478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MFNG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829203CNV Loss20364138
    nsv915028CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MFNG
    DNA2.0 Custom Variant and Variant Library Synthesis for MFNG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602577    OMIM disorders: --


    Find genes that share disorders with MFNG           About GenesLikeMe

    Genetic Association Database (GAD): MFNG
    Human Genome Epidemiology (HuGE) Navigator: MFNG (2 documents)

    Export disorders for MFNG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MFNG gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with MFNG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. (PubMed id 9187150)1, 2, 3 Johnston S.H....Vogt T.F. (Development 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    4. Fringe is a glycosyltransferase that modifies Notch. (PubMed id 10935626)1, 2 Moloney D.J.... Vogt T.F. (Nature 2000)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. (PubMed id 9878264)1, 3 Egan S....Scherer S.W. (Genomics 1998)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (PubMed id 18617639)4 Litonjua A.A....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. (PubMed id 15280477)1 Veeraraghavalu K....Krishna S. (J. Virol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4242 HGNC: 7038 AceView: MFNG Ensembl:ENSG00000100060 euGenes: HUgn4242
    ECgene: MFNG Kegg: 4242 H-InvDB: MFNG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MFNG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MFNG Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MFNG
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_552

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MFNG gene:
    Search GeneIP for patents involving MFNG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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