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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MFN1 Gene

protein-coding GIFtS: 60
GCID: GC03P179065

mitofusin 1

Explore 7 diseases affiliated with
MFN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitofusin 1¹ ²		Mitochondrial Transmembrane GTPase Fzo-1²
Fzo Homolog² ³		Mitochondrial Transmembrane GTPase FZO-2²
Transmembrane GTPase MFN1² ³		Mitofusin-1¹
FLJ20693¹		Putative Transmembrane GTPase²
Hfzo1¹		EC 3.6.5.-³
Hfzo2¹		EC 3.6.5⁸

External Ids:	HGNC: 18262¹	Entrez Gene: 55669²	Ensembl: ENSG00000171109⁷	OMIM: 608506⁵	UniProtKB: Q8IWA4³

Export aliases for MFN1 gene to outside databases

Previous GC identifers: GC03P175825 GC03P179908 GC03P180467 GC03P180386 GC03P180548 GC03P176468

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MFN1:

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of

the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to

facilitate mitochondrial targeting. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MFN1_HUMAN, Q8IWA4

Function: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many

cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission.

MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks

Gene Wiki entry for MFN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MFN1 gene promoter:
ER-alpha Elk-1 Brachyury NCX/Ncx Cdc5 LCR-F1 Nkx6-1 FOXO4 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MFN1 promoter sequence

Search SABiosciences Chromatin IP Primers for MFN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q26.32

MFN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFN1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P179065: view genomic region (about GC identifiers)

Start:	179,065,480 bp from pter	End:	179,112,719 bp from pter
Size:	47,240 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MFN1_HUMAN, Q8IWA4 (See protein sequence)

Recommended Name: Mitofusin-1

Size: 741 amino acids; 84100 Da

Subunit: Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled

coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular

weight multiprotein complex. Interacts with VAT1 (By similarity)

Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein (Probable)

Subcellular location: Isoform 2: Cytoplasm

Secondary accessions: B2RAR1 D3DNR6 O15323 O60639 Q9BZB5 Q9NWQ2

Alternative splicing: 3 isoforms: Q8IWA4-1 Q8IWA4-2 Q8IWA4-3

Explore the universe of human proteins at neXtProt for MFN1: NX_Q8IWA4

Post-translational modifications:

Ubiquitinated by MARCH5¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWA4

4 DME Specific Peptides for MFN1 (Q8IWA4)

KLLRNKA

FILNNRWD

FEECISQSAVKTKF

EKKSVKTVNQLAHALH

MFN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_284941.2

ENSEMBL proteins:

ENSP00000420617 ENSP00000349963 ENSP00000419134 ENSP00000263969 ENSP00000420148

ENSP00000419926 ENSP00000280653

Reactome Protein details: Q8IWA4
Human Recombinant Protein Products for MFN1:

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	Novus Biologicals MFN1 Proteins Novus Biologicals MFN1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MFN1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0016021	integral to membrane	NAS	--

MFN1 for ontologies About GeneDecksing

MFN1 Antibody Products:

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	Uscn ELISAs and CLIAs for MFN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MFN1 for domains About GeneDecksing

4 InterPro domains/families:

IPR006884 Fzo/mitofusin_HR2

IPR001401 Dynamin_GTPase

IPR027088 Mitofusin-1

IPR027094 Mitofusin_fam

Graphical View of Domain Structure for InterPro Entry Q8IWA4

ProtoNet protein and cluster: Q8IWA4

UniProtKB/Swiss-Prot: MFN1_HUMAN, Q8IWA4

Similarity: Belongs to the mitofusin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MFN1_HUMAN, Q8IWA4

Function: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many

cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission.

MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks

Catalytic activity: GTP + H(2)O = GDP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.5² EC 3.6.5.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	NAS	--
GO:0005515	protein binding	--	--
GO:0005525	GTP binding	IEA	--

MFN1 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mfn1):

behavior/neurological	cellular	embryogenesis	growth/size	mortality/aging
nervous system	normal

MFN1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mfn1^tm1Dcc for MFN1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MFN1

miRNA Products:		OriGene 3'-UTR Clone: MFN1 Browse MicroRNA Expression Plasmids
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		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MFN1 (see all 22):
		hsa-miR-4254 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-539 hsa-miR-485-3p hsa-miR-488 hsa-miR-374c hsa-miR-483-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MFN1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for MFN1

	Hemostasis
	Factors involved in megakaryocyte development and platelet production

MFN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MFN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/10 Interacting proteins for MFN1 (Q8IWA4^{2, 3} ENSP00000263969⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MFN2	O95140²^,³	MINT-8258771 I2D: score=1
MAVS	Q7Z434²^,³, ENSP00000401980⁴	MINT-7714001 MINT-7713992 I2D: score=2 STRING: ENSP00000401980
BAK1	Q16611²^,³, ENSP00000363591⁴	MINT-8258771 I2D: score=1 STRING: ENSP00000363591
PARK2	O60260³, ENSP00000355865⁴	I2D: score=1 STRING: ENSP00000355865
MARCH5	Q9NX47³, ENSP00000351813⁴	I2D: score=1 STRING: ENSP00000351813

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0008053	mitochondrial fusion	IDA	--

MFN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MFN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MFN1

1 HMDB Compound for MFN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for MFN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide	0	5	16874299 (2), 17053808 (1)

Search CenterWatch for drugs/clinical trials and news about MFN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MFN1 gene (2 alternative transcripts):

NM_033540.2 NM_017927.2

Unigene Cluster for MFN1:

Mitofusin 1

Hs.478383 [show with all ESTs]

Unigene Representative Sequence: NM_033540

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000471841(uc003fjs.3 uc010hxb.3 uc003fjt.3 uc010hxc.3)

ENST00000357390 ENST00000467174 ENST00000263969 ENST00000489329 ENST00000474903

ENST00000466287 ENST00000482661 ENST00000480636 ENST00000280653

miRNA Products:		OriGene 3'-UTR Clone: MFN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFN1
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MFN1 (see all 22):
		hsa-miR-4254 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-539 hsa-miR-485-3p hsa-miR-488 hsa-miR-374c hsa-miR-483-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MFN1 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MFN1

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Additional cDNA sequence:

AB043588.1 AB043589.1 AF054986.1 AF329637.1 AK314306.1 BC020661.1 BC040557.1 CR627379.1

U95822.1

9 DOTS entries:

DT.451792 DT.99954192 DT.92052320 DT.92052321 DT.120906512 DT.120906526 DT.91689734 DT.431038

DT.91814703

24/149 AceView cDNA sequences (see all 149):

AW418886 AI902954 BU150424 CB044379 BF446140 AI675611 AW291883 NM_017927

AK000700 BQ428225 BQ922217 AA374362 BG187256 NM_033540 BC040557 BX279677

AA258842 AW089222 CF540966 CN481819 BM827314 CR627379 BC020661 BU182892

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MFN1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:																					-		-
SP2:
SP3:

ECgene alternative splicing isoforms for MFN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MFN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGCTATGT

About this image

MFN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MFN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MFN1

SOURCE GeneReport for Unigene cluster: Hs.478383

UniProtKB/Swiss-Prot: MFN1_HUMAN, Q8IWA4

Tissue specificity: Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed

in some tumors, such as lung cancers

SABiosciences Expression via Pathway-Focused PCR Array including MFN1:

Mitochondria in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MFN1 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mfn1^{1 , 5}	mitofusin 1^{1, 5}	86.59(n)¹ 90.55(a)¹		3 (15.75 cM)⁵ 67414¹ NM_024200.4¹ NP_077162.2¹ 32529465⁵
chicken (Gallus gallus)	Aves	MFN1¹	mitofusin 1	76.53(n) 81.55(a)		424973 NM_001012931.2 NP_001012949.1
lizard (Anolis carolinensis)	Reptilia	MFN1⁶	--	80(a)	1 ↔ 1	3(2249664-2270603)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13448²	Xenopus laevis transcribed sequence with moderate similarity more	80.86(n)		CF520154.1
zebrafish (Danio rerio)	Actinopterygii	zgc66150²	hypothetical protein MGC66150	73.57(n)		393620 BC057468.1
fruit fly (Drosophila melanogaster)	Insecta	Marf⁶ fzo⁶	fuzzy onions	41(a) 32(a)	many → 1 possible ortholog	X(6259982-6264960) 3R(19027366-19029756)
worm (Caenorhabditis elegans)	Secernentea	fzo-1⁶	Transmembrane GTPase fzo-1	32(a)	possible ortholog	II(5833307-5836182)

ENSEMBL Gene Tree for MFN1 (if available)
TreeFam Gene Tree for MFN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MFN1 gene

MFN2²

4 SIMAP similar genes for MFN1 using alignment to 5 protein entries: MFN1_HUMAN (see all proteins):

hfzo1 DKFZp762F247 hfzo2 MFN2

MFN1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for MFN1
PGOHUM00000236247 PGOHUM00000236248 PGOHUM00000241944

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11302834^1,2	C,F	--	176506194(+)	`AGTCCT/-TTTTT`	1	--	int¹ trp³		3		NA CSA	6
rs150177728^1,2		--	179063532(+)	`GCACCC/TGGCAA`	1	--	us2k¹		0	--	--	--	--
rs76966506^1,2	C	--	179063565(+)	`GTAATA/GGAAAG`	1	--	us2k¹		0	--	--	--	--
rs11927084^1,2	C,F,H	--	179063935(+)	`ACACAC/TACACA`	1	--	us2k¹		6		NA WA	310
rs77817375^1,2	F	--	179063999(+)	`TGCTAT/AAATTT`	1	--	us2k¹		1		WA	118
rs186797379^1,2		--	179064075(+)	`CAGAAC/TTAATA`	1	--	us2k¹		0	--	--	--	--
rs191188416^1,2		--	179064105(+)	`TTTAAA/GATTCA`	1	--	us2k¹		0	--	--	--	--
rs80176723^1,2	F	--	179064209(+)	`GTGTCC/TCCCAA`	1	--	us2k¹		2		WA NA	238
rs75085157^1,2	F	--	179064337(+)	`TGCTCC/TCCAGT`	1	--	us2k¹		1		WA	118
rs138652583^1,2		--	179064495(+)	`TTACCA/GTCCGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MFN1 (179065480 - 179112719 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MFN1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MFN1 for disorders           About GeneDecksing

OMIM gene information: 608506    OMIM disorders: --

7 diseases for MFN1:    About MalaCards

charcot-marie-tooth disease tooth disease optic atrophy glaucoma

lung cancer obesity neuronitis

1 disease from the University of Copenhagen DISEASES database for MFN1:

Optic atrophy

Human Genome Epidemiology (HuGE) Navigator: MFN1 (2 documents)

Export disorders for MFN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MFN1 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with MFN1)

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Control of mitochondrial morphology by a human mitofusin. (PubMed id 11181170)^{1, 2, 3, 9} Santel A. and Fuller M.T. (2001)
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. (PubMed id 12759376)^{1, 2, 9} Santel A.... Fuller M.T. (2003)
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. (PubMed id 12475957)^{1, 2, 9} Legros F.... Rojo M. (2002)
Loss of MARCH5 mitochondrial E3 ubiquitin ligase indu ces cellular senescence through dynamin-related protein 1 and mitofusin 1. (PubMed id 20103533)^{1, 2, 9} Park Y.Y....Cho H. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. (PubMed id 11950885)^{1, 2} Rojo M.... Lombes A. (2002)
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display. (PubMed id 11751411)^{1, 2} Chung J.-G....Ho H.-C. (2001)
Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. (PubMed id 9230308)^{1, 2} Hales K.G. and Fuller M.T. (1997)
3,400 new expressed sequence tags identify diversity of transcripts in human brain. (PubMed id 8358434)^{1, 3} Adams M.D.... Venter J.C. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55669	HGNC: 18262	AceView: MFN1	Ensembl:ENSG00000171109	euGenes: HUgn55669
ECgene: MFN1	H-InvDB: MFN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MFN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MFN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MFN1 gene:
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