Aliases for MFN1 Gene
External Ids for MFN1 Gene
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
GeneCards Summary for MFN1 Gene
MFN1 (Mitofusin 1) is a Protein Coding gene. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MFN2.
UniProtKB/Swiss-Prot for MFN1 Gene
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.