Aliases for MFI2 Gene
External Ids for MFI2 Gene
Previous GeneCards Identifiers for MFI2 Gene
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for MFI2 Gene
MFI2 (Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5) is a Protein Coding gene. Diseases associated with MFI2 include melanotic neuroectodermal tumor and melanoma. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include iron ion binding and ferric iron binding. An important paralog of this gene is TF.
UniProtKB/Swiss-Prot for MFI2 Gene
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.