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MFI2 Gene

protein-coding   GIFtS: 65
GCID: GC03M196715

Antigen P97 (Melanoma Associated) Identified By Monoclonal...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies
133.2 And 96.51 2
     Melanoma-Associated Antigen P972 3
MAP972 3 5     CD2282
melanotransferrin1 2     MTF12
Membrane-Bound Transferrin-Like Protein1 2     CD228 Antigen3

External Ids:    HGNC: 70371   Entrez Gene: 42412   Ensembl: ENSG000001639757   OMIM: 1557505   UniProtKB: P085823   

Export aliases for MFI2 gene to outside databases

Previous GC identifers: GC03M192695 GC03M197078 GC03M198136 GC03M198056 GC03M198218 GC03M194028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MFI2 Gene:
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares
sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of
the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as
members of the transferrin superfamily. Alternative splicing results in two transcript variants. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MFI2 Gene:
MFI2 (antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5) is a protein-coding gene. Diseases associated with MFI2 include melanoma, and melanotic neuroectodermal tumor. GO annotations related to this gene include ferric iron binding and iron ion binding. An important paralog of this gene is LTF.

UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
Function: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane.
Binds a single atom of iron per subunit. Could also bind zinc

Gene Wiki entry for MFI2 (Melanotransferrin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFI2 gene promoter:
         Bach1   MEF-2A   FAC1   aMEF-2   NF-E2 p45   NF-E2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFI2 promoter sequence
   Search Chromatin IP Primers for MFI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28-q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q28-q29

MFI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196715:  view genomic region     (about GC identifiers)

Start:
196,715,492 bp from pter      End:
196,756,687 bp from pter
Size:
41,196 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582 (See protein sequence)
Recommended Name: Melanotransferrin precursor  
Size: 738 amino acids; 80215 Da
Secondary accessions: Q9BQE2
Alternative splicing: 2 isoforms:  P08582-1   P08582-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFI2: NX_P08582

Explore proteomics data for MFI2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn135, Asn515
  • Modification sites at PhosphoSitePlus

  • See MFI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005920.2  NP_201573.1  

    ENSEMBL proteins: 
     ENSP00000296350   ENSP00000296351   ENSP00000393439  

    MFI2 Human Recombinant Protein Products:

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    MFI2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR018195 Transferrin_Fe_BS
     IPR016357 Transferrin
     IPR001156 Transferrin_fam

    Graphical View of Domain Structure for InterPro Entry P08582

    ProtoNet protein and cluster: P08582

    1 Blocks protein domain: IPB001156 Transferrin

    UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
    Similarity: Belongs to the transferrin family
    Similarity: Contains 2 transferrin-like domains


    MFI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRFM_HUMAN, P08582
    Function: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane.
    Binds a single atom of iron per subunit. Could also bind zinc

         Genatlas biochemistry entry for MFI2:
    antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IMP7556058
    GO:0005515protein binding IPI19815549
    GO:0008199ferric iron binding IEA--
         
    MFI2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MFI2:
     Increased S DNA content, incre 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mfi2):
     hematopoietic system  homeostasis/metabolism 

    MFI2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MFI2: Mfi2tm1Lex Mfi2tm1Drrn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFI2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFI2

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    miRTarBase miRNAs that target MFI2:
    hsa-mir-192-5p (MIRT026173), hsa-mir-215-5p (MIRT024379)

    Block miRNA regulation of human, mouse, rat MFI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MFI2 (see all 10):
    hsa-miR-148b* hsa-miR-875-3p hsa-miR-3186-3p hsa-miR-516b hsa-miR-942 hsa-miR-214* hsa-miR-3202 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidMFI2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MFI2

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    GenScript: all cDNA clones in your preferred vector (see all 2): MFI2 (NM_033316)
    Sino Biological Human cDNA Clone for MFI2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFI2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRFM_HUMAN, P08582: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005887integral component of plasma membrane TAS2419904
    GO:0009986cell surface IDA7556058
    GO:0031225anchored component of membrane ----
    GO:0046658anchored component of plasma membrane IDA7556058

    MFI2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFI2
    Interactions:

        GeneGlobe Interaction Network for MFI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for MFI2 (P085822, 3 ENSP000002963504) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301273 I2D: score=1 
    DERL3Q96Q803, ENSP000003847444I2D: score=1 STRING: ENSP00000384744
    DERL1Q9BUN83, ENSP000002595124I2D: score=1 STRING: ENSP00000259512
    DERL2Q9GZP93, ENSP000001587714I2D: score=1 STRING: ENSP00000158771
    UBQLN1Q9UMX03I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558NOT regulation of cell growth IMP7556058
    GO:0006826iron ion transport ----
    GO:0006879cellular iron ion homeostasis IEA--
    GO:0010756positive regulation of plasminogen activation IDA16713448
    GO:0042127NOT regulation of cell proliferation IMP7556058

    MFI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFI2 (TRFM)

    1 HMDB Compound for MFI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--

    6 Novoseek inferred chemical compound relationships for MFI2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ferric ammonium citrate 73.5 4 1629195 (1), 1543713 (1)
    iron 64.2 41 2001412 (3), 2049409 (3), 10813095 (3), 2364114 (2) (see all 21)
    deferoxamine 50.3 4 1629195 (1), 1543713 (1)
    fe3+ 39.3 1 1544447 (1)
    zinc 32.2 9 8867702 (1), 11005378 (1), 14568174 (1), 18158319 (1) (see all 6)
    oxygen 0 1 15544971 (1)



    MFI2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MFI2 gene (2 alternative transcripts): 
    NM_005929.5  NM_033316.3  

    Unigene Cluster for MFI2:

    Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
    Hs.184727  [show with all ESTs]
    Unigene Representative Sequence: NM_005929
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469783 ENST00000296350(uc003fxk.4) ENST00000296351(uc003fxl.4 uc011bua.2)
    ENST00000489445 ENST00000439320 ENST00000491399 ENST00000473501

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    Selected qRT-PCR Assays for microRNAs that regulate MFI2 (see all 10):
    hsa-miR-148b* hsa-miR-875-3p hsa-miR-3186-3p hsa-miR-516b hsa-miR-942 hsa-miR-214* hsa-miR-3202 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidMFI2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MFI2
      QuantiFast Probe-based Assays in human, mouse, rat MFI2

    Additional mRNA sequence: 

    BC001875.1 BC002623.2 BC007550.1 BC032752.1 BC034933.1 BC068085.1 BC071910.1 BC082761.1 
    BC093920.1 BC111947.1 BC143257.1 BT007377.1 M12154.1 

    11 DOTS entries:

    DT.307020  DT.435323  DT.95267529  DT.97854195  DT.86852992  DT.100739522  DT.100744222  DT.86836189 
    DT.65285498  DT.75162465  DT.95072562 

    Selected AceView cDNA sequences (see all 181):

    AU105451 BM784846 BM758005 AU099352 NM_033316 BE408902 BC007550 BM758992 
    BM749748 CK903419 BM749714 BE275242 CK903420 BM835633 BC071910 BM759376 
    BC002623 BM758926 BE274850 BC001875 BM748323 BE818634 AA876192 BE390516 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MFI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -     -     -                 -                             -                                                               
    SP2:              -     -     -                 -                                                                                             
    SP3:              -           -                                                                                                               
    SP4:                                            -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for MFI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MFI2 expression in normal human tissues (normalized intensities)      MFI2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGAGGCTTG
    MFI2 Expression
    About this image


    MFI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Stomach (Gastrointestinal Tract)
    MFI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184727

    UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
    Tissue specificity: Found predominantly in human melanomas and in certain fetal tissues; also found in liver,
    epithelium, umbilical chord, placenta and sweat gland ducts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MFI2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfi21 , 5 antigen p97 (melanoma associated) identified by monoclonal more1, 5 83.22(n)1
    84.81(a)1
      16 (22.40 cM)5
    300601  NM_013900.21  NP_038928.11 
     318788105 
    chicken
    (Gallus gallus)
    Aves MFI21 antigen p97 (melanoma associated) identified by monoclonal more 65.21(n)
    62.91(a)
      396127  NM_205207.1  NP_990538.1 
    lizard
    (Anolis carolinensis)
    Reptilia MFI26
    antigen p97 (melanoma associated) identified by mo...
    54(a)
    1 ↔ 1
    GL343829.1(691-8119)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mfi21 antigen p97 (melanoma associated) identified by monoclonal more 59.11(n)
    59.16(a)
      100158653  XM_002937831.2  XP_002937877.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mfi21 antigen p97 (melanoma associated) identified by monoclonal more 56.32(n)
    49.71(a)
      565942  XM_689207.6  XP_694299.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsf21 , 3 iron ion transporter3
    Transferrin 21
    37(a)3
    49.57(n)1
    38.47(a)1
      394351  NM_079320.31  NP_524044.11 


    ENSEMBL Gene Tree for MFI2 (if available)
    TreeFam Gene Tree for MFI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MFI2 gene
    LTF2  TF2  
    2 SIMAP similar genes for MFI2 using alignment to 3 protein entries:     TRFM_HUMAN (see all proteins):
    LTF    TF

    MFI2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MFI2 (see all 756)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505847551,2
    C--196732117(+) AAGACC/TGGAGT 1 -- int10--------
    rs1125708281,2
    C--196732195(+) AGGGAC/TGGGGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1810958061,2
    --196732435(+) GGGAGA/GAAATC 1 -- int10--------
    rs1861821561,2
    --196732516(+) CAGGGA/GAAGGT 1 -- int10--------
    rs1122014281,2
    F--196732528(+) TTTCCC/AGGAGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1835263751,2
    C--196732649(+) GGCCCC/TGGTGG 1 -- int10--------
    rs1995439981,2
    C--196732688(+) AAGAGA/GGGCCA 1 -- int10--------
    rs2008043491,2
    C--196732696(+) CCAGAA/GGAGAG 1 -- int10--------
    rs757059401,2
    C--196732708(+) ACTTGC/TTAACT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs799358221,2
    C--196732741(+) CCAGAA/GGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MFI2 (196715492 - 196756687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MFI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29143CNV Loss19812545
    nsv878191CNV Loss21882294
    nsv822421CNV Loss20364138
    nsv822422CNV Loss20364138
    nsv517987CNV Loss19592680
    nsv878192CNV Gain21882294

    Human Gene Mutation Database (HGMD): MFI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MFI2
    DNA2.0 Custom Variant and Variant Library Synthesis for MFI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 155750    OMIM disorders: --

    14 diseases for MFI2:    About MalaCards
    melanoma    melanotic neuroectodermal tumor    clear cell sarcoma    menkes disease
    angiomyolipoma    alzheimer's disease    b-cell lymphomas    sarcoma
    hypoxia    endotheliitis    thyroiditis    prostatitis
    prostate cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for MFI2:
    Melanoma

    MFI2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for MFI2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 67.7 34 12494997 (3), 2001412 (2), 8615605 (2), 19017294 (2) (see all 24)
    senile plaques 19.1 2 8705294 (2)
    alzheimers disease 11.3 7 12809550 (4), 10529437 (1), 8705294 (1)
    tumors 7.56 11 20087061 (5), 8608223 (1), 1707934 (1), 17196552 (1) (see all 7)
    metastasis 0 2 1707934 (1), 19017294 (1)
    carcinoma 0 2 9258449 (1), 8090582 (1)
    cancer 0 1 17196552 (1)

    Genetic Association Database (GAD): MFI2
    Human Genome Epidemiology (HuGE) Navigator: MFI2 (1 document)

    Export disorders for MFI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MFI2 gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with MFI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human melanotransferrin (p97) has only one functional iron-binding site. (PubMed id 1544447)1, 2, 9 Baker E.N.... Hellstroem I. (FEBS Lett. 1992)
    2. A novel iron uptake mechanism mediated by GPI-anchored human p97. (PubMed id 7556058)1, 2, 9 Kennard M.L....Jefferies W.A. (EMBO J. 1995)
    3. Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. (PubMed id 8300636)1, 2, 9 Food M.R....Jefferies W.A. (J. Biol. Chem. 1994)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function. (PubMed id 1633859)1, 2 Garrat R.C. and Jhoti H. (FEBS Lett. 1992)
    6. A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97. (PubMed id 2463331)1, 2 Furukawa K.S.... Lloyd K.O. (J. Exp. Med. 1989)
    7. Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. (PubMed id 2419904)1, 2 Rose T.M....Brown J.P. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    8. Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease. (PubMed id 12809550)1, 9 Desrosiers R.R....BAcliveau R. (Biochem. J. 2003)
    9. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. (PubMed id 18691669)1, 9 Farnaud S....Richardson D.R. (amp 2008)
    10. Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II. (PubMed id 17570828)1, 9 Michaud-Levesque J....BAcliveau R. (Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4241 HGNC: 7037 AceView: MFI2 Ensembl:ENSG00000163975 euGenes: HUgn4241
    ECgene: MFI2 H-InvDB: MFI2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MFI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MFI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MFI2 gene:
    Search GeneIP for patents involving MFI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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