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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFI2 Gene

protein-coding   GIFtS: 59
GCID: GC03M196715

antigen p97 (melanoma associated) identified by monoclonal...
 Explore 14 diseases affiliated with
MFI2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MFI2    

Aliases
for MFI2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2
And 96.51 2
     FLJ388631
MAP971 2 3 5     MGC48561
CD2281 2     Melanotransferrin1
MTF11 2     Membrane-Bound Transferrin-Like Protein2
Melanoma-Associated Antigen P972 3     CD228 Antigen3

External Ids:    HGNC: 70371   Entrez Gene: 42412   Ensembl: ENSG000001639757   OMIM: 1557505   UniProtKB: P085823   

Export aliases for MFI2 gene to outside databases

Previous GC identifers: GC03M192695 GC03M197078 GC03M198136 GC03M198056 GC03M198218 GC03M194028


Summaries
for MFI2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MFI2:
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence
similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding
function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the
transferrin superfamily. Alternative splicing results in two transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
Function: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds
a single atom of iron per subunit. Could also bind zinc

Gene Wiki entry for MFI2 (Melanotransferrin)


Genomic Views
for MFI2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFI2 gene promoter:
         Bach1   MEF-2A   FAC1   aMEF-2   NF-E2 p45   NF-E2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MFI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MFI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28-q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q28-q29

MFI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196715:  view genomic region     (about GC identifiers)

Start:
 196,715,492 bp from pter      End:
 196,756,687 bp from pter
Size:
 41,196 bases      Orientation:
 minus strand

Proteins
for MFI2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582 (See protein sequence)
Recommended Name: Melanotransferrin precursor  
Size: 738 amino acids; 80215 Da
Subcellular location: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q9BQE2
Alternative splicing: 2 isoforms:  P08582-1   P08582-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFI2: NX_P08582

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08582

    • MFI2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005920.2  NP_201573.1  

    ENSEMBL proteins: 
     ENSP00000296350   ENSP00000296351   ENSP00000393439  

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    Novus Biologicals MFI2 Protein
    Novus Biologicals MFI2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MFI2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral to plasma membrane TAS2419904
    GO:0031225anchored to membrane IEA--


    MFI2 for ontologies           About GeneDecksing



    MFI2 Antibody Products: 
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    Uscn ELISAs and CLIAs for MFI2

    Protein Domains /
    Families
    for MFI2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MFI2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018195 Transferrin_Fe_BS
     IPR016357 Transferrin
     IPR001156 Transferrin_fam

    Graphical View of Domain Structure for InterPro Entry P08582

    ProtoNet protein and cluster: P08582

    1 Blocks protein family: IPB001156 Transferrin

    UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
    Similarity: Belongs to the transferrin family
    Similarity: Contains 2 transferrin-like domains


    Function
    for MFI2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
    Function: Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds
    a single atom of iron per subunit. Could also bind zinc

         Genatlas biochemistry entry for MFI2:
    antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFI2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MFI2 (see all 10):
    hsa-miR-148b* hsa-miR-875-3p hsa-miR-3186-3p hsa-miR-516b hsa-miR-942 hsa-miR-214* hsa-miR-3202 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmid: MFI2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFI2 (see all 7)
    OriGene shRNA RFP: MFI2
    OriGene siRNA: MFI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFI2

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFI2 

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    Search LifeMap BioReagents cell lines for MFI2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding TAS2419904
    GO:0005515protein binding IPI19815549
    GO:0008199ferric iron binding IEA--


    MFI2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MFI2:
     Increased S DNA content, incre 

    Animal Models:
         Mouse knock-outs for MFI2: Mfi2tm1Lex Mfi2tm1Drrn
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mfi2):
     hematopoietic system  homeostasis/metabolism 

    MFI2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MFI2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MFI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for MFI2 (P085822, 3 ENSP000002963504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301273 I2D: score=1 
    DERL3Q96Q803, ENSP000003847444I2D: score=1 STRING: ENSP00000384744
    DERL1Q9BUN83, ENSP000002595124I2D: score=1 STRING: ENSP00000259512
    DERL2Q9GZP93, ENSP000001587714I2D: score=1 STRING: ENSP00000158771
    UBQLN1Q9UMX03I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006826iron ion transport IEA--
    GO:0006879cellular iron ion homeostasis IEA--


    MFI2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MFI2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MFI2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFI2

    1 HMDB Compound for MFI2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    6 Novoseek chemical compound relationships for MFI2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ferric ammonium citrate 73.5 4 1629195 (1), 1543713 (1)
    iron 64.2 41 2001412 (3), 2049409 (3), 10813095 (3), 2364114 (2) (see all 21)
    deferoxamine 50.3 4 1629195 (1), 1543713 (1)
    fe3+ 39.3 1 1544447 (1)
    zinc 32.2 9 8867702 (1), 11005378 (1), 14568174 (1), 18158319 (1) (see all 6)
    oxygen 0 1 15544971 (1)

    Search CenterWatch for drugs/clinical trials and news about MFI2 / TRFM 

    Transcripts
    for MFI2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MFI2 gene (2 alternative transcripts): 
    NM_005929.5  NM_033316.3  

    Unigene Cluster for MFI2:

    Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
    Hs.184727  [show with all ESTs]
    Unigene Representative Sequence: NM_005929
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469783 ENST00000296350(uc003fxk.4) ENST00000296351(uc003fxl.4 uc011bua.2)
    ENST00000489445 ENST00000439320 ENST00000491399 ENST00000473501

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MFI2 (see all 10):
    hsa-miR-148b* hsa-miR-875-3p hsa-miR-3186-3p hsa-miR-516b hsa-miR-942 hsa-miR-214* hsa-miR-3202 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmid: MFI2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFI2 (see all 7)
    OriGene shRNA RFP: MFI2
    OriGene siRNA: MFI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFI2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MFI2 (NM_033316)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFI2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFI2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFI2

    Additional cDNA sequence: 

    BC001875.1 BC002623.2 BC007550.1 BC032752.1 BC034933.1 BC068085.1 BC071910.1 BC082761.1 
    BC093920.1 BC111947.1 BC143257.1 BT007377.1 M12154.1 

    11 DOTS entries:

    DT.307020  DT.435323  DT.95267529  DT.97854195  DT.86852992  DT.100739522  DT.100744222  DT.86836189 
    DT.65285498  DT.75162465  DT.95072562 

    24/181 AceView cDNA sequences (see all 181):

    BC007550 BM835633 BE275242 CK903420 AU105451 BC001875 BM758926 BC002623 
    BM749748 BC071910 BM758992 BE408902 BM759376 BM749714 BE274850 AU099352 
    BM784846 NM_033316 BM758005 CK903419 BM758260 BM758459 BM757503 BM748474 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MFI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -     -     -                 -                             -                                                               
    SP2:              -     -     -                 -                                                                                             
    SP3:              -           -                                                                                                               
    SP4:                                            -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for MFI2

    Expression
    for MFI2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCGAGGCTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MFI2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneMandibular FossaBone
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MFI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFI2

    SOURCE GeneReport for Unigene cluster: Hs.184727

    UniProtKB/Swiss-Prot: TRFM_HUMAN, P08582
    Tissue specificity: Found predominantly in human melanomas and in certain fetal tissues; also found in liver,
    epithelium, umbilical chord, placenta and sweat gland ducts

        SABiosciences Custom PCR Arrays for MFI2
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    In Situ
    Assay Products:     
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    Orthologs
    for MFI2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MFI2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mfi25 antigen p97 (melanoma associated) identified by monoclonal more   --   16 (22.40 cM) 31878810 
    chicken
    (Gallus gallus)    		 Aves MFI26
    		 melanotransferrin/EOS47
    		 61(a)
    		 1 ↔ 1
    		 9(13556869-13573461)
    lizard
    (Anolis carolinensis)    		 Reptilia MFI26
    		 --
    		 54(a)
    		 1 ↔ 1
    		 GL343829.1(691-8119)
    zebrafish
    (Danio rerio)    		 Actinopterygii mfi26
    otomp6
    		 otolith matrix protein
    		 48(a)
    37(a)
    		 1 ↔ 1
    possible ortholog
    		 6(29805607-29823233)
    2(41589199-41603527)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsf23 iron ion transporter 37(a)     --


    ENSEMBL Gene Tree for MFI2 (if available)
    TreeFam Gene Tree for MFI2 (if available) 

    Paralogs
    for MFI2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFI2 gene
    LTF2  TF2  
    3 SIMAP similar genes for MFI2 using alignment to 3 protein entries:     TRFM_HUMAN (see all proteins):
    LTF    GIG12    TF

    MFI2 for paralogs           About GeneDecksing



    Genomic Variants
    for MFI2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/631 NCBI SNPs in MFI2 are shown (see all 631)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136089791,2
    		--196728118(+) GTGAAG/ACCATG 2 -- ds5001 us2k11Minor allele frequency- A:0.50CSA 2
    rs1472579721,2
    		--196728263(+) GCCCCA/CCTCCA 2 -- ds5001 us2k10--------
    rs1397583311,2
    		--196728270(+) TCCAGA/TGAGTT 2 -- ds5001 us2k10--------
    rs575302411,2
    		C,--196728483(+) GGCGCG/-GGGGG 2 -- us2k1 ds50011Minor allele frequency- -:0.50CSA 2
    rs126323831,2
    		C,F,A,H--196728540(+) AATGGA/GATCTG 2 -- us2k1 ds50014Minor allele frequency- G:0.01EA NS NA 302
    rs1495371641,2
    		--196728544(+) GAATCC/TGCCCT 2 -- ds5001 us2k10--------
    rs5517791,2
    		C,F,A,H,--196728580(+) AGTGCC/GTAACA 2 -- us2k1 ds500111Minor allele frequency- G:0.02NA EA MN NS 862
    rs10603571,2
    		C,F,A,H,--196728633(-) CATGCC/AGAGGC 2 -- ut31 us2k116Minor allele frequency- A:0.30EA NA WA CSA 2220
    rs5395101,2
    		C,F,A,H,--196728706(-) AGGGGG/ACCCCT 2 -- ut31 us2k122Minor allele frequency- A:0.29NA EA NS WA CSA 2341
    rs1440094221,2
    		--196728789(+) TAGCCC/TAGAGT 2 -- ut31 us2k10--------

    HapMap Linkage Disequilibrium report for MFI2 (196715492 - 196756687 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MFI2
         1 CNV: 68560
         2 Inversions: 37243 0568
    Human Gene Mutation Database (HGMD): MFI2

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    Disorders / Diseases
    for MFI2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MFI2 for disorders           About GeneDecksing

    OMIM gene information: 155750    OMIM disorders: --

    14 diseases for MFI2:    About MalaCards
    melanoma    melanotic neuroectodermal tumor    b-cell lymphomas    neuroectodermal tumors
    clear cell sarcoma    menkes disease    angiomyolipoma    alzheimer's disease
    sarcoma    prostate cancer    hypoxia    prostatitis
    thyroiditis    leukemia

    1 disease from the University of Copenhagen DISEASES database for MFI2:
    Melanoma

    7 Novoseek disease relationships for MFI2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 67.7 34 12494997 (3), 2001412 (2), 8615605 (2), 19017294 (2) (see all 24)
    senile plaques 19.1 2 8705294 (2)
    alzheimers disease 11.3 7 12809550 (4), 10529437 (1), 8705294 (1)
    tumors 7.56 11 20087061 (5), 8608223 (1), 1707934 (1), 17196552 (1) (see all 7)
    metastasis 0 2 1707934 (1), 19017294 (1)
    carcinoma 0 2 9258449 (1), 8090582 (1)
    cancer 0 1 17196552 (1)

    Human Genome Epidemiology (HuGE) Navigator: MFI2 (1 document)

    Export disorders for MFI2 gene to outside databases

    Publications
    for MFI2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFI2 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with MFI2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human melanotransferrin (p97) has only one functional iron-binding site. (PubMed id 1544447)1, 2, 9 Baker E.N.... Hellstroem I. (1992)
    2. A novel iron uptake mechanism mediated by GPI-anchored human p97. (PubMed id 7556058)1, 2, 9 Kennard M.L....Jefferies W.A. (1995)
    3. Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. (PubMed id 8300636)1, 2, 9 Food M.R....Jefferies W.A. (1994)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function. (PubMed id 1633859)1, 2 Garrat R.C. and Jhoti H. (1992)
    6. A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97. (PubMed id 2463331)1, 2 Furukawa K.S.... Lloyd K.O. (1989)
    7. Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. (PubMed id 2419904)1, 2 Rose T.M....Brown J.P. (1986)
    8. Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease. (PubMed id 12809550)1, 9 Desrosiers R.R....Beliveau R. (2003)
    9. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. (PubMed id 18691669)1, 9 Farnaud S....Richardson D.R. (2008)
    10. Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II. (PubMed id 17570828)1, 9 Michaud-Levesque J....Beliveau R. (2007)

    External Searches for MFI2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing MFI2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4241 HGNC: 7037 AceView: MFI2 Ensembl:ENSG00000163975 euGenes: HUgn4241
    ECgene: MFI2 H-InvDB: MFI2

    Other Databases showing MFI2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MFI2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MFI2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MFI2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MFI2 gene:
    Search GeneIP for patents involving MFI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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