Aliases for MFI2 Gene
External Ids for MFI2 Gene
Previous GeneCards Identifiers for MFI2 Gene
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for MFI2 Gene
MFI2 (Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5) is a Protein Coding gene. Diseases associated with MFI2 include melanotic neuroectodermal tumor and melanoma. GO annotations related to this gene include iron ion binding and ferric iron binding. An important paralog of this gene is TF.
UniProtKB/Swiss-Prot for MFI2 Gene
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.