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MFGE8 Gene

protein-coding GIFtS: 62

GC15M087243

milk fat globule-EGF factor 8 protein
(Previous name: sperm associated antigen 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SPAG10)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BA46 ^¹, ²
EDIL1 ^¹, ²
HMFG ^³
HsT19888 ^¹, ²
MFG-E8 ^¹, ², ³
MFGM ^³
OAcGD3S ^¹, ²
SED1 ^¹, ²
SPAG10 ^²
hP47 ^¹, ²
lactadherin ^²
medin ^²

Descriptions
Breast epithelial antigen BA46 ^³
Milk fat globule-EGF factor 8 ^³
O-acetyl disialoganglioside synthase ^²
milk fat globule-EGF factor 8 protein ^²
sperm associated antigen 10 ^¹, ²
sperm surface protein hP47 ^²

External Ids
HGNC: 7036¹
Entrez Gene: 4240²
UniProtKB: Q08431³
Ensembl: ENSG00000140545⁷

Search outside databases for aliases for MFGE8 gene

Previous GC identifers: GC15M085781 GC15M082807 GC15M087029 GC15M087172 GC15M087173

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MFGM_HUMAN, Q08431

Function: Medin is the main constituent of aortic medial amyloid

Gene Wiki entry for MFGE8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MFGE8 gene

Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25

MFGE8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M087243: (about GC identifiers)

Start:	87,242,920 bp from pter
End:	87,257,614 bp from pter
Size:	14,695 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010274.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MFGM_HUMAN, Q08431 (See protein sequence)

Recommended Name: Lactadherin precursor

Size: 387 amino acids; 43123 Da

Subcellular location: Membrane; Peripheral membrane protein

Secondary accessions: B2R6M7 Q53FU9

Post-translational modifications:

Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001108086.1 NP_005919.2

ENSEMBL proteins:

ENSP00000268151 ENSP00000268150

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for MFGE8 (MFG-E8)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Human Milk Fat Globule 1)
	Human Recombinant Proteins from Abnova (MFGE8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0009897	external side of plasma membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0019897	extrinsic to plasma membrane	IEA	--

About this table

Antibodies for MFGE8:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MFGE8
	Sigma-Aldrich Antibodies for MFGE8
	R&D Systems Antibodies for MFGE8 (MFG-E8)
	Antibodies from Abcam (Human Milk Fat Globule 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MFGE8)
	Novus Biologicals Antibodies for MFGE8

Assays for MFGE8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q08431

ProtoNet protein and cluster: Q08431

3 Blocks protein families:

IPB000421 Coagulation factor 5/8 type C domain (FA58C)

IPB001438 Type II EGF-like signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: MFGM_HUMAN, Q08431

Similarity: Contains 1 EGF-like domain

Similarity: Contains 2 F5/8 type C domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MFGE8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MFGE8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114614

Applied Biosystems Silencer® siRNAs for MFGE8

Sigma-Aldrich siRNA for MFGE8

Sigma-Aldrich shRNA Panels and shRNA for MFGE8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MFGE8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114614
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114614
untagged cDNA clones in CMV expression vector (see all 2): NM_001114614

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005928

UniProtKB/Swiss-Prot: MFGM_HUMAN, Q08431

Function: Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to

phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding

protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits

its replication

Function: Medin is the main constituent of aortic medial amyloid

Genatlas biochemistry entry for MFGE8:

human milk fat globule protein,46kDa,murine mammary protein MFG-E8 homolog,associated to apoptosis

7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mfge8):

	endocrine/exocrine gland	hematopoietic system	immune system	renal/urinary system
reproductive system	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	phosphatidylserine binding	IEA	--
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008429	phosphatidylethanolamine binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for MFGE8

5/8 Interacting proteins for MFGE8 (ENSP00000268150³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGAV	ENSP00000364042³	STRING (score=.957)
MC3R	ENSP00000360442³	STRING (score=.934)
ITGB3	ENSP00000262017³	STRING (score=.919)
ELN	ENSP00000351807³	STRING (score=.844)
EGFLAM	ENSP00000346964³	STRING (score=.775)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006910	phagocytosis, recognition	IEA	--
GO:0006911	phagocytosis, engulfment	IEA	--
GO:0007155	cell adhesion	TAS	8639264
GO:0007338	single fertilization	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MFGE8
3 Novoseek chemical compound relationships for MFGE8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid	47.12	15	12517809 (3), 17905307 (1), 18820763 (1), 10821695 (1)
whey	26.39	1	17183076 (1)
lipid	0.00	3	17420351 (1), 17905307 (1), 10821695 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MFGE8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MFGE8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114614

Sigma-Aldrich siRNA for MFGE8

Sigma-Aldrich shRNA Panels and shRNA for MFGE8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114614 NM_005928

REFSEQ mRNAs for MFGE8 gene (2 alternative transcripts):

NM_001114614.1 NM_005928.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114614 NM_005928

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114614
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114614
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001114614

Additional cDNA sequence:

AK092157.1 AK095908.1 AK222735.1 AK223182.1 AK304627.1 AK310357.1 AK312640.1 AY141974.1

BC003610.2 BT006948.1 BX537974.1 CR590960.1 CR591207.1 CR592072.1 CR592357.1 CR595108.1

CR603150.1 CR609258.1 CR622104.1 CR624080.1 CR624954.1 S56151.1 U58516.1

24/31 DOTS entries (see all 31 ):

DT.92453118 DT.95331148 DT.95329332 DT.91870799 DT.100845960 DT.102843217 DT.100845946 DT.95264516

DT.121080280 DT.92453126 DT.100845957 DT.121080273 DT.100845948 DT.121080300 DT.95118753 DT.100038124

DT.100845963 DT.121080306 DT.100038123 DT.121080284 DT.100845955 DT.102843215 DT.121080245 DT.100845954

24/675 AceView cDNA sequences (see all 675 ):

CB153003 AW276464 AA477212 AI660445 AL524657 BQ446436 F10041 BQ219455

AA026693 BG677052 CR609258 AU151937 BU149720 F01452 BQ026509 CD621387

AW513662 AA292038 BP365294 CR590960 AI244278 H25538 CR622104 BQ436244

highest scoring ESTs for MFGE8:

U58516 AA019189 AA080914 AA115999 AI272315 AK095908 AL519278 AL530483 AL530950 AL531012

Unigene Cluster for MFGE8:

Milk fat globule-EGF factor 8 protein

Hs.3745 [show with all ESTs]

Unigene Representative Sequence: AK092157

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MFGE8 (see all 13 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	·	13c	·	13d	^	14a	·	14b	^	15a	·
SP1:							-				-		-														-				-		-		-		-		-
SP2:							-		-		-		-														-				-		-		-		-		-
SP3:							-		-		-		-														-				-		-		-		-		-								-		-
SP4:							-		-		-		-														-				-		-		-		-		-		-
SP5:							-		-		-		-		-												-				-		-		-		-		-

ExUns:	15b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MFGE8

2 Ensembl transcripts including schematic representations:

ENST00000268151 ENST00000268150

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MFGE8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MFGE8

¹ / ² / ³

5 probe-sets matching MFGE8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34403_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U58516	1.00	1.00	1.00	1
210605_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003610	0.80	1.00	0.91	1
210605_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1567540_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1567539_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks MFGE8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGTTGGCAGG

SOURCE GeneReport for Unigene cluster: Hs.3745
Expression variation in blood from EXPOLDB for MFGE8
UniProtKB/Swiss-Prot: MFGM_HUMAN, Q08431
Tissue specificity: Mammary epithelial cell surfaces and aortic media. Overexpressed in several
carcinomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MFGE8 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MFGE8¹	--	milk fat globule-EGF factor 8 protein	99.57(n) 99.48(a)	453631 XM_001165789.1 XP_001165789.1
mouse (Mus musculus)	Mfge8⁵	7 (41.20 cM)	milk fat globule-EGF factor 8 protein	--	Y11684
zebrafish (Danio rerio)	Dr.28901²	--	Transcribed sequence with weak similarity to protein more	73.78(n)	CK398618.1
African clawed frog (Xenopus laevis)	Xl.12862²	--	Xenopus laevis transcribed sequence with weak similarity more	69.59(n)	CF549359.1

About this table Species with no ortholog for MFGE8

ENSEMBL Gene Tree for MFGE8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MFGE8 gene

EDIL3² NRP2² NRP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/161 NCBI SNPs in MFGE8 are shown (see all 161 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8530^1,2	A,C,F,H	87243182(-)	`CCTGCG/ATCGGC`	2	--	ut3¹ ese³		13		MN EU EA WA NA	1348
	rs2280214^1,2	A,C,F,H	87243610(-)	`CCCCAG/AGTCTT`	2	--	ut3¹ ese³		8		EA NA EU WA	2032
	rs1878326^1,2	A,C,F,H	87251591(-)	`TGGGCA/CTGGAG`	2	L/M	mis¹		16		NA EA EU WA	2698
	rs10859^1,2	A,C,F,H	87243470(-)	`CCACCC/GTCCAC`	2	--	ut3¹		6		MN EU EA WA	784
	rs2280215^1,2	A,C,F	87243436(+)	`CGGGGC/GTTAGG`	2	--	ut3¹		2		MN	368
--	rs12161973^1,2	A	87242646(+)	`taaaaA/Cttagc`	1	--	ng5¹		0	--	--	--	--
	rs4945^1,2	F	87257548(-)	`TGCCGC/AGCCCC`	2	S/R	mis¹		3		MN EA	584
	rs1042915^1,2	H	87250900(-)	`GGACAC/GGAATT`	2	H/Q	mis¹ ese³		5		MN EU EA WA	586
	rs1878327^1,2	A,C,F,H,O	87251550(-)	`GCCTCA/GTCTGT`	2	S/S	syn¹		7		EA NA WA	1142
	rs2271714^1,2	A,C,F,H,O	87251007(-)	`TGAACC/TTGCTG`	2	L/L	syn¹		12		EA NA EU WA	2418

About this table

HapMap Linkage Disequilibrium images for MFGE8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602281

6 Novoseek disease relationships for MFGE8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rotavirus infections	62.28	7	9643686 (3), 15545370 (2), 11787681 (1), 9773837 (1)
breast carcinoma	21.30	6	9260929 (3), 10821695 (1)
tumors	4.06	3	12189239 (1), 17877156 (1)
cancer	0.00	1	17637751 (1)
breast cancer	0.00	2	17637751 (1), 15565181 (1)
alzheimers disease	0.00	2	17322377 (6), 19208933 (1), 19281242 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/115 PubMed articles for MFGE8 gene (see all 115 ):

Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. (PubMed id 9260929)^{1, 3, 4} Taylor M.R.... Peterson J.A. (1997)
Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. (PubMed id 10411933)^{1, 3, 4} Haeggqvist B.... Westermark P. (1999)
Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25. (PubMed id 9027496)^{1, 2, 3} Collins C....Parry G. (1997)
Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain. (PubMed id 8639264)^{1, 3, 4} Couto J.R.... Peterson J.A. (1996)
SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions. (PubMed id 19204935)^{1, 2, 3} Raymond A....Shur B.D. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes. (PubMed id 9535276)^{3, 4} Giuffrida M.G....Godovac-Zimmermann J. (1998)
A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains. (PubMed id 1909932)^{3, 4} Larocca D....Ceriani R.L. (1991)
p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms. (PubMed id 17637751)^{1, 3} Okuyama T....Katoh I. (2008)
Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. (PubMed id 11856354)^{1, 3} Oshima K....Matsuda T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4240	HGNC: 7036	AceView: MFGE8	Ensembl:ENSG00000140545	euGenes: HUgn4240
ECgene: MFGE8	H-InvDB: MFGE8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MFGE8	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MFGE8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MFGE8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MFGE8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MFGE8		Antibodies for MFGE8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MFGE8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MFGE8)
	Antibodies (MFGE8)
	Chimera RNAi (MFGE8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Human Milk Fat Globule 1)
	Antibodies (Human Milk Fat Globule 1)

Search OriGene for MFGE8

Search Tocris compounds for MFGE8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MFGE8

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MFGE8 Gene at Home site.
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MFGE8 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for MFGE8

Summaries
for MFGE8

Genomic Location
for MFGE8

Proteins
for MFGE8

Protein Domains/
Families
for MFGE8

Gene Function
for MFGE8

Pathways & Interactions
for MFGE8

Drugs & Compounds
for MFGE8

Transcripts
for MFGE8

Expression
for MFGE8

Orthologs
for MFGE8

Paralogs
for MFGE8

SNPs/Variants
for MFGE8

Disorders & Mutations
for MFGE8

Medical News
for MFGE8

Publications
for MFGE8

Search for MFGE8

Genome Databases showing MFGE8

Other Databases showing MFGE8

Specialized Databases showing MFGE8

Licensable Technologies
for MFGE8

Services
for MFGE8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MFGE8 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor MFGE8

Summariesfor MFGE8

Genomic Locationfor MFGE8

Proteinsfor MFGE8

Protein Domains/Familiesfor MFGE8

Gene Functionfor MFGE8

Pathways & Interactionsfor MFGE8

Drugs & Compoundsfor MFGE8

Transcriptsfor MFGE8

Expression for MFGE8

Orthologsfor MFGE8

Paralogsfor MFGE8

SNPs/Variantsfor MFGE8

Disorders & Mutationsfor MFGE8

Medical Newsfor MFGE8

Publicationsfor MFGE8

Search for MFGE8

Genome Databases showing MFGE8

Other Databases showing MFGE8

Specialized Databases showing MFGE8

Licensable Technologiesfor MFGE8

Servicesfor MFGE8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MFGE8

Summaries
for MFGE8

Genomic Location
for MFGE8

Proteins
for MFGE8

Protein Domains/
Families
for MFGE8

Gene Function
for MFGE8

Pathways & Interactions
for MFGE8

Drugs & Compounds
for MFGE8

Transcripts
for MFGE8

Expression
for MFGE8

Orthologs
for MFGE8

Paralogs
for MFGE8

SNPs/Variants
for MFGE8

Disorders & Mutations
for MFGE8

Medical News
for MFGE8

Publications
for MFGE8

Licensable Technologies
for MFGE8

Services
for MFGE8