Aliases for MFGE8 Gene
External Ids for MFGE8 Gene
Previous Symbols for MFGE8 Gene
GeneCards Summary for MFGE8 Gene
MFGE8 (Milk Fat Globule-EGF Factor 8 Protein) is a Protein Coding gene. Diseases associated with MFGE8 include simultanagnosia and hidrocystoma. Among its related pathways are Disease and Integrins in angiogenesis. GO annotations related to this gene include integrin binding and phosphatidylethanolamine binding. An important paralog of this gene is NRP2.
UniProtKB/Swiss-Prot for MFGE8 Gene
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.
Medin is the main constituent of aortic medial amyloid.