Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFF Gene

protein-coding   GIFtS: 48
GCID: GC02P228189

mitochondrial fission factor

(Previous name: chromosome 2 open reading frame 33 )
(Previous symbol: C2orf33)
 Explore 13 diseases affiliated with
MFF via our new
 Human Malady Compendium 
Biological research products
for MFF
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Fission Factor1 2
C2orf331 2 3
GL0041 2
Chromosome 2 Open Reading Frame 331

External Ids:    HGNC: 248581   Entrez Gene: 569472   Ensembl: ENSG000001689587   OMIM: 6147855   UniProtKB: Q9GZY83   

Export aliases for MFF gene to outside databases

Previous GC identifers: GC02P227899 GC02P220036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8
Function: Plays a role in mitochondrial and peroxisomal fission

Gene Wiki entry for MFF (Mitochondrial fission factor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFF gene promoter:
         C/EBPbeta   MEF-2   Pax-6   MyoD   Meis-1b   MEF-2A   aMEF-2   Meis-1a   MRF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFF promoter sequence
   Search SABiosciences Chromatin IP Primers for MFF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36

MFF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFF gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P228189:  view genomic region     (about GC identifiers)

Start:
228,189,867 bp from pter      End:
228,222,550 bp from pter
Size:
32,684 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 (See protein sequence)
Recommended Name: Mitochondrial fission factor  
Size: 342 amino acids; 38465 Da
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein
Secondary accessions: Q567U1 Q658R6 Q9BVZ1 Q9H690 Q9NRG8
Alternative splicing: 5 isoforms:  Q9GZY8-1   Q9GZY8-2   Q9GZY8-3   Q9GZY8-4   Q9GZY8-5   (Contains a phosphoserine at position 146)

Explore the universe of human proteins at neXtProt for MFF: NX_Q9GZY8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZY8

  • MFF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064579.3  
    ENSEMBL proteins: 
     ENSP00000390165   ENSP00000304898   ENSP00000302037   ENSP00000346498   ENSP00000431725  
     ENSP00000432447   ENSP00000386964   ENSP00000415996   ENSP00000386641   ENSP00000338412  
     ENSP00000436920   ENSP00000435354   ENSP00000436289   ENSP00000304134   ENSP00000411386  
     ENSP00000391829   ENSP00000407547   ENSP00000415313   ENSP00000375912  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MFF
    OriGene Custom Protein Services for MFF 
    GenScript Custom Purified and Recombinant Proteins Services for MFF
    Novus Biologicals MFF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MFF

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005741mitochondrial outer membrane IDA--
    GO:0005777peroxisome IDA18353969
    GO:0032592integral to mitochondrial membrane IDA18353969


    MFF for ontologies           About GeneDecksing



    MFF Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: MFF
    OriGene Custom Antibody Services for MFF 
    GenScript Custom Superior Antibodies Services for MFF
    Novus Biologicals MFF Antibodies
    Abcam antibodies for MFF 
    Uscn Antibodies for MFF
    Search ThermoFisher Antibodies for MFF

    Assay Products for MFF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MFF
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MFF


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MFF for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008518 FATE/Miff/Tango-11

    Graphical View of Domain Structure for InterPro Entry Q9GZY8

    ProtoNet protein and cluster: Q9GZY8

    UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8
    Similarity: Belongs to the tango11 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8
    Function: Plays a role in mitochondrial and peroxisomal fission

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: MFF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFF
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MFF:
    hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMFF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFF (see all 4)
    OriGene shRNA RFP: MFF
    OriGene siRNA: MFF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MFF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFF (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MFF (NM_020194)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFF 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MFF
    Search LifeMap BioReagents cell lines for MFF

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFF

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    MFF for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MFF:
     Decreased viability with pacli  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFF

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MFF (Q9GZY83 ENSP000003020374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IMP18353969
    GO:0006626protein targeting to mitochondrion IMP--
    GO:0010821regulation of mitochondrion organization IMP--
    GO:0016559peroxisome fission IMP--
    GO:0043653mitochondrial fragmentation involved in apoptotic process IMP18353969


    MFF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFF
    Search CenterWatch for drugs/clinical trials and news about MFF 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MFF gene: 
    NM_020194.4  

    Unigene Cluster for MFF:

    Mitochondrial fission factor
    Hs.471528  [show with all ESTs]
    Unigene Representative Sequence: NM_020194
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000423098 ENST00000304593(uc002vot.3 uc021vxu.1) ENST00000476924
    ENST00000489696 ENST00000353339(uc002vos.3) ENST00000354503 ENST00000530359
    ENST00000531278 ENST00000409565 ENST00000452930 ENST00000409616 ENST00000460756
    ENST00000337110(uc002vow.3 uc002voz.3) ENST00000525195 ENST00000470090
    ENST00000534203 ENST00000524634 ENST00000349901

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: MFF
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFF
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MFF:
    hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMFF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFF (see all 4)
    OriGene shRNA RFP: MFF
    OriGene siRNA: MFF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFF
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFF (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MFF (NM_020194)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFF 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFF
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFF

    Additional cDNA sequence: 

    AF226049.1 AF246239.1 AF258660.1 AK026137.1 AL833032.1 BC000797.1 BC093024.1 

    24/46 DOTS entries (see all 46):

    DT.100039364  DT.95095294  DT.91862879  DT.419092  DT.100889797  DT.100039362  DT.100039363  DT.91776269 
    DT.92017025  DT.100889748  DT.100889791  DT.95342457  DT.121013360  DT.91776249  DT.121013432  DT.121013429 
    DT.95342420  DT.100889784  DT.91735333  DT.100889785  DT.100889790  DT.40211143  DT.437069  DT.95342398 

    24/466 AceView cDNA sequences (see all 466):

    AI367703 AI342923 BM973677 AA400179 AW771799 AI262825 BG924948 CR593325 
    BM969628 AA444123 AW512653 AA666306 BM888353 AW009042 H97310 AW131824 
    N22129 BG527935 CA414040 AW952181 BU626027 BQ774137 AI783628 CR604101 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MFF (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
    SP1:                                            -                 -     -     -     -                                         -     -     -     -     -     -   
    SP2:                                            -                 -     -     -     -                                         -     -     -     -               
    SP3:                                            -                 -     -     -     -                                         -     -     -     -     -     -   
    SP4:                                                              -     -     -     -                                                     -     -               
    SP5:                                                                                                                                            -               

    ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
    SP1:  -                                                         
    SP2:                                                            
    SP3:  -     -                                                   
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MFF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTGAACAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MFF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFF

    SOURCE GeneReport for Unigene cluster: Hs.471528

    UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8
    Tissue specificity: Highly expressed in heart, kidney, liver, brain, muscle, and stomach

        SABiosciences Custom PCR Arrays for MFF
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFF
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MFF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MFF gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mff1 , 5 mitochondrial fission factor1, 5 91.87(n)1
    94.85(a)1
      1 (42.45 cM)5
    757341  NM_029409.21  NP_083685.21 
     827248905 
    chicken
    (Gallus gallus)
    Aves MFF1 mitochondrial fission factor 81.71(n)
    84.45(a)
      424796  XM_001233529.2  XP_001233530.1 
    lizard
    (Anolis carolinensis)
    Reptilia MFF6
    --
    76(a)
    1 ↔ 1
    3(23431660-23454290)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.314322 Xenopus laevis transcribed sequences 74.08(n)    CF548786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660222 hypothetical protein MGC66022 71.93(n)   393508  BC056301.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango116
    Transport and Golgi organization 11
    25(a)
    1 ↔ 1
    2R(17604285-17607466)


    ENSEMBL Gene Tree for MFF (if available)
    TreeFam Gene Tree for MFF (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFF gene

    MFF for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for MFF (see all 6)
    PGOHUM00000243904 PGOHUM00000243905 PGOHUM00000245103 PGOHUM00000235421 PGOHUM00000241732


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/594 NCBI SNPs in MFF are shown (see all 594    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112994151,2
    --220033844(+) AACCCG/TGACTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs756708381,2
    F,--220033851(+) ACTTTT/ACCGAC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs789040541,2
    F,--220034504(+) GAGAGC/GCCAAA 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs756349561,2
    C,F,--220035265(+) TTAACT/CGTAGC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs766806891,2
    C,F,--220035324(+) TTGGCA/GAGTTA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1458556031,2
    C,--228190251(+) CCCGG-/CCCCCC 2 -- nc-transcript-variantus2k10--------
    rs101767151,2
    C,F,H,--228190367(+) GAGCGC/TCTTCT 2 -- us2k116Minor allele frequency- T:0.04NS EA NA WA CSA 787
    rs1900485381,2
    --228190400(+) CTTCAC/TCTTGT 2 -- us2k10--------
    rs1427837991,2
    --228190896(+) GAAGAA/GCACCC 2 -- us2k10--------
    rs1502009971,2
    --228190975(+) TCTGCC/GCAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MFF (228189867 - 228222550 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MFF: --
    Human Gene Mutation Database (HGMD): MFF

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFF
    DNA2.0 Custom Variant and Variant Library Synthesis for MFF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MFF for disorders           About GeneDecksing

    OMIM gene information: 614785    OMIM disorders: --

    13 diseases for MFF:    About MalaCards
    intestinal volvulus    sclerosing keratitis    elephantiasis    hypermobility syndrome
    hydrocele    keratitis    papillary thyroid carcinoma    trichuriasis
    folliculitis    filariasis    thyroid carcinoma    thyroiditis
    carcinoma

    6 diseases from the University of Copenhagen DISEASES database for MFF:
    Filariasis     Elephantiasis     Hydrocele     Sclerosing keratitis
    Intestinal volvulus     Trichuriasis

    Export disorders for MFF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFF gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with MFF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PubMed id 18353969)1, 2, 3 Gandre-Babbe S. and van der Bliek A.M. (2008)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Differential expression of a set of genes in follicul ar and classic variants of papillary thyroid carcinoma. (PubMed id 21509594)1 Igci Y.Z....Demiryurek A.T. (2011)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56947 HGNC: 24858 AceView: C2orf33 Ensembl:ENSG00000168958 euGenes: HUgn56947
    ECgene: MFF H-InvDB: MFF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MFF gene:
    Search GeneIP for patents involving MFF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MFF   OriGene shRNA RFP for MFF  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFF   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MFF  
     OriGene Protein Over-expression Lysate for MFF   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MFF   OriGene 3'-UTR Clone for MFF  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFF   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFF  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MFF   OriGene Custom Protein Services for MFF  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MFF
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MFF
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFF
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFF
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFF
     GenScript Custom Purified and Recombinant Proteins Services for MFF GenScript cDNA clones with any tag delivered in your preferred vector for MFF
     GenScript Custom Assay Services for MFF GenScript Custom Superior Antibodies Services for MFF
     GenScript Custom overexpressing Cell Line Services for MFF CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MFF promoter
     Search Chromatin IP Primers for MFF
     RT2 qPCR Primer Assay in human, mouse, rat MFF
     Search GNC Networks for MFF
     SABiosciences Custom PCR Arrays for MFF
     Search Tocris compounds for MFF
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MFF antibodies
     MFF lysates
     Antibodies for MFF
     See all of Abcam's Antibodies, Kits and Proteins for MFF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MFF Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MFF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFF
     SwitchGear 3'UTR luciferase reporter plasmids for MFF
     SwitchGear Promoter luciferase reporter plasmids for MFF
     Search ThermoFisher Antibodies for MFF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFF
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MFF gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4