Aliases for MFF Gene
External Ids for MFF Gene
Previous HGNC Symbols for MFF Gene
Previous GeneCards Identifiers for MFF Gene
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
GeneCards Summary for MFF Gene
MFF (Mitochondrial Fission Factor) is a Protein Coding gene. Diseases associated with MFF include Sclerosing Keratitis and Anterior Scleritis. Among its related pathways are Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity.
UniProtKB/Swiss-Prot for MFF Gene
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.