Aliases for MFF Gene
External Ids for MFF Gene
Previous HGNC Symbols for MFF Gene
Previous GeneCards Identifiers for MFF Gene
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
GeneCards Summary for MFF Gene
MFF (Mitochondrial Fission Factor) is a Protein Coding gene. Diseases associated with MFF include Encephalopathy Due To Defective Mitochondrial And Peroxisomal Fission 2 and Sclerosing Keratitis. Among its related pathways are Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity.
UniProtKB/Swiss-Prot for MFF Gene
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.