Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MFAP5 Gene

protein-coding   GIFtS: 56
GCID: GC12M008806

Microfibrillar Associated Protein 5

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Microfibrillar Associated Protein 51 2     MFAP-52 3
MAGP22 3 5     MP252 3
Microfibril-Associated Glycoprotein 22 3     Microfibril-Associated Glycoprotein-22
MAGP-22 3     Microfibrillar-Associated Protein 52

External Ids:    HGNC: 296731   Entrez Gene: 80762   Ensembl: ENSG000001976147   OMIM: 6011035   UniProtKB: Q133613   

Export aliases for MFAP5 gene to outside databases

Previous GC identifers: GC12M008690 GC12M008689 GC12M008798 GC12M008585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MFAP5 Gene:
This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It
lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are
characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between
these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues
occurs. The structural differences suggest that this encoded protein has some functions that are distinct from
those of MFAP2. (provided by RefSeq, Jul 2008)

GeneCards Summary for MFAP5 Gene:
MFAP5 (microfibrillar associated protein 5) is a protein-coding gene. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MFAP2.

UniProtKB/Swiss-Prot: MFAP5_HUMAN, Q13361
Function: Component of the elastin-associated microfibrils

Gene Wiki entry for MFAP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFAP5 gene promoter:
         Bach1   RFX1   Brachyury   GCNF   MIF-1   Cdc5   HSF2   GCNF-1   GCNF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFAP5 promoter sequence
   Search Chromatin IP Primers for MFAP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1-p12.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.1-p12.3

MFAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFAP5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008806:  view genomic region     (about GC identifiers)

Start:
8,789,942 bp from pter      End:
8,815,484 bp from pter
Size:
25,543 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MFAP5_HUMAN, Q13361 (See protein sequence)
Recommended Name: Microfibrillar-associated protein 5 precursor  
Size: 173 amino acids; 19612 Da
Secondary accessions: B0AZL6 D3DUV1

Explore the universe of human proteins at neXtProt for MFAP5: NX_Q13361

Explore proteomics data for MFAP5 at MOPED

Post-translational modifications: 

  • Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the
    microfibrils1
  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycan heterogeneity at Thr-54:
    HexHexNAc (major) and HexHexNAc + sulfate (minor)1
  • Glycosylation2 at Thr54, Asn79

  • See MFAP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003471.1  
    ENSEMBL proteins: 
     ENSP00000441185   ENSP00000444531   ENSP00000352455   ENSP00000411997   ENSP00000379798  
     ENSP00000441492   ENSP00000443839   ENSP00000438525   ENSP00000439289   ENSP00000445799  
     ENSP00000440496  
    Reactome Protein details: Q13361

    MFAP5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MFAP5 (MAGP-2/MFAP5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MFAP5
    OriGene Protein Over-expression Lysate for MFAP5
    OriGene MassSpec for MFAP5
    OriGene Custom Protein Services for MFAP5
    GenScript Custom Purified and Recombinant Proteins Services for MFAP5
    Novus Biologicals MFAP5 Proteins
    Novus Biologicals MFAP5 Lysates
    Sino Biological Recombinant Protein for MFAP5
    Sino Biological Cell Lysate for MFAP5
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MFAP5

     
    Search eBioscience for Proteins for MFAP5 

    MFAP5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MFAP5
    R&D Systems Antibodies for MFAP5 (MAGP-2/MFAP5)
    OriGene Antibodies for MFAP5
    OriGene Custom Antibody Services for MFAP5
    Novus Biologicals MFAP5 Antibodies
    Abcam antibodies for MFAP5
    Cloud-Clone Corp. Antibodies for MFAP5
    ThermoFisher Antibodies for MFAP5
    LSBio Antibodies in human, mouse, rat for MFAP5

    MFAP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MFAP5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MFAP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MFAP5
    Cloud-Clone Corp. CLIAs for MFAP5
    Search eBioscience for ELISAs for MFAP5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008673 MAGP

    Graphical View of Domain Structure for InterPro Entry Q13361

    ProtoNet protein and cluster: Q13361

    1 Blocks protein domain: IPB008673 Microfibril-associated glycoprotein

    UniProtKB/Swiss-Prot: MFAP5_HUMAN, Q13361
    Similarity: Belongs to the MFAP family


    Find genes that share domains with MFAP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFAP5_HUMAN, Q13361
    Function: Component of the elastin-associated microfibrils

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS8557636
         
    Find genes that share ontologies with MFAP5           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mfap5):
     cardiovascular system  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with MFAP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mfap5tm1Mech for MFAP5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFAP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFAP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFAP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFAP5

    miRNA
    Products:
        
    miRTarBase miRNAs that target MFAP5:
    hsa-mir-124-3p (MIRT022336)

    Block miRNA regulation of human, mouse, rat MFAP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MFAP5 (see all 14):
    hsa-miR-374b* hsa-miR-549 hsa-miR-1288 hsa-miR-130a* hsa-miR-586 hsa-miR-23c hsa-miR-545 hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidMFAP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MFAP5
    Predesigned siRNA for gene silencing in human, mouse, rat MFAP5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MFAP5

    Clone
    Products:
         
    OriGene clones in human, mouse for MFAP5 (see all 6)
    OriGene ORF clones in mouse, rat for MFAP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MFAP5 (NM_003480)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFAP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MFAP5
    Browse ESI BIO Cell Lines and PureStem Progenitors for MFAP5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MFAP5_HUMAN, Q13361: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001527microfibril IEA--
    GO:0005576extracellular region TAS--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with MFAP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MFAP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Elastic fibre formation
    Elastic fibre formation0.73
    Molecules associated with elastic fibres0.73
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3Notch Signaling Pathways
    Notch Signaling Pathways
    4Notch signaling pathway (Pathway Interaction Database)
    Notch signaling pathway


    Find genes that share SuperPaths with MFAP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MFAP5
        Notch Signaling Pathways


    1 BioSystems Pathway for MFAP5
        Notch signaling pathway


    2 Reactome Pathways for MFAP5
        Molecules associated with elastic fibres
    Elastic fibre formation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFAP5
    Interactions:

        GeneGlobe Interaction Network for MFAP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for MFAP5 (Q133613 ENSP000003524554) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBN2P355563, ENSP000002624644I2D: score=2 STRING: ENSP00000262464
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
    MEGF6O750953, ENSP000003489824I2D: score=1 STRING: ENSP00000348982
    VWFP042753, ENSP000002614054I2D: score=1 STRING: ENSP00000261405
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization TAS--
    GO:0043206extracellular fibril organization IEA--

    Find genes that share ontologies with MFAP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFAP5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MFAP5 gene: 
    NM_003480.2  

    Unigene Cluster for MFAP5:

    Microfibrillar associated protein 5
    Hs.512842  [show with all ESTs]
    Unigene Representative Sequence: NM_003480
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535411 ENST00000543467 ENST00000359478(uc001qut.1 uc001qus.2 uc009zge.1)
    ENST00000433590 ENST00000396549 ENST00000543369 ENST00000544211 ENST00000535336
    ENST00000538694 ENST00000537009 ENST00000534833 ENST00000544889 ENST00000538107
    ENST00000537128 ENST00000540087
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MFAP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MFAP5 (see all 14):
    hsa-miR-374b* hsa-miR-549 hsa-miR-1288 hsa-miR-130a* hsa-miR-586 hsa-miR-23c hsa-miR-545 hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidMFAP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MFAP5
    Predesigned siRNA for gene silencing in human, mouse, rat MFAP5
    Clone
    Products:
         
    OriGene clones in human, mouse for MFAP5 (see all 6)
    OriGene ORF clones in mouse, rat for MFAP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MFAP5 (NM_003480)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFAP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MFAP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFAP5
      QuantiTect SYBR Green Assays in human, mouse, rat MFAP5
      QuantiFast Probe-based Assays in human, mouse, rat MFAP5

    Additional mRNA sequence: 

    AK124368.1 AK290585.1 AK299475.1 AK315807.1 AL833019.1 AY339060.1 BC005901.1 U37283.1 

    13 DOTS entries:

    DT.113811  DT.95159281  DT.95200920  DT.100793261  DT.100793263  DT.100793260  DT.121146226  DT.121146234 
    DT.75102969  DT.92442590  DT.95136801  DT.100736320  DT.100736337 

    Selected AceView cDNA sequences (see all 166):

    CA446239 AA694112 CA414334 AA256368 AI186956 CB052517 AY339060 AI741710 
    CB143610 NM_003480 BF439125 CA440409 AA256939 AI243130 AW452469 AI199801 
    AI277687 AA031469 CB962020 AA423884 CR609578 BF439813 AI367994 AI090889 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MFAP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCTTCTG
    MFAP5 Expression
    About this image


    MFAP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Mature Cardiac Fibroblasts Myocardium
             Atrioventricular Node
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    MFAP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFAP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512842
        Custom PCR Arrays for MFAP5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MFAP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFAP5
    QuantiTect SYBR Green Assays in human, mouse, rat MFAP5
    QuantiFast Probe-based Assays in human, mouse, rat MFAP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MFAP5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfap51 , 5 microfibrillar associated protein 51, 5 82.52(n)1
    81.1(a)1
      6 (57.61 cM)5
    505301  NM_015776.21  NP_056591.11 
     1225058455 
    chicken
    (Gallus gallus)
    Aves MFAP51 microfibrillar associated protein 5 58.61(n)
    49.02(a)
      418256  XM_004938101.1  XP_004938158.1 
    lizard
    (Anolis carolinensis)
    Reptilia MFAP56
    microfibrillar associated protein 5
    43(a)
    1 ↔ 1
    2(81436029-81459930)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017348191 microfibrillar-associated protein 5-like 61.76(n)
    60.29(a)
      101734819  XM_004921020.1  XP_004921077.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mfap56
    microfibrillar associated protein 5
    33(a)
    1 ↔ 1
    16(14421237-14440378) ENSDARG00000090560


    ENSEMBL Gene Tree for MFAP5 (if available)
    TreeFam Gene Tree for MFAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MFAP5 gene
    MFAP22  
    2 SIMAP similar genes for MFAP5 using alignment to 9 protein entries:     MFAP5_HUMAN (see all proteins):
    MAGP2    MFAP2

    Find genes that share paralogs with MFAP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MFAP5 (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364304
    A breast cancer sample4--see VAR_0364302 V D mis40--------
    rs123210161,2
    C,F,A,H--8798128(+) AAAAAT/CATATT 1 -- ds500111Minor allele frequency- C:0.08NS EA NA WA CSA 772
    rs1874970421,2
    --8798267(+) TCAAGC/TGATTC 1 -- ds50010--------
    rs1932032521,2
    --8798368(+) TATCAC/TGTTGG 1 -- ds50010--------
    rs1846685461,2
    --8798409(+) TGATCC/TGCCCA 1 -- ds50010--------
    rs1884047741,2
    --8798458(+) CACCAC/TGCCCG 1 -- ds50010--------
    rs1473885771,2
    C--8798466(+) CCGGCC/TGATAC 1 -- ds50010--------
    rs1401255991,2
    C--8798579(+) ATTGG-/AAAAAA 1 -- ut310--------
    rs1927390751,2
    --8798731(+) GTTTCC/TCTAAA 1 -- ut310--------
    rs1835266241,2
    --8798811(+) AGATTA/GTATGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MFAP5 (8789942 - 8815484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MFAP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667162CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MFAP5
    DNA2.0 Custom Variant and Variant Library Synthesis for MFAP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601103    OMIM disorders: --


    Find genes that share disorders with MFAP5           About GenesLikeMe

    1 Novoseek inferred disease relationship for MFAP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skin fibrosis 83.5 1 15934076 (1)


    Export disorders for MFAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MFAP5 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with MFAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region. (PubMed id 9792630)1, 2, 3, 9 Hatzinikolas G. and Gibson M.A. (J. Biol. Chem. 1998)
    2. Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). (PubMed id 8557636)1, 2, 3 Gibson M.A.... Cleary E.G. (J. Biol. Chem. 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. (PubMed id 18417156)1, 9 Albig A.R....Schiemann W.P. (Microvasc. Res. 2008)
    5. A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2. (PubMed id 19962670)1, 9 Mok S.C....Birrer M.J. (Cancer Cell 2009)
    6. NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment. (PubMed id 22885067)1 Turkyilmaz E....Menevse S. (Gene 2012)
    7. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (Mol. Cell. Proteomics 2011)
    8. Identification of the chondrocyte lineage using microfibril-associated glycoprotein-2, a novel marker that distinguishes chondrocytes from synovial cells. (PubMed id 20345228)1 Rapko S....Duguay S. (Tissue Eng Part C Methods 2010)
    9. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8076 HGNC: 29673 AceView: MFAP5 Ensembl:ENSG00000197614 euGenes: HUgn8076
    ECgene: MFAP5 H-InvDB: MFAP5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MFAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MFAP5 gene:
    Search GeneIP for patents involving MFAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of MFAP5
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for MFAP5 (MAGP-2/MFAP5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for MFAP5 (MAGP-2/MFAP5)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MFAP5   OriGene RNAi products in human, mouse, rat for MFAP5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MFAP5  
     OriGene MassSpec something-or-other for MFAP5   OriGene clones in human, mouse for MFAP5  
     OriGene qSTAR qPCR primer pairs in human, mouse for MFAP5   OriGene Purified Protein for MFAP5  
     OriGene ORF clones in mouse, rat for MFAP5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MFAP5   OriGene Custom Protein Services for MFAP5  

     
     
     Block miRNA regulation of human, mouse, rat MFAP5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MFAP5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFAP5 Predesigned siRNA for gene silencing in human, mouse, rat MFAP5
     QuantiFast Probe-based Assays in human, mouse, rat MFAP5 QuantiTect SYBR Green Assays in human, mouse, rat MFAP5
     Custom PCR Arrays for MFAP5 Search Chromatin IP Primers for MFAP5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFAP5  GeneGlobe Interaction Network for MFAP5
     Regulatory tfbs in MFAP5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MFAP5 GenScript cDNA clones with any tag delivered in your preferred vector for MFAP5
     GenScript Custom Assay Services for MFAP5 GenScript Custom overexpressing Cell Line Services for MFAP5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MFAP5
     Proteins for MFAP5
     Cell Lysates for MFAP5
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MFAP5 antibodies
     MFAP5 proteins
     MFAP5 lysates
     Antibodies for MFAP5
     See all of Abcam's Antibodies, Kits and Proteins for MFAP5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MFAP5
     Antibodies for MFAP5
     ELISAs for MFAP5
     CLIAs for MFAP5



     Browse ESI BIO Cell Lines and PureStem Progenitors for MFAP5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP5
     SwitchGear 3'UTR luciferase reporter plasmids for MFAP5
     SwitchGear Promoter luciferase reporter plasmids for MFAP5
     ThermoFisher Antibodies for MFAP5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFAP5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFAP5
     LSBio Antibodies in human, mouse, rat for MFAP5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MFAP5
      Search eBioscience for proteins for MFAP5
      Search eBioscience for elisas for MFAP5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MFAP5 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4