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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFAP4 Gene

protein-coding   GIFtS: 59
GCID: GC17M019286

microfibrillar-associated protein 4
 Explore 4 diseases affiliated with
MFAP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MFAP4    

Aliases
for MFAP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microfibrillar-Associated Protein 41 2
Microfibril-Associated Glycoprotein 42

External Ids:    HGNC: 70351   Entrez Gene: 42392   Ensembl: ENSG000001664827   OMIM: 6005965   UniProtKB: P550833   

Export aliases for MFAP4 gene to outside databases

Previous GC identifers: GC17M019418 GC17M020758 GC17M019191 GC17M019448 GC17M019227 GC17M018666


Summaries
for MFAP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MFAP4:
This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding
specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is
involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region.
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: MFAP4_HUMAN, P55083
Function: Could be involved in calcium-dependent cell adhesion or intercellular interactions




Genomic Views
for MFAP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFAP4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MFAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MFAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MFAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFAP4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M019286:  view genomic region     (about GC identifiers)

Start:
 19,286,755 bp from pter      End:
 19,290,553 bp from pter
Size:
 3,799 bases      Orientation:
 minus strand

Proteins
for MFAP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MFAP4_HUMAN, P55083 (See protein sequence)
Recommended Name: Microfibril-associated glycoprotein 4 precursor  
Size: 255 amino acids; 28648 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=AAB00968.1; Type=Erroneous initiation; Sequence=BAG65329.1; Type=Erroneous termination;
Positions=256; Note=Translated as stop;
Secondary accessions: A8KAJ1 A8MVM2 B4E317 Q6P680
Alternative splicing: 2 isoforms:  P55083-1   P55083-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MFAP4: NX_P55083

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55083

    • MFAP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185624.1  NP_002395.1  

    ENSEMBL proteins: 
     ENSP00000468578   ENSP00000378957   ENSP00000299610  
    Reactome Protein details: P55083
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): MFAP4
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    Novus Biologicals MFAP4 Proteins
    Novus Biologicals MFAP4 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MFAP4
    Uscn Proteins for MFAP4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001527microfibril NAS7633408
    GO:0031012colocalizes with extracellular matrix IDA--


    MFAP4 for ontologies           About GeneDecksing



    MFAP4 Antibody Products: 
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    Uscn ELISAs and CLIAs for MFAP4

    Protein Domains /
    Families
    for MFAP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MFAP4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry P55083

    ProtoNet protein and cluster: P55083

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: MFAP4_HUMAN, P55083
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for MFAP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MFAP4_HUMAN, P55083
    Function: Could be involved in calcium-dependent cell adhesion or intercellular interactions

         Genatlas biochemistry entry for MFAP4:
    microfibrillar associated glycoprotein 4,36kDa,component of microfibrils in the extracellular matrix,commonly deleted
    in Smith-Magenis syndrome

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFAP4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MFAP4:
    hsa-miR-3194-5p hsa-miR-222* hsa-miR-769-5p hsa-miR-16-1* hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmid: MFAP4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFAP4 (see all 7)
    OriGene shRNA RFP: MFAP4
    OriGene siRNA: MFAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFAP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MFAP4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MFAP4 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP4 

    Cell Line
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    Search LifeMap BioReagents cell lines for MFAP4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005102receptor binding IEA--


    MFAP4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for MFAP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Elastic fibre formation
    		Elastic fibre formation1.00
    		Molecules associated with elastic fibres0.84
    2Collagen formation
    		Extracellular matrix organization0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for MFAP4
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Elastic fibre formation



    MFAP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MFAP4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MFAP4 (P550833 ENSP000002996104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFTPDP352473, ENSP000003613664I2D: score=1 STRING: ENSP00000361366
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--
    GO:0007165signal transduction IEA--


    MFAP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MFAP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFAP4

    1 HMDB Compound for MFAP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about MFAP4 

    Transcripts
    for MFAP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MFAP4 gene (2 alternative transcripts): 
    NM_001198695.1  NM_002404.2  

    Unigene Cluster for MFAP4:

    Microfibrillar-associated protein 4
    Hs.296049  [show with all ESTs]
    Unigene Representative Sequence: NM_001198695
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497081 ENST00000395592(uc002gvs.3) ENST00000299610(uc002gvt.3)
    ENST00000574313 ENST00000571210

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MFAP4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MFAP4:
    hsa-miR-3194-5p hsa-miR-222* hsa-miR-769-5p hsa-miR-16-1* hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmid: MFAP4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFAP4 (see all 7)
    OriGene shRNA RFP: MFAP4
    OriGene siRNA: MFAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFAP4
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MFAP4
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    GenScript: all cDNA clones in your preferred vector (see all 2): MFAP4 (NM_001198695)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MFAP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MFAP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFAP4

    Additional cDNA sequence: 

    AK293056.1 AK304528.1 BC035560.1 BC047725.1 BC062415.1 L38486.1 

    16 DOTS entries:

    DT.443309  DT.100824034  DT.95336579  DT.91754809  DT.101980689  DT.100781325  DT.120954326  DT.95174007 
    DT.100693349  DT.100824044  DT.95351237  DT.97817448  DT.100770627  DT.80100329  DT.95364057  DT.95364060 

    24/281 AceView cDNA sequences (see all 281):

    BE550933 BP374351 BX463318 BP373541 AW245172 CD108825 BP371800 CR599896 
    BP373466 BF197033 CR617970 BP374294 AI471718 BI823428 BG059591 AI682763 
    BQ017631 BU735693 AI131565 BX417973 BP340930 CD514791 CR620310 BP373385 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MFAP4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:              -     -                                                               
    SP2:              -     -                                                               
    SP3:                    -                                                               
    SP4:              -     -                                                               
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MFAP4

    Expression
    for MFAP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGAGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MFAP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    BoneZeugopod Epiphyseal EndBone
    KidneyMetanephrosKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Primitive streak-like cells (Generation of endode...)
    Trophoblast-like cells (Generation of tropho...)
    Mesendoderm-like cells (Generation of mesend...)

    See MFAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFAP4

    SOURCE GeneReport for Unigene cluster: Hs.296049
        SABiosciences Custom PCR Arrays for MFAP4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP4

    Orthologs
    for MFAP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MFAP4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MFAP46
    --
    (see all 4)    		 --
    		 85(a)
    39(a)
    (see all 4)    		 1 ↔ 1
    possible ortholog
    (see all 4)    		 GL343287.1(1714451-1719951)
    1(77130430-77139418)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia CF378083.12   -- 78.4(n)    CF378083.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.188352 Transcribed sequence with weak similarity to protein more 73.44(n)    BQ449931.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG55503   -- 42(a)
    (best of 7)    		   53D1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T15B7.16
    		 --
    		 19(a)
    		 1 ↔ 1
    		 V(6842757-6846651)


    ENSEMBL Gene Tree for MFAP4 (if available)
    TreeFam Gene Tree for MFAP4 (if available) 

    Paralogs
    for MFAP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFAP4 gene
    TNR2  FIBCD12  FCN32  FCN12  FCN22  TNXB2  TNN2  FN12  
    TNC2  ANGPTL52  
    18/21 SIMAP similar genes for MFAP4 using alignment to 2 protein entries:     MFAP4_HUMAN (see all proteins) (see all similar genes):
    ANGPTL2    FIBCD1    ANGPT4    ANGPTL7    TNR    TNC
    TNC variant protein    TNN    TNXB    FCN2    ANGPT2    FCN3
    ANGPT1    FCN1    FGL1    LFIRE1    ANGPTL4    DKFZp779N0926

    MFAP4 for paralogs           About GeneDecksing



    Genomic Variants
    for MFAP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 NCBI SNPs in MFAP4 are shown (see all 96)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs772964671,2
    		C,--18666111(+) ACCCCG/TGAGGC 2 -- ds50010--------
    rs120731,2
    		C,F,--18666369(-) AGACAG/ATGTAA 2 -- ut311Minor allele frequency- A:0.08WA 118
    rs22746401,2
    		C,F,--18666700(-) ACCACC/GCTGAA 2 -- ut31 ese31Minor allele frequency- G:0.01EA 1496
    rs10542061,2
    		C,F,H,--18666988(-) GTGGTC/GCATCT 2 -- ut31 ese313Minor allele frequency- G:0.09MN NS EA NA 1886
    rs617435641,2
    		F--18667491(+) AACCAG/AAAGGC 4 /F syn11Minor allele frequency- A:0.20NS 20
    rs756534901,2
    		F,--18667692(+) CGTGGC/TAGCCT 2 -- int11Minor allele frequency- T:0.05WA 118
    rs178557491,2
    		H--18667983(+) TACCTG/ACCCCG 4 /A /V mis14Minor allele frequency- A:0.00NS EA 420
    rs16349311,2
    		H--18668202(-) CCCCAG/AGGCCA 2 -- int17Minor allele frequency- A:0.00NA EA NS 456
    rs1137813661,2
    		F--18669276(+) ACGCCG/ATCTGA 4 /D syn12Minor allele frequency- A:0.50CSA 4
    rs1120648961,2
    		C--18669721(+) AGTGCG/CTGGCG 2 -- spa11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for MFAP4 (19286755 - 19290553 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MFAP4: --

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    Disorders / Diseases
    for MFAP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MFAP4 for disorders           About GeneDecksing

    OMIM gene information: 600596    OMIM disorders: --

    4 diseases for MFAP4:    About MalaCards
    smith-magenis syndrome    intracranial aneurysm    liver cirrhosis    ovarian cancer

    Human Genome Epidemiology (HuGE) Navigator: MFAP4 (3 documents)

    Export disorders for MFAP4 gene to outside databases

    Publications
    for MFAP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFAP4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with MFAP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients. (PubMed id 7633408)1, 2, 3, 9 Zhao Z.... Patel P.I. (1995)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung. (PubMed id 16867155)1, 9 Schlosser A....Holmskov U. (2006)
    6. Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D. (PubMed id 10542261)1, 9 Lausen M....Holmskov U. (1999)
    7. Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1 Johnatty S.E.... . (2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

    External Searches for MFAP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MFAP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4239 HGNC: 7035 AceView: MFAP4 Ensembl:ENSG00000166482 euGenes: HUgn4239
    ECgene: MFAP4 H-InvDB: MFAP4

    Other Databases showing MFAP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MFAP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFAP4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MFAP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MFAP4 gene:
    Search GeneIP for patents involving MFAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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