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Aliases for MFAP3L Gene

Aliases for MFAP3L Gene

  • Microfibrillar-Associated Protein 3-Like 2 3
  • Testis Development Protein NYD-SP9 3 4
  • KIAA0626 4
  • NYD-Sp9 3

External Ids for MFAP3L Gene

Previous GeneCards Identifiers for MFAP3L Gene

  • GC04M171604
  • GC04M171282
  • GC04M171144
  • GC04M170907
  • GC04M166662

Summaries for MFAP3L Gene

GeneCards Summary for MFAP3L Gene

MFAP3L (Microfibrillar-Associated Protein 3-Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP3L Gene

Genomics for MFAP3L Gene

Regulatory Elements for MFAP3L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MFAP3L Gene

Start:
169,986,597 bp from pter
End:
170,033,031 bp from pter
Size:
46,435 bases
Orientation:
Minus strand

Genomic View for MFAP3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFAP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP3L Gene

Proteins for MFAP3L Gene

  • Protein details for MFAP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75121-MFA3L_HUMAN
    Recommended name:
    Microfibrillar-associated protein 3-like
    Protein Accession:
    O75121
    Secondary Accessions:
    • A8K1X6
    • D3DP35
    • Q4W5N7
    • Q4W5N9
    • Q6TNA8
    • Q9BVE1
    • Q9BXK0

    Protein attributes for MFAP3L Gene

    Size:
    409 amino acids
    Molecular mass:
    45380 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31601.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFAP3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFAP3L Gene

Proteomics data for MFAP3L Gene at MOPED

Post-translational modifications for MFAP3L Gene

  • Ubiquitination at Lys200, Lys215, Lys221, and Lys226
  • Glycosylation at Asn33, Asn37, Asn67, Asn111, and Asn135
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFAP3L Gene

Domains for MFAP3L Gene

Gene Families for MFAP3L Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for MFAP3L Gene

Suggested Antigen Peptide Sequences for MFAP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75121

UniProtKB/Swiss-Prot:

MFA3L_HUMAN :
  • O75121
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with MFAP3L: view

Function for MFAP3L Gene

Gene Ontology (GO) - Molecular Function for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MFAP3L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFAP3L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MFAP3L Gene

Localization for MFAP3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP3L Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFAP3L Gene COMPARTMENTS Subcellular localization image for MFAP3L gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFAP3L: view

Pathways for MFAP3L Gene

SuperPathways for MFAP3L Gene

No Data Available

Interacting Proteins for MFAP3L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354583%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354583 for MFAP3L Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MFAP3L Gene

None

No data available for Pathways by source for MFAP3L Gene

Transcripts for MFAP3L Gene

Unigene Clusters for MFAP3L Gene

Microfibrillar-associated protein 3-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFAP3L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MFAP3L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP3L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6:
SP7: - -
SP8: - - -
SP9: - - - - - - - - - - - - -

Relevant External Links for MFAP3L Gene

GeneLoc Exon Structure for
MFAP3L
ECgene alternative splicing isoforms for
MFAP3L

Expression for MFAP3L Gene

mRNA expression in normal human tissues for MFAP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MFAP3L Gene

SOURCE GeneReport for Unigene cluster for MFAP3L Gene Hs.593942

mRNA Expression by UniProt/SwissProt for MFAP3L Gene

O75121-MFA3L_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with MFAP3L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MFAP3L Gene

Orthologs for MFAP3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFAP3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFAP3L 35
  • 99.59 (n)
  • 99.76 (a)
MFAP3L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFAP3L 35
  • 79.18 (n)
  • 81.61 (a)
MFAP3L 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFAP3L 35
  • 90.03 (n)
  • 92.4 (a)
MFAP3L 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfap3l 35
  • 86.88 (n)
  • 89.98 (a)
Mfap3l 16
Mfap3l 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MFAP3L 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFAP3L 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfap3l 35
  • 87.04 (n)
  • 90.22 (a)
chicken
(Gallus gallus)
Aves MFAP3L 35
  • 71.32 (n)
  • 72.89 (a)
MFAP3L 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFAP3L 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap3l 35
  • 67.55 (n)
  • 70.09 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4128 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13816 35
LOC557798 35
  • 72.22 (n)
  • 73.55 (a)
MFAP3L 36
  • 55 (a)
OneToOne
Species with no ortholog for MFAP3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFAP3L Gene

ENSEMBL:
Gene Tree for MFAP3L (if available)
TreeFam:
Gene Tree for MFAP3L (if available)

Paralogs for MFAP3L Gene

Selected SIMAP similar genes for MFAP3L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MFAP3L: view

No data available for Paralogs for MFAP3L Gene

Variants for MFAP3L Gene

Sequence variations from dbSNP and Humsavar for MFAP3L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs733672 -- 170,029,092(-) CATGC(G/T)AGGTG upstream-variant-2KB, intron-variant
rs931145 -- 170,018,678(-) AAACA(C/T)TTTTG intron-variant
rs931146 -- 170,015,929(-) GCCTT(A/G)GTCAG intron-variant
rs1480541 -- 170,032,047(+) AGGGA(C/G)GCTGC intron-variant
rs1480542 -- 170,032,463(+) ATGCC(C/T)GGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MFAP3L Gene

Variant ID Type Subtype PubMed ID
nsv830149 CNV Loss 17160897
nsv881074 CNV Gain 21882294
esv2661256 CNV Deletion 23128226
nsv822827 CNV Gain 20364138

Relevant External Links for MFAP3L Gene

HapMap Linkage Disequilibrium report
MFAP3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP3L Gene

Disorders for MFAP3L Gene

No disorders were found for MFAP3L Gene.

No data available for UniProtKB/Swiss-Prot for MFAP3L Gene

Publications for MFAP3L Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for MFAP3L Gene

Sources for MFAP3L Gene

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