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Aliases for MFAP3L Gene

Aliases for MFAP3L Gene

  • Microfibrillar Associated Protein 3 Like 2 3 5
  • Testis Development Protein NYD-SP9 3 4
  • Microfibrillar-Associated Protein 3-Like 3
  • KIAA0626 4
  • NYD-Sp9 3

External Ids for MFAP3L Gene

Previous GeneCards Identifiers for MFAP3L Gene

  • GC04M171604
  • GC04M171282
  • GC04M171144
  • GC04M170907
  • GC04M166662

Summaries for MFAP3L Gene

GeneCards Summary for MFAP3L Gene

MFAP3L (Microfibrillar Associated Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is MFAP3.

UniProtKB/Swiss-Prot for MFAP3L Gene

  • May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP3L Gene

Genomics for MFAP3L Gene

Regulatory Elements for MFAP3L Gene

Enhancers for MFAP3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MFAP3L on UCSC Golden Path with GeneCards custom track

Genomic Location for MFAP3L Gene

Chromosome:
4
Start:
169,986,597 bp from pter
End:
170,033,031 bp from pter
Size:
46,435 bases
Orientation:
Minus strand

Genomic View for MFAP3L Gene

Genes around MFAP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFAP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFAP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP3L Gene

Proteins for MFAP3L Gene

  • Protein details for MFAP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75121-MFA3L_HUMAN
    Recommended name:
    Microfi brillar-associated protein 3-like
    Protein Accession:
    O75121
    Secondary Accessions:
    • A8K1X6
    • D3DP35
    • Q4W5N7
    • Q4W5N9
    • Q6TNA8
    • Q9BVE1
    • Q9BXK0

    Protein attributes for MFAP3L Gene

    Size:
    409 amino acids
    Molecular mass:
    45380 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31601.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFAP3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFAP3L Gene

Proteomics data for MFAP3L Gene at MOPED

Post-translational modifications for MFAP3L Gene

  • Glycosylation at Asn 33, Asn 37, Asn 67, Asn 111, and Asn 135
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFAP3L Gene

Domains & Families for MFAP3L Gene

Gene Families for MFAP3L Gene

Protein Domains for MFAP3L Gene

Suggested Antigen Peptide Sequences for MFAP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75121

UniProtKB/Swiss-Prot:

MFA3L_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with MFAP3L: view

Function for MFAP3L Gene

Molecular function for MFAP3L Gene

UniProtKB/Swiss-Prot Function:
May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.
genes like me logo Genes that share phenotypes with MFAP3L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFAP3L

miRNA for MFAP3L Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFAP3L Gene

Localization for MFAP3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP3L Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus (PubMed:24735981). {ECO:0000269 PubMed:24735981}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFAP3L Gene COMPARTMENTS Subcellular localization image for MFAP3L gene
Compartment Confidence
nucleus 5
plasma membrane 5
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24735981
GO:0005886 plasma membrane IDA 24735981
genes like me logo Genes that share ontologies with MFAP3L: view

Pathways & Interactions for MFAP3L Gene

SuperPathways for MFAP3L Gene

No Data Available

Interacting Proteins for MFAP3L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354583%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354583 for MFAP3L Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MFAP3L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFAP3L Gene

Drugs & Compounds for MFAP3L Gene

No Compound Related Data Available

Transcripts for MFAP3L Gene

Unigene Clusters for MFAP3L Gene

Microfibrillar-associated protein 3-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP3L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6:
SP7: - -
SP8: - - -
SP9: - - - - - - - - - - - - -

Relevant External Links for MFAP3L Gene

GeneLoc Exon Structure for
MFAP3L
ECgene alternative splicing isoforms for
MFAP3L

Expression for MFAP3L Gene

mRNA expression in normal human tissues for MFAP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFAP3L Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFAP3L Gene



SOURCE GeneReport for Unigene cluster for MFAP3L Gene Hs.593942

mRNA Expression by UniProt/SwissProt for MFAP3L Gene

O75121-MFA3L_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with MFAP3L: view

Protein tissue co-expression partners for MFAP3L Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MFAP3L Gene

Orthologs for MFAP3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFAP3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MFAP3L 35
  • 79.18 (n)
  • 81.61 (a)
MFAP3L 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFAP3L 35
  • 90.03 (n)
  • 92.4 (a)
MFAP3L 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfap3l 35
  • 86.88 (n)
  • 89.98 (a)
Mfap3l 16
Mfap3l 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MFAP3L 35
  • 99.59 (n)
  • 99.76 (a)
MFAP3L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfap3l 35
  • 87.04 (n)
  • 90.22 (a)
oppossum
(Monodelphis domestica)
Mammalia MFAP3L 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MFAP3L 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MFAP3L 35
  • 71.32 (n)
  • 72.89 (a)
MFAP3L 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFAP3L 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap3l 35
  • 67.55 (n)
  • 70.09 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13816 35
LOC557798 35
  • 72.22 (n)
  • 73.55 (a)
MFAP3L 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4128 35
Species with no ortholog for MFAP3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFAP3L Gene

ENSEMBL:
Gene Tree for MFAP3L (if available)
TreeFam:
Gene Tree for MFAP3L (if available)

Paralogs for MFAP3L Gene

Paralogs for MFAP3L Gene

(1) SIMAP similar genes for MFAP3L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MFAP3L: view

Variants for MFAP3L Gene

Sequence variations from dbSNP and Humsavar for MFAP3L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs733672 -- 170,029,092(-) CATGC(G/T)AGGTG intron-variant, upstream-variant-2KB
rs931145 -- 170,018,678(-) AAACA(C/T)TTTTG intron-variant
rs931146 -- 170,015,929(-) GCCTT(A/G)GTCAG intron-variant
rs1480541 -- 170,032,047(+) AGGGA(C/G)GCTGC intron-variant
rs1480542 -- 170,032,463(+) ATGCC(C/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFAP3L Gene

Variant ID Type Subtype PubMed ID
nsv830149 CNV Loss 17160897
nsv881074 CNV Gain 21882294
esv2661256 CNV Deletion 23128226
nsv822827 CNV Gain 20364138

Variation tolerance for MFAP3L Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MFAP3L Gene

Disorders for MFAP3L Gene

Relevant External Links for MFAP3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFAP3L

No disorders were found for MFAP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFAP3L Gene

Publications for MFAP3L Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. MFAP3L activation promotes colorectal cancer cell invasion and metastasis. (PMID: 24735981) Lou X. … Liu S. (Biochim. Biophys. Acta 2014) 3
  3. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T. … Hettema J.M. (PLoS ONE 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MFAP3L Gene

Sources for MFAP3L Gene

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