Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MFAP3L Gene

Aliases for MFAP3L Gene

  • Microfibrillar Associated Protein 3 Like 2 3 5
  • Testis Development Protein NYD-SP9 3 4
  • Microfi Brillar-Associated Protein 3-Like 3
  • Microfibrillar-Associated Protein 3-Like 3
  • KIAA0626 4
  • NYD-Sp9 3

External Ids for MFAP3L Gene

Previous GeneCards Identifiers for MFAP3L Gene

  • GC04M171604
  • GC04M171282
  • GC04M171144
  • GC04M170907
  • GC04M166662

Summaries for MFAP3L Gene

GeneCards Summary for MFAP3L Gene

MFAP3L (Microfibrillar Associated Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is MFAP3.

UniProtKB/Swiss-Prot for MFAP3L Gene

  • May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP3L Gene

Genomics for MFAP3L Gene

Regulatory Elements for MFAP3L Gene

Enhancers for MFAP3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F170025 1.1 ENCODE 39.8 +6.3 6254 2.2 ATF1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 CBX5 KLF7 MFAP3L AADAT ENSG00000251200 GC04M169997
GH04F169933 1 Ensembl ENCODE 24.1 +98.4 98434 2.5 MTA2 TAL1 MAFG ZEB2 ARID1B ZNF121 GATA3 ZNF316 NCOR1 GATA2 MFAP3L LOC100506085 ENSG00000249955 AADAT ENSG00000251200 LOC105377530
GH04F169867 0.3 FANTOM5 50.3 +165.7 165667 0.1 MFAP3L GC04M169880 LOC402192
GH04F169974 0.8 ENCODE 18.8 +57.3 57348 2.0 SOX13 RAD21 RARA TEAD3 YY1 ZNF316 SCRT2 HNF4G NR2F6 CREM MFAP3L AADAT LOC100506085 ENSG00000251200
GH04F169968 0.7 Ensembl ENCODE 21.3 +63.6 63636 1.9 JUND EP300 MFAP3L ENSG00000251200 AADAT LOC100506085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MFAP3L on UCSC Golden Path with GeneCards custom track

Genomic Location for MFAP3L Gene

169,986,597 bp from pter
170,033,031 bp from pter
46,435 bases
Minus strand

Genomic View for MFAP3L Gene

Genes around MFAP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFAP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFAP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP3L Gene

Proteins for MFAP3L Gene

  • Protein details for MFAP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microfibrillar-associated protein 3-like
    Protein Accession:
    Secondary Accessions:
    • A8K1X6
    • D3DP35
    • Q4W5N7
    • Q4W5N9
    • Q6TNA8
    • Q9BVE1
    • Q9BXK0

    Protein attributes for MFAP3L Gene

    409 amino acids
    Molecular mass:
    45380 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31601.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFAP3L Gene


neXtProt entry for MFAP3L Gene

Post-translational modifications for MFAP3L Gene

  • Glycosylation at Asn 33, Asn 37, Asn 67, Asn 111, and Asn 135
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFAP3L Gene

Domains & Families for MFAP3L Gene

Gene Families for MFAP3L Gene

Suggested Antigen Peptide Sequences for MFAP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with MFAP3L: view

Function for MFAP3L Gene

Molecular function for MFAP3L Gene

UniProtKB/Swiss-Prot Function:
May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.

Gene Ontology (GO) - Molecular Function for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24735981
genes like me logo Genes that share ontologies with MFAP3L: view
genes like me logo Genes that share phenotypes with MFAP3L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFAP3L

miRNA for MFAP3L Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFAP3L Gene

Localization for MFAP3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP3L Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus (PubMed:24735981). {ECO:0000269 PubMed:24735981}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFAP3L gene
Compartment Confidence
plasma membrane 5
nucleus 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24735981
GO:0005737 cytoplasm IEA,IDA 24735981
GO:0005886 plasma membrane IEA,IDA 24735981
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFAP3L: view

Pathways & Interactions for MFAP3L Gene

SuperPathways for MFAP3L Gene

No Data Available

Interacting Proteins for MFAP3L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000354583 for MFAP3L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MFAP3L Gene


No data available for Pathways by source and SIGNOR curated interactions for MFAP3L Gene

Transcripts for MFAP3L Gene

Unigene Clusters for MFAP3L Gene

Microfibrillar-associated protein 3-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP3L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP7: - -
SP8: - - -
SP9: - - - - - - - - - - - - -

Relevant External Links for MFAP3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFAP3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFAP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFAP3L Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFAP3L Gene

Protein tissue co-expression partners for MFAP3L Gene

NURSA nuclear receptor signaling pathways regulating expression of MFAP3L Gene:


SOURCE GeneReport for Unigene cluster for MFAP3L Gene:


mRNA Expression by UniProt/SwissProt for MFAP3L Gene:

Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with MFAP3L: view

Primer Products

No data available for mRNA differential expression in normal tissues for MFAP3L Gene

Orthologs for MFAP3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFAP3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFAP3L 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia MFAP3L 34 35
  • 90.03 (n)
(Rattus norvegicus)
Mammalia Mfap3l 34
  • 87.04 (n)
(Mus musculus)
Mammalia Mfap3l 34 16 35
  • 86.88 (n)
(Bos Taurus)
Mammalia MFAP3L 34 35
  • 79.18 (n)
(Monodelphis domestica)
Mammalia MFAP3L 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MFAP3L 35
  • 59 (a)
(Gallus gallus)
Aves MFAP3L 34 35
  • 71.32 (n)
(Anolis carolinensis)
Reptilia MFAP3L 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap3l 34
  • 67.55 (n)
(Danio rerio)
Actinopterygii LOC557798 34
  • 72.22 (n)
  • 55 (a)
Dr.13816 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4128 34
Species where no ortholog for MFAP3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFAP3L Gene

Gene Tree for MFAP3L (if available)
Gene Tree for MFAP3L (if available)

Paralogs for MFAP3L Gene

Paralogs for MFAP3L Gene

(1) SIMAP similar genes for MFAP3L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MFAP3L: view

Variants for MFAP3L Gene

Sequence variations from dbSNP and Humsavar for MFAP3L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10006800 -- 169,990,592(+) AGGCT(C/T)ACTCA utr-variant-3-prime
rs10011869 -- 170,018,440(+) TAAAG(A/G)GGACT intron-variant
rs10033730 -- 170,027,660(+) AGGTT(A/G)ATGTA upstream-variant-2KB, utr-variant-5-prime
rs10520171 -- 169,993,471(+) TGGTA(A/G)TGAGT intron-variant
rs10520172 -- 169,994,816(+) CCACA(A/G)ACTAA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MFAP3L Gene

Variant ID Type Subtype PubMed ID
nsv830149 CNV loss 17160897
nsv822827 CNV gain 20364138
nsv1131843 CNV deletion 24896259
nsv1020188 CNV loss 25217958
esv3603133 CNV loss 21293372
esv2661256 CNV deletion 23128226

Variation tolerance for MFAP3L Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFAP3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP3L Gene

Disorders for MFAP3L Gene

Relevant External Links for MFAP3L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MFAP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFAP3L Gene

Publications for MFAP3L Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. MFAP3L activation promotes colorectal cancer cell invasion and metastasis. (PMID: 24735981) Lou X. … Liu S. (Biochim. Biophys. Acta 2014) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T. … Hettema J.M. (PLoS ONE 2014) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for MFAP3L Gene

Sources for MFAP3L Gene

Loading form....