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Aliases for MFAP3 Gene

Aliases for MFAP3 Gene

  • Microfibrillar-Associated Protein 3 2 3

External Ids for MFAP3 Gene

Previous GeneCards Identifiers for MFAP3 Gene

  • GC05P153490
  • GC05P153447
  • GC05P153398
  • GC05P148559

Summaries for MFAP3 Gene

GeneCards Summary for MFAP3 Gene

MFAP3 (Microfibrillar-Associated Protein 3) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. An important paralog of this gene is MFAP3L.

UniProtKB/Swiss-Prot for MFAP3 Gene

  • Component of the elastin-associated microfibrils

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP3 Gene

Genomics for MFAP3 Gene

Regulatory Elements for MFAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MFAP3 Gene

154,038,906 bp from pter
154,220,478 bp from pter
181,573 bases
Plus strand

Genomic View for MFAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP3 Gene

Proteins for MFAP3 Gene

  • Protein details for MFAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microfibril-associated glycoprotein 3
    Protein Accession:
    Secondary Accessions:
    • B2RDK0
    • B4DKA1
    • Q9NXA7

    Protein attributes for MFAP3 Gene

    362 amino acids
    Molecular mass:
    40165 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91108.1; Type=Frameshift; Positions=238; Evidence={ECO:0000305};

    Alternative splice isoforms for MFAP3 Gene


neXtProt entry for MFAP3 Gene

Proteomics data for MFAP3 Gene at MOPED

Post-translational modifications for MFAP3 Gene

Other Protein References for MFAP3 Gene

Antibody Products

No data available for DME Specific Peptides for MFAP3 Gene

Domains for MFAP3 Gene

Gene Families for MFAP3 Gene

Protein Domains for MFAP3 Gene

Suggested Antigen Peptide Sequences for MFAP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with MFAP3: view

Function for MFAP3 Gene

Molecular function for MFAP3 Gene

GENATLAS Biochemistry:
microfibrillar associated glycoprotein 3,4.kDa,component of microfibrils in the extracellular matrix
UniProtKB/Swiss-Prot Function:
Component of the elastin-associated microfibrils

Gene Ontology (GO) - Molecular Function for MFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MFAP3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MFAP3 Gene

Localization for MFAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for MFAP3 Gene COMPARTMENTS Subcellular localization image for MFAP3 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for MFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFAP3: view

Pathways for MFAP3 Gene

genes like me logo Genes that share pathways with MFAP3: view

Pathways by source for MFAP3 Gene

Interacting Proteins for MFAP3 Gene

Gene Ontology (GO) - Biological Process for MFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with MFAP3: view

Transcripts for MFAP3 Gene

Unigene Clusters for MFAP3 Gene

Microfibrillar-associated protein 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MFAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for MFAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFAP3 Gene

mRNA expression in normal human tissues for MFAP3 Gene

Protein differential expression in normal tissues for MFAP3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFAP3 Gene

SOURCE GeneReport for Unigene cluster for MFAP3 Gene Hs.432818

genes like me logo Genes that share expressions with MFAP3: view

Expression partners for MFAP3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFAP3 Gene

Orthologs for MFAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MFAP3 35
  • 88.67 (n)
  • 87.57 (a)
MFAP3 36
  • 88 (a)
(Canis familiaris)
Mammalia MFAP3 35
  • 90.7 (n)
  • 89.23 (a)
MFAP3 36
  • 89 (a)
(Mus musculus)
Mammalia Mfap3 35
  • 84.2 (n)
  • 84.68 (a)
Mfap3 16
Mfap3 36
  • 84 (a)
(Pan troglodytes)
Mammalia MFAP3 35
  • 99.63 (n)
  • 99.72 (a)
MFAP3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mfap3 35
  • 83.29 (n)
  • 84.73 (a)
(Monodelphis domestica)
Mammalia MFAP3 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves MFAP3 35
  • 69.73 (n)
  • 67.06 (a)
MFAP3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia MFAP3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap3 35
  • 66.32 (n)
  • 68.17 (a)
Species with no ortholog for MFAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MFAP3 Gene

Gene Tree for MFAP3 (if available)
Gene Tree for MFAP3 (if available)

Paralogs for MFAP3 Gene

Paralogs for MFAP3 Gene

(1) SIMAP similar genes for MFAP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MFAP3: view

Variants for MFAP3 Gene

Sequence variations from dbSNP and Humsavar for MFAP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9159 -- 154,057,275(+) CTCCT(A/G)GATTT utr-variant-3-prime
rs11783 -- 154,056,689(-) AAGAT(C/G)TTCAA utr-variant-3-prime
rs411245 -- 154,046,393(-) ATATT(G/T)ATGGA intron-variant
rs478020 -- 154,049,609(-) AGTGG(C/T)AGATC intron-variant, utr-variant-5-prime
rs544908 -- 154,044,038(-) CTGAA(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFAP3 Gene

Variant ID Type Subtype PubMed ID
nsv508385 CNV Loss 20534489

Relevant External Links for MFAP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP3 Gene

Disorders for MFAP3 Gene

Relevant External Links for MFAP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MFAP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MFAP3 Gene

Publications for MFAP3 Gene

  1. Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2. (PMID: 7782085) Abrams W.R. … Rosenbloom J. (Genomics 1995) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association of BMI in African Americans. (PMID: 21701570) Ng M.C. … Bowden D.W. (Obesity (Silver Spring) 2012) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for MFAP3 Gene

Sources for MFAP3 Gene

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