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MFAP2 Gene

protein-coding   GIFtS: 61
GCID: GC01M017300

Microfibrillar-Associated Protein 2

  Search for MFAP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Microfibrillar-Associated Protein 21 2
MAGP2 3 5
MAGP12 3 5
Microfibril-Associated Glycoprotein 12 3
MAGP-12 3
MFAP-23

External Ids:    HGNC: 70331   Entrez Gene: 42372   Ensembl: ENSG000001171227   OMIM: 1567905   UniProtKB: P550013   
ORGUL members:         

Export aliases for MFAP2 gene to outside databases

Previous GC identifers: GC01M017038 GC01M016341 GC01M016682 GC01M017046 GC01M017173 GC01M015545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MFAP2 Gene:
Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for
involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for MFAP2 Gene:
MFAP2 (microfibrillar-associated protein 2) is a protein-coding gene. GO annotations related to this gene include fibronectin binding and fibrinogen binding. An important paralog of this gene is MFAP5.

UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001
Function: Component of the elastin-associated microfibrils

Gene Wiki entry for MFAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFAP2 gene promoter:
         AREB6   p53   Brachyury   Lmo2   ATF6   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFAP2 promoter sequence
   Search Chromatin IP Primers for MFAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.1-p35

MFAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017300:  view genomic region     (about GC identifiers)

Start:
17,300,997 bp from pter      End:
17,308,081 bp from pter
Size:
7,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001 (See protein sequence)
Recommended Name: Microfibrillar-associated protein 2 precursor  
Size: 183 amino acids; 20826 Da
Subunit: Forms a ternary complex with BGN and ELN (By similarity)
Secondary accessions: Q53X60 Q5JXY0
Alternative splicing: 3 isoforms:  P55001-1   P55001-2   P55001-3   

Explore the universe of human proteins at neXtProt for MFAP2: NX_P55001

Explore proteomics data for MFAP2 at MOPED

Post-translational modifications: 

  • Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the
    microfibrils. May form transglutaminase cross-links1
  • O-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MFAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128719.1  NP_001128720.1  NP_002394.1  NP_059453.1  

    ENSEMBL proteins: 
     ENSP00000364684   ENSP00000364685   ENSP00000417029  
    Reactome Protein details: P55001

    MFAP2 Human Recombinant Protein Products:

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    Novus Biologicals MFAP2 Proteins
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    Cloud-Clone Corp. Proteins for MFAP2

     
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    MFAP2 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008673 MAGP
     IPR003582 ShKT_dom

    Graphical View of Domain Structure for InterPro Entry P55001

    ProtoNet protein and cluster: P55001

    2 Blocks protein domains:
    IPB003582 Metridin-like ShK toxin
    IPB008673 Microfibril-associated glycoprotein


    UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001
    Similarity: Belongs to the MFAP family
    Similarity: Contains 1 ShKT domain


    Find genes that share domains with MFAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFAP2_HUMAN, P55001
    Function: Component of the elastin-associated microfibrils

         Genatlas biochemistry entry for MFAP2:
    microfibrillar associated glycoprotein 2,component of elastin microfibrils in the extracellular matrix

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding ----
    GO:0070051fibrinogen binding IEA--
         
    Find genes that share ontologies with MFAP2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mfap2):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  skeleton 

    Find genes that share phenotypes with MFAP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mfap2tm1Mech for MFAP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MFAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MFAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MFAP2

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate MFAP2:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1207-3p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidMFAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MFAP2

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    Sino Biological Human cDNA Clone for MFAP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MFAP2_HUMAN, P55001: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001527microfibril IEA--
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with MFAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MFAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Elastic fibre formation
    Elastic fibre formation0.73
    Molecules associated with elastic fibres0.73
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3Notch signaling pathway (Pathway Interaction Database)
    Notch signaling pathway


    Find genes that share SuperPaths with MFAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MFAP2
        Notch signaling pathway


    2 Reactome Pathways for MFAP2
        Molecules associated with elastic fibres
    Elastic fibre formation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFAP2
    Interactions:

        GeneGlobe Interaction Network for MFAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for MFAP2 (P550013 ENSP000003646854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BGNP218103, ENSP000003273364I2D: score=2 STRING: ENSP00000327336
    FBN2P355563, ENSP000002624644I2D: score=1 STRING: ENSP00000262464
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
    COL4A3Q019553, ENSP000003798234I2D: score=3 STRING: ENSP00000379823
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization TAS--
    GO:0030220platelet formation IEA--

    Find genes that share ontologies with MFAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFAP2

    4 Novoseek inferred chemical compound relationships for MFAP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 29.8 1 14578398 (1)
    proline 19.8 2 8557636 (1), 11723825 (1)
    gold 11.7 1 8985131 (1)
    tyrosine 0 3 11284693 (2), 7961786 (1)



    Find genes that share compounds with MFAP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MFAP2 gene (4 alternative transcripts): 
    NM_001135247.1  NM_001135248.1  NM_002403.3  NM_017459.2  

    Unigene Cluster for MFAP2:

    Microfibrillar-associated protein 2
    Hs.389137  [show with all ESTs]
    Unigene Representative Sequence: BC028033
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375534 ENST00000490075 ENST00000375535(uc001azw.3 uc001azx.3 uc001azy.3 uc010ocl.2)
    ENST00000476788 ENST00000478684 ENST00000492598 ENST00000438542
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate MFAP2:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1207-3p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidMFAP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): MFAP2 (NM_017459)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFAP2
      QuantiTect SYBR Green Assays in human, mouse, rat MFAP2
      QuantiFast Probe-based Assays in human, mouse, rat MFAP2

    Additional mRNA sequence: 

    AK222751.1 BC015039.1 BC028033.1 CR407678.1 U19718.1 

    10 DOTS entries:

    DT.448848  DT.97820931  DT.97795411  DT.91748612  DT.100714835  DT.100810700  DT.95162772  DT.121394746 
    DT.91748607  DT.95261000 

    Selected AceView cDNA sequences (see all 192):

    CR597163 CR590231 BF435957 BM712871 AL553496 AA329559 AU280150 AI262436 
    BG720193 AI280922 BC028033 N86551 AI990853 AA317293 AL712483 CR619947 
    AI149517 BM673729 AA341820 CR619798 AI741278 BU849854 AA359221 BU633087 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MFAP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                              -     -                           
    SP2:                                                              -     -                           
    SP3:                                                              -     -                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MFAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MFAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCACCTTT
    MFAP2 Expression
    About this image


    MFAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
    MFAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389137
        Custom PCR Arrays for MFAP2
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    QuantiFast Probe-based Assays in human, mouse, rat MFAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MFAP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfap21 , 5 microfibrillar-associated protein 21, 5 85.93(n)1
    90.56(a)1
      4 (73.31 cM)5
    171501  NM_001161799.11  NP_001155271.11 
     1410104185 
    chicken
    (Gallus gallus)
    Aves MFAP21 microfibrillar-associated protein 2 73.48(n)
    75.69(a)
      100858555  XM_003642512.2  XP_003642560.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia mfap2-prov2 microfibrillar-associated protein 2 78.03(n)    BC041238.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mfap21 microfibrillar-associated protein 2 64.96(n)
    65.38(a)
      556677  NM_001039357.1  NP_001034446.1 


    ENSEMBL Gene Tree for MFAP2 (if available)
    TreeFam Gene Tree for MFAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MFAP2 gene
    MFAP52  
    2 SIMAP similar genes for MFAP2 using alignment to 1 protein entry:     MFAP2_HUMAN:
    MFAP5    MAGP2

    Find genes that share paralogs with MFAP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MFAP2
    PGOHUM00000245290


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MFAP2 (see all 207)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120371101,2
    C--15545668(-) GGGGTA/TGGGGG 7 -- int10--------
    rs602841301,2
    C--17307265(+) CTCCT-/G/GG  
            
    GGGGG
    4 -- int1 us2k10--------
    rs557383281,2
    C--17506719(-) TTGGGA/GAGTTG 4 -- ds50010--------
    rs563781381,2
    C--17506831(-) GTGAGC/TACATT 4 -- ds50010--------
    rs9102141,2
    C,F,O,A--17507107(-) AGATCA/GAGTCA 4 -- ds500110Minor allele frequency- C:0.04NA EA 357
    rs558354421,2
    C--17507161(+) CCATGC/TCCACG 4 -- ut310--------
    rs10512251,2
    C,F--17507340(-) GGCACA/GATGGG 4 -- ut31 ese34Minor allele frequency- G:0.45MN NA 190
    rs22359331,2
    C,F,O--17507563(-) GTGGCA/GGCCTC 8 A syn1 ese34Minor allele frequency- G:0.45EA NA CSA 1506
    rs617384871,2
    F--17507563(+) GAGGCC/TGCCAC 8 A syn11Minor allele frequency- T:0.28NS 76
    rs1998070691,2
    C--17507598(+) CATCAC/TGCCAC 8 M V mis10--------

    HapMap Linkage Disequilibrium report for MFAP2 (17300997 - 17308081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MFAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508947CNV Insertion20534489
    dgv185n71CNV Loss21882294
    nsv834269CNV Loss17160897
    dgv184n71CNV Loss21882294
    nsv871590CNV Loss21882294
    nsv834280CNV Loss17160897
    nsv428421CNV Gain+Loss18775914
    dgv30e1CNV Complex17122850
    dgv40e1CNV Complex17122850
    dgv29e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156790    OMIM disorders: --


    Find genes that share disorders with MFAP2           About GenesLikeMe

    1 Novoseek inferred disease relationship for MFAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    connective tissue diseases 35.1 2 7759096 (1)

    Genetic Association Database (GAD): MFAP2
    Human Genome Epidemiology (HuGE) Navigator: MFAP2 (1 document)

    Export disorders for MFAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MFAP2 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with MFAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170. (PubMed id 7759096)1, 2, 3, 9 Faraco J.... Francke U. (Genomics 1995)
    2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    4. Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. (PubMed id 19182256)1, 4 Krumbiegel M....Reis A. (amp 2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. (PubMed id 9278443)1, 9 Finnis M.L. and Gibson M.A. (J. Biol. Chem. 1997)
    8. Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. (PubMed id 11481325)1, 9 Jensen S.A....Weiss A.S. (J. Biol. Chem. 2001)
    9. Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. (PubMed id 10664011)1, 9 Fujimoto N....Ishibashi A. (Arch. Dermatol. Res. 2000)
    10. Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. (PubMed id 15233806)1, 9 Clarke A.W. and Weiss A.S. (Eur. J. Biochem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4237 HGNC: 7033 AceView: MFAP2 Ensembl:ENSG00000117122 euGenes: HUgn4237
    ECgene: MFAP2 H-InvDB: MFAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MFAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MFAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MFAP2 gene:
    Search GeneIP for patents involving MFAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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