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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MFAP2 Gene

protein-coding   GIFtS: 59
GCID: GC01M017300

microfibrillar-associated protein 2
 Explore 6 diseases affiliated with
MFAP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MFAP2    

Aliases
for MFAP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microfibrillar-Associated Protein 21 2
MAGP1 2 3 5
MAGP-11 2 3
MAGP12 3 5
Microfibril-Associated Glycoprotein 12 3
MFAP-23

External Ids:    HGNC: 70331   Entrez Gene: 42372   Ensembl: ENSG000001171227   OMIM: 1567905   UniProtKB: P550013   

Export aliases for MFAP2 gene to outside databases

Previous GC identifers: GC01M017038 GC01M016341 GC01M016682 GC01M017046 GC01M017173 GC01M015545


Summaries
for MFAP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MFAP2:
Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for
involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different
isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001
Function: Component of the elastin-associated microfibrils

Gene Wiki entry for MFAP2


Genomic Views
for MFAP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MFAP2 gene promoter:
         AREB6   p53   Brachyury   Lmo2   ATF6   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MFAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MFAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MFAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.1-p35

MFAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017300:  view genomic region     (about GC identifiers)

Start:
 17,300,997 bp from pter      End:
 17,308,081 bp from pter
Size:
 7,085 bases      Orientation:
 minus strand

Proteins
for MFAP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001 (See protein sequence)
Recommended Name: Microfibrillar-associated protein 2 precursor  
Size: 183 amino acids; 20826 Da
Subunit: Forms a ternary complex with BGN and ELN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q53X60 Q5JXY0
Alternative splicing: 3 isoforms:  P55001-1   P55001-2   P55001-3   

Explore the universe of human proteins at neXtProt for MFAP2: NX_P55001

Post-translational modifications:

  • Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils.
    • May form transglutaminase cross-links1
  • O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55001

    • MFAP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128719.1  NP_001128720.1  NP_002394.1  NP_059453.1  

    ENSEMBL proteins: 
     ENSP00000364685   ENSP00000364684   ENSP00000417029  
    Reactome Protein details: P55001
    Human Recombinant Protein Products: 
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    Novus Biologicals MFAP2 Protein
    Novus Biologicals MFAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MFAP2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001527microfibril IEA--


    MFAP2 for ontologies           About GeneDecksing



    MFAP2 Antibody Products: 
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    Assay Products for MFAP2: 
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    Uscn ELISAs and CLIAs for MFAP2

    Protein Domains /
    Families
    for MFAP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MFAP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008673 MAGP
     IPR003582 ShK_toxin

    Graphical View of Domain Structure for InterPro Entry P55001

    ProtoNet protein and cluster: P55001

    2 Blocks protein families:
    IPB003582 Metridin-like ShK toxin
    IPB008673 Microfibril-associated glycoprotein


    UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001
    Similarity: Belongs to the MFAP family
    Similarity: Contains 1 SXC (ShKT) domain


    Function
    for MFAP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MFAP2_HUMAN, P55001
    Function: Component of the elastin-associated microfibrils

         Genatlas biochemistry entry for MFAP2:
    microfibrillar associated glycoprotein 2,component of elastin microfibrils in the extracellular matrix

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MFAP2:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1207-3p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: MFAP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFAP2 (see all 7)
    OriGene shRNA RFP: MFAP2
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MFAP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MFAP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding ----
    GO:0070051fibrinogen binding IEA--


    MFAP2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mfap2tm1Mech for MFAP2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mfap2):
     hematopoietic system  homeostasis/metabolism 

    MFAP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MFAP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Elastic fibre formation
    		Elastic fibre formation1.00
    		Molecules associated with elastic fibres0.84
    2Tropoelastin associates with microfibrils
    		Tropoelastin associates with microfibrils1.00
    		Elastin cross-linking by lysyl oxidase0.55
    3Notch signaling pathway
    		Notch signaling pathway1.00
    4Collagen formation
    		Extracellular matrix organization0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MFAP2 
        Notch signaling pathway

    5        Reactome Pathways for MFAP2
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Elastic fibre formation
    Tropoelastin associates with microfibrils
    Elastin cross-linking by lysyl oxidase



    MFAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MFAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for MFAP2 (P550013 ENSP000003646854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BGNP218103, ENSP000003273364I2D: score=2 STRING: ENSP00000327336
    FBN2P355563, ENSP000002624644I2D: score=1 STRING: ENSP00000262464
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
    COL4A3Q019553, ENSP000003798234I2D: score=3 STRING: ENSP00000379823
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030220platelet formation IEA--


    MFAP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MFAP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MFAP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MFAP2
    4 Novoseek chemical compound relationships for MFAP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 29.8 1 14578398 (1)
    proline 19.8 2 8557636 (1), 11723825 (1)
    gold 11.7 1 8985131 (1)
    tyrosine 0 3 11284693 (2), 7961786 (1)

    Search CenterWatch for drugs/clinical trials and news about MFAP2 

    Transcripts
    for MFAP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MFAP2 gene (4 alternative transcripts): 
    NM_001135247.1  NM_001135248.1  NM_002403.3  NM_017459.2  

    Unigene Cluster for MFAP2:

    Microfibrillar-associated protein 2
    Hs.389137  [show with all ESTs]
    Unigene Representative Sequence: BC028033
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375535(uc001azw.3 uc001azx.3 uc001azy.3 uc010ocl.2)
    ENST00000490075 ENST00000375534 ENST00000476788 ENST00000478684 ENST00000492598
    ENST00000438542

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MFAP2:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1207-3p hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: MFAP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MFAP2 (see all 7)
    OriGene shRNA RFP: MFAP2
    OriGene siRNA: MFAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MFAP2
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MFAP2

    Additional cDNA sequence: 

    AK222751.1 BC015039.1 BC028033.1 CR407678.1 U19718.1 

    10 DOTS entries:

    DT.448848  DT.97820931  DT.97795411  DT.91748612  DT.100714835  DT.100810700  DT.95162772  DT.121394746 
    DT.91748607  DT.95261000 

    24/192 AceView cDNA sequences (see all 192):

    N86551 AA359221 BM712871 AL553496 AA341820 CR619798 AA317293 CR619947 
    AI149517 BG720193 AI262436 AI741278 AI990853 BM673729 AA329559 AI280922 
    CR590231 AU280150 BF435957 BC028033 CR597163 AL712483 BU849854 AI394109 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MFAP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                              -     -                           
    SP2:                                                              -     -                           
    SP3:                                                              -     -                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MFAP2

    Expression
    for MFAP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MFAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCACCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MFAP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See MFAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MFAP2

    SOURCE GeneReport for Unigene cluster: Hs.389137
        SABiosciences Custom PCR Arrays for MFAP2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP2

    Orthologs
    for MFAP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MFAP2 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008585551 microfibrillar-associated protein 2-like 73.48(n)
    75.69(a)    		   100858555  XM_003642512.1  XP_003642560.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia mfap2-prov2 microfibrillar-associated protein 2 78.03(n)    BC041238.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mfap21 microfibrillar-associated protein 2 66.03(n)
    67.31(a)    		   556677  NM_001039357.1  NP_001034446.1 


    ENSEMBL Gene Tree for MFAP2 (if available)
    TreeFam Gene Tree for MFAP2 (if available) 

    Paralogs
    for MFAP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MFAP2 gene
    MFAP52  
    2 SIMAP similar genes for MFAP2 using alignment to 1 protein entry:     MFAP2_HUMAN:
    MFAP5    MAGP2

    MFAP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MFAP2
    PGOHUM00000245290


    Genomic Variants
    for MFAP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 NCBI SNPs in MFAP2 are shown (see all 157)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs557383281,2
    		C--15544686(-) TTGGGA/GAGTTG 4 -- ds50010--------
    rs563781381,2
    		C--15544798(-) GTGAGC/TACATT 4 -- ds50010--------
    rs9102141,2
    		C,F,O,A--15545074(-) AGATCA/GAGTCA 4 -- ds500110Minor allele frequency- C:0.04NA EA 357
    rs558354421,2
    		C--15545128(+) CCATGC/TCCACG 4 -- ut310--------
    rs10512251,2
    		C,F--15545307(-) GGCACA/GATGGG 4 -- ut31 ese34Minor allele frequency- G:0.45MN NA 190
    rs617384871,2
    		F--15545530(+) GAGGCC/TGCCAC 8 A syn11Minor allele frequency- T:0.28NS 76
    rs561907651,2
    		C--15545615(-) CTCCTC/TCCTGC 4 -- int10--------
    rs561247481,2
    		C--15545625(+) GGCAGA/GGTCAG 4 -- int10--------
    rs779877171,2
    		--15546087(+) TCAACC/TACAGA 4 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs740583551,2
    		C,--15546390(+) AGGGCC/TTAGTC 4 -- int13Minor allele frequency- T:0.21WA CSA 122

    HapMap Linkage Disequilibrium report for MFAP2 (17300997 - 17308081 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MFAP2
         4 CNVs: 4212 2301 3284 4211

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    Disorders / Diseases
    for MFAP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MFAP2 for disorders           About GeneDecksing

    OMIM gene information: 156790    OMIM disorders: --

    6 diseases for MFAP2:    About MalaCards
    connective tissue disease    buphthalmos    costello syndrome    glaucoma
    polyneuropathy    tuberculosis

    1 Novoseek disease relationship for MFAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    connective tissue diseases 35.1 2 7759096 (1)

    Human Genome Epidemiology (HuGE) Navigator: MFAP2 (1 document)

    Export disorders for MFAP2 gene to outside databases

    Publications
    for MFAP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MFAP2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with MFAP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170. (PubMed id 7759096)1, 2, 3, 9 Faraco J.... Francke U. (1995)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. (PubMed id 9278443)1, 9 Finnis M.L. and Gibson M.A. (1997)
    5. Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. (PubMed id 11481325)1, 9 Jensen S.A....Weiss A.S. (2001)
    6. Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. (PubMed id 10664011)1, 9 Fujimoto N....Ishibashi A. (2000)
    7. Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. (PubMed id 15233806)1, 9 Clarke A.W. and Weiss A.S. (2004)
    8. Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). (PubMed id 11284693)1, 9 Trask B.C....Mecham R.P. (2001)
    9. The intracellular form of human MAGP1 elicits a complex and specific transcriptional response. (PubMed id 17692555)1, 9 Segade F....Mecham R.P. (2007)
    10. Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly. (PubMed id 8761465)1, 9 Brown-Augsburger P....Mecham R.P. (1996)

    External Searches for MFAP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MFAP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4237 HGNC: 7033 AceView: MFAP2 Ensembl:ENSG00000117122 euGenes: HUgn4237
    ECgene: MFAP2 H-InvDB: MFAP2

    Other Databases showing MFAP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MFAP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MFAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MFAP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MFAP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MFAP2 gene:
    Search GeneIP for patents involving MFAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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