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Aliases for MFAP1 Gene

Aliases for MFAP1 Gene

  • Microfibrillar Associated Protein 1 2 3 5

External Ids for MFAP1 Gene

Previous GeneCards Identifiers for MFAP1 Gene

  • GC15M039463
  • GC15M036992
  • GC15M041675
  • GC15M041812
  • GC15M041884
  • GC15M044096
  • GC15M020919

Summaries for MFAP1 Gene

GeneCards Summary for MFAP1 Gene

MFAP1 (Microfibrillar Associated Protein 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for MFAP1 Gene

  • Component of the elastin-associated microfibrils.

Gene Wiki entry for MFAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP1 Gene

Genomics for MFAP1 Gene

Regulatory Elements for MFAP1 Gene

Promoters for MFAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MFAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MFAP1 Gene

Chromosome:
15
Start:
43,804,492 bp from pter
End:
43,824,802 bp from pter
Size:
20,311 bases
Orientation:
Minus strand

Genomic View for MFAP1 Gene

Genes around MFAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP1 Gene

Proteins for MFAP1 Gene

  • Protein details for MFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55081-MFAP1_HUMAN
    Recommended name:
    Microfibrillar-associated protein 1
    Protein Accession:
    P55081
    Secondary Accessions:
    • Q86TG6

    Protein attributes for MFAP1 Gene

    Size:
    439 amino acids
    Molecular mass:
    51958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFAP1 Gene

Proteomics data for MFAP1 Gene at MOPED

Post-translational modifications for MFAP1 Gene

  • Ubiquitination at Lys 357, Lys 376, Lys 381, Lys 390, and Lys 415
  • Modification sites at PhosphoSitePlus

Other Protein References for MFAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MFAP1

No data available for DME Specific Peptides for MFAP1 Gene

Domains & Families for MFAP1 Gene

Protein Domains for MFAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55081

UniProtKB/Swiss-Prot:

MFAP1_HUMAN :
  • Belongs to the MFAP1 family.
Family:
  • Belongs to the MFAP1 family.
genes like me logo Genes that share domains with MFAP1: view

No data available for Gene Families for MFAP1 Gene

Function for MFAP1 Gene

Molecular function for MFAP1 Gene

GENATLAS Biochemistry:
microfibrillar associated glycoprotein 1,54kDa,located in non elastic fibrils of ocular zonules
UniProtKB/Swiss-Prot Function:
Component of the elastin-associated microfibrils.
genes like me logo Genes that share phenotypes with MFAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MFAP1 Gene

Localization for MFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFAP1 Gene COMPARTMENTS Subcellular localization image for MFAP1 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MFAP1 Gene

Pathways & Interactions for MFAP1 Gene

genes like me logo Genes that share pathways with MFAP1: view

Pathways by source for MFAP1 Gene

Gene Ontology (GO) - Biological Process for MFAP1 Gene

None

No data available for SIGNOR curated interactions for MFAP1 Gene

Drugs & Compounds for MFAP1 Gene

No Compound Related Data Available

Transcripts for MFAP1 Gene

mRNA/cDNA for MFAP1 Gene

Unigene Clusters for MFAP1 Gene

Microfibrillar-associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP1 Gene

No ASD Table

Relevant External Links for MFAP1 Gene

GeneLoc Exon Structure for
MFAP1
ECgene alternative splicing isoforms for
MFAP1

Expression for MFAP1 Gene

mRNA expression in normal human tissues for MFAP1 Gene

Protein differential expression in normal tissues from HIPED for MFAP1 Gene

This gene is overexpressed in Esophagus (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFAP1 Gene



SOURCE GeneReport for Unigene cluster for MFAP1 Gene Hs.61418

genes like me logo Genes that share expression patterns with MFAP1: view

Protein tissue co-expression partners for MFAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFAP1 Gene

Orthologs for MFAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFAP1 35
  • 99.85 (n)
  • 100 (a)
MFAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFAP1 36
  • 99 (a)
OneToOne
MFAP1 35
  • 93.24 (n)
  • 98.86 (a)
dog
(Canis familiaris)
Mammalia MFAP1 35
  • 94.23 (n)
  • 100 (a)
MFAP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfap1b 16
Mfap1a 36
  • 100 (a)
OneToMany
Mfap1b 36
  • 100 (a)
OneToMany
Mfap1a 35
  • 91.19 (n)
  • 99.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MFAP1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfap1a 35
  • 91.88 (n)
  • 99.54 (a)
chicken
(Gallus gallus)
Aves MFAP1 36
  • 95 (a)
OneToOne
MFAP1 35
  • 80.56 (n)
  • 94.99 (a)
lizard
(Anolis carolinensis)
Reptilia MFAP1 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mfap1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap1 35
  • 76.81 (n)
  • 89.24 (a)
Str.8236 35
zebrafish
(Danio rerio)
Actinopterygii mfap1 36
  • 83 (a)
OneToOne
mfap1 35
  • 73.17 (n)
  • 81.42 (a)
zgc56551 35
fruit fly
(Drosophila melanogaster)
Insecta Mfap1 36
  • 53 (a)
OneToOne
CG1017 37
  • 60 (a)
Mfap1 35
  • 58.64 (n)
  • 57.8 (a)
worm
(Caenorhabditis elegans)
Secernentea mfap-1 35
  • 58.74 (n)
  • 53.63 (a)
mfap-1 36
  • 41 (a)
OneToOne
F43G9.10 37
  • 52 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12928 35
rice
(Oryza sativa)
Liliopsida Os02g0280100 35
  • 49.21 (n)
  • 42.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4749 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9241 36
  • 51 (a)
OneToOne
Species with no ortholog for MFAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFAP1 Gene

ENSEMBL:
Gene Tree for MFAP1 (if available)
TreeFam:
Gene Tree for MFAP1 (if available)

Paralogs for MFAP1 Gene

Pseudogenes.org Pseudogenes for MFAP1 Gene

genes like me logo Genes that share paralogs with MFAP1: view

No data available for Paralogs for MFAP1 Gene

Variants for MFAP1 Gene

Sequence variations from dbSNP and Humsavar for MFAP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs671112 -- 43,813,714(+) accat(A/C)ttggc intron-variant
rs693919 -- 43,810,130(-) AGAAT(C/T)AACTT intron-variant
rs2930529 -- 43,819,467(+) TTTTT(A/T)AAAAA intron-variant
rs2930530 -- 43,823,268(+) ggtgt(A/G)agcca intron-variant
rs3736180 -- 43,814,426(+) AAGAC(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFAP1 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850

Variation tolerance for MFAP1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MFAP1 Gene

HapMap Linkage Disequilibrium report
MFAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP1 Gene

Disorders for MFAP1 Gene

Relevant External Links for MFAP1

Genetic Association Database (GAD)
MFAP1
Human Genome Epidemiology (HuGE) Navigator
MFAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MFAP1

No disorders were found for MFAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFAP1 Gene

Publications for MFAP1 Gene

  1. Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21. (PMID: 7835894) Yeh H. … Rosenbloom J. (Genomics 1994) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for MFAP1 Gene

Sources for MFAP1 Gene

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