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Aliases for MFAP1 Gene

Aliases for MFAP1 Gene

  • Microfibrillar-Associated Protein 1 2 3

External Ids for MFAP1 Gene

Summaries for MFAP1 Gene

GeneCards Summary for MFAP1 Gene

MFAP1 (Microfibrillar-Associated Protein 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation.

UniProtKB/Swiss-Prot for MFAP1 Gene

  • Component of the elastin-associated microfibrils

Gene Wiki entry for MFAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP1 Gene

Genomics for MFAP1 Gene

Genomic Location for MFAP1 Gene

Start:
43,804,492 bp from pter
End:
43,824,802 bp from pter
Size:
20,311 bases
Orientation:
Minus strand

Genomic View for MFAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP1 Gene

Regulatory Elements for MFAP1 Gene

Proteins for MFAP1 Gene

  • Protein details for MFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55081-MFAP1_HUMAN
    Recommended name:
    Microfibrillar-associated protein 1
    Protein Accession:
    P55081
    Secondary Accessions:
    • Q86TG6

    Protein attributes for MFAP1 Gene

    Size:
    439 amino acids
    Molecular mass:
    51958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFAP1 Gene

Proteomics data for MFAP1 Gene at MOPED

Post-translational modifications for MFAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys357, Lys376, Lys381, Lys390, and Lys415

Other Protein References for MFAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MFAP1 Gene

Domains for MFAP1 Gene

Protein Domains for MFAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55081

UniProtKB/Swiss-Prot:

MFAP1_HUMAN
Family:
  • Belongs to the MFAP1 family.:
    • P55081
genes like me logo Genes that share domains with MFAP1: view

No data available for Gene Families for MFAP1 Gene

Function for MFAP1 Gene

Molecular function for MFAP1 Gene

GENATLAS Biochemistry: microfibrillar associated glycoprotein 1,54kDa,located in non elastic fibrils of ocular zonules
UniProtKB/Swiss-Prot Function: Component of the elastin-associated microfibrils

Gene Ontology (GO) - Molecular Function for MFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MFAP1: view
genes like me logo Genes that share phenotypes with MFAP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MFAP1 Gene

Localization for MFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MFAP1 Gene COMPARTMENTS Subcellular localization image for MFAP1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001527 microfibril IDA 1374398
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with MFAP1: view

Pathways for MFAP1 Gene

genes like me logo Genes that share pathways with MFAP1: view

Pathways by source for MFAP1 Gene

Gene Ontology (GO) - Biological Process for MFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with MFAP1: view

Transcripts for MFAP1 Gene

mRNA/cDNA for MFAP1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MFAP1 Gene

Microfibrillar-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP1 Gene

No ASD Table

Relevant External Links for MFAP1 Gene

GeneLoc Exon Structure for
MFAP1
ECgene alternative splicing isoforms for
MFAP1

Expression for MFAP1 Gene

mRNA expression in normal human tissues for MFAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MFAP1 Gene

SOURCE GeneReport for Unigene cluster for MFAP1 Gene Hs.61418

genes like me logo Genes that share expressions with MFAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MFAP1 Gene

Orthologs for MFAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MFAP1 35
  • 99.85 (n)
  • 100 (a)
MFAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MFAP1 35
  • 93.24 (n)
  • 98.86 (a)
MFAP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MFAP1 35
  • 94.23 (n)
  • 100 (a)
MFAP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mfap1a 35
  • 91.19 (n)
  • 99.54 (a)
Mfap1a 16
Mfap1a 36
  • 100 (a)
OneToMany
Mfap1b 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MFAP1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mfap1a 35
  • 91.88 (n)
  • 99.54 (a)
chicken
(Gallus gallus)
Aves MFAP1 35
  • 80.56 (n)
  • 94.99 (a)
MFAP1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MFAP1 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mfap1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap1 35
  • 76.81 (n)
  • 89.24 (a)
Str.8236 35
zebrafish
(Danio rerio)
Actinopterygii mfap1 35
  • 73.17 (n)
  • 81.42 (a)
mfap1 36
  • 83 (a)
OneToOne
zgc56551 35
fruit fly
(Drosophila melanogaster)
Insecta Mfap1 35
  • 58.64 (n)
  • 57.8 (a)
Mfap1 36
  • 53 (a)
OneToOne
CG1017 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea mfap-1 35
  • 58.74 (n)
  • 53.63 (a)
mfap-1 36
  • 41 (a)
OneToOne
F43G9.10 37
  • 52 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12928 35
rice
(Oryza sativa)
Liliopsida Os02g0280100 35
  • 49.21 (n)
  • 42.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4749 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9241 36
  • 51 (a)
OneToOne
Species with no ortholog for MFAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFAP1 Gene

ENSEMBL:
Gene Tree for MFAP1 (if available)
TreeFam:
Gene Tree for MFAP1 (if available)

Paralogs for MFAP1 Gene

Pseudogenes.org Pseudogenes for MFAP1 Gene

genes like me logo Genes that share paralogs with MFAP1: view

No data available for Paralogs for MFAP1 Gene

Variants for MFAP1 Gene

Sequence variations from dbSNP and Humsavar for MFAP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs534638 -- 43,824,677(-) GCGCA(C/G)GTGTG utr-variant-5-prime
rs575082 -- 43,817,944(+) TACCT(A/G)TTTCT intron-variant
rs617233 -- 43,824,677(+) ACACA(C/G)CTGCG utr-variant-5-prime
rs663214 -- 43,821,584(+) AAAAA(G/T)CAGTA intron-variant
rs671112 -- 43,813,714(+) accat(A/C)ttggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MFAP1 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850

Relevant External Links for MFAP1 Gene

HapMap Linkage Disequilibrium report
MFAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP1 Gene

Disorders for MFAP1 Gene

Relevant External Links for MFAP1

Genetic Association Database (GAD)
MFAP1
Human Genome Epidemiology (HuGE) Navigator
MFAP1
genes like me logo Genes that share disorders with MFAP1: view

No data available for UniProtKB/Swiss-Prot for MFAP1 Gene

Publications for MFAP1 Gene

  1. Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21. (PMID: 7835894) Yeh H. … Rosenbloom J. (Genomics 1994) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PMID: 21319273) Neganova I. … Lako M. (Stem Cells 2011) 3

Products for MFAP1 Gene

Sources for MFAP1 Gene

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