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MFAP1 Gene

protein-coding   GIFtS: 56
GCID: GC15M044096

Microfibrillar-Associated Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microfibrillar-Associated Protein 11 2

External Ids:    HGNC: 70321   Entrez Gene: 42362   Ensembl: ENSG000001402597   OMIM: 6002155   UniProtKB: P550813   

Export aliases for MFAP1 gene to outside databases

Previous GC identifers: GC15M039463 GC15M036992 GC15M041675 GC15M041812 GC15M041884 GC15M020919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MFAP1 Gene:
MFAP1 (microfibrillar-associated protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: MFAP1_HUMAN, P55081
Function: Component of the elastin-associated microfibrils

Gene Wiki entry for MFAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MFAP1 gene promoter:
         c-Fos   NF-1   NF-1/L   JunB   Fra-1   FosB   JunD   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMFAP1 promoter sequence
   Search Chromatin IP Primers for MFAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MFAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15-q21   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15-q21

MFAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MFAP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M044096:  view genomic region     (about GC identifiers)

Start:
44,096,690 bp from pter      End:
44,117,000 bp from pter
Size:
20,311 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MFAP1_HUMAN, P55081 (See protein sequence)
Recommended Name: Microfibrillar-associated protein 1  
Size: 439 amino acids; 51958 Da
Secondary accessions: Q86TG6

Explore the universe of human proteins at neXtProt for MFAP1: NX_P55081

Explore proteomics data for MFAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys357, Lys376, Lys381, Lys390, Lys415
  • Modification sites at PhosphoSitePlus

  • See MFAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005917.2  
    ENSEMBL proteins: 
     ENSP00000267812  
    Reactome Protein details: P55081

    MFAP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009730 MFAP1_C

    Graphical View of Domain Structure for InterPro Entry P55081

    ProtoNet protein and cluster: P55081

    UniProtKB/Swiss-Prot: MFAP1_HUMAN, P55081
    Similarity: Belongs to the MFAP1 family


    Find genes that share domains with MFAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MFAP1_HUMAN, P55081
    Function: Component of the elastin-associated microfibrils

         Genatlas biochemistry entry for MFAP1:
    microfibrillar associated glycoprotein 1,54kDa,located in non elastic fibrils of ocular zonules

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MFAP1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for MFAP1:
     Abundance of large cells with   Cell division defect  Decreased cell number, increas  Decreased influenza A virus in 
     Decreased viability of wild-ty  G0/1 arrest  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MFAP1
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    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MFAP1:
    hsa-miR-520f hsa-miR-581 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMFAP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MFAP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MFAP1_HUMAN, P55081: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001527microfibril IDA1374398
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with MFAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MFAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Elastic fibre formation
    Elastic fibre formation0.73
    Molecules associated with elastic fibres0.73
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with MFAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MFAP1
        Molecules associated with elastic fibres


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MFAP1
    Interactions:

        Search GeneGlobe Interaction Network for MFAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MFAP1 (P550811, 2, 3 ENSP000002678124) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKQ131231, 2, ENSP000003963014EBI-1048159,EBI-713456 MINT-8332251 MINT-8337409 STRING: ENSP00000396301
    YWHAGP619812, 3, ENSP000003063304MINT-50820 I2D: score=4 STRING: ENSP00000306330
    PRPF3O433951, 2, ENSP000003153794EBI-1048159,EBI-744322 MINT-8331701 MINT-8336419 STRING: ENSP00000315379
    PRPF38AQ8NAV13, ENSP000002571814I2D: score=2 STRING: ENSP00000257181
    GIT1Q9Y2X73, ENSP000003783384I2D: score=1 STRING: ENSP00000378338
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with MFAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MFAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MFAP1 gene: 
    NM_005926.2  

    Unigene Cluster for MFAP1:

    Microfibrillar-associated protein 1
    Hs.61418  [show with all ESTs]
    Unigene Representative Sequence: NM_005926
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267812(uc001zth.1) ENST00000484386
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MFAP1:
    hsa-miR-520f hsa-miR-581 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMFAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MFAP1
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    Primer
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    OriGene qPCR primer pairs and template standards for MFAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MFAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MFAP1
      QuantiTect SYBR Green Assays in human, mouse, rat MFAP1
      QuantiFast Probe-based Assays in human, mouse, rat MFAP1

    Additional mRNA sequence: 

    AK312867.1 BC023557.2 BC050742.1 U04209.1 

    11 DOTS entries:

    DT.412514  DT.100794705  DT.95376398  DT.91754608  DT.95328562  DT.100794701  DT.100794707  DT.121064892 
    DT.86852240  DT.95376395  DT.97771513 

    Selected AceView cDNA sequences (see all 185):

    AI282951 BE886323 BE504960 BU554087 BQ638299 BF197395 BE348695 NM_005926 
    AW304783 BU161359 CR603002 BM550744 BQ056767 BC023557 CB159009 AI288473 
    AA315627 AI753612 AI608759 BP372999 BM807546 BM662222 BE467592 BG116731 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MFAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAAATA
    MFAP1 Expression
    About this image

    MFAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MFAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.61418
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MFAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MFAP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfap1a1 , 5 microfibrillar-associated protein 1A1, 5 91.19(n)1
    99.54(a)1
      2 (60.40 cM)5
    675321  NM_026220.41  NP_080496.11 
     1214919115 
    chicken
    (Gallus gallus)
    Aves MFAP11 microfibrillar-associated protein 1 80.56(n)
    94.99(a)
      415586  NM_001256948.1  NP_001243877.1 
    lizard
    (Anolis carolinensis)
    Reptilia MFAP16
    microfibrillar-associated protein 1
    93(a)
    1 ↔ 1
    GL343759.1(177289-186315)
    African clawed frog
    (Xenopus laevis)
    Amphibia mfap1-prov2 microfibrillar-associated protein 1 77.38(n)    BC044036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565512 similar to microfibrillar-associated protein 1 76.89(n)   393992  BC052118.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG10173
    Mfap11
    Microfibril-associated protein 11 60(a)3
    58.64(n)1
    57.8(a)1
      62B113
    382561  NM_139422.31  NP_647679.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F43G9.103
    mfap-11
    MICROFIBRILLAR-ASSOCIATED PROTEIN 1
    (ASSOCIATED more3
    mfap-11
    52(a)3
    58.74(n)1
    53.63(a)1
      I(8646658-8648295)3
    1726611  NM_059939.51  NP_492340.11 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.129282 Vitis vinifera transcribed sequence with moderate similarity more 72.02(n)    CB979492.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02801001 Os02g0280100 49.21(n)
    42.43(a)
      4329017  NM_001053088.1  NP_001046553.1 


    ENSEMBL Gene Tree for MFAP1 (if available)
    TreeFam Gene Tree for MFAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MFAP1 gene

    Find genes that share paralogs with MFAP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MFAP1
    PGOHUM00000248352


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MFAP1 (see all 413)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379442121,2
    --44096256(+) AGGCAC/TTCTAG 1 -- ds50010--------
    rs2002270021,2
    C--44096287(+) CTTTA-/AAAC  
            
    AAACA
    1 -- ds50010--------
    rs720655481,2
    C--44096303(+) CAAAC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs762387601,2
    C,F--44096454(+) TACCTG/ATGTTC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1841339661,2
    --44096466(+) TCTTTA/GTGTAT 1 -- ds50010--------
    rs1444294121,2
    C--44096520(+) ACACT-/AAACTA 1 -- ds50010--------
    rs1432117411,2
    --44096731(+) TTAATA/TCTTGT 1 -- ds50010--------
    rs1387541821,2
    --44096781(+) TCCTTG/TTTGTG 1 -- ut310--------
    rs10485251,2
    C,H--44096787(-) GAATCA/CCACAA 1 -- ut313Minor allele frequency- C:0.01NS NA 174
    rs774291341,2
    C,F--44096862(+) CAAGCA/GAAAAT 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for MFAP1 (44096690 - 44117000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MFAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv742e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MFAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MFAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600215    OMIM disorders: --


    Find genes that share disorders with MFAP1           About GenesLikeMe

    Genetic Association Database (GAD): MFAP1
    Human Genome Epidemiology (HuGE) Navigator: MFAP1 (3 documents)

    Export disorders for MFAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MFAP1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with MFAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21. (PubMed id 7835894)1, 2, 3 Yeh H.... Rosenbloom J. (Genomics 1994)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4236 HGNC: 7032 AceView: MFAP1 Ensembl:ENSG00000140259 euGenes: HUgn4236
    ECgene: MFAP1 H-InvDB: MFAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MFAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MFAP1 gene:
    Search GeneIP for patents involving MFAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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